生体分子情報学

研究成果 1992 2019

フィルター
記事
2003
22 引用 (Scopus)

Determination of endogenous melatonin in the individual pineal glands of inbred mice using precolumn oxidation reversed-phase micro-high-performance liquid chromatography

Tomita, T., Hamase, K., Hayashi, H., Fukuda, H., Hirano, J. & Zaitsu, K., 5 15 2003, : : Analytical Biochemistry. 316, 2, p. 154-161 8 p.

研究成果: ジャーナルへの寄稿記事

Pineal Gland
High performance liquid chromatography
Melatonin
High Pressure Liquid Chromatography
Oxidation
4 引用 (Scopus)
Ethyldimethylaminopropyl Carbodiimide
Dendrimers
Chemiluminescence
Cationic surfactants
Luminescence
8 引用 (Scopus)

Lasting chemiluminescence of 3-indoleglyoxylyl chloride and its enhancement

Nakazono, M., Sho, Y. & Zaitsu, K., 1 1 2003, : : analytical sciences. 19, 1, p. 123-127 5 p.

研究成果: ジャーナルへの寄稿記事

Chemiluminescence
Chlorides
Skatole
Cyclodextrins
Bovine Serum Albumin
2004
31 引用 (Scopus)
Mammals
High performance liquid chromatography
Reverse-Phase Chromatography
Melatonin
High Pressure Liquid Chromatography
7 引用 (Scopus)

Assay method for Escherichia coli photolyase activity using single-strand cis-syn cyclobutane pyrimidine dimer DNA as substrate

Nakayama, T., Todo, T., Notsu, S., Nakazono, M. & Zaitsu, K., 6 15 2004, : : Analytical Biochemistry. 329, 2, p. 263-268 6 p.

研究成果: ジャーナルへの寄稿記事

Deoxyribodipyrimidine Photo-Lyase
Pyrimidine Dimers
Escherichia coli
Assays
DNA
14 引用 (Scopus)

Chronopharmacology of Melatonin in Mice to Maximize the Antitumor Effect and Minimize the Rhythm Disturbance Effect

Akagi, T., Ushinohama, K., Ikesue, S., Yukawa, E., Higuchi, S., Hamase, K., Zaitsu, K. & Ohdo, S., 1 1 2004, : : Journal of Pharmacology and Experimental Therapeutics. 308, 1, p. 378-384 7 p.

研究成果: ジャーナルへの寄稿記事

Melatonin
Melatonin Receptors
Light
Inbred ICR Mouse
Suprachiasmatic Nucleus
23 引用 (Scopus)
Mammals
Enantiomers
High performance liquid chromatography
Threonine
High Pressure Liquid Chromatography

Development of selective methods for the determination of small amounts of D-amino acids in mammals

Hamase, K. & Zaitsu, K., 7 1 2004, : : bunseki kagaku. 53, 7, p. 677-690 14 p.

研究成果: ジャーナルへの寄稿記事

Mammals
Alanine
Tissue
Amino Acids
D-Aspartic Acid
16 引用 (Scopus)

In Vivo Measurement of Redox Status in Streptozotocin-Induced Diabetic Rat Using Targeted Nitroxyl Probes

Yamada, K-I., Inoue, D., Matsumoto, S. & Utsumi, H., 1 1 2004, : : Antioxidants and Redox Signaling. 6, 3, p. 605-611 7 p.

研究成果: ジャーナルへの寄稿記事

Streptozocin
Oxidation-Reduction
Rats
Ascorbic Acid
Free radical reactions
292 引用 (Scopus)
Artificial Receptors
Molecular recognition
Titration
Peptides
Zinc
165 引用 (Scopus)

Molecular recognition in a supramolecular hydrogel to afford a semi-wet sensor chip

Yoshimura, I., Miyahara, Y., Kasagi, N., Yamane, H., Ojida, A. & Hamachi, I., 10 6 2004, : : Journal of the American Chemical Society. 126, 39, p. 12204-12205 2 p.

研究成果: ジャーナルへの寄稿記事

Molecular recognition
Hydrogel
Hydrogels
Sensors
Immobilization
10 引用 (Scopus)

Novel stable fluorophore, 6-methoxy-4-quinolone, with strong fluorescence in wide pH range of aqueous media, and its application as a fluorescent labeling reagent

Hirano, J., Hamase, K., Fukuda, H., Tomita, T. & Zaitsu, K., 12 3 2004, : : Journal of Chromatography A. 1059, 1-2, p. 225-231 7 p.

研究成果: ジャーナルへの寄稿記事

Fluorophores
Labeling
Fluorescence
Wavelength
Quantum yield
42 引用 (Scopus)

Pharmacokinetics of a triarylmethyl-type paramagnetic spin probe used in EPR oximetry

Matsumoto, K. I., English, S., Yoo, J., Yamada, K-I., Devasahayam, N., Cook, J. A., Mitchell, J. B., Subramanian, S. & Krishna, M. C., 10 1 2004, : : Magnetic Resonance in Medicine. 52, 4, p. 885-892 8 p.

研究成果: ジャーナルへの寄稿記事

Oximetry
Electron Spin Resonance Spectroscopy
Pharmacokinetics
Oxygen
Intravenous Infusions
32 引用 (Scopus)

Phosphoprotein-selective recognition and staining in SDS-PAGE by bis-Zn(II)-dipycolylamine-appended anthracene

Ojida, A., Kohira, T. & Hamachi, I., 8 5 2004, : : Chemistry Letters. 33, 8, p. 1024-1025 2 p.

研究成果: ジャーナルへの寄稿記事

Phosphoproteins
Electrophoresis
Fluorescent Dyes
Gels
Fluorescence
30 引用 (Scopus)

Recognition and Fluorescence Sensing of Specific Amino Acid Residue on Protein Surface Using Designed Molecules

Ojida, A., Miyahara, Y., Kohira, T. & Hamachi, I., 5 6 2004, : : Biopolymers - Peptide Science Section. 76, 2, p. 177-184 8 p.

研究成果: ジャーナルへの寄稿記事

Amino acids
Membrane Proteins
Fluorescence
Proteins
Amino Acids
6 引用 (Scopus)

Stereocontrolled synthesis of (1S)-1-(1H-imidazol-4-yl)-1-(6-methoxy-2- naphthyl)-2-methylpropan-1-ol as a potent C17,20-lyase inhibitor

Ojida, A., Matsunaga, N., Kaku, T. & Tasaka, A., 5 24 2004, : : Tetrahedron Asymmetry. 15, 10, p. 1555-1559 5 p.

研究成果: ジャーナルへの寄稿記事

Lyases
imidazoles
inhibitors
Grignard reactions
Propanol
6 引用 (Scopus)

Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice

Nakazono, M., Hasegawa, S., Yamamoto, T. & Zaitsu, K., 11 15 2004, : : Bioorganic and Medicinal Chemistry Letters. 14, 22, p. 5619-5621 3 p.

研究成果: ジャーナルへの寄稿記事

Fullerenes
Catalepsy
Haloperidol
Derivatives
61-bis(1-adamantylcarbamoyl)-1,2-methano(60)fullerene
5 引用 (Scopus)

Synthesis of photosensitive luminol releasing compound, luminol-O-2-nitrobenzylate

Nakazono, M., Asechi, M. & Zaitsu, K., 4 15 2004, : : Journal of Photochemistry and Photobiology A: Chemistry. 163, 1-2, p. 149-152 4 p.

研究成果: ジャーナルへの寄稿記事

Luminol
releasing
synthesis
proportion
Irradiation
16 引用 (Scopus)

Synthetic studies on (1S)-1-(6,7-dimethoxy-2-naphthyl)-1-(1H-imidazol-4-yl) -2-methylpropan-1-ol as a selective C17,20-lyase inhibitor

Matsunaga, N., Kaku, T., Ojida, A. & Tasaka, A., 7 5 2004, : : Tetrahedron Asymmetry. 15, 13, p. 2021-2028 8 p.

研究成果: ジャーナルへの寄稿記事

Grignard reactions
Lyases
Ketones
imidazoles
ketones
2005
14 引用 (Scopus)

A composite resonator assembly suitable for EPR/NMR coregistration imaging

Matsumoto, S., Nagai, M., Yamada, K., Hyodo, F., Yasukawa, K., Muraoka, M., Hirata, H., Ono, M. & Utsumi, H., 4 1 2005, : : Concepts in Magnetic Resonance Part B: Magnetic Resonance Engineering. 25, 1, p. 1-11 11 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Paramagnetic resonance
Resonators
electron paramagnetic resonance
Magnetic Resonance Spectroscopy
15 引用 (Scopus)

In vivo EPR spectroscopic imaging for a liposomal drug delivery system

Matsumoto, K. I., Yahiro, T., Yamada, K-I. & Utsumi, H., 5 1 2005, : : Magnetic Resonance in Medicine. 53, 5, p. 1158-1165 8 p.

研究成果: ジャーナルへの寄稿記事

Drug Delivery Systems
Thigh
Ammonium Compounds
Liposomes
Suspensions
123 引用 (Scopus)

pH-responsive shrinkage/swelling of a supramolecular hydrogel composed of two small amphiphilic molecules

Zhou, S. L., Matsumoto, S., Tian, H. D., Yamane, H., Ojida, A., Kiyonaka, S. & Hamachi, I., 2 4 2005, : : Chemistry - A European Journal. 11, 4, p. 1130-1136 7 p.

研究成果: ジャーナルへの寄稿記事

Hydrogel
Hydrogels
Swelling
Molecules
Carboxylic Acids
64 引用 (Scopus)

Suzuki coupling for protein modification

Ojida, A., Tsutsumi, H., Kasagi, N. & Hamachi, I., 5 9 2005, : : Tetrahedron Letters. 46, 19, p. 3301-3305 5 p.

研究成果: ジャーナルへの寄稿記事

Cross Reactions
Biosensing Techniques
Fluorescent Dyes
Biosensors
Membrane Proteins
56 引用 (Scopus)

Thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (DEP) by scavenging reactive oxygen species and by inhibiting DEP-induced downregulation of Akt

Kaimul Ahsan, M., Nakamura, H., Tanito, M., Yamada, K., Utsumi, H. & Yodoi, J., 12 15 2005, : : Free Radical Biology and Medicine. 39, 12, p. 1549-1559 11 p.

研究成果: ジャーナルへの寄稿記事

Vehicle Emissions
Thioredoxins
Scavenging
Lung Injury
Reactive Oxygen Species
2006
3 引用 (Scopus)

Crystallization and preliminary crystallographic analysis of the N-terminal domain of PriA from Escherichia coli

Tabata, K., Ose, T., Tanaka, T., Mizukoshi, T., Ishigaki, T., Maenaka, K., Masai, H. & Kohda, D., 1 1 2006, : : Biochimica et Biophysica Acta - Proteins and Proteomics. 1764, 1, p. 157-160 4 p.

研究成果: ジャーナルへの寄稿記事

Crystallization
Escherichia coli
DNA Helicases
DNA
DNA Replication
87 引用 (Scopus)

Design of dual-emission chemosensors for ratiometric detection of ATP derivatives

Ojida, A., Miyahara, Y., Wongkongkatep, J., Tamaru, S. I., Sada, K. & Hamachi, I., 11 9 2006, : : Chemistry - An Asian Journal. 1, 4, p. 555-563 9 p.

研究成果: ジャーナルへの寄稿記事

Nucleosides
Adenosine Triphosphate
Derivatives
Fluorescence
Apyrase
44 引用 (Scopus)

Dynamic nuclear polarization properties of nitroxyl radicals used in Overhauser-enhanced MRI for simultaneous molecular imaging

Benial, A. M. F., Ichikawa, K., Murugesan, R., Yamada, K. I. & Utsumi, H., 10 1 2006, : : Journal of Magnetic Resonance. 182, 2, p. 273-282 10 p.

研究成果: ジャーナルへの寄稿記事

Molecular imaging
Molecular Imaging
Magnetic resonance imaging
Magnetic resonance
Magnetic Resonance Imaging
77 引用 (Scopus)

Effective disruption of phosphoprotein-protein surface interaction using Zn(II) dipicolylamine-based artificial receptors via two-point interaction

Ojida, A., Inoue, M. A., Mito-Oka, Y., Tsutsumi, H., Sada, K. & Hamachi, I., 2 15 2006, : : Journal of the American Chemical Society. 128, 6, p. 2052-2058 7 p.

研究成果: ジャーナルへの寄稿記事

Artificial Receptors
Phosphoproteins
Membrane Proteins
Proteins
Peptides
16 引用 (Scopus)

Enhanced intraarticular free radical reactions in adjuvant arthritis rats

Yamada, K. I., Nakamura, T. & Utsumi, H., 5 1 2006, : : Free Radical Research. 40, 5, p. 455-460 6 p.

研究成果: ジャーナルへの寄稿記事

Free radical reactions
Experimental Arthritis
Free Radicals
Rats
Joints
16 引用 (Scopus)
4-Quinolones
Orbital calculations
Molecular orbitals
Anions
Substitution reactions
4 引用 (Scopus)

High-throughput determination of free d-aspartic acid in mammals by enzyme immunoassay using specific monoclonal antibody

Ohgusu, T., Hamase, K., Tanaka, H., Shoyama, Y. & Zaitsu, K., 10 1 2006, : : Analytical Biochemistry. 357, 1, p. 15-20 6 p.

研究成果: ジャーナルへの寄稿記事

Mammals
Immunoenzyme Techniques
Aspartic Acid
Immunosorbents
Assays
56 引用 (Scopus)

In vivo detection of free radicals induced by diethylnitrosamine in rat liver tissue

Yamada, K-I., Yamamiya, I. & Utsumi, H., 6 1 2006, : : Free Radical Biology and Medicine. 40, 11, p. 2040-2046 7 p.

研究成果: ジャーナルへの寄稿記事

Diethylnitrosamine
Liver
Free Radicals
Rats
Tissue
47 引用 (Scopus)

Noninvasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats

Utsumi, H., Yasukawa, K., Soeda, T., Yamada, K. I., Shigemi, R., Yao, T. & Tsuneyoshi, M., 4 1 2006, : : Journal of Pharmacology and Experimental Therapeutics. 317, 1, p. 228-235 8 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Stomach Ulcer
Indomethacin
Reactive Oxygen Species
Ulcer
139 引用 (Scopus)

Oligo-Asp Tag/Zn(II) complex probe as a new pair for labeling and fluorescence imaging of proteins

Ojida, A., Honda, K., Shinmi, D., Kiyonaka, S., Mori, Y. & Hamachi, I., 8 16 2006, : : Journal of the American Chemical Society. 128, 32, p. 10452-10459 8 p.

研究成果: ジャーナルへの寄稿記事

Optical Imaging
Labeling
Fluorescence
Proteins
Imaging techniques
33 引用 (Scopus)

Presence and origin of large amounts of d-proline in the urine of mutant mice lacking d-amino acid oxidase activity

Hamase, K., Takagi, S., Morikawa, A., Konno, R., Niwa, A. & Zaitsu, K., 10 1 2006, : : Analytical and Bioanalytical Chemistry. 386, 3, p. 705-711 7 p.

研究成果: ジャーナルへの寄稿記事

Proline
Oxidoreductases
Urine
Tissue
Amino Acids
41 引用 (Scopus)

Ratiometric fluorescence detection of a tag fused protein using the dual-emission artificial molecular probe

Honda, K., Nakata, E., Ojida, A. & Hamachi, I., 10 3 2006, : : Chemical Communications. 38, p. 4024-4026 3 p.

研究成果: ジャーナルへの寄稿記事

Molecular Probes
Aspartic Acid
Peptides
Fluorescence
Proteins
19 引用 (Scopus)

Sensitive high-performance liquid chromatographic assay for D-amino-acid oxidase activity in mammalian tissues using a fluorescent non-natural substrate, 5-fluoro-D-tryptophan

Hamase, K., Nagayasu, R., Morikawa, A., Konno, R. & Zaitsu, K., 2 17 2006, : : Journal of Chromatography A. 1106, 1-2, p. 159-164 6 p.

研究成果: ジャーナルへの寄稿記事

D-Amino-Acid Oxidase
Tryptophan
Assays
Oxidoreductases
Tissue
123 引用 (Scopus)

Simultaneous molecular imaging of redox reactions monitored by Overhauser-enhanced MRI with 14N- and 15N-labeled nitroxyl radicals

Utsumi, H., Yamada, K. I., Ichikawa, K., Sakai, K., Kinoshita, Y., Matsumoto, S. & Nagai, M., 1 31 2006, : : Proceedings of the National Academy of Sciences of the United States of America. 103, 5, p. 1463-1468 6 p.

研究成果: ジャーナルへの寄稿記事

Molecular Imaging
Oxidation-Reduction
Electron Spin Resonance Spectroscopy
Membranes
Reactive Oxygen Species
26 引用 (Scopus)

Spatially resolved time-course studies of free radical reactions with an EPRI/MRI fusion technique

Hyodo, F., Yasukawa, K., Yamada, K-I. & Utsumi, H., 10 1 2006, : : Magnetic Resonance in Medicine. 56, 4, p. 938-943 6 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Free Radicals
Pharmacokinetics
Fiducial Markers
Feasibility Studies
6 引用 (Scopus)
Pyrroles
Chemiluminescence
Electrospray ionization
Curcumin
Liquid chromatography
2007
32 引用 (Scopus)

Advantageous application of a surface coil to EPR irradiation in overhauser-enhanced MRI

Matsumoto, S., Yamada, K-I., Hirata, H., Yasukawa, K., Hyodo, F., Ichikawa, K. & Utsumi, H., 4 1 2007, : : Magnetic Resonance in Medicine. 57, 4, p. 806-811 6 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Free Radicals
Protons
77 引用 (Scopus)

A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia

Morita, Y., Ujike, H., Tanaka, Y., Otani, K., Kishimoto, M., Morio, A., Kotaka, T., Okahisa, Y., Matsushita, M., Morikawa, A., Hamase, K., Zaitsu, K. & Kuroda, S., 5 15 2007, : : Biological Psychiatry. 61, 10, p. 1200-1203 4 p.

研究成果: ジャーナルへの寄稿記事

Schizophrenia
Alleles
Serine
Genes
Single Nucleotide Polymorphism
28 引用 (Scopus)

Alterations in D-amino acid levels in the brains of mice and rats after the administration of D-amino acids

Morikawa, A., Hamase, K., Inoue, T., Konno, R. & Zaitsu, K., 1 1 2007, : : Amino Acids. 32, 1, p. 13-20 8 p.

研究成果: ジャーナルへの寄稿記事

Rats
Brain
Amino Acids
Pineal Gland
Pituitary Gland
13 引用 (Scopus)

A ratiometric fluorescent chemosensor, 1,10-phenanthroline-4,7-dione, for anions in aqueous-organic media

Hirano, J., Miyata, H., Hamase, K. & Zaitsu, K., 7 9 2007, : : Tetrahedron Letters. 48, 28, p. 4861-4864 4 p.

研究成果: ジャーナルへの寄稿記事

Anions
4-Quinolones
Molecules
4,7-phenanthroline
chemosensor 1
41 引用 (Scopus)

Bisindolylmaleimides with large stokes shift and long-lasting chemiluminescence properties

Nakazono, M., Nanbu, S., Uesaki, A., Kuwano, R., Kashiwabara, M. & Zaitsu, K., 8 30 2007, : : Organic Letters. 9, 18, p. 3583-3586 4 p.

研究成果: ジャーナルへの寄稿記事

Chemiluminescence
chemiluminescence
Luminescence
Fluorescence
Wavelength
71 引用 (Scopus)
Mammals
Amino Acids
Liquids
Enantiomers
Tissue
164 引用 (Scopus)

Crystal structure of measles virus hemagglutinin provides insight into effective vaccines

Hashiguchi, T., Kajikawa, M., Maita, N., Takeda, M., Kuroki, K., Sasaki, K., Kohda, D., Yanagi, Y. & Maenaka, K., 12 4 2007, : : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19535-19540 6 p.

研究成果: ジャーナルへの寄稿記事

Measles virus
Hemagglutinins
Vaccines
Measles Vaccine
HIV Envelope Protein gp120
28 引用 (Scopus)

Escherichia coli PriA protein, two modes of DNA binding and activation of ATP hydrolysis

Tanaka, T., Mizukoshi, T., Tabata, K., Kohda, D. & Masai, H., 7 6 2007, : : Journal of Biological Chemistry. 282, 27, p. 19917-19927 11 p.

研究成果: ジャーナルへの寄稿記事

Escherichia coli Proteins
Escherichia coli
Hydrolysis
Adenosine Triphosphate
Chemical activation
36 引用 (Scopus)

Identification and characterization of cannabinoids that induce cell death through mitochondrial permeability transition in cannabis leaf cells

Morimoto, S., Tanaka, Y., Sasaki, K., Tanaka, H., Fukamizu, T., Shoyama, Y., Shoyama, Y. & Taura, F., 7 13 2007, : : Journal of Biological Chemistry. 282, 28, p. 20739-20751 13 p.

研究成果: ジャーナルへの寄稿記事

Cannabinoids
Cell death
Cannabis
Permeability
Cell Death
39 引用 (Scopus)

Immunohistochemical localization of d-alanine to β-cells in rat pancreas

Morikawa, A., Hamase, K., Ohgusu, T., Etoh, S., Tanaka, H., Koshiishi, I., Shoyama, Y. & Zaitsu, K., 4 20 2007, : : Biochemical and Biophysical Research Communications. 355, 4, p. 872-876 5 p.

研究成果: ジャーナルへの寄稿記事

Alanine
Rats
Pancreas
Staining and Labeling
Amino Acids