生体分子情報学

研究成果 1992 2019

フィルター
記事
記事
18 引用 (Scopus)
Alanine
Rats
Habits
Mammals
Insulin
71 引用 (Scopus)
Mammals
Amino Acids
Liquids
Enantiomers
Tissue
5 引用 (Scopus)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Connexins
varespladib methyl
Astrocytes
Parkinson Disease
27 引用 (Scopus)

Constituents of holothuroidea, 12. Isolation and structure of glucocerebrosides from the sea cucumber Holothuria pervicax

Yamada, K., Sasaki, K., Harada, Y., Isobe, R. & Higuchi, R., 11 1 2002, : : Chemical and Pharmaceutical Bulletin. 50, 11, p. 1467-1470 4 p.

研究成果: ジャーナルへの寄稿記事

Holothuria
Sea Cucumbers
Glucosylceramides
Recycling
Chloroform
6 引用 (Scopus)

Construction, expression, and characterization of a single-chain variable fragment antibody against 2,4-dichlorophenoxyacetic acid in the hemolymph of silkworm larvae

Sakamoto, S., Pongkitwitoon, B., Nakamura, S., Tabata, K., Tanizaki, Y., Maenaka, K., Tanaka, H. & Morimoto, S., 7 1 2011, : : Applied Biochemistry and Biotechnology. 164, 6, p. 715-728 14 p.

研究成果: ジャーナルへの寄稿記事

Single-Chain Antibodies
2,4-Dichlorophenoxyacetic Acid
Bombyx
Hemolymph
Antibodies
12 引用 (Scopus)

Coordination ligand exchange of a xanthene probe-Ce(iii) complex for selective fluorescence sensing of inorganic pyrophosphate

Kittiloespaisan, E., Takashima, I., Kiatpathomchai, W., Wongkongkatep, J. & Ojida, A., 2 28 2014, : : Chemical Communications. 50, 17, p. 2126-2128 3 p.

研究成果: ジャーナルへの寄稿記事

Xanthenes
Amplification
Fluorescence
Ligands
DNA-Directed DNA Polymerase
101 引用 (Scopus)

Cross-linking strategy for molecular recognition and fluorescent sensing of a multi-phosphorylated peptide in aqueous solution

Ojida, A., Inoue, M. A., Mito-oka, Y. & Hamachi, I., 8 27 2003, : : Journal of the American Chemical Society. 125, 34, p. 10184-10185 2 p.

研究成果: ジャーナルへの寄稿記事

Molecular recognition
Peptides
Membrane Proteins
Artificial Receptors
Proteins
3 引用 (Scopus)

Crystallization and preliminary crystallographic analysis of the N-terminal domain of PriA from Escherichia coli

Tabata, K., Ose, T., Tanaka, T., Mizukoshi, T., Ishigaki, T., Maenaka, K., Masai, H. & Kohda, D., 1 1 2006, : : Biochimica et Biophysica Acta - Proteins and Proteomics. 1764, 1, p. 157-160 4 p.

研究成果: ジャーナルへの寄稿記事

Crystallization
Escherichia coli
DNA Helicases
DNA
DNA Replication
164 引用 (Scopus)

Crystal structure of measles virus hemagglutinin provides insight into effective vaccines

Hashiguchi, T., Kajikawa, M., Maita, N., Takeda, M., Kuroki, K., Sasaki, K., Kohda, D., Yanagi, Y. & Maenaka, K., 12 4 2007, : : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19535-19540 6 p.

研究成果: ジャーナルへの寄稿記事

Measles virus
Hemagglutinins
Vaccines
Measles Vaccine
HIV Envelope Protein gp120
108 引用 (Scopus)

D-Amino acid oxidase controls motoneuron degeneration through D-serine

Sasabe, J., Miyoshi, Y., Suzuki, M., Mita, M., Konno, R., Matsuoka, M., Hamase, K. & Aiso, S., 1 10 2012, : : Proceedings of the National Academy of Sciences of the United States of America. 109, 2, p. 627-632 6 p.

研究成果: ジャーナルへの寄稿記事

D-Amino-Acid Oxidase
Motor Neurons
Serine
Amyotrophic Lateral Sclerosis
Mitogen-Activated Protein Kinase Kinases
6 引用 (Scopus)

Design and synthesis of a novel pre-column derivatization reagent with a 6-methoxy-4-quinolone moiety for fluorescence and tandem mass spectrometric detection and its application to chiral amino acid analysis

Oyama, T., Negishi, E., Onigahara, H., Kusano, N., Miyoshi, Y., Mita, M., Nakazono, M., Ohtsuki, S., Ojida, A., Lindner, W. & Hamase, K., 12 10 2015, : : Journal of Pharmaceutical and Biomedical Analysis. 116, p. 71-79 9 p.

研究成果: ジャーナルへの寄稿記事

Fluorescence
Amino Acids
4-Quinolones
Electrospray ionization
Enantiomers
7 引用 (Scopus)

Design of a binuclear Ni(II)-iminodiacetic acid (IDA) complex for selective recognition and covalent labeling of His-tag fused proteins

Takahira, I., Fuchida, H., Tabata, S., Shindo, N., Uchinomiya, S., Hamachi, I. & Ojida, A., 7 1 2014, : : Bioorganic and Medicinal Chemistry Letters. 24, 13, p. 2855-2858 4 p.

研究成果: ジャーナルへの寄稿記事

His-His-His-His-His-His
Labeling
Molecular Probes
Proteins
G-Protein-Coupled Receptors
20 引用 (Scopus)

Design of a multinuclear Zn(ii) complex as a new molecular probe for fluorescence imaging of His-tag fused proteins

Fujishima, S. H., Nonaka, H., Uchinomiya, S., Kawase, Y. A., Ojida, A. & Hamachi, I., 1 14 2012, : : Chemical Communications. 48, 4, p. 594-596 3 p.

研究成果: ジャーナルへの寄稿記事

Molecular Probes
G-Protein-Coupled Receptors
Fluorescent Dyes
Histidine
Fluorescence
3 引用 (Scopus)

Design of coordination interaction of Zn(II) complex with oligo-aspartate peptide to afford a high-affinity tag-probe pair

Fuchida, H., Tabata, S., Shindo, N., Takashima, I., Leng, Q., Hatsuyama, Y., Hamachi, I. & Ojida, A., 1 1 2015, : : Bulletin of the Chemical Society of Japan. 88, 6, p. 784-791 8 p.

研究成果: ジャーナルへの寄稿記事

Aspartic Acid
Peptides
Zinc
Maltose-Binding Proteins
Pyridines
87 引用 (Scopus)

Design of dual-emission chemosensors for ratiometric detection of ATP derivatives

Ojida, A., Miyahara, Y., Wongkongkatep, J., Tamaru, S. I., Sada, K. & Hamachi, I., 11 9 2006, : : Chemistry - An Asian Journal. 1, 4, p. 555-563 9 p.

研究成果: ジャーナルへの寄稿記事

Nucleosides
Adenosine Triphosphate
Derivatives
Fluorescence
Apyrase
23 引用 (Scopus)

Design of ratiometric fluorescent probes based on arene-metal-ion interactions and their application to CdII and hydrogen sulfide imaging in living cells

Takashima, I., Kinoshita, M., Kawagoe, R., Nakagawa, S., Sugimoto, M., Hamachi, I. & Ojida, A., 2 17 2014, : : Chemistry - A European Journal. 20, 8, p. 2184-2192 9 p.

研究成果: ジャーナルへの寄稿記事

Hydrogen Sulfide
Hydrogen sulfide
Fluorescent Dyes
Metal ions
Cells
3 引用 (Scopus)

Detection and inhibition of lipid-derived radicals in low-density lipoprotein

Ishida, Y., Okamoto, Y., Matsuoka, Y., Tada, A., Janprasit, J., Yamato, M., Morales, N. P. & Yamada, K-I., 12 1 2017, : : Free Radical Biology and Medicine. 113, p. 487-493 7 p.

研究成果: ジャーナルへの寄稿記事

LDL Lipoproteins
Lipids
Iron
Deferoxamine
Oxidative stress

Detection and inhibition of redox reaction and lipid derived radicals

Yamada, K-I., 1 1 2018, : : Drug Delivery System. 33, 3, p. 197-203 7 p.

研究成果: ジャーナルへの寄稿記事

Oxidation-Reduction
Lipids
Free Radicals
Animal Models
Carcinogenesis
81 引用 (Scopus)

Determination of D-alanine in the rat central nervous system and periphery using column-switching high-performance liquid chromatography

Morikawa, A., Hamase, K. & Zaitsu, K., 1 1 2003, : : Analytical Biochemistry. 312, 1, p. 66-72 7 p.

研究成果: ジャーナルへの寄稿記事

High performance liquid chromatography
Neurology
Alanine
Rats
Central Nervous System
23 引用 (Scopus)
Mammals
Enantiomers
High performance liquid chromatography
Threonine
High Pressure Liquid Chromatography
78 引用 (Scopus)
High performance liquid chromatography
Alanine
Serine
Oxidoreductases
Fluorescence
22 引用 (Scopus)

Determination of endogenous melatonin in the individual pineal glands of inbred mice using precolumn oxidation reversed-phase micro-high-performance liquid chromatography

Tomita, T., Hamase, K., Hayashi, H., Fukuda, H., Hirano, J. & Zaitsu, K., 5 15 2003, : : Analytical Biochemistry. 316, 2, p. 154-161 8 p.

研究成果: ジャーナルへの寄稿記事

Pineal Gland
High performance liquid chromatography
Melatonin
High Pressure Liquid Chromatography
Oxidation
118 引用 (Scopus)

Determination of free D-aspartic acid, D-serine and D-alanine in the brain of mutant mice lacking D-amino-acid oxidase activity

Morikawa, A., Hamase, K., Inoue, T., Konno, R., Niwa, A. & Zaitsu, K., 6 5 2001, : : Journal of Chromatography B: Biomedical Sciences and Applications. 757, 1, p. 119-125 7 p.

研究成果: ジャーナルへの寄稿記事

D-Amino-Acid Oxidase
D-Aspartic Acid
Alanine
Serine
Brain
65 引用 (Scopus)

Determination of free D-proline and D-leucine in the brains of mutant mice lacking D-amino acid oxidase activity

Hamase, K., Inoue, T., Morikawa, A., Konno, R. & Zaitsu, K., 12 15 2001, : : Analytical Biochemistry. 298, 2, p. 253-258 6 p.

研究成果: ジャーナルへの寄稿記事

D-Amino-Acid Oxidase
Proline
Leucine
Brain
Pineal Gland
45 引用 (Scopus)
Enantiomers
High performance liquid chromatography
Leucine
Rats
Brain
25 引用 (Scopus)
High performance liquid chromatography
Reverse-Phase Chromatography
Melatonin
Circadian Rhythm
Rats
5 引用 (Scopus)

Determination of polyphenols with HPLC-sensitized chemiluminescence

Ma, L., Nakazono, M., Ohba, Y. & Zaitsu, K., 10 1 2002, : : analytical sciences. 18, 10, p. 1163-1165 3 p.

研究成果: ジャーナルへの寄稿記事

Polyphenols
Luminescence
High Pressure Liquid Chromatography
22 引用 (Scopus)

Determination of reactive oxygen species associated with the degeneration of dopaminergic neurons during dopamine metabolism

Yamato, M., Kudo, W., Shiba, T., Yamada, K. I., Watanabe, T. & Utsumi, H., 3 1 2010, : : Free Radical Research. 44, 3, p. 249-257 9 p.

研究成果: ジャーナルへの寄稿記事

Tyramine
Dopaminergic Neurons
Metabolism
Neurons
Reactive Oxygen Species
5 引用 (Scopus)

Development of a fully-automated on-line oxidation column-switching HPLC system for the determination of endogenous melatonin in human clinical samples

Oyama, T., Nagai, R., Fujimoto, M., Konishi, R., Mita, M., Uezono, K., Zaitsu, K. & Hamase, K., 1 1 2015, : : analytical sciences. 31, 11, p. 1129-1135 7 p.

研究成果: ジャーナルへの寄稿記事

Switching systems
Melatonin
Oxidation
Plasma (human)
Hydrogen Peroxide
19 引用 (Scopus)

Development of an AND logic-gate-type fluorescent probe for ratiometric imaging of autolysosome in cell autophagy

Takashima, I., Kawagoe, R., Hamachi, I. & Ojida, A., 1 26 2015, : : Chemistry - A European Journal. 21, 5, p. 2038-2044 7 p.

研究成果: ジャーナルへの寄稿記事

Logic gates
Fluorescent Dyes
Xanthenes
Fluorescence
Xanthones
13 引用 (Scopus)

Development of an enzyme immunoassay using a monoclonal antibody against the psychoactive diterpenoid salvinorin A

Paudel, M. K., Shirota, O., Tabata, K., Tanaka, H., Sekita, S. & Morimoto, S., 9 27 2013, : : Journal of Natural Products. 76, 9, p. 1654-1660 7 p.

研究成果: ジャーナルへの寄稿記事

salvinorin A
Diterpenes
Immunosorbents
Immunoenzyme Techniques
Assays
14 引用 (Scopus)

Development of an indirect competitive enzyme-linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel

Chao, Z., Tan, M., Paudel, M. K., Sakamoto, S., Ma, L., Tabata, K., Tanaka, H., Shoyama, Y., Xuan, L. & Morimoto, S., 7 1 2013, : : Journal of Natural Medicines. 67, 3, p. 512-518 7 p.

研究成果: ジャーナルへの寄稿記事

Immunosorbents
Paclitaxel
Assays
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
8 引用 (Scopus)
Amino Acids
Fluids
Liquids
High Pressure Liquid Chromatography
L Forms

Development of a simultaneous two-dimensional micro-HPLC analysis system for the chiral amino acid metabolomics study in mammals

Miyoshi, Y., Tojo, Y., Han, H., Mita, M. & Hamase, K., 1 1 2012, : : bunseki kagaku. 61, 6, p. 489-499 11 p.

研究成果: ジャーナルへの寄稿記事

Mammals
Amino Acids
Enantiomers
Biomarkers
Animals
30 引用 (Scopus)

Development of novel nitroxyl radicals for controlling reactivity with ascorbic acid

Kinoshita, Y., Yamada, K. I., Yamasaki, T., Sadasue, H., Sakai, K. & Utsumi, H., 7 27 2009, : : Free Radical Research. 43, 6, p. 565-571 7 p.

研究成果: ジャーナルへの寄稿記事

Ascorbic Acid
Reducing Agents
Contrast Media
Antioxidants
Radiation-Protective Agents
9 引用 (Scopus)

Development of pH-Responsive BODIPY Probes for Staining Late Endosome in Live Cells

Miao, F., Uchinomiya, S., Ni, Y., Chang, Y. T. & Wu, J., 11 1 2016, : : ChemPlusChem. 81, 11, p. 1209-1215 7 p.

研究成果: ジャーナルへの寄稿記事

Coloring Agents
Fluorescent Dyes
Fusion reactions
Cells
Infrared radiation

Development of selective methods for the determination of small amounts of D-amino acids in mammals

Hamase, K. & Zaitsu, K., 7 1 2004, : : bunseki kagaku. 53, 7, p. 677-690 14 p.

研究成果: ジャーナルへの寄稿記事

Mammals
Alanine
Tissue
Amino Acids
D-Aspartic Acid
19 引用 (Scopus)

D -Glutamate is metabolized in the heart mitochondria

Ariyoshi, M., Katane, M., Hamase, K., Miyoshi, Y., Nakane, M., Hoshino, A., Okawa, Y., Mita, Y., Kaimoto, S., Uchihashi, M., Fukai, K., Ono, K., Tateishi, S., Hato, D., Yamanaka, R., Honda, S., Fushimura, Y., Iwai-Kanai, E., Ishihara, N., Mita, M. および2人, Homma, H. & Matoba, S., 3 7 2017, : : Scientific reports. 7, 43911.

研究成果: ジャーナルへの寄稿記事

Heart Mitochondria
Glutamic Acid
glutamate racemase
Amino Acids
Proline
52 引用 (Scopus)

Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage

Xavier, S., Yamada, K-I., Samuni, A. M., Samuni, A., DeGraff, W., Krishna, M. C. & Mitchell, J. B., 11 14 2002, : : Biochimica et Biophysica Acta - General Subjects. 1573, 2, p. 109-120 12 p.

研究成果: ジャーナルへの寄稿記事

Hydroxylamines
Metal ions
Metals
Ions
Radiation

Diffusion studies of redox-sensitive nitroxyl spin probes through bilayer lipid membranes using 300 MHz electron spin resonance spectrometer

Benial, A. M. F., Dhas, M. K., Ichikawa, K., Yamada, K., Hyodo, F., Jawahar, A. & Utsumi, H., 1 1 2015, : : Biofizika. 60, 1, p. 88-94 7 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Lipid Bilayers
Membrane Lipids
Oxidation-Reduction
Liposomes
1 引用 (Scopus)

Discovery of highly reactive peptide tag by ELISA-type screening for specific cysteine conjugation

Kurashige, N., Fuchida, H., Tabata, S., Uchinomiya, S. & Ojida, A., 4 18 2017, (受理済み/印刷中) : : Bioorganic and Medicinal Chemistry Letters.

研究成果: ジャーナルへの寄稿記事

Cysteine
Screening
Enzyme-Linked Immunosorbent Assay
Peptides
Labeling
101 引用 (Scopus)

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

Kaku, T., Hitaka, T., Ojida, A., Matsunaga, N., Adachi, M., Tanaka, T., Hara, T., Yamaoka, M., Kusaka, M., Okuda, T., Asahi, S., Furuya, S. & Tasaka, A., 11 1 2011, : : Bioorganic and Medicinal Chemistry. 19, 21, p. 6383-6399 17 p.

研究成果: ジャーナルへの寄稿記事

Steroid 17-alpha-Hydroxylase
Prostatic Neoplasms
Derivatives
Phase III Clinical Trials
Dehydroepiandrosterone
1 引用 (Scopus)

D -Serine reflects kidney function and diseases

Hesaka, A., Sakai, S., Hamase, K., Ikeda, T., Matsui, R., Mita, M., Horio, M., Isaka, Y. & Kimura, T., 12 1 2019, : : Scientific reports. 9, 1, 5104.

研究成果: ジャーナルへの寄稿記事

公開
Kidney Diseases
Serine
Chronic Renal Insufficiency
Kidney
Amino Acids
91 引用 (Scopus)

D-Serine regulates cerebellar LTD and motor coordination through the δ glutamate receptor

Kakegawa, W., Miyoshi, Y., Hamase, K., Matsuda, S., Matsuda, K., Kohda, K., Emi, K., Motohashi, J., Konno, R., Zaitsu, K. & Yuzaki, M., 5 1 2011, : : Nature Neuroscience. 14, 5, p. 603-613 11 p.

研究成果: ジャーナルへの寄稿記事

Glutamate Receptors
Cerebellum
Serine
Neuronal Plasticity
Purkinje Cells
44 引用 (Scopus)

Dynamic nuclear polarization properties of nitroxyl radicals used in Overhauser-enhanced MRI for simultaneous molecular imaging

Benial, A. M. F., Ichikawa, K., Murugesan, R., Yamada, K. I. & Utsumi, H., 10 1 2006, : : Journal of Magnetic Resonance. 182, 2, p. 273-282 10 p.

研究成果: ジャーナルへの寄稿記事

Molecular imaging
Molecular Imaging
Magnetic resonance imaging
Magnetic resonance
Magnetic Resonance Imaging
20 引用 (Scopus)

Dynamic nuclear polarization studies of redox-sensitive nitroxyl spin probes in liposomal solution

Benial, A. M. F., Utsumi, H., Ichikawa, K., Murugesan, R., Yamada, K-I., Kinoshita, Y., Naganuma, T. & Kato, M., 5 2010, : : Journal of Magnetic Resonance. 204, 1, p. 131-138 8 p.

研究成果: ジャーナルへの寄稿記事

Liposomes
Oxidation-Reduction
Magnetic resonance
Magnetic Resonance Imaging
Electron Spin Resonance Spectroscopy
39 引用 (Scopus)

Effective 2,6-substitution of piperidine nitroxyl radical by carbonyl compound

Sakai, K., Yamada, K. I., Yamasaki, T., Kinoshita, Y., Mito, F. & Utsumi, H., 3 27 2010, : : Tetrahedron. 66, 13, p. 2311-2315 5 p.

研究成果: ジャーナルへの寄稿記事

Carbonyl compounds
Substitution reactions
Contrast Media
Antioxidants
nitroxyl
77 引用 (Scopus)

Effective disruption of phosphoprotein-protein surface interaction using Zn(II) dipicolylamine-based artificial receptors via two-point interaction

Ojida, A., Inoue, M. A., Mito-Oka, Y., Tsutsumi, H., Sada, K. & Hamachi, I., 2 15 2006, : : Journal of the American Chemical Society. 128, 6, p. 2052-2058 7 p.

研究成果: ジャーナルへの寄稿記事

Artificial Receptors
Phosphoproteins
Membrane Proteins
Proteins
Peptides
102 引用 (Scopus)

Efficient fluorescent ATP-sensing based on coordination chemistry under aqueous neutral conditions

Ojida, A., Park, S. K., Mito-Oka, Y. & Hamachi, I., 8 26 2002, : : Tetrahedron Letters. 43, 35, p. 6193-6195 3 p.

研究成果: ジャーナルへの寄稿記事

Adenosine Triphosphate
bis-dipicolylamine-Zinc(II)
anthracene
8 引用 (Scopus)

Efficient silkworm expression of human GPCR (nociceptin receptor) by a Bombyx mori bacmid DNA system

Kajikawa, M., Tabata, K., Wakimoto, Y., Toyooka, M., Motohashi, T., Shimojima, T., Takeda, S., Park, E. Y. & Maenaka, K., 7 31 2009, : : Biochemical and Biophysical Research Communications. 385, 3, p. 375-379 5 p.

研究成果: ジャーナルへの寄稿記事

Bombyx
G-Protein-Coupled Receptors
Nucleopolyhedrovirus
DNA
Fusion reactions