有機・生物化学

研究成果

1999
22 引用 (Scopus)

Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide

Tani, M., Okino, N., Mitsutake, S. & Ito, M., 1999, : : Journal of Biochemistry. 125, 4, p. 746-749 4 p.

研究成果: ジャーナルへの寄稿記事

37 引用 (Scopus)
2000

Chemical syntheses of phenylalanine derivatives containing halogenated benzene ring as structural explorers for elucidation of molecular mechanisms of receptor interactions

Matsushima, A., Fujita, T., Okada, K., Yamauchi, Y., Nose, T. & Shimohigashi, Y., 2000, Peptide Science 1999. p. 141-142

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Edge-to-face CH/π interaction between ligand Phe-phenyl and receptor aromatic group in the thrombin receptor activation

Matsushima, A., Fujita, T., Nose, T. & Shimohigashi, Y., 1 1 2000, : : Journal of biochemistry. 128, 2, p. 225-232 8 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

Enthalpy- and/or entropy-controlled asymmetric oxidation: Stereocontrolling factors in Mn-salen-catalyzed oxidation

Nishida, T., Miyafuji, A., Ito, Y. N. & Katsuki, T., 9 2 2000, : : Tetrahedron Letters. 41, 36, p. 7053-7058 6 p.

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

Exploration of the role of phenylalanine in the thrombin receptor tethered-ligand peptide by substitution with a series of trifluorophenylalanines

Matsushima, A., Fujita, T., Okada, K., Shirasu, N., Nose, T. & Shimohigashi, Y., 11 1 2000, : : Bulletin of the Chemical Society of Japan. 73, 11, p. 2531-2538 8 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Glycine-rich region of mitochondrial processing peptidase α-subunit is essential for binding and cleavage of the precursor proteins

Nagao, Y., Kitada, S., Kojima, K., Toh, H., Kuhara, S., Ogishima, T. & Ito, A., 11 3 2000, : : Journal of Biological Chemistry. 275, 44, p. 34552-34556 5 p.

研究成果: ジャーナルへの寄稿記事

37 引用 (Scopus)

Highly potent peptide ligands for thrombin receptor

Fujita, T., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., 2000, Peptide Science 1999. p. 421-424

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases

Tani, M., Okino, N., Mori, K., Tanigawa, T., Izu, H. & Ito, M., 4 14 2000, : : Journal of Biological Chemistry. 275, 15, p. 11229-11234 6 p.

研究成果: ジャーナルへの寄稿記事

92 引用 (Scopus)

Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells

Romiti, E., Meacci, E., Tani, M., Nuti, F., Farnararo, M., Ito, M. & Bruni, P., 9 7 2000, : : Biochemical and Biophysical Research Communications. 275, 3, p. 746-751 6 p.

研究成果: ジャーナルへの寄稿記事

41 引用 (Scopus)
71 引用 (Scopus)

Synthesis of a complete set of L-difluorophenylalanines, L-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor

Fujita, T., Nose, T., Matsushima, A., Okada, K., Asai, D., Yamauchi, Y., Shirasu, N., Honda, T., Shigehiro, D. & Shimohigashi, Y., 2 5 2000, : : Tetrahedron Letters. 41, 6, p. 923-927 5 p.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)
2001

Activity Enhancement by Introduction of two different halogen atoms into Phe-2-phenyl group of thrombin receptor tetherd-ligand analogs.

Fujita, T., Inoue, N., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2001, Peptide Science 2000. p. 135-138

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

A proposed common structure of substrates bound to mitochondrial processing peptidase

Kojima, K., Kitada, S., Ogishima, T. & Ito, A., 1 19 2001, : : Journal of Biological Chemistry. 276, 3, p. 2115-2121 7 p.

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

cDNA cloning of a circadian rhythm pacemaker hormone PDF of the house fly Musca domestica

Matsushima, A., Chuman, Y., Sato, S., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2001, Comparative Biochemistry and Physiology. p. 876

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

cDNA Cloning of circadian rhythm pacemaker neuropeptide PDF in Gryllus bimaculatus and its neuclear localization

Chuman, Y., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 2001, Peptide Science 2000. p. 59-62

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Convergent strategy for synthesizing polycyclic ether marine toxins: Synthesis of the ABCDE ring fragment of ciguatoxin CTX3C

Maruyama, M., Maeda, K., Oishi, T., Oguri, H. & Hirama, M., 1 1 2001, : : Heterocycles. 54, 1, p. 93-99 7 p.

研究成果: ジャーナルへの寄稿記事

36 引用 (Scopus)

Gene expression of a circadian pacemaker hormone peptide PDF in cricket Gryllus bimaculatus

Matsushima, A., Chuman, Y., Onoue, H., Ito, Y., Tomioka, K., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2001, Peptide Science 2000. p. 63-66

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Highly diastereoselective aziridination of α,β-unsaturated amides using diaziridine

Ishihara, H., Ito, Y. N. & Katsuki, T., 1 1 2001, : : Chemistry Letters. 10, p. 984-985 2 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

PERIOD clock protein of the summer cicada Meimuna opalifera: cDNA cloning and structural analysis

Sato, S., Chuman, Y., Matsushima, A., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2001, Comparative Biochemistry and Physiology. 巻 130. p. 876

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Purification, Characterization, Molecular Cloning, and Subcellular Distribution of Neutral Ceramidase of Rat Kidney

Mitsutake, S., Tani, M., Okino, N., Mori, K., Ichinose, S., Omori, A., Iida, H., Nakamura, T. & Ito, M., 7 13 2001, : : Journal of Biological Chemistry. 276, 28, p. 26249-26259 11 p.

研究成果: ジャーナルへの寄稿記事

92 引用 (Scopus)

Purification of phosphatidylglycerophosphate synthase from Chinese hamster ovary cells

Kawasaki, K., Kuge, O., Yamakawa, Y. & Nishijima, M., 2 15 2001, : : Biochemical Journal. 354, 1, p. 9-15 7 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Recognition of mitochondrial protein precursor lacking arginine at position -2 by Mitochondrial Processing Peptidase: Processing of bovine cytochrome p450(SCC) precursor

Kojima, K., Yamasaki, E., Kitada, S., Ogishima, T. & Ito, A., 2001, : : Journal of biochemistry. 130, 4, p. 497-502 6 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)
2002

cDNA cloning and nuclear localization of the circadian neuropeptide designated as pigment-dispersing factor PDF in the cricket Gryllus bimaculatus

Chuman, Y., Matsushima, A., Sato, S., Tomioka, K., Tominaga, Y., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., 1 1 2002, : : Journal of Biochemistry. 131, 6, p. 895-903 9 p.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

cDNA cloning of PDF peptide precursors in housefly and last summer cicada

Sato, S., Matsushima, A., Chuman, Y., Tominaga, K., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 139-142

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Circadian rhythm pacemaker neuropeptide 'PDF' in nocturnal insect cricket gryllus bimaculatus: cDNA cloning, mRNA expression, and nuclear localization

Chuman, Y., Matsushima, A., Nose, T., Shimohigashi, Y. & Shimohigashi, M., 2002, American Peptide Society 2001. p. 797-798

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Contractile activity of Drosophila FMRFamide-related peptides in the Meretrix Lusoria heart muscle.

Tokunaga, T., Ohtani, M., Matsushima, A., Chuman, Y., Nose, T. & Shimohigashi, Y., 2002, Peptide Science 2001. p. 167-170

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Design and preparation of universal anti-PERIOD antibodies and their immunoresponses.

Asai, D., Tokunaga, T., Matsushima, A., Sato, S., Chuman, Y., Nose, T., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 399-402

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Highly diastereo- and enantioselective aziridination of α,β-unsaturated amides with diaziridine and mechanistic consideration on its stereochemistry

Ishihara, H., Hori, K., Sugihara, H., Ito, Y. & Katsuki, T., 12 1 2002, : : Helvetica Chimica Acta. 85, 12, p. 4272-4286 15 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

Molecular cloning and characterization of a secretory neutral ceramidase of Drosophila melanogaster

Yoshimura, Y., Okino, N., Tani, M. & Ito, M., 8 2002, : : Journal of biochemistry. 132, 2, p. 229-236 8 p.

研究成果: ジャーナルへの寄稿記事

47 引用 (Scopus)

Structure and function of nuclear localization signal peptide present in circadian rhythm hormone peptide precursor

Matsushima, A., Chuman, Y., Sato, S., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 159-162

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2003

A neutral ceramidase homologue from Dictyostelium discoideum exhibits an acidic pH optimum

Monjusho, H., Okino, N., Tani, M., Maeda, M., Yoshida, M. & Ito, M., 12 1 2003, : : Biochemical Journal. 376, 2, p. 473-479 7 p.

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells

Ogishima, T., Kinoshita, J. Y., Mitani, F., Suematsu, M. & Ito, A., 6 6 2003, : : Journal of Biological Chemistry. 278, 23, p. 21204-21211 8 p.

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

Localization profiles of the precursor protein of circadian rhythm pacemaker hormone PDF in Gryllus brain

Honda, T., Chuman, Y., Matsushima, A., Asai, D., Nose, T., Sakaguchi, K., Onoue, H., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2003, Peptide Science 2002. p. 433-436

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Molecular cloning and circadian expression profile of insect neuropeptide PDF in black blowfly, Phormia regina

Matsushima, A., Yokotani, S., Lui, X., Sumida, K., Honda, T., Sato, S., Kaneki, A., Takeda, Y., Chuman, Y., Ozaki, M., Asai, D., Nose, T., Onoue, H., Ito, Y., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 11 1 2003, : : Letters in Peptide Science. 10, 5-6, p. 419-430 12 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation

Matsumoto, N., Tamura, S., Furuki, S., Miyata, N., Moser, A., Shimozawa, N., Moser, H. W., Suzuki, Y., Kondo, N. & Fujiki, Y., 8 1 2003, : : American journal of human genetics. 73, 2, p. 233-246 14 p.

研究成果: ジャーナルへの寄稿記事

56 引用 (Scopus)
52 引用 (Scopus)

Purification and Characterization of Chinese Hamster Phosphatidylserine Synthase 2

Kuge, O., Hasegawa, K., Ohsawa, T., Saito, K. & Nishijima, M., 10 24 2003, : : Journal of Biological Chemistry. 278, 43, p. 42692-42698 7 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Structural analysis of PERIOD-PAS domain binding regions in insect clock protein TIMELESS

Sato, S., Oka, H., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2003, Peptide Science 2002. p. 429-432

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structural characterization of the house fly PDF, a circadian rhythm pacemaker hormone

Matsushima, A., Nose, T., Tomioka, K., Shimohigashi, M. & Shimohigashi, Y., 2003, Peptide Science 2002. p. 333-336

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

The Structure-activity studies of Drosophila FMRFamide-related peptides

Tokunaga, T., Ohtahi, M., Matsushima, A., Nose, T., Aimoto, S. & Shimohigashi, Y., 2003, Peptide Science 2002. p. 265-268

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2004

cDNA cloning and in situ hybridization studies of sulfated peptide, sulfakinin, on housefly Musca domestica

Matsushima, A., Yokotani, S., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2004, Peptide Science 2003. p. 459-462

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

cDNA cloning of the housefly pigment-dispersing factor (PDF) precursor protein and its peptides comparison among the insect circadian neuropeptides

Matsushima, A., Sato, S., Chuman, Y., Takeda, Y., Yokotani, S., Nose, T., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., 2 1 2004, : : Journal of Peptide Science. 10, 2, p. 82-91 10 p.

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)
7 引用 (Scopus)

Effect of the Phe-Phenyl H-F subsutitution in the sea hare Aplysia neuropeptide H-Asn-d-Phe-NH2 on the conformation and contraction activity

Kaneki, A., Matsushima, A., Takeda, Y., Yokotani, S., Ozaki, M., Shimohigashi, M. & Shimohigashi, Y., 2004, Peptide Science 2003. p. 459-462

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Effects of the Phe-Phenyl H→F Substitutions in the Sea Hare Aplysia Neuropeptide H-Asn-D-Trp-Phe-NH2 on the Conformation and Contractile Activity

Yokotani, S., Matsushima, A., Nose, T., Shimohigashi, Y. & Morishita, F., 3 2004, Peptide Science 2003. p. 263-266 4 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Functional analysis of Chinese hamster phosphatidylserine synthase 1 through systematic alanine mutagenesis

Ohsawa, T., Nishijima, M. & Kuge, O., 8 1 2004, : : Biochemical Journal. 381, 3, p. 853-859 7 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

Localization profiles of circadian neuropeptide PDF in brain of the cricket Gryllus bimaculatus

Honda, T., Chuman, Y., Matsushima, A., Nose, T., Sakaguchi, K., Onoue, H., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2004, Peptide Science 2003. p. 483-486

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Molecular cloning and functional analysis of zebrafish neutral ceramidase

Yoshimura, Y., Tani, M., Okino, N., Iida, H. & Ito, M., 10 15 2004, : : Journal of Biological Chemistry. 279, 42, p. 44012-44022 11 p.

研究成果: ジャーナルへの寄稿記事

45 引用 (Scopus)

Possible participation of outer mitochondrial membrane cytochrome B 5 in steroidogenesis in zona glomerulosa of rat adrenal cortex

Mitani, F., Ogishima, T., Mukai, K., Hoshino, R., Watanabe, K. & Suematsu, M., 12 1 2004, : : Endocrine Research. 30, 4, p. 639-644 6 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)