生体分子情報学

研究成果 1992 2019

フィルター
記事
2010
179 引用 (Scopus)

Rational design of FRET-based ratiometric chemosensors for in vitro and in cell fluorescence analyses of nucleoside polyphosphates

Kurishita, Y., Kohira, T., Ojida, A. & Hamachi, I., 9 29 2010, : : Journal of the American Chemical Society. 132, 38, p. 13290-13299 10 p.

研究成果: ジャーナルへの寄稿記事

Polyphosphates
Fluorescence Resonance Energy Transfer
Nucleosides
Fluorescence
Adenosinetriphosphate
High pressure liquid chromatography
Stereoisomerism
Animals
Amino Acids
57 引用 (Scopus)

Simultaneous determination of hydrophilic amino acid enantiomers in mammalian tissues and physiological fluids applying a fully automated micro-two-dimensional high-performance liquid chromatographic concept

Hamase, K., Miyoshi, Y., Ueno, K., Han, H., Hirano, J., Morikawa, A., Mita, M., Kaneko, T., Lindner, W. & Zaitsu, K., 2 12 2010, : : Journal of Chromatography A. 1217, 7, p. 1056-1062 7 p.

研究成果: ジャーナルへの寄稿記事

Enantiomers
Tissue
Amino Acids
Fluids
Liquids
2009
75 引用 (Scopus)
High performance liquid chromatography
Alanine
Serine
Oxidoreductases
Fluorescence
28 引用 (Scopus)

Development of novel nitroxyl radicals for controlling reactivity with ascorbic acid

Kinoshita, Y., Yamada, K-I., Yamasaki, T., Sadasue, H., Sakai, K. & Utsumi, H., 7 27 2009, : : Free Radical Research. 43, 6, p. 565-571 7 p.

研究成果: ジャーナルへの寄稿記事

Ascorbic Acid
Reducing Agents
Contrast Media
Antioxidants
Radiation-Protective Agents
8 引用 (Scopus)

Efficient silkworm expression of human GPCR (nociceptin receptor) by a Bombyx mori bacmid DNA system

Kajikawa, M., Tabata, K., Wakimoto, Y., Toyooka, M., Motohashi, T., Shimojima, T., Takeda, S., Park, E. Y. & Maenaka, K., 7 31 2009, : : Biochemical and Biophysical Research Communications. 385, 3, p. 375-379 5 p.

研究成果: ジャーナルへの寄稿記事

Bombyx
G-Protein-Coupled Receptors
Nucleopolyhedrovirus
DNA
Fusion reactions
21 引用 (Scopus)

Enantioselective visualization of D-alanine in rat anterior pituitary gland: Localization to ACTH-secreting cells

Etoh, S., Hamase, K., Morikawa, A., Ohgusu, T. & Zaitsu, K., 1 1 2009, : : Analytical and Bioanalytical Chemistry. 393, 1, p. 217-223 7 p.

研究成果: ジャーナルへの寄稿記事

Anterior Pituitary Gland
Alanine
Adrenocorticotropic Hormone
Rats
Visualization
10 引用 (Scopus)

Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1)

Nakamura, S., Kuroki, K., Ohki, I., Tabata, K., Kajikawa, M., Maruyama, T., Ito, M., Kameda, Y., Ikura, M., Yamamoto, K., Matsumoto, N. & Maenaka, K., 10 2 2009, : : Journal of Biological Chemistry. 284, 40, p. 27327-27335 9 p.

研究成果: ジャーナルへの寄稿記事

NK Cell Lectin-Like Receptors
Cadherins
T-cells
Natural Killer T-Cells
Natural Killer Cells
42 引用 (Scopus)

Noninvasive assessment of the brain redox status after transient middle cerebral artery occlusion using Overhauser-enhanced magnetic resonance imaging

Yamato, M., Shiba, T., Yamada, K-I., Watanabe, T. & Utsumi, H., 10 1 2009, : : Journal of Cerebral Blood Flow and Metabolism. 29, 10, p. 1655-1664 10 p.

研究成果: ジャーナルへの寄稿記事

Middle Cerebral Artery Infarction
Reperfusion
Oxidation-Reduction
Magnetic Resonance Imaging
Brain
1 引用 (Scopus)

Rapid separation of hydrophobic compounds by UPLC: In case of bisindolylmaleimides, indolocarbazoles or fullerene C60 derivatives

Nakazono, M., Sato, Y., Hasegawa, S., Arisuda, N., Miyamoto, A. & Zaitsu, K., 9 1 2009, : : Chromatographia. 70, 5-6, p. 933-937 5 p.

研究成果: ジャーナルへの寄稿記事

Derivatives
Fullerenes
Injections
Liquid chromatography
Liquid Chromatography
255 引用 (Scopus)

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

Kiyonaka, S., Kato, K., Nishida, M., Mio, K., Numaga, T., Sawaguchi, Y., Yoshida, T., Wakamori, M., Mori, E., Numata, T., Ishii, M., Takemoto, H., Ojida, A., Watanabe, K., Uemura, A., Kurose, H., Morii, T., Kobayashi, T., Sato, Y., Sato, C. および2人, Hamachi, I. & Mori, Y., 3 31 2009, : : Proceedings of the National Academy of Sciences of the United States of America. 106, 13, p. 5400-5405 6 p.

研究成果: ジャーナルへの寄稿記事

Cardiomegaly
Type C Phospholipases
B-Lymphocytes
Cell Membrane
NFATC Transcription Factors
4 引用 (Scopus)

Separable detection of lipophilic-and hydrophilic-phase free radicals from the ESR spectrum of nitroxyl radical in transient MCAO mice

Yamato, M., Shiba, T., Yamada, K-I., Watanabe, T. & Utsumi, H., 11 30 2009, : : Free Radical Research. 43, 9, p. 844-851 8 p.

研究成果: ジャーナルへの寄稿記事

Middle Cerebral Artery Infarction
Free Radicals
Paramagnetic resonance
Free radical reactions
Reperfusion
13 引用 (Scopus)

Silkworm expression and sugar profiling of human immune cell surface receptor, KIR2DL1

Tabata, K., Kajikawa, M., Kuroki, K., Motohashi, T., Shimojima, T., Park, E. Y., Kondo, S., Yagi, H., Kato, K. & Maenaka, K., 9 25 2009, : : Biochemical and Biophysical Research Communications. 387, 3, p. 575-580 6 p.

研究成果: ジャーナルへの寄稿記事

Bombyx
Cell Surface Receptors
Sugars
Post Translational Protein Processing
Proteins
5 引用 (Scopus)

Simple and rapid genotyping of D-amino acid oxidase gene recognizing a crucial variant in the ddY strain using microchip electrophoresis

Tojo, Y., Hamase, K., Konno, R., Satoru, K., Ohdo, S. & Zaitsu, K., 2 1 2009, : : Journal of Separation Science. 32, 3, p. 430-436 7 p.

研究成果: ジャーナルへの寄稿記事

D-Amino-Acid Oxidase
Electrophoresis
Amino acids
Genes
Amino Acids
43 引用 (Scopus)

Site-specific covalent labeling of His-tag fused proteins with a reactive Ni(ii)-NTA probe

Uchinomiya, S., Nonaka, H., Fujishima, S. H., Tsukiji, S., Ojida, A. & Hamachi, I., 10 12 2009, : : Chemical Communications. 39, p. 5880-5882 3 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Proteins
Histidine
21 引用 (Scopus)

Theoretical study of photophysical properties of bisindolylmaleimide derivatives

Saita, K., Nakazono, M., Zaitsu, K., Nanbu, S. & Sekiya, H., 7 23 2009, : : Journal of Physical Chemistry A. 113, 29, p. 8213-8220 8 p.

研究成果: ジャーナルへの寄稿記事

indoles
Dione
Derivatives
Anions
anions
2008
5 引用 (Scopus)

Analysis of nitroxyl spin probes in mouse brain by X-band ESR with microanalysis technique

Shiba, T., Yamato, M., Kudou, W., Ichikawa, K., Yamada, K-I., Watanabe, T. & Utsumi, H., 1 1 2008, : : Journal of Pharmaceutical Sciences. 97, 9, p. 4101-4107 7 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Brain
Head
Urine
Dialysis Solutions
30 引用 (Scopus)

Automated and simultaneous two-dimensional micro-high-performance liquid chromatographic determination of proline and hydroxyproline enantiomers in mammals

Tojo, Y., Hamase, K., Nakata, M., Morikawa, A., Mita, M., Ashida, Y., Lindner, W. & Zaitsu, K., 11 1 2008, : : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 875, 1, p. 174-179 6 p.

研究成果: ジャーナルへの寄稿記事

Mammals
Enantiomers
Hydroxyproline
Proline
Skin
5 引用 (Scopus)

Chemiluminescence change of polyphenol dendrimers with different core molecules

Agawa, H., Nakazono, M., Nanbu, S. & Zaitsu, K., 12 1 2008, : : Organic Letters. 10, 22, p. 5171-5174 4 p.

研究成果: ジャーナルへの寄稿記事

Dendrimers
Chemiluminescence
chemiluminescence
dendrimers
Polyphenols
17 引用 (Scopus)
Alanine
Rats
Habits
Mammals
Insulin
12 引用 (Scopus)

Formation of TEMPOL-hydroxylamine during reaction between TEMPOL and hydroxyl radical: HPLC/ECD study

Kudo, W., Yamato, M., Yamada, K-I., Kinoshita, Y., Shiba, T., Watanabe, T. & Utsumi, H., 5 1 2008, : : Free Radical Research. 42, 5, p. 505-512 8 p.

研究成果: ジャーナルへの寄稿記事

Hydroxylamine
Hydroxyl Radical
High Pressure Liquid Chromatography
NAD
Antioxidants
3 引用 (Scopus)

Homogeneous sugar modification improves crystallization of measles virus hemagglutinin

Hashiguchi, T., Kajikawa, M., Maita, N., Takeda, M., Kuroki, K., Tabata, K., Kohda, D., Yanagi, Y. & Maenaka, K., 4 1 2008, : : Journal of Virological Methods. 149, 1, p. 171-174 4 p.

研究成果: ジャーナルへの寄稿記事

Measles virus
Hemagglutinins
Crystallization
Viral Envelope Proteins
Virus Attachment
13 引用 (Scopus)

Structural and photophysical properties of novel dual fluorescent compounds, 1-aryl-substituted 6-methoxy-4-quinolones

Hirano, J., Hamase, K., Akita, T. & Zaitsu, K., 10 1 2008, : : Luminescence. 23, 5, p. 350-355 6 p.

研究成果: ジャーナルへの寄稿記事

Fluorescence
Acidity
X-Rays
X rays
Temperature
20 引用 (Scopus)

Synthesis of nitroxyl radicals for overhauser-enhanced magnetic resonance imaging

Yamada, K-I., Kinoshita, Y., Yamasaki, T., Sadasue, H., Mito, F., Nagai, M., Matsumoto, S., Aso, M., Suemune, H., Sakai, K. & Utsumi, H., 9 1 2008, : : Archiv der Pharmazie. 341, 9, p. 548-553 6 p.

研究成果: ジャーナルへの寄稿記事

Magnetic Resonance Imaging
Free Radicals
Protons
Deuterium
Electron Spin Resonance Spectroscopy
2007
31 引用 (Scopus)

Advantageous application of a surface coil to EPR irradiation in overhauser-enhanced MRI

Matsumoto, S., Yamada, K-I., Hirata, H., Yasukawa, K., Hyodo, F., Ichikawa, K. & Utsumi, H., 4 1 2007, : : Magnetic Resonance in Medicine. 57, 4, p. 806-811 6 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Free Radicals
Protons
77 引用 (Scopus)

A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia

Morita, Y., Ujike, H., Tanaka, Y., Otani, K., Kishimoto, M., Morio, A., Kotaka, T., Okahisa, Y., Matsushita, M., Morikawa, A., Hamase, K., Zaitsu, K. & Kuroda, S., 5 15 2007, : : Biological Psychiatry. 61, 10, p. 1200-1203 4 p.

研究成果: ジャーナルへの寄稿記事

Schizophrenia
Alleles
Serine
Genes
Single Nucleotide Polymorphism
28 引用 (Scopus)

Alterations in D-amino acid levels in the brains of mice and rats after the administration of D-amino acids

Morikawa, A., Hamase, K., Inoue, T., Konno, R. & Zaitsu, K., 1 1 2007, : : Amino Acids. 32, 1, p. 13-20 8 p.

研究成果: ジャーナルへの寄稿記事

Rats
Brain
Amino Acids
Pineal Gland
Pituitary Gland
12 引用 (Scopus)

A ratiometric fluorescent chemosensor, 1,10-phenanthroline-4,7-dione, for anions in aqueous-organic media

Hirano, J., Miyata, H., Hamase, K. & Zaitsu, K., 7 9 2007, : : Tetrahedron Letters. 48, 28, p. 4861-4864 4 p.

研究成果: ジャーナルへの寄稿記事

Anions
4-Quinolones
Molecules
4,7-phenanthroline
chemosensor 1
40 引用 (Scopus)

Bisindolylmaleimides with large stokes shift and long-lasting chemiluminescence properties

Nakazono, M., Nanbu, S., Uesaki, A., Kuwano, R., Kashiwabara, M. & Zaitsu, K., 8 30 2007, : : Organic Letters. 9, 18, p. 3583-3586 4 p.

研究成果: ジャーナルへの寄稿記事

Chemiluminescence
chemiluminescence
Luminescence
Fluorescence
Wavelength
70 引用 (Scopus)
Mammals
Amino Acids
Liquids
Enantiomers
Tissue
161 引用 (Scopus)

Crystal structure of measles virus hemagglutinin provides insight into effective vaccines

Hashiguchi, T., Kajikawa, M., Maita, N., Takeda, M., Kuroki, K., Tabata, K., Kohda, D., Yanagi, Y. & Maenaka, K., 12 4 2007, : : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19535-19540 6 p.

研究成果: ジャーナルへの寄稿記事

Measles virus
Hemagglutinins
Vaccines
Measles Vaccine
HIV Envelope Protein gp120
28 引用 (Scopus)

Escherichia coli PriA protein, two modes of DNA binding and activation of ATP hydrolysis

Tanaka, T., Mizukoshi, T., Tabata, K., Kohda, D. & Masai, H., 7 6 2007, : : Journal of Biological Chemistry. 282, 27, p. 19917-19927 11 p.

研究成果: ジャーナルへの寄稿記事

Escherichia coli Proteins
Escherichia coli
Hydrolysis
Adenosine Triphosphate
Chemical activation
36 引用 (Scopus)

Identification and characterization of cannabinoids that induce cell death through mitochondrial permeability transition in cannabis leaf cells

Morimoto, S., Tanaka, Y., Tabata, K., Tanaka, H., Fukamizu, T., Shoyama, Y., Shoyama, Y. & Taura, F., 7 13 2007, : : Journal of Biological Chemistry. 282, 28, p. 20739-20751 13 p.

研究成果: ジャーナルへの寄稿記事

Cannabinoids
Cell death
Cannabis
Permeability
Cell Death
38 引用 (Scopus)

Immunohistochemical localization of d-alanine to β-cells in rat pancreas

Morikawa, A., Hamase, K., Ohgusu, T., Etoh, S., Tanaka, H., Koshiishi, I., Shoyama, Y. & Zaitsu, K., 4 20 2007, : : Biochemical and Biophysical Research Communications. 355, 4, p. 872-876 5 p.

研究成果: ジャーナルへの寄稿記事

Alanine
Rats
Pancreas
Staining and Labeling
Amino Acids
4 引用 (Scopus)

Photosensitive luminol derivatives and measurement of ultraviolet ray power

Nakazono, M., Hino, T. & Zaitsu, K., 2 5 2007, : : Journal of Photochemistry and Photobiology A: Chemistry. 186, 1, p. 99-105 7 p.

研究成果: ジャーナルへの寄稿記事

Luminol
rays
Derivatives
Photolysis
Quantum yield
33 引用 (Scopus)

Structural basis of the 3′-end recognition of a leading strand in stalled replication forks by PriA

Tabata, K., Ose, T., Okamoto, N., Maenaka, K., Tanaka, T., Masai, H., Saito, M., Shirai, T. & Kohda, D., 5 16 2007, : : EMBO Journal. 26, 10, p. 2584-2593 10 p.

研究成果: ジャーナルへの寄稿記事

DNA
Oligonucleotides
Nucleotides
Deoxyribose
Fluorescence Spectrometry
2006
3 引用 (Scopus)

Crystallization and preliminary crystallographic analysis of the N-terminal domain of PriA from Escherichia coli

Tabata, K., Ose, T., Tanaka, T., Mizukoshi, T., Ishigaki, T., Maenaka, K., Masai, H. & Kohda, D., 1 1 2006, : : Biochimica et Biophysica Acta - Proteins and Proteomics. 1764, 1, p. 157-160 4 p.

研究成果: ジャーナルへの寄稿記事

Crystallization
Escherichia coli
DNA Helicases
DNA
DNA Replication
44 引用 (Scopus)

Dynamic nuclear polarization properties of nitroxyl radicals used in Overhauser-enhanced MRI for simultaneous molecular imaging

Benial, A. M. F., Ichikawa, K., Murugesan, R., Yamada, K-I. & Utsumi, H., 10 1 2006, : : Journal of Magnetic Resonance. 182, 2, p. 273-282 10 p.

研究成果: ジャーナルへの寄稿記事

Molecular imaging
Molecular Imaging
Magnetic resonance imaging
Magnetic resonance
Magnetic Resonance Imaging
77 引用 (Scopus)

Effective disruption of phosphoprotein-protein surface interaction using Zn(II) dipicolylamine-based artificial receptors via two-point interaction

Ojida, A., Inoue, M. A., Mito-Oka, Y., Tsutsumi, H., Sada, K. & Hamachi, I., 2 15 2006, : : Journal of the American Chemical Society. 128, 6, p. 2052-2058 7 p.

研究成果: ジャーナルへの寄稿記事

Artificial Receptors
Phosphoproteins
Membrane Proteins
Proteins
Peptides
16 引用 (Scopus)

Enhanced intraarticular free radical reactions in adjuvant arthritis rats

Yamada, K-I., Nakamura, T. & Utsumi, H., 5 1 2006, : : Free Radical Research. 40, 5, p. 455-460 6 p.

研究成果: ジャーナルへの寄稿記事

Free radical reactions
Experimental Arthritis
Free Radicals
Rats
Joints
16 引用 (Scopus)
4-Quinolones
Orbital calculations
Molecular orbitals
Anions
Substitution reactions
4 引用 (Scopus)

High-throughput determination of free d-aspartic acid in mammals by enzyme immunoassay using specific monoclonal antibody

Ohgusu, T., Hamase, K., Tanaka, H., Shoyama, Y. & Zaitsu, K., 10 1 2006, : : Analytical Biochemistry. 357, 1, p. 15-20 6 p.

研究成果: ジャーナルへの寄稿記事

Mammals
Immunoenzyme Techniques
Aspartic Acid
Immunosorbents
Assays
56 引用 (Scopus)

In vivo detection of free radicals induced by diethylnitrosamine in rat liver tissue

Yamada, K-I., Yamamiya, I. & Utsumi, H., 6 1 2006, : : Free Radical Biology and Medicine. 40, 11, p. 2040-2046 7 p.

研究成果: ジャーナルへの寄稿記事

Diethylnitrosamine
Liver
Free Radicals
Rats
Tissue
47 引用 (Scopus)

Noninvasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats

Utsumi, H., Yasukawa, K., Soeda, T., Yamada, K-I., Shigemi, R., Yao, T. & Tsuneyoshi, M., 4 1 2006, : : Journal of Pharmacology and Experimental Therapeutics. 317, 1, p. 228-235 8 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Stomach Ulcer
Indomethacin
Reactive Oxygen Species
Ulcer
32 引用 (Scopus)

Presence and origin of large amounts of d-proline in the urine of mutant mice lacking d-amino acid oxidase activity

Hamase, K., Takagi, S., Morikawa, A., Konno, R., Niwa, A. & Zaitsu, K., 10 1 2006, : : Analytical and Bioanalytical Chemistry. 386, 3, p. 705-711 7 p.

研究成果: ジャーナルへの寄稿記事

Proline
Oxidoreductases
Urine
Tissue
Amino Acids
19 引用 (Scopus)

Sensitive high-performance liquid chromatographic assay for D-amino-acid oxidase activity in mammalian tissues using a fluorescent non-natural substrate, 5-fluoro-D-tryptophan

Hamase, K., Nagayasu, R., Morikawa, A., Konno, R. & Zaitsu, K., 2 17 2006, : : Journal of Chromatography A. 1106, 1-2, p. 159-164 6 p.

研究成果: ジャーナルへの寄稿記事

D-Amino-Acid Oxidase
Tryptophan
Assays
Oxidoreductases
Tissue
123 引用 (Scopus)

Simultaneous molecular imaging of redox reactions monitored by Overhauser-enhanced MRI with 14N- and 15N-labeled nitroxyl radicals

Utsumi, H., Yamada, K-I., Ichikawa, K., Sakai, K., Kinoshita, Y., Matsumoto, S. & Nagai, M., 1 31 2006, : : Proceedings of the National Academy of Sciences of the United States of America. 103, 5, p. 1463-1468 6 p.

研究成果: ジャーナルへの寄稿記事

Molecular Imaging
Oxidation-Reduction
Electron Spin Resonance Spectroscopy
Membranes
Reactive Oxygen Species
26 引用 (Scopus)

Spatially resolved time-course studies of free radical reactions with an EPRI/MRI fusion technique

Hyodo, F., Yasukawa, K., Yamada, K-I. & Utsumi, H., 10 1 2006, : : Magnetic Resonance in Medicine. 56, 4, p. 938-943 6 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Free Radicals
Pharmacokinetics
Fiducial Markers
Feasibility Studies
6 引用 (Scopus)
Pyrroles
Chemiluminescence
Electrospray ionization
Curcumin
Liquid chromatography
2005
14 引用 (Scopus)

A composite resonator assembly suitable for EPR/NMR coregistration imaging

Matsumoto, S., Nagai, M., Yamada, K-I., Hyodo, F., Yasukawa, K., Muraoka, M., Hirata, H., Ono, M. & Utsumi, H., 4 1 2005, : : Concepts in Magnetic Resonance Part B: Magnetic Resonance Engineering. 25, 1, p. 1-11 11 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Paramagnetic resonance
Resonators
electron paramagnetic resonance
Magnetic Resonance Spectroscopy