有機・生物化学

研究成果 1979 2019

2019
Glycosylation
Stereoselectivity
Oligosaccharides
linkages
reactivity

Biosynthetic Short Neuropeptides: A Rational Theory Based on Experimental Results for the Missing Pain-Relief Opioid Endomorphin Precursor Gene

Matsushima, A., Sese, J. & Koyanagi, K. O., 1 1 2019, : : ChemBioChem. 20, 16, p. 2054-2058 5 p.

研究成果: ジャーナルへの寄稿記事

Neuropeptides
Opioid Analgesics
Genes
Pain
Peptides
1 引用 (Scopus)

Design and synthesis of artificial ladder-shaped polyethers for exploring biological functions

Oishi, T., 1 1 2019, : : Heterocycles. 99, 1, p. 21-53 33 p.

研究成果: ジャーナルへの寄稿記事

Dinoflagellida
Polyethers
Ladders
Molecular Structure
Biological Products

Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors

Masuya, T., Iwamoto, M., Liu, X. & Matsushima, A., 12 1 2019, : : Scientific reports. 9, 1, 9954.

研究成果: ジャーナルへの寄稿記事

公開
Cytoplasmic and Nuclear Receptors
Estrogens
Estrogen Receptors
Epoxy Resins
Endocrine Disruptors

Evaluation of the binding ability of an orphan nuclear receptor nurr1 to synthetic peptides.

Masuya, T., Tada, Y., Liu, X. & Matsushima, A., 2019, Peptide Science 2018. p. 133

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

5 引用 (Scopus)

Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

Sakaue, H., Shiota, T., Ishizaka, N., Kawano, S., Tamura, Y., Tan, K. S., Imai, K., Motono, C., Hirokawa, T., Taki, K., Miyata, N., Kuge, O., Lithgow, T. & Endo, T., 3 7 2019, : : Molecular Cell. 73, 5, p. 1044-1055.e8

研究成果: ジャーナルへの寄稿記事

Porins
Mitochondrial Proteins
TOM translocase

Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors

Liu, X., Sakai, H., Nishigori, M., Suyama, K., Nawaji, T., Ikeda, S., Nishigouchi, M., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 8 15 2019, : : Toxicology and Applied Pharmacology. 377, 114610.

研究成果: ジャーナルへの寄稿記事

Cytoplasmic and Nuclear Receptors
Assays
Endocrine Disruptors
Peroxisome Proliferator-Activated Receptors
Competitive Binding

Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region

Yoshinaka, T., Kosako, H., Yoshizumi, T., Furukawa, R., Hirano, Y., Kuge, O., Tamada, T. & Koshiba, T., 9 27 2019, : : iScience. 19, p. 1065-1078 14 p.

研究成果: ジャーナルへの寄稿記事

公開
Signal Transduction
Mitochondria
Mitochondrial Dynamics
Biotin
prohibitin

Unified synthesis of the DEF and GhI ring systems of maitotoxin

Yasudomi, T., Yakushiji, H., Torikai, K., Ebine, M. & Oishi, T., 1 1 2019, : : Chemistry Letters. 48, 9, p. 1156-1159 4 p.

研究成果: ジャーナルへの寄稿記事

Acetals
Methylation
Ethers
Alkenes
Derivatives
2018
2 引用 (Scopus)
wildlife
Endocrine Disruptors
disrupting
bisphenols
DDT
DDT
wildlife
Endocrine Disruptors
disrupting
bisphenols
Amphotericin B
Nuclear magnetic resonance
Anti-Bacterial Agents
Membranes
Ergosterol

Cell death or survival against oxidative stress

Miyata, N., Okumoto, K. & Fujiki, Y., 1 1 2018, Subcellular Biochemistry. Springer New York, p. 463-471 9 p. (Subcellular Biochemistry; 巻数 89).

研究成果: 著書/レポートタイプへの貢献

Peroxisomes
Oxidative stress
Cell death
Catalase
Cell Survival
4 引用 (Scopus)

Convergent syntheses of the WXYZ ring of maitotoxin and the HIJK ring of brevisulcenal-F

Osato, N., Onoue, H., Toma, Y., Torikai, K., Ebine, M., Satake, M. & Oishi, T., 1 1 2018, : : Chemistry Letters. 47, 3, p. 265-268 4 p.

研究成果: ジャーナルへの寄稿記事

Ketones
Stereochemistry
Methylation
Lithium
Aldehydes

Flow synthesis of (3R)- and (3S)-(E)-1-iodohexa-1,5-dien-3-ol: Chiral building blocks for natural product synthesis

Katayama, S., Koge, T., Katsuragi, S., Akai, S. & Oishi, T., 1 1 2018, : : Chemistry Letters. 47, 9, p. 1116-1118 3 p.

研究成果: ジャーナルへの寄稿記事

Ion Exchange Resins
Biological Products
Lipase
Evaporation
Acetates

Homodimer function of human nuclear receptor ERR evidenced using -helix peptides in the dimer interface

Liu, X., Nakagawa, H., Sugiyama, M., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2018, Peptide Science 2017. p. 190 191 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Identification of peroxisomal protein complexes with PTS receptors, pex5 and pex7, in mammalian cells

Okumoto, K., Miyata, N. & Fujiki, Y., 1 1 2018, Subcellular Biochemistry. Springer New York, p. 287-298 12 p. (Subcellular Biochemistry; 巻数 89).

研究成果: 著書/レポートタイプへの貢献

Cells
Proteins
Purification
Protein Interaction Maps
Peroxisomes
2 引用 (Scopus)

Mannosylinositol phosphorylceramides and ergosterol coodinately maintain cell wall integrity in the yeast Saccharomyces cerevisiae

Tanaka, S. & Tani, M., 7 1 2018, : : FEBS Journal. 285, 13, p. 2405-2427 23 p.

研究成果: ジャーナルへの寄稿編集

Ergosterol
Yeast
Cell Wall
Saccharomyces cerevisiae
Yeasts

Mutual co-work between nuclear receptor ERalpha and ERRgamma requires their homodimerization

Liu, X., Shimohigashi, M., Sugiyama, M., Matsushima, A. & Shimohigashi, Y., 2018, Peptide Science 2017,. p. 198 199 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Overexpression of PDR16 confers resistance to complex sphingolipid biosynthesis inhibitor aureobasidin A in yeast Saccharomyces cerevisiae

Katsuki, Y., Yamaguchi, Y. & Tani, M., 2 1 2018, : : FEMS microbiology letters. 365, 3, fnx255.

研究成果: ジャーナルへの寄稿記事

Sphingolipids
Saccharomyces cerevisiae
Yeasts
Tetracycline
Growth

Phe 2715.39 of Thronbin Receptor PAR-1 is a specific target of Phe-2-phenl group of its tethered ligand

Sugiyama, M., Fujita, T., Liu, X., Matsuyama, Y., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2018, Peptide Science 2017. p. 94 95 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

4 引用 (Scopus)

Porin proteins have critical functions in mitochondrial phospholipid metabolism in yeast

Miyata, N., Fujii, S. & Kuge, O., 11 9 2018, : : The Journal of biological chemistry. 293, 45, p. 17593-17605 13 p.

研究成果: ジャーナルへの寄稿記事

Porins
Cardiolipins
Metabolism
Yeast
Phospholipids
6 引用 (Scopus)

Protection mechanisms against aberrant metabolism of sphingolipids in budding yeast

Tani, M. & Funato, K., 10 1 2018, : : Current Genetics. 64, 5, p. 1021-1028 8 p.

研究成果: ジャーナルへの寄稿評論記事

Sphingolipids
Saccharomycetales
Osmolar Concentration
Glycerol
Yeasts
5 引用 (Scopus)

Protective role of the HOG pathway against the growth defect caused by impaired biosynthesis of complex sphingolipids in yeast Saccharomyces cerevisiae

Yamaguchi, Y., Katsuki, Y., Tanaka, S., Kawaguchi, R., Denda, H., Ikeda, T., Funato, K. & Tani, M., 2 1 2018, : : Molecular Microbiology. 107, 3, p. 363-386 24 p.

研究成果: ジャーナルへの寄稿記事

Sphingolipids
Osmolar Concentration
Glycerol
Saccharomyces cerevisiae
Yeasts
1 引用 (Scopus)

Synthesis and complete structure determination of a sperm-activating and -attracting factor isolated from the ascidian ascidia sydneiensis

Watanabe, T., Shibata, H., Ebine, M., Tsuchikawa, H., Matsumori, N., Murata, M., Yoshida, M., Morisawa, M., Lin, S., Yamauchi, K., Sakai, K. & Oishi, T., 4 27 2018, : : Journal of Natural Products. 81, 4, p. 985-997 13 p.

研究成果: ジャーナルへの寄稿記事

Ergosterol
Urochordata
Biological Products
Ketones
Eggs
3 引用 (Scopus)

Synthesis and Stereochemical Revision of the C31–C67 Fragment of Amphidinol 3

Wakamiya, Y., Ebine, M., Murayama, M., Omizu, H., Matsumori, N., Murata, M. & Oishi, T., 5 22 2018, : : Angewandte Chemie - International Edition. 57, 21, p. 6060-6064 5 p.

研究成果: ジャーナルへの寄稿記事

Degradation
Biological Products
Carbon
Nuclear magnetic resonance
Availability
1 引用 (Scopus)

Synthesis of 6/6/6-tricyclic ether system via Achmatowicz and intramolecular oxa-michael reactions

Yamamoto, H., Torikai, K., Ebine, M. & Oishi, T., 1 1 2018, : : Heterocycles. 97, 1, p. 158-162 5 p.

研究成果: ジャーナルへの寄稿記事

Ethers
Aldehydes
Isomers
Ether
Alcohols

Synthesis of an analog of amphidinol 3 corresponding to the c31-c67 section

Koge, T., Wakamiya, Y., Ebine, M. & Oishi, T., 1 1 2018, : : Heterocycles. 96, 7, p. 1197-1202 6 p.

研究成果: ジャーナルへの寄稿記事

Structure-Activity Relationship
Derivatives
amphidinol 3
polyol
2 引用 (Scopus)

Synthesis of anti-tubercular marine alkaloids denigrins A and B

Karak, M., Oishi, T. & Torikai, K., 7 18 2018, : : Tetrahedron Letters. 59, 29, p. 2800-2803 4 p.

研究成果: ジャーナルへの寄稿記事

Maleic Anhydrides
Alkaloids
Cross Reactions
Palladium
Salts
2017
1 引用 (Scopus)

1-Naphthylmethyl and 1-naphthylmethoxymethyl protecting groups: New members of the benzyl- and benzyloxymethyl-type family

Sato, T., Joh, Y., Oishi, T. & Torikai, K., 1 1 2017, : : Tetrahedron Letters. 58, 23, p. 2178-2181 4 p.

研究成果: ジャーナルへの寄稿記事

Oxidation
Hydrogenolysis
Nucleophiles
Temperature
Acids
2 引用 (Scopus)

Adaptation of a genetic screen reveals an inhibitor for mitochondrial protein import component Tim44

Miyata, N., Tang, Z., Conti, M. A., Johnson, M. E., Douglas, C. J., Hasson, S. A., Damoiseaux, R., Chang, C. E. A. & Koehler, C. M., 3 31 2017, : : Journal of Biological Chemistry. 292, 13, p. 5429-5442 14 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Proteins
Membranes
Mitochondria
Proteins
Molecules
5 引用 (Scopus)

BAK regulates catalase release from peroxisomes

Fujiki, Y., Miyata, N., Mukai, S., Okumoto, K. & Cheng, E. H., 3 17 2017, : : Molecular & Cellular Oncology . 4, 3, e1306610.

研究成果: ジャーナルへの寄稿記事

Voltage-Dependent Anion Channel 2
Peroxisomes
Catalase
Permeability
Mitochondria
4 引用 (Scopus)

Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae

Miyata, N., Goda, N., Matsuo, K., Hoketsu, T. & Kuge, O., 12 1 2017, : : Scientific reports. 7, 1, 16447.

研究成果: ジャーナルへの寄稿記事

Cardiolipins
Saccharomyces cerevisiae
Mitochondrial Membranes
Yeasts
Phosphatidic Acids
5 引用 (Scopus)

Design and synthesis of benzoacridines as estrogenic and anti-estrogenic agents

Torikai, K., Koga, R., Liu, X., Umehara, K., Kitano, T., Watanabe, K., Oishi, T., Noguchi, H. & Shimohigashi, Y., 1 1 2017, : : Bioorganic and Medicinal Chemistry. 25, 20, p. 5216-5237 22 p.

研究成果: ジャーナルへの寄稿記事

Estrogens
Estrogen Receptors
Orphan Nuclear Receptors
Selective Estrogen Receptor Modulators
Inhibitory Concentration 50

Docking simulation to elucidate the labeled cysteine residue of the nociception receptor ORL1 using a Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X. & Shimohigashi, Y., 2017, Peptide Science 2016. p. 87-88

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

21 引用 (Scopus)

Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism

Nishimoto, K., Koga, M., Seki, T., Oki, K., Gomez-Sanchez, E. P., Gomez-Sanchez, C. E., Naruse, M., Sakaguchi, T., Morita, S., Kosaka, T., Oya, M., Ogishima, T., Yasuda, M., Suematsu, M., Kabe, Y., Omura, M., Nishikawa, T. & Mukai, K., 2 5 2017, : : Molecular and Cellular Endocrinology. 441, p. 124-133 10 p.

研究成果: ジャーナルへの寄稿評論記事

Cytochrome P-450 CYP11B2
Hyperaldosteronism
Steroid 11-beta-Hydroxylase
Zona Glomerulosa
Aldosterone
3 引用 (Scopus)

Syntheses and Biological Activities of the LMNO, ent-LMNO, and NOPQR(S) Ring Systems of Maitotoxin

Onoue, H., Marubayashi, R., Ishikawa, E., Konoki, K., Torikai, K., Ebine, M., Murata, M. & Oishi, T., 1 1 2017, : : Journal of Organic Chemistry. 82, 18, p. 9595-9618 24 p.

研究成果: ジャーナルへの寄稿記事

Bioactivity
Enantiomers
Aldehydes
Alkynes
Biological Products
3 引用 (Scopus)

Synthesis of a truncated analog of amphidinol 3 corresponding to the C21C39/C52C67 section

Ebine, M., Takada, Y., Yanai, N. & Oishi, T., 1 1 2017, : : Chemistry Letters. 46, 5, p. 662-664 3 p.

研究成果: ジャーナルへの寄稿記事

Polyenes
amphidinol 3
20 引用 (Scopus)

The VDAC2-BAK axis regulates peroxisomal membrane permeability

Hosoi, K., Miyata, N., Mukai, S., Furuki, S., Okumoto, K., Cheng, E. H. & Fujiki, Y., 3 6 2017, : : Journal of Cell Biology. 216, 3, p. 709-722

研究成果: ジャーナルへの寄稿記事

Peroxisomes
Permeability
Membranes
Peroxisomal Disorders
Inborn Genetic Diseases
2016

Comparative analysis of the ligand binding domain secondary structures of human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 337-338

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Comprehensive structural analysis of the nociceptin ORL1 receptor by means of virtual and experimental Ala-scanning combinated methods

Matsushima, A., Nishimura, H., Liu, X., Takesue, Y., Matsuyama, Y. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 149-150

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Do the estrogen receptors function as a homodimer? experimental validation of homodimerization by inhibitory peptides

Sakito, S., Fujiyama, A., Motomatsu, Y., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 335-336

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Do the estrogen receptors function as a homodimer? experimental validation of homodimerization by inhibitory peptides

Sakito, S., Liu, X., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 335-336

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

68 引用 (Scopus)

Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling

Otera, H., Miyata, N., Kuge, O. & Mihara, K., 1 1 2016, : : Journal of Cell Biology. 212, 5, p. 531-544 14 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Dynamics
Cytochromes c
Apoptosis
Cytoplasm
Phenotype

Expression analysis of neuropeptide PDF mRNA in the hypoactive and hyperactive fruit flies Drosophila melanogaster

Asuka, T., Matsuo, A., Shotaro, U., Matsuyama, Y., masayuki, N., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 317-318

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Functional role of the Phe-Phe stacking microswitch in the ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 147-148

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

ORL1 Nociceptin receptor response of opioid peptides derived from proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsuyama, Y., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 181-182

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

27 引用 (Scopus)

Phosphatidylserine transport by Ups2-Mdm35 in respiration-active mitochondria

Miyata, N., Watanabe, Y., Tamura, Y., Endo, T. & Kuge, O., 7 1 2016, : : Journal of Cell Biology. 214, 1, p. 77-88 12 p.

研究成果: ジャーナルへの寄稿記事

Phosphatidylserines
Mitochondria
Respiration
Mitochondrial Membranes
Endoplasmic Reticulum

SCN Circadian rhythm signal transduction neuropeptides evoke hypoactive phenotype differently in male and female mice

Sugiyama, M., Motomatsu, Y., Matsuyama, Y., Kajiyama, S., Kameda, T., Uchimura, E., Saito, T., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 53-54

研究成果: 著書/レポートタイプへの貢献章 (査読済み)