生体分子情報学

研究成果 1992 2019

2011
56 引用 (Scopus)

D-Amino acid metabolism in mammals: Biosynthesis, degradation and analytical aspects of the metabolic study

Ohide, H., Miyoshi, Y., Maruyama, R., Hamase, K. & Konno, R., 11 1 2011, : : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 29, p. 3162-3168 7 p.

研究成果: ジャーナルへの寄稿評論記事

Mammals
Biosynthesis
Metabolism
Aspartic Acid
Amino Acids
99 引用 (Scopus)

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

Kaku, T., Hitaka, T., Ojida, A., Matsunaga, N., Adachi, M., Tanaka, T., Hara, T., Yamaoka, M., Kusaka, M., Okuda, T., Asahi, S., Furuya, S. & Tasaka, A., 11 1 2011, : : Bioorganic and Medicinal Chemistry. 19, 21, p. 6383-6399 17 p.

研究成果: ジャーナルへの寄稿記事

Steroid 17-alpha-Hydroxylase
Prostatic Neoplasms
Derivatives
Phase III Clinical Trials
Dehydroepiandrosterone
91 引用 (Scopus)

D-Serine regulates cerebellar LTD and motor coordination through the δ glutamate receptor

Kakegawa, W., Miyoshi, Y., Hamase, K., Matsuda, S., Matsuda, K., Kohda, K., Emi, K., Motohashi, J., Konno, R., Zaitsu, K. & Yuzaki, M., 5 1 2011, : : Nature Neuroscience. 14, 5, p. 603-613 11 p.

研究成果: ジャーナルへの寄稿記事

Glutamate Receptors
Cerebellum
Serine
Neuronal Plasticity
Purkinje Cells
8 引用 (Scopus)

Enantioselective micro-2D-HPLC determination of aspartic acid in the pineal glands of rodents with various melatonin contents

Han, H., Miyoshi, Y., Oyama, T., Konishi, R., Mita, M. & Hamase, K., 10 1 2011, : : Journal of Separation Science. 34, 20, p. 2847-2853 7 p.

研究成果: ジャーナルへの寄稿記事

D-Aspartic Acid
Melatonin
Aspartic Acid
Acids
Rodentia
10 引用 (Scopus)

Flavone-catalyzed apoptosis in Scutellaria baicalensis

Hirunuma, M., Shoyama, Y., Tabata, K., Sakamoto, S., Taura, F., Shoyama, Y., Tanaka, H. & Morimoto, S., 6 1 2011, : : Phytochemistry. 72, 8, p. 752-760 9 p.

研究成果: ジャーナルへの寄稿記事

flavone
Scutellaria baicalensis
flavones
Scutellaria
apoptosis
3 引用 (Scopus)

Fluorescence properties of 2-aryl substituted indoles

Nakazono, M., Saita, K., Oshikawa, Y., Tani, K., Nanbu, S. & Zaitsu, K., 2 1 2011, : : Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 78, 2, p. 905-908 4 p.

研究成果: ジャーナルへの寄稿記事

Indoles
indoles
Fluorescence
fluorescence
Anthracene
13 引用 (Scopus)
Alanine Racemase
Molting
Alanine
High Pressure Liquid Chromatography
Tissue
33 引用 (Scopus)

In vivo imaging of mitochondrial function in methamphetamine-treated rats

Shiba, T., Yamato, M., Kudo, W., Watanabe, T., Utsumi, H. & Yamada, K-I., 8 1 2011, : : NeuroImage. 57, 3, p. 866-872 7 p.

研究成果: ジャーナルへの寄稿記事

Methamphetamine
Electron Transport
Oxidative Stress
Adenosine Triphosphate
Oxygen
9 引用 (Scopus)

Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

Mito, F., Yamasaki, T., Ito, Y., Yamato, M., Mino, H., Sadasue, H., Shirahama, C., Sakai, K., Utsumi, H. & Yamada, K-I., 5 7 2011, : : Chemical Communications. 47, 17, p. 5070-5072 3 p.

研究成果: ジャーナルへの寄稿記事

Amyloid
Agglomeration
Monitoring
Spin Labels
Paramagnetic resonance
3 引用 (Scopus)

Nifedipine treatment reduces brain damage after transient focal ischemia, possibly through its antioxidative effects

Yamato, M., Shiba, T., Ide, T., Honda, Y., Yamada, K-I. & Tsutsui, H., 7 1 2011, : : Hypertension Research. 34, 7, p. 840-845 6 p.

研究成果: ジャーナルへの寄稿記事

Nifedipine
Ischemia
Middle Cerebral Artery Infarction
Brain
Brain Ischemia
13 引用 (Scopus)

Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats

Deguchi, H., Yasukawa, K., Yamasaki, T., Mito, F., Kinoshita, Y., Naganuma, T., Sato, S., Yamato, M., Ichikawa, K., Sakai, K., Utsumi, H. & Yamada, K-I., 11 1 2011, : : Free Radical Biology and Medicine. 51, 9, p. 1799-1805 7 p.

研究成果: ジャーナルへの寄稿記事

Experimental Arthritis
Indomethacin
Rats
Reactive Oxygen Species
Stomach
17 引用 (Scopus)

Overhauser-enhanced magnetic resonance imaging characterization of mitochondria functional changes in the 6-hydroxydopamine rat model

Yamato, M., Shiba, T., Naganuma, T., Ichikawa, K., Utsumi, H. & Yamada, K-I., 11 1 2011, : : Neurochemistry International. 59, 6, p. 804-811 8 p.

研究成果: ジャーナルへの寄稿記事

Oxidopamine
Oxidation-Reduction
Mitochondria
Magnetic Resonance Imaging
Electron Spin Resonance Spectroscopy
9 引用 (Scopus)

Oxygen concentration dependence of lipid peroxidation and lipid-derived radical generation: Application of profluorescent nitroxide switch

Mito, F., Kitagawa, K., Yamasaki, T., Shirahama, C., Oishi, T., Ito, Y., Yamato, M. & Yamada, K-I., 9 1 2011, : : Free Radical Research. 45, 9, p. 1103-1110 8 p.

研究成果: ジャーナルへの寄稿記事

Lipid Peroxides
Lipid Peroxidation
Switches
Oxygen
Lipids
39 引用 (Scopus)

Simultaneous determination of d-aspartic acid and d-glutamic acid in rat tissues and physiological fluids using a multi-loop two-dimensional HPLC procedure

Han, H., Miyoshi, Y., Ueno, K., Okamura, C., Tojo, Y., Mita, M., Lindner, W., Zaitsu, K. & Hamase, K., 11 1 2011, : : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 29, p. 3196-3202 7 p.

研究成果: ジャーナルへの寄稿記事

Aspartic Acid
Rats
Glutamic Acid
Enantiomers
High Pressure Liquid Chromatography
37 引用 (Scopus)

Simultaneous two-dimensional HPLC determination of free d-serine and d-alanine in the brain and periphery of mutant rats lacking d-amino-acid oxidase

Miyoshi, Y., Hamase, K., Okamura, T., Konno, R., Kasai, N., Tojo, Y. & Zaitsu, K., 11 1 2011, : : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 29, p. 3184-3189 6 p.

研究成果: ジャーナルへの寄稿記事

Alanine
Serine
Rats
Brain
Oxidoreductases
13 引用 (Scopus)

Structural concept of nitroxide as a lipid peroxidation inhibitor

Yamasaki, T., Ito, Y., Mito, F., Kitagawa, K., Matsuoka, Y., Yamato, M. & Yamada, K-I., 5 20 2011, : : Journal of Organic Chemistry. 76, 10, p. 4144-4148 5 p.

研究成果: ジャーナルへの寄稿記事

Thiobarbituric Acid Reactive Substances
Assays
Lipids
lipid peroxidation inhibitor
45 引用 (Scopus)

Structure-reactivity relationship of piperidine nitroxide: Electrochemical, ESR and computational studies

Yamasaki, T., Mito, F., Ito, Y., Pandian, S., Kinoshita, Y., Nakano, K., Murugesan, R., Sakai, K., Utsumi, H. & Yamada, K-I., 1 21 2011, : : Journal of Organic Chemistry. 76, 2, p. 435-440 6 p.

研究成果: ジャーナルへの寄稿記事

Paramagnetic resonance
Molecular orbitals
Screening
Energy gap
Derivatives
2010
6 引用 (Scopus)

6,7-Difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid, a newly designed fluorescence enhancement-type derivatizing reagent for amino compounds

Hirano, J., Hamase, K., Miyata, H. & Zaitsu, K., 3 1 2010, : : Journal of Fluorescence. 20, 2, p. 615-624 10 p.

研究成果: ジャーナルへの寄稿記事

Fluorescence
Derivatives
efficiency
Quantum efficiency
High Pressure Liquid Chromatography
62 引用 (Scopus)

Brain-specific Phgdh deletion reveals a pivotal role for l-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain

Yang, J. H., Wada, A., Yoshida, K., Miyoshi, Y., Sayano, T., Esaki, K., Kinoshita, M. O., Tomonaga, S., Azuma, N., Watanabe, M., Hamase, K., Zaitsu, K., MacHida, T., Messing, A., Itohara, S., Hirabayashi, Y. & Furuya, S., 12 31 2010, : : Journal of Biological Chemistry. 285, 53, p. 41380-41390 11 p.

研究成果: ジャーナルへの寄稿記事

Biosynthesis
N-Methyl-D-Aspartate Receptors
Serine
Brain
Hippocampus

Chemiluminescence enhancement of 1,2-di[3,4,5-tri(3,4,5-trihydroxybenzoyloxy)benzoyloxy] benzene in the presence of quaternary ammonium ions

Nakazono, M., Agawa, H., Nanbu, S. & Zaitsu, K., 9 1 2010, : : Luminescence. 25, 5, p. 360-363 4 p.

研究成果: ジャーナルへの寄稿記事

Chemiluminescence
Choline
Luminescence
Ammonium Compounds
Ions
22 引用 (Scopus)

Determination of reactive oxygen species associated with the degeneration of dopaminergic neurons during dopamine metabolism

Yamato, M., Kudo, W., Shiba, T., Yamada, K-I., Watanabe, T. & Utsumi, H., 3 1 2010, : : Free Radical Research. 44, 3, p. 249-257 9 p.

研究成果: ジャーナルへの寄稿記事

Tyramine
Dopaminergic Neurons
Metabolism
Neurons
Reactive Oxygen Species
20 引用 (Scopus)

Dynamic nuclear polarization studies of redox-sensitive nitroxyl spin probes in liposomal solution

Benial, A. M. F., Utsumi, H., Ichikawa, K., Murugesan, R., Yamada, K-I., Kinoshita, Y., Naganuma, T. & Kato, M., 5 2010, : : Journal of Magnetic Resonance. 204, 1, p. 131-138 8 p.

研究成果: ジャーナルへの寄稿記事

Liposomes
Oxidation-Reduction
Magnetic resonance
Magnetic Resonance Imaging
Electron Spin Resonance Spectroscopy
38 引用 (Scopus)

Effective 2,6-substitution of piperidine nitroxyl radical by carbonyl compound

Sakai, K., Yamada, K-I., Yamasaki, T., Kinoshita, Y., Mito, F. & Utsumi, H., 3 27 2010, : : Tetrahedron. 66, 13, p. 2311-2315 5 p.

研究成果: ジャーナルへの寄稿記事

Carbonyl compounds
Substitution reactions
Contrast Media
Antioxidants
nitroxyl
13 引用 (Scopus)

Fluorescence and chemiluminescence properties of indolylmaleimides: Experimental and theoretical studies

Nakazono, M., Jinguji, A., Nanbu, S., Kuwano, R., Zheng, Z., Saita, K., Oshikawa, Y., Mikuni, Y., Murakami, T., Zhao, Y., Sasaki, S. & Zaitsu, K., 1 1 2010, : : Physical Chemistry Chemical Physics. 12, 33, p. 9783-9793 11 p.

研究成果: ジャーナルへの寄稿記事

Chemiluminescence
chemiluminescence
Fluorescence
indoles
fluorescence
4 引用 (Scopus)

Intramolecular energy transfer in 3-amino-N-(7′-methoxy-4′-methylcoumaryl)phthalimide

Nakazono, M., Saita, K., Kurihara, C., Nanbu, S. & Zaitsu, K., 11 15 2010, : : Journal of Photochemistry and Photobiology A: Chemistry. 208, 1, p. 21-26 6 p.

研究成果: ジャーナルへの寄稿記事

phthalimides
Energy transfer
Fluorescence
energy transfer
fluorescence

In vivo ESR/Spin Probe Technique.

Yasukawa, K., Yamada, K-I., Ichikawa, K. & Utsumi, H., 2010, Westchester Book Service.

研究成果: 著書/レポートタイプ著書

34 引用 (Scopus)

In vivo evaluation of novel nitroxyl radicals with reduction stability

Kinoshita, Y., Yamada, K-I., Yamasaki, T., Mito, F., Yamato, M., Kosem, N., Deguchi, H., Shirahama, C., Ito, Y., Kitagawa, K., Okukado, N., Sakai, K. & Utsumi, H., 12 1 2010, : : Free Radical Biology and Medicine. 49, 11, p. 1703-1709 7 p.

研究成果: ジャーナルへの寄稿記事

Ascorbic Acid
Reducing Agents
Contrast Media
Antioxidants
Acid resistance
20 引用 (Scopus)

Mutant mice and rats lacking D-amino acid oxidase

Konno, R., Hamase, K., Maruyama, R. & Zaitsu, K., 1 1 2010, : : Chemistry and Biodiversity. 7, 6, p. 1450-1458 9 p.

研究成果: ジャーナルへの寄稿評論記事

D-Amino-Acid Oxidase
Amino acids
Rats
Amino Acids
Serine
179 引用 (Scopus)

Rational design of FRET-based ratiometric chemosensors for in vitro and in cell fluorescence analyses of nucleoside polyphosphates

Kurishita, Y., Kohira, T., Ojida, A. & Hamachi, I., 9 29 2010, : : Journal of the American Chemical Society. 132, 38, p. 13290-13299 10 p.

研究成果: ジャーナルへの寄稿記事

Polyphosphates
Fluorescence Resonance Energy Transfer
Nucleosides
Fluorescence
Adenosinetriphosphate
High pressure liquid chromatography
Stereoisomerism
Animals
Amino Acids
57 引用 (Scopus)

Simultaneous determination of hydrophilic amino acid enantiomers in mammalian tissues and physiological fluids applying a fully automated micro-two-dimensional high-performance liquid chromatographic concept

Hamase, K., Miyoshi, Y., Ueno, K., Han, H., Hirano, J., Morikawa, A., Mita, M., Kaneko, T., Lindner, W. & Zaitsu, K., 2 12 2010, : : Journal of Chromatography A. 1217, 7, p. 1056-1062 7 p.

研究成果: ジャーナルへの寄稿記事

Enantiomers
Tissue
Amino Acids
Fluids
Liquids
2009
1 引用 (Scopus)

Analysis of in vivo redox status with magnetic resonance technique

Ichikawa, K., Yamada, K-I., Yasukawa, K. & Utsumi, H., 3 1 2009, : : Yakugaku Zasshi. 129, 3, p. 273-278 6 p.

研究成果: ジャーナルへの寄稿評論記事

Oxidation-Reduction
Magnetic Resonance Spectroscopy
Free Radicals
Pharmaceutical Preparations
Process Assessment (Health Care)
44 引用 (Scopus)

Analysis of small smounts of D-Amino acids and the study of their physiological functions in mammals

Hamase, K., Morikawa, A., Etoh, S., Tojo, Y., Miyoshi, Y. & Zaitsu, K., 1 1 2009, : : analytical sciences. 25, 8, p. 961-968 8 p.

研究成果: ジャーナルへの寄稿評論記事

Mammals
Amino Acids
Enantiomers
Manuscripts
Biomarkers
75 引用 (Scopus)
High performance liquid chromatography
Alanine
Serine
Oxidoreductases
Fluorescence
28 引用 (Scopus)

Development of novel nitroxyl radicals for controlling reactivity with ascorbic acid

Kinoshita, Y., Yamada, K-I., Yamasaki, T., Sadasue, H., Sakai, K. & Utsumi, H., 7 27 2009, : : Free Radical Research. 43, 6, p. 565-571 7 p.

研究成果: ジャーナルへの寄稿記事

Ascorbic Acid
Reducing Agents
Contrast Media
Antioxidants
Radiation-Protective Agents
8 引用 (Scopus)

Efficient silkworm expression of human GPCR (nociceptin receptor) by a Bombyx mori bacmid DNA system

Kajikawa, M., Tabata, K., Wakimoto, Y., Toyooka, M., Motohashi, T., Shimojima, T., Takeda, S., Park, E. Y. & Maenaka, K., 7 31 2009, : : Biochemical and Biophysical Research Communications. 385, 3, p. 375-379 5 p.

研究成果: ジャーナルへの寄稿記事

Bombyx
G-Protein-Coupled Receptors
Nucleopolyhedrovirus
DNA
Fusion reactions
21 引用 (Scopus)

Enantioselective visualization of D-alanine in rat anterior pituitary gland: Localization to ACTH-secreting cells

Etoh, S., Hamase, K., Morikawa, A., Ohgusu, T. & Zaitsu, K., 1 1 2009, : : Analytical and Bioanalytical Chemistry. 393, 1, p. 217-223 7 p.

研究成果: ジャーナルへの寄稿記事

Anterior Pituitary Gland
Alanine
Adrenocorticotropic Hormone
Rats
Visualization
10 引用 (Scopus)

Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1)

Nakamura, S., Kuroki, K., Ohki, I., Tabata, K., Kajikawa, M., Maruyama, T., Ito, M., Kameda, Y., Ikura, M., Yamamoto, K., Matsumoto, N. & Maenaka, K., 10 2 2009, : : Journal of Biological Chemistry. 284, 40, p. 27327-27335 9 p.

研究成果: ジャーナルへの寄稿記事

NK Cell Lectin-Like Receptors
Cadherins
T-cells
Natural Killer T-Cells
Natural Killer Cells
42 引用 (Scopus)

Noninvasive assessment of the brain redox status after transient middle cerebral artery occlusion using Overhauser-enhanced magnetic resonance imaging

Yamato, M., Shiba, T., Yamada, K-I., Watanabe, T. & Utsumi, H., 10 1 2009, : : Journal of Cerebral Blood Flow and Metabolism. 29, 10, p. 1655-1664 10 p.

研究成果: ジャーナルへの寄稿記事

Middle Cerebral Artery Infarction
Reperfusion
Oxidation-Reduction
Magnetic Resonance Imaging
Brain
1 引用 (Scopus)

Rapid separation of hydrophobic compounds by UPLC: In case of bisindolylmaleimides, indolocarbazoles or fullerene C60 derivatives

Nakazono, M., Sato, Y., Hasegawa, S., Arisuda, N., Miyamoto, A. & Zaitsu, K., 9 1 2009, : : Chromatographia. 70, 5-6, p. 933-937 5 p.

研究成果: ジャーナルへの寄稿記事

Derivatives
Fullerenes
Injections
Liquid chromatography
Liquid Chromatography
255 引用 (Scopus)

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

Kiyonaka, S., Kato, K., Nishida, M., Mio, K., Numaga, T., Sawaguchi, Y., Yoshida, T., Wakamori, M., Mori, E., Numata, T., Ishii, M., Takemoto, H., Ojida, A., Watanabe, K., Uemura, A., Kurose, H., Morii, T., Kobayashi, T., Sato, Y., Sato, C. および2人, Hamachi, I. & Mori, Y., 3 31 2009, : : Proceedings of the National Academy of Sciences of the United States of America. 106, 13, p. 5400-5405 6 p.

研究成果: ジャーナルへの寄稿記事

Cardiomegaly
Type C Phospholipases
B-Lymphocytes
Cell Membrane
NFATC Transcription Factors
4 引用 (Scopus)

Separable detection of lipophilic-and hydrophilic-phase free radicals from the ESR spectrum of nitroxyl radical in transient MCAO mice

Yamato, M., Shiba, T., Yamada, K-I., Watanabe, T. & Utsumi, H., 11 30 2009, : : Free Radical Research. 43, 9, p. 844-851 8 p.

研究成果: ジャーナルへの寄稿記事

Middle Cerebral Artery Infarction
Free Radicals
Paramagnetic resonance
Free radical reactions
Reperfusion
13 引用 (Scopus)

Silkworm expression and sugar profiling of human immune cell surface receptor, KIR2DL1

Tabata, K., Kajikawa, M., Kuroki, K., Motohashi, T., Shimojima, T., Park, E. Y., Kondo, S., Yagi, H., Kato, K. & Maenaka, K., 9 25 2009, : : Biochemical and Biophysical Research Communications. 387, 3, p. 575-580 6 p.

研究成果: ジャーナルへの寄稿記事

Bombyx
Cell Surface Receptors
Sugars
Post Translational Protein Processing
Proteins
5 引用 (Scopus)

Simple and rapid genotyping of D-amino acid oxidase gene recognizing a crucial variant in the ddY strain using microchip electrophoresis

Tojo, Y., Hamase, K., Konno, R., Satoru, K., Ohdo, S. & Zaitsu, K., 2 1 2009, : : Journal of Separation Science. 32, 3, p. 430-436 7 p.

研究成果: ジャーナルへの寄稿記事

D-Amino-Acid Oxidase
Electrophoresis
Amino acids
Genes
Amino Acids
43 引用 (Scopus)

Site-specific covalent labeling of His-tag fused proteins with a reactive Ni(ii)-NTA probe

Uchinomiya, S., Nonaka, H., Fujishima, S. H., Tsukiji, S., Ojida, A. & Hamachi, I., 10 12 2009, : : Chemical Communications. 39, p. 5880-5882 3 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Proteins
Histidine
21 引用 (Scopus)

Theoretical study of photophysical properties of bisindolylmaleimide derivatives

Saita, K., Nakazono, M., Zaitsu, K., Nanbu, S. & Sekiya, H., 7 23 2009, : : Journal of Physical Chemistry A. 113, 29, p. 8213-8220 8 p.

研究成果: ジャーナルへの寄稿記事

indoles
Dione
Derivatives
Anions
anions
2008
5 引用 (Scopus)

Analysis of nitroxyl spin probes in mouse brain by X-band ESR with microanalysis technique

Shiba, T., Yamato, M., Kudou, W., Ichikawa, K., Yamada, K-I., Watanabe, T. & Utsumi, H., 1 1 2008, : : Journal of Pharmaceutical Sciences. 97, 9, p. 4101-4107 7 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Brain
Head
Urine
Dialysis Solutions
30 引用 (Scopus)

Automated and simultaneous two-dimensional micro-high-performance liquid chromatographic determination of proline and hydroxyproline enantiomers in mammals

Tojo, Y., Hamase, K., Nakata, M., Morikawa, A., Mita, M., Ashida, Y., Lindner, W. & Zaitsu, K., 11 1 2008, : : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 875, 1, p. 174-179 6 p.

研究成果: ジャーナルへの寄稿記事

Mammals
Enantiomers
Hydroxyproline
Proline
Skin
5 引用 (Scopus)

Chemiluminescence change of polyphenol dendrimers with different core molecules

Agawa, H., Nakazono, M., Nanbu, S. & Zaitsu, K., 12 1 2008, : : Organic Letters. 10, 22, p. 5171-5174 4 p.

研究成果: ジャーナルへの寄稿記事

Dendrimers
Chemiluminescence
chemiluminescence
dendrimers
Polyphenols
17 引用 (Scopus)
Alanine
Rats
Habits
Mammals
Insulin