有機・生物化学

研究成果

2005

cDNA cloning and mRNA expression of the circadian neuropeptide PDF in the silk moth Bombyx mori

Sato, S., Sumida, K., Hiramura, D., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 197-200

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Conformation change-senseing assay using monoclonal antibody for N-terminal octapeptide repreat region of prion protein

Kawano, M., Honda, T., Horiuchi, Y., Yokotani, S., Matsushima, A., Nose, T. & Shimohigashi, Y., 2005, Peptide Science 2004.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Convergent total synthesis of gymnocin-A and evaluation of synthetic analogues

Tsukano, C., Ebine, M. & Sasaki, M., 3 30 2005, : : Journal of the American Chemical Society. 127, 12, p. 4326-4335 10 p.

研究成果: ジャーナルへの寄稿記事

88 引用 (Scopus)

FMRFamide-related peptides in the nervous system of the housefly Musca domestica: cDNA cloning and actions on clam heart contraction.

Matsushima, A., Yokotani, S., Koretsune, Y., Meinertzhagen, I. A., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 157-160

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Immunocytochemical identification of mature peptide formation for the circadian neuromodulator PDF in the housefly Musca domestica

Sumida, K., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Immunocytochemical studies on the circadian neuropeptide PDF in the Cricket Gryllus bimaculatus

Shimohigashi, M., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 339-342

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu

Tani, M., Igarashi, Y. & Ito, M., 11 4 2005, : : Journal of Biological Chemistry. 280, 44, p. 36592-36600 9 p.

研究成果: ジャーナルへの寄稿記事

41 引用 (Scopus)

Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase

Oshima, T., Yamasaki, E., Ogishima, T., Kadowaki, K. I., Ito, A. & Kitada, S., 2 1 2005, : : Biochemical Journal. 385, 3, p. 755-761 7 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export

Miyata, N. & Fujiki, Y., 12 1 2005, : : Molecular and cellular biology. 25, 24, p. 10822-10832 11 p.

研究成果: ジャーナルへの寄稿記事

149 引用 (Scopus)

Structural characteristics of Drosophila estrogen-related receptor ligand binding domain to capture the peptide and non-peptide ligands

Liu, X., Matsushima, A., Shirasu, N., Tominaga, Y., Shimohigashi, M., Shimohigashi, Y. & Nose, T., 2005, Peptide Science 2004. p. 303-304

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structural characteristics of the N-Terminal octapeptide repeat region of Prion protein in self-polymerization

Horiuchi, Y., Kawano, M., Yokotani, S., Honda, T., Matsushima, A., Nose, T. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 317-318

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Subcellular localization of human neutral ceramidase expressed in HEK293 cells

Hwang, Y. H., Tani, M., Nakagawa, T., Okino, N. & Ito, M., 5 27 2005, : : Biochemical and Biophysical Research Communications. 331, 1, p. 37-42 6 p.

研究成果: ジャーナルへの寄稿記事

52 引用 (Scopus)

Triplicate alternative splicings that produce multiple variants of the PERIOD protein in the silk moth Bombyx mori by deletion/Insertion of peptides

Takeda, Y., Shirasu, N., Sato, S., Matsushima, A., Chuman, Y., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 203-206

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2006

a-helix peptides for bio-panning in the phage display method to obtain the antibodies specific for conformation-change nuclear receptors

Okada, H., Tokunaga, T., Shirasu, N., Matsushima, A., Nose, T. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Conformation change of α-helix peptide for sensing of deactivation of nuclear peceptor: Immunoassay using polyclonal antibody specific for the C-terminal a-helix 12 of estrogen-related receptor γ (ERRγ)

Tokunaga, T., Liu, X., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 176

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Cytocidal actions of parasporin-2, an anti-tumor crystal toxin from Bacillus thuringiensis

Kitada, S., Abe, Y., Shimada, H., Kusaka, Y., Matsuo, Y., Katayama, H., Okumura, S., Akao, T., Mizuki, E., Kuge, O., Sasaguri, Y., Ohba, M. & Ito, A., 9 8 2006, : : Journal of Biological Chemistry. 281, 36, p. 26350-26360 11 p.

研究成果: ジャーナルへの寄稿記事

45 引用 (Scopus)

Design and synthesis of a-helix peptide binding to prion protein N-terminal octarepeat domain

Koga, K., Sato, S., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor γ (ERRγ) with high constitutive activity

Takayanagi, S., Tokunaga, T., Liu, X., Okada, H., Matsushima, A. & Shimohigashi, Y., 12 1 2006, : : Toxicology Letters. 167, 2, p. 95-105 11 p.

研究成果: ジャーナルへの寄稿記事

247 引用 (Scopus)

Identification of novel isoforms of the circadian neuropeptide PDF in the silk moth Bombyx mori and their expression in brain

Sato, S., Jonathan, C., Takeda, Y., Kaneki, A., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 99-100

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Immunological confirmation of circadian-related neuropeptide PDF-isoform peptide in the cricket Gryllus bimaculatus

Koga, K., Hiramura, D., Takeda, Y., Kaneki, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 262

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Molecular cloning and in situ hybridization of circadian neuropeptide PDF receptor in the fruit fly Drosophila melanogaster

Kaneki, A., Yoshida, T., Isozaki, K., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 263

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Monoclonal antibody sensing assay for conformation change induced by metal binding to prion protein N-terminal octarepear domain

Yokotani, S., Honda, T., Kawano, M., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 455-456

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Multiple post-transcriptional regulations in circadian pacemaker neuropeptide pdf gene

Takeda, Y., Sumiyoshi, M., Koga, K., Ito, M., Matsushima, A., Shimohigashi, Y. & Shimohigashi, M., 2006, Peptide Science 2006. p. 260

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

33 引用 (Scopus)

Neutral ceramidase as an integral modulator for the generation of S1P and S1P-mediated signaling

Ito, M., Tani, M. & Yoshimura, Y., 2006, Sphingolipid Biology. Springer Japan, p. 183-196 14 p.

研究成果: 著書/レポートタイプへの貢献

2 引用 (Scopus)

Phosphatidylserine is involved in gene expression from Sindbis virus subgenomic promoter

Saito, K., Nishijima, M. & Kuge, O., 6 30 2006, : : Biochemical and Biophysical Research Communications. 345, 2, p. 878-885 8 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Requirement of an IκB-β COOH terminal region protein for acidic-adaptation in CHO cells

Lao, Q., Fukamachi, T., Saito, H., Kuge, O., Nishijima, M. & Kobayashi, H., 4 1 2006, : : Journal of cellular physiology. 207, 1, p. 238-243 6 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Specific dimerization of prion protein N-terminal domain

Matsushima, A., Horiuchi, Y., Yokotani, S., Kawano, M. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: Immunocytochemical evidence from specific monoclonal antibodies

Honda, T., Matsushima, A., Sumida, K., Chuman, Y., Sakaguchi, K., Onoue, H., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., 11 20 2006, : : Journal of Comparative Neurology. 499, 3, p. 404-421 18 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

Structure-activity studies of FMRFamide-related peptides in activating the specific receptor present in the housefly Musca domestica

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 174

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Total synthesis, structure revision, and absolute configuration of (-)-brevenal

Fuwa, H., Ebine, M., Bourdelais, A. J., Baden, D. G. & Sasaki, M., 12 27 2006, : : Journal of the American Chemical Society. 128, 51, p. 16989-16999 11 p.

研究成果: ジャーナルへの寄稿記事

108 引用 (Scopus)

Total synthesis of the proposed structure of brevenal

Fuwa, H., Ebine, M. & Sasaki, M., 8 2 2006, : : Journal of the American Chemical Society. 128, 30, p. 9648-9650 3 p.

研究成果: ジャーナルへの寄稿記事

52 引用 (Scopus)
2007

A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria

Kitada, S., Uchiyama, T., Funatsu, T., Kitada, Y., Ogishima, T. & Ito, A., 2 1 2007, : : Journal of bacteriology. 189, 3, p. 844-850 7 p.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

Double-labelled in situ hybridization reveals the lack of co-localization of mRNAs for the circadian neuropeptide PDF and FMRFamide in brains of the flies Musca domestica and Drosophila melanogaster

Matsushima, A., Takano, K., Yoshida, T., Takeda, Y., Yokotani, S., Shimohigashi, Y. & Shimohigashi, M., 6 1 2007, : : Journal of biochemistry. 141, 6, p. 867-877 11 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Haeme-regulated degradation of δ-aminolevulinate synthase 1 in rat liver mitochondria

Yoshino, K., Munakata, H., Kuge, O., Ito, A. & Ogishima, T., 10 1 2007, : : Journal of biochemistry. 142, 4, p. 453-458 6 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

Klotho-related protein is a novel cytosolic neutral β- glycosylceramidase

Hayashi, Y., Okino, N., Kakuta, Y., Shikanai, T., Tani, M., Narimatsu, H. & Ito, M., 10 19 2007, : : Journal of Biological Chemistry. 282, 42, p. 30889-30900 12 p.

研究成果: ジャーナルへの寄稿記事

66 引用 (Scopus)

Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis

Chida, D., Nakagawa, S., Nagai, S., Sagara, H., Katsumata, H., Imaki, T., Suzuki, H., Mitani, F., Ogishima, T., Shimizu, C., Kotaki, H., Kakuta, S., Sudo, K., Koike, T., Kubo, M. & Iwakura, Y., 11 13 2007, : : Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18205-18210 6 p.

研究成果: ジャーナルへの寄稿記事

95 引用 (Scopus)
29 引用 (Scopus)

Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer

Nishino, T. G., Kitano, K., Kojima, K., Ogishima, T., Ito, A. & Kitada, S., 6 1 2007, : : Journal of biochemistry. 141, 6, p. 889-895 7 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ

Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S. I., Kimura, M. & Shimohigashi, Y., 10 1 2007, : : Journal of biochemistry. 142, 4, p. 517-524 8 p.

研究成果: ジャーナルへの寄稿記事

149 引用 (Scopus)

Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary

Taketoh, J., Mutoh, J., Takeda, T., Ogishima, T., Takeda, S., Ishii, Y., Ishida, T. & Yamada, H., 3 13 2007, : : Life Sciences. 80, 14, p. 1259-1267 9 p.

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)
2008

Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase

Briggs, L. C., Baldwin, G. S., Miyata, N., Kondo, H., Zhang, X. & Freemont, P. S., 5 16 2008, : : Journal of Biological Chemistry. 283, 20, p. 13745-13752 8 p.

研究成果: ジャーナルへの寄稿記事

59 引用 (Scopus)

Cytochrome P-45017α in β-cells of rat pancreas and its local steroidogenesis

Ogishima, T., Mitani, F. & Suematsu, M., 7 1 2008, : : Journal of Steroid Biochemistry and Molecular Biology. 111, 1-2, p. 80-86 7 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist

Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 3 1 2008, : : Bioorganic and Medicinal Chemistry. 16, 5, p. 2635-2644 10 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Direct evidence revealing structural elements essential for the high binding ability of bisphenol a to human estrogen-related receptor-γ

Okada, H., Tokunaga, T., Liu, X., Takayanagi, S., Matsushima, A. & Shimohigashi, Y., 1 1 2008, : : Environmental Health Perspectives. 116, 1, p. 32-38 7 p.

研究成果: ジャーナルへの寄稿記事

288 引用 (Scopus)
20 引用 (Scopus)

ERRγ tethers strongly bisphenol A and 4-α-cumylphenol in an induced-fit manner

Matsushima, A., Teramoto, T., Okada, H., Liu, X., Tokunaga, T., Kakuta, Y. & Shimohigashi, Y., 8 29 2008, : : Biochemical and Biophysical Research Communications. 373, 3, p. 408-413 6 p.

研究成果: ジャーナルへの寄稿記事

56 引用 (Scopus)

Optimization of the N-terminal group of Ac-RYYRIK-NH2 as ORL1 receptor antagonist

Li, J., Isozaki, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 257-260

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Radar chart deviation analysis of prion protein amino acid composition defines characteristic structural abnormalities of the N-terminal octapeptide tandem repeat

Yokotani, S., Nose, T., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 9 1 2008, : : Protein and Peptide Letters. 15, 9, p. 949-955 7 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Structural requirement of housefly FMRFamide peptides in its receptor activation

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 313-314

研究成果: 著書/レポートタイプへの貢献章 (査読済み)