生体分子情報学

研究成果 1992 2019

フィルター
記事
2019

2-Oxo-histidine-containing dipeptides are functional oxidation products

Ihara, H., Kakihana, Y., Yamakage, A., Kai, K., Shibata, T., Nishida, M., Yamada, K-I. & Uchida, K., 1 1 2019, : : Journal of Biological Chemistry. 294, 4, p. 1279-1289 11 p.

研究成果: ジャーナルへの寄稿記事

Carnosine
Dipeptides
Histidine
Oxidation
Antioxidants

A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats

Shimizu, Y., Yanobu-Takanashi, R., Nakano, K., Hamase, K., Shimizu, T. & Okamura, T., 2 13 2019, : : Mammalian Genome. 30, 1-2, p. 23-33 11 p.

研究成果: ジャーナルへの寄稿記事

Cystine
Kidney
Glucose
Cystinosis
Genes

D -Serine reflects kidney function and diseases

Hesaka, A., Sakai, S., Hamase, K., Ikeda, T., Matsui, R., Mita, M., Horio, M., Isaka, Y. & Kimura, T., 12 1 2019, : : Scientific reports. 9, 1, 5104.

研究成果: ジャーナルへの寄稿記事

公開
Kidney Diseases
Serine
Chronic Renal Insufficiency
Kidney
Amino Acids
1 引用 (Scopus)

In Vivo Imaging of the Intra-and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging

Yasukawa, K., Shigemi, R., Kanbe, T., Mutsumoto, Y., Oda, F., Ichikawa, K., Yamada, K-I., Tun, X. & Utsumi, H., 1 1 2019, : : Antioxidants and Redox Signaling. 30, 9, p. 1147-1161 15 p.

研究成果: ジャーナルへの寄稿記事

Stomach Ulcer
Indomethacin
Oxidation-Reduction
Rats
Stomach
1 引用 (Scopus)

Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model

Emoto, M. C., Sato-Akaba, H., Matsuoka, Y., Yamada, K-I. & Fujii, H. G., 1 18 2019, : : Neuroscience Letters. 690, p. 6-10 5 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Glutathione
Brain
Brain Mapping
Pentylenetetrazole

Optimized reaction pair of the Cyshis tag and Ni(II)-Nta probe for highly selective chemical labeling of membrane proteins

Zenmyo, N., Tokumaru, H., Uchinomiya, S., Fuchida, H., Tabata, S., Hamachi, I., Shigemoto, R. & Ojida, A., 1 1 2019, : : Bulletin of the Chemical Society of Japan. 92, 5, p. 995-1000 6 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Membrane Proteins
Proteins
Cells
Molecular Probes
7 引用 (Scopus)

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

Shindo, N., Fuchida, H., Sato, M., Watari, K., Shibata, T., Kuwata, K., Miura, C., Okamoto, K., Hatsuyama, Y., Tokunaga, K., Sakamoto, S., Morimoto, S., Abe, Y., Shiroishi, M., Caaveiro, J. M. M., Ueda, T., Tamura, T., Matsunaga, N., Nakao, T., Koyanagi, S. および5人, Ohdo, S., Yamaguchi, Y., Hamachi, I., Ono, M. & Ojida, A., 1 14 2019, : : Nature Chemical Biology.

研究成果: ジャーナルへの寄稿記事

Quinazolines
Epidermal Growth Factor Receptor
Cysteine
Phosphotransferases
Hydrolysis
Acridines
Chemiluminescence
Choline
Hydrogen peroxide
Hydrogen Peroxide
2018
1 引用 (Scopus)

Antioxidant nitroxides protect hepatic cells from oxidative stress-induced cell death

Shinto, S., Matsuoka, Y., Yamato, M. & Yamada, K-I., 3 1 2018, : : Journal of Clinical Biochemistry and Nutrition. 62, 2, p. 132-138 7 p.

研究成果: ジャーナルへの寄稿記事

Oxidative stress
Cell death
Hepatocytes
Oxidative Stress
Cell Death
5 引用 (Scopus)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Connexins
varespladib methyl
Astrocytes
Parkinson Disease

Detection and inhibition of redox reaction and lipid derived radicals

Yamada, K-I., 1 1 2018, : : Drug Delivery System. 33, 3, p. 197-203 7 p.

研究成果: ジャーナルへの寄稿記事

Oxidation-Reduction
Lipids
Free Radicals
Animal Models
Carcinogenesis
5 引用 (Scopus)
Amino Acids
Fluids
Liquids
High Pressure Liquid Chromatography
L Forms
2 引用 (Scopus)
Plasma (human)
3-Hydroxybutyric Acid
High performance liquid chromatography
Lactic Acid
Enantiomers
2 引用 (Scopus)

Endogenous Membrane Receptor Labeling by Reactive Cytokines and Growth Factors to Chase Their Dynamics in Live Cells

Takaoka, Y., Uchinomiya, S., Kobayashi, D., Endo, M., Hayashi, T., Fukuyama, Y., Hayasaka, H., Miyasaka, M., Ueda, T., Shimada, I. & Hamachi, I., 6 14 2018, : : Chem. 4, 6, p. 1451-1464 14 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Intercellular Signaling Peptides and Proteins
Cytokines
membrane
Membranes
1 引用 (Scopus)

Enhancement effect on the chemiluminescence of acridinium esters under neutral conditions

Nakazono, M. & Nanbu, S., 3 1 2018, : : Luminescence. 33, 2, p. 345-348 4 p.

研究成果: ジャーナルへの寄稿記事

Chemiluminescence
Luminescence
Esters
Acridines
Derivatives

Fluorescence tumor-imaging using a thermo-responsive molecule with an emissive aminoquinoline derivative

Araki, T., Fuchi, Y., Murayama, S., Shiraishi, R., Oyama, T., Aso, M., Aoki, I., Kobayashi, S., Yamada, K-I. & Karasawa, S., 10 2 2018, : : Nanomaterials. 8, 10, 782.

研究成果: ジャーナルへの寄稿記事

Aminoquinolines
Tumors
Fluorescence
Derivatives
Imaging techniques
3 引用 (Scopus)

Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells

Yamamoto, K., Yasui, H., Bo, T., Yamamori, T., Hiraoka, W., Yamasaki, T., Yamada, K-I. & Inanami, O., 8 1 2018, : : Applied Magnetic Resonance. 49, 8, p. 837-851 15 p.

研究成果: ジャーナルへの寄稿記事

oxygen consumption
electron paramagnetic resonance
respiration
tumors
mitochondria

Gut microbiota-derived D-serine protects against acute kidney injury

Nakade, Y., Iwata, Y., Furuichi, K., Mita, M., Hamase, K., Konno, R., Miyake, T., Sakai, N., Kitajima, S., Toyama, T., Shinozaki, Y., Sagara, A., Miyagawa, T., Hara, A., Shimizu, M., Kamikawa, Y., Sato, K., Oshima, M., Yoneda-Nakagawa, S., Yamamura, Y. および8人, Kaneko, S., Miyamoto, T., Katane, M., Homma, H., Morita, H., Suda, W., Hattori, M. & Wada, T., 10 18 2018, : : JCI insight. 3, 20

研究成果: ジャーナルへの寄稿記事

公開
Acute Kidney Injury
Serine
Kidney
Amino Acids
Dysbiosis
8 引用 (Scopus)

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence

Nishimura, A., Shimauchi, T., Tanaka, T., Shimoda, K., Toyama, T., Kitajima, N., Ishikawa, T., Shindo, N., Numaga-Tomita, T., Yasuda, S., Sato, Y., Kuwahara, K., Kumagai, Y., Akaike, T., Ide, T., Ojida, A., Mori, Y. & Nishida, M., 11 13 2018, : : Science Signaling. 11, 556, eaat5185.

研究成果: ジャーナルへの寄稿記事

Filamins
Dynamins
Actins
Mitochondrial Dynamics
Proteins

Imaging Doxorubicin Free Radical in Mice with Overhauser Enhanced MRI and its Tumor Suppression Effect in Mice

Kato, N., Sato, S., Yamada, K-I. & Ichikawa, K., 8 1 2018, : : Applied Magnetic Resonance. 49, 8, p. 869-879 11 p.

研究成果: ジャーナルへの寄稿記事

free radicals
mice
tumors
retarding
magnetic resonance
2 引用 (Scopus)

Internal-Edge-Substituted Coumarin-Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self-Assembly

Usui, K., Yamamoto, K., Ueno, Y., Igawa, K., Hagihara, R., Masuda, T., Ojida, A., Karasawa, S., Tomooka, K., Hirai, G. & Suemune, H., 10 1 2018, : : Chemistry - A European Journal. 24, 55, p. 14617-14621 5 p.

研究成果: ジャーナルへの寄稿記事

Self assembly
X ray crystallography
Quantum yield
Electronic structure
Physical properties
1 引用 (Scopus)

Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury

Homma, T., Shirato, T., Akihara, R., Kobayashi, S., Lee, J., Yamada, K-I., Miyata, S., Takahashi, M. & Fujii, J., 9 15 2018, : : Toxicology Letters. 294, p. 37-43 7 p.

研究成果: ジャーナルへの寄稿記事

Thioacetamide
Liver
Wounds and Injuries
Metabolites
Cytochrome P-450 CYP2E1
Protein Phosphatase 2
Dextran Sulfate
Toll-Like Receptor 4
Protein Tyrosine Phosphatases
Colitis

Structural and enzymatic properties of mammalian D-glutamate cyclase

Katane, M., Ariyoshi, M., Tateishi, S., Koiwai, S., Takaku, K., Nagai, K., Nakayama, K., Saitoh, Y., Miyamoto, T., Sekine, M., Mita, M., Hamase, K., Matoba, S. & Homma, H., 9 15 2018, : : Archives of Biochemistry and Biophysics. 654, p. 10-18 9 p.

研究成果: ジャーナルへの寄稿記事

Proline
Glutamic Acid
Heart Failure
D-glutamate cyclase
Oligomerization
1 引用 (Scopus)

The first multicenter, randomized, controlled trial of home telemonitoring for Japanese patients with heart failure: home telemonitoring study for patients with heart failure (HOMES-HF)

On Behalf Of The Homes-Hf Study Investigators, 8 1 2018, : : Heart and Vessels. 33, 8, p. 866-876 11 p.

研究成果: ジャーナルへの寄稿記事

Randomized Controlled Trials
Heart Failure
Home Care Services
Physiologic Monitoring
Registries
2017
2 引用 (Scopus)

A host-guest system based on collagen-like triple-helix hybridization

Delsuc, N., Uchinomiya, S., Ojida, A. & Hamachi, I., 1 1 2017, : : Chemical Communications. 53, 51, p. 6856-6859 4 p.

研究成果: ジャーナルへの寄稿記事

Collagen
Proteins
2 引用 (Scopus)

Detection and inhibition of lipid-derived radicals in low-density lipoprotein

Ishida, Y., Okamoto, Y., Matsuoka, Y., Tada, A., Janprasit, J., Yamato, M., Morales, N. P. & Yamada, K-I., 12 1 2017, : : Free Radical Biology and Medicine. 113, p. 487-493 7 p.

研究成果: ジャーナルへの寄稿記事

LDL Lipoproteins
Lipids
Iron
Deferoxamine
Oxidative stress
17 引用 (Scopus)

D -Glutamate is metabolized in the heart mitochondria

Ariyoshi, M., Katane, M., Hamase, K., Miyoshi, Y., Nakane, M., Hoshino, A., Okawa, Y., Mita, Y., Kaimoto, S., Uchihashi, M., Fukai, K., Ono, K., Tateishi, S., Hato, D., Yamanaka, R., Honda, S., Fushimura, Y., Iwai-Kanai, E., Ishihara, N., Mita, M. および2人, Homma, H. & Matoba, S., 3 7 2017, : : Scientific reports. 7, 43911.

研究成果: ジャーナルへの寄稿記事

Heart Mitochondria
Glutamic Acid
glutamate racemase
Amino Acids
Proline
1 引用 (Scopus)

Discovery of highly reactive peptide tag by ELISA-type screening for specific cysteine conjugation

Kurashige, N., Fuchida, H., Tabata, S., Uchinomiya, S. & Ojida, A., 4 18 2017, (受理済み/印刷中) : : Bioorganic and Medicinal Chemistry Letters.

研究成果: ジャーナルへの寄稿記事

Cysteine
Screening
Enzyme-Linked Immunosorbent Assay
Peptides
Labeling

Feasibility of magnetic resonance redox imaging at low magnetic field: Comparison at 1 T and 7 T

Nakamura, M., Shibata, S., Yamasaki, T., Ueno, M., Nakanishi, I., Matsumoto, K. I., Kamada, T., Yamada, K-I. & Aoki, I., 1 1 2017, : : American Journal of Translational Research. 9, 10, p. 4481-4491 11 p., AJTR0054131.

研究成果: ジャーナルへの寄稿記事

Magnetic resonance
Magnetic Fields
Oxidation-Reduction
Magnetic Resonance Imaging
Magnetic fields

Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a)

Homma, T., Akihara, R., Okano, S., Shichiri, M., Yoshida, Y., Yamada, K-I., Miyata, S., Nakajima, O. & Fujii, J., 2 15 2017, : : Behavioural Brain Research. 319, p. 219-224 6 p.

研究成果: ジャーナルへの寄稿記事

Ascorbic Acid
Aggression
Aldehyde Reductase
carbonyl reductase (NADPH)
Social Behavior
10 引用 (Scopus)

Heterogeneity of D-serine distribution in the human central nervous system

Suzuki, M., Imanishi, N., Mita, M., Hamase, K., Aiso, S. & Sasabe, J., 5 1 2017, : : ASN Neuro. 9, 3

研究成果: ジャーナルへの寄稿記事

Serine
Central Nervous System
Cerebrum
4 alpha-glucanotransferase
Neurophysiology
4 引用 (Scopus)

Lipid radicals cause light-induced retinal degeneration

Enoki, M., Shinto, S., Matsuoka, Y., Otsuka, A., Kaidzu, S., Tanito, M., Shibata, T., Uchida, K., Ohira, A., Yamato, M. & Yamada, K-I., 1 1 2017, : : Chemical Communications. 53, 79, p. 10922-10925 4 p.

研究成果: ジャーナルへの寄稿記事

Lipids
Animals
Imaging techniques
Molecules

Lipid radicals cause light-induced retinal degeneration

Enoki, M., Shinto, S., Matsuoka, Y., Otsuka, A., Kaidzu, S., Tanito, M., Shibata, T., Uchida, K., Ohira, A., Yamato, M. & Yamada, K-I., 9 20 2017, : : Chemical Communications.

研究成果: ジャーナルへの寄稿記事

Lipids
Animals
Imaging techniques
Molecules
6 引用 (Scopus)

Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells

Yasui, H., Yamamoto, K., Suzuki, M., Sakai, Y., Bo, T., Nagane, M., Nishimura, E., Yamamori, T., Inanami, O., Yamada, K-I. & Yamasaki, T., 4 1 2017, : : Cancer Letters. 390, p. 160-167 8 p.

研究成果: ジャーナルへの寄稿記事

Energy Metabolism
Radiation
Neoplasms
Adenosine Triphosphate
Cations
8 引用 (Scopus)
Electron Spin Resonance Spectroscopy
Oxidation-Reduction
Glutathione
Paramagnetic resonance
Brain
32 引用 (Scopus)

Reversible ratiometric detection of highly reactive hydropersulfides using a FRET-based dual emission fluorescent probe

Kawagoe, R., Takashima, I., Uchinomiya, S. & Ojida, A., 1 1 2017, : : Chemical Science. 8, 2, p. 1134-1140 7 p.

研究成果: ジャーナルへの寄稿記事

Fluorescent Dyes
Pyronine
Cells
Cell signaling
Mammals
6 引用 (Scopus)

Strongly Chemiluminescent Acridinium Esters under Neutral Conditions: Synthesis, Properties, Determination, and Theoretical Study

Nakazono, M., Oshikawa, Y., Nakamura, M., Kubota, H. & Nanbu, S., 3 3 2017, : : Journal of Organic Chemistry. 82, 5, p. 2450-2461 12 p.

研究成果: ジャーナルへの寄稿記事

Acridines
Chemiluminescence
Esters
Salts
Hydrogen Peroxide
2016
6 引用 (Scopus)

Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress

Akihara, R., Homma, T., Lee, J., Yamada, K-I., Miyata, S. & Fujii, J., 9 16 2016, : : Biochemical and Biophysical Research Communications. 478, 2, p. 765-771 7 p.

研究成果: ジャーナルへの寄稿記事

Aldehyde Reductase
Endoplasmic Reticulum Stress
Oxidative stress
Carbon Tetrachloride
Ablation
19 引用 (Scopus)

A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats

Kimura, S., Inoguchi, T., Yamasaki, T., Yamato, M., Ide, M., Sonoda, N., Yamada, K-I. & Takayanagi, R., 3 1 2016, : : Metabolism: Clinical and Experimental. 65, 3, p. 138-145 8 p.

研究成果: ジャーナルへの寄稿記事

Dipeptidyl-Peptidase IV Inhibitors
Electron Spin Resonance Spectroscopy
Hydroxyl Radical
Dipeptidyl Peptidase 4
Experimental Diabetes Mellitus
5 引用 (Scopus)

A profluorescent nitroxide probe for ascorbic acid detection and its application to quantitative analysis of diabetic rat plasma

Matsuoka, Y., Ohkubo, K., Yamasaki, T., Yamato, M., Ohtabu, H., Shirouzu, T., Fukuzumi, S. & Yamada, K-I., 1 1 2016, : : RSC Advances. 6, 65, p. 60907-60915 9 p.

研究成果: ジャーナルへの寄稿記事

Ascorbic acid
Ascorbic Acid
Rats
Plasmas
Chemical analysis
14 引用 (Scopus)

Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy

Kurahashi, T., Lee, J., Nabeshima, A., Homma, T., Kang, E. S., Saito, Y., Yamada, S., Nakayama, T., Yamada, K-I., Miyata, S. & Fujii, J., 8 15 2016, : : Archives of Biochemistry and Biophysics. 604, p. 36-46 11 p.

研究成果: ジャーナルへの寄稿記事

Autophagy
Acetaminophen
Ascorbic Acid
Glutathione
Recovery
2 引用 (Scopus)

Brain contrasting ability of blood-brain-barrier–permeable nitroxyl contrast agents for magnetic resonance redox imaging

Matsumoto, K. I., Yamasaki, T., Nakamura, M., Ishikawa, J., Ueno, M., Nakanishi, I., Sekita, A., Ozawa, Y., Kamada, T., Aoki, I. & Yamada, K-I., 9 1 2016, : : Magnetic Resonance in Medicine. 76, 3, p. 935-945 11 p.

研究成果: ジャーナルへの寄稿記事

Contrast Media
Oxidation-Reduction
Magnetic Resonance Imaging
Brain
Pharmacokinetics
8 引用 (Scopus)

Cell Surface-Anchored Fluorescent Probe Capable of Real-Time Imaging of Single Mast Cell Degranulation Based on Histamine-Induced Coordination Displacement

Oshikawa, Y., Furuta, K., Tanaka, S. & Ojida, A., 2 2 2016, : : Analytical Chemistry. 88, 3, p. 1526-1529 4 p.

研究成果: ジャーナルへの寄稿記事

Fluorescent Dyes
Histamine
Imaging techniques
Fluorescence
Coloring Agents
39 引用 (Scopus)

Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease

Kimura, T., Hamase, K., Miyoshi, Y., Yamamoto, R., Yasuda, K., Mita, M., Rakugi, H., Hayashi, T. & Isaka, Y., 5 18 2016, : : Scientific reports. 6, 26137.

研究成果: ジャーナルへの寄稿記事

Metabolomics
Chronic Renal Insufficiency
Biomarkers
Amino Acids
Kidney Diseases
8 引用 (Scopus)

Development of pH-Responsive BODIPY Probes for Staining Late Endosome in Live Cells

Miao, F., Uchinomiya, S., Ni, Y., Chang, Y. T. & Wu, J., 11 1 2016, : : ChemPlusChem. 81, 11, p. 1209-1215 7 p.

研究成果: ジャーナルへの寄稿記事

Coloring Agents
Fluorescent Dyes
Fusion reactions
Cells
Infrared radiation
12 引用 (Scopus)

Enantioselective determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice using a two-dimensional high-performance liquid chromatographic system

Koga, R., Miyoshi, Y., Sato, Y., Mita, M., Konno, R., Lindner, W. & Hamase, K., 10 7 2016, : : Journal of Chromatography A. 1467, p. 312-317 6 p.

研究成果: ジャーナルへの寄稿記事

D-Amino-Acid Oxidase
Citrulline
Ornithine
Enantiomers
Urine
13 引用 (Scopus)

Fluorescence probes to detect lipid-derived radicals

Yamada, K-I., Mito, F., Matsuoka, Y., Ide, S., Shikimachi, K., Fujiki, A., Kusakabe, D., Ishida, Y., Enoki, M., Tada, A., Ariyoshi, M., Yamasaki, T. & Yamato, M., 8 1 2016, : : Nature Chemical Biology. 12, 8, p. 608-613 6 p.

研究成果: ジャーナルへの寄稿記事

Fluorescence
Lipids
Diethylnitrosamine
Apoptosis
Inflammation
4 引用 (Scopus)

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Naoya, M., Ikeda, E., Kakimoto, K., Watanabe, M., Shindo, N., Tsuruta, A., Ikeyama, H., Hamamura, K., Higashi, K., Yamashita, T., Kondo, H., Yoshida, Y., Matsuda, M., Ogino, T., Tokushige, K., Itcho, K., Furuichi, Y., Nakao, T., Yasuda, K., Doi, A. および7人, Amamoto, T., Aramaki, H., Makoto, T., Inoue, K., Ojida, A., Satoru, K. & Ohdo, S., 11 1 2016, : : EBioMedicine. 13, p. 262-273 12 p.

研究成果: ジャーナルへの寄稿記事

Chronic Renal Insufficiency
Switches
Inflammation
Kidney
Gene encoding
28 引用 (Scopus)

Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota

Sasabe, J., Miyoshi, Y., Rakoff-Nahoum, S., Zhang, T., Mita, M., Davis, B. M., Hamase, K. & Waldor, M. K., 7 25 2016, : : Nature Microbiology. 1, 16125.

研究成果: ジャーナルへの寄稿記事

Oxidoreductases
Amino Acids
Microbiota
Small Intestine
Gastrointestinal Microbiome