有機・生物化学

研究成果 1979 2019

2016
28 引用 (Scopus)

Phosphatidylserine transport by Ups2-Mdm35 in respiration-active mitochondria

Miyata, N., Watanabe, Y., Tamura, Y., Endo, T. & Kuge, O., 7 1 2016, : : Journal of Cell Biology. 214, 1, p. 77-88 12 p.

研究成果: ジャーナルへの寄稿記事

Phosphatidylserines
Mitochondria
Respiration
Mitochondrial Membranes
Endoplasmic Reticulum

SCN Circadian rhythm signal transduction neuropeptides evoke hypoactive phenotype differently in male and female mice

Sugiyama, M., Motomatsu, Y., Matsuyama, Y., Kajiyama, S., Kameda, T., Uchimura, E., Saito, T., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 53-54

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

4 引用 (Scopus)

Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X., Costa, T. & Shimohigashi, Y., 11 4 2016, : : Biopolymers. p. 460-469 10 p.

研究成果: ジャーナルへの寄稿記事

Sulfhydryl Compounds
Labeling
Peptides
Ligands
Binding sites
2 引用 (Scopus)

Structure-function relationship of complex sphingolipids in yeast

Tani, M., 1 1 2016, : : Trends in Glycoscience and Glycotechnology. 28, 164, p. E109-E116

研究成果: ジャーナルへの寄稿評論記事

Sphingolipids
Yeast
Yeasts
Saccharomyces cerevisiae
Ceramides

Structure-function relationship of complex sphingolipids in yeast

Tani, M., 1 1 2016, : : Trends in Glycoscience and Glycotechnology. 28, 164, p. J107-J114

研究成果: ジャーナルへの寄稿評論記事

Sphingolipids
Yeast
Yeasts
Saccharomyces cerevisiae
Ceramides

Structure-function studies between the hormone-disrupting chemical bisphenols and the nuclear receptors

Matsushima, A., 1 1 2016, : : Seikagaku. 88, 6, p. 733-743 11 p.

研究成果: ジャーナルへの寄稿評論記事

Benzhydryl Compounds
Phenols
Structure-Activity Relationship
Cytoplasmic and Nuclear Receptors
Hormones
11 引用 (Scopus)

The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores

Nakagawa, Y., Umegawa, Y., Matsushita, N., Yamamoto, T., Tsuchikawa, H., Hanashima, S., Oishi, T., Matsumori, N. & Murata, M., 6 21 2016, : : Biochemistry. 55, 24, p. 3392-3402 11 p.

研究成果: ジャーナルへの寄稿記事

Ergosterol
Amphotericin B
Membranes
Macrolides
Polyenes
4 引用 (Scopus)

Yeast lacking the amphiphysin family protein Rvs167 is sensitive to disruptions in sphingolipid levels

Toume, M. & Tani, M., 8 1 2016, : : FEBS Journal. p. 2911-2928 18 p.

研究成果: ジャーナルへの寄稿記事

Serine C-Palmitoyltransferase
Sphingolipids
Yeast
Yeasts
Biosynthesis
1 引用 (Scopus)

α-Helix-peptides comprising the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 11 4 2016, : : Biopolymers. p. 547-554 8 p.

研究成果: ジャーナルへの寄稿記事

Dimerization
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Peptides
Estrogens

核内受容体が示す有害化学物質ビスフェノール応答

Matsushima, A., 12 2016, : : Seikagaku. The Journal of Japanese Biochemical Society. 88, 6, p. 733-43 11 p.

研究成果: ジャーナルへの寄稿記事

2015
2 引用 (Scopus)

2-Naphthylmethoxymethyl as a Mildly Introducible and Oxidatively Removable Benzyloxymethyl-Type Protecting Group

Sato, T., Oishi, T. & Torikai, K., 6 19 2015, : : Organic Letters. 17, 12, p. 3110-3113 4 p.

研究成果: ジャーナルへの寄稿記事

Chlorides
Temperature
compatibility
chlorides
2,6-lutidine
9 引用 (Scopus)
Vacuolar Proton-Translocating ATPases
Sphingolipids
Saccharomyces cerevisiae
Yeasts
Ceramides

Alternative polyadenylation analyses of neuropeptide genes in bisphenol A-exposed hypoactive mouse brain

Sugiyama, M., Kajiyama, S., Saito, T., Uchimura, E., Motomatsu, Y., Matsuo, A., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 345-346

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

An in silico genomic search of endomorphin-like opioid peptides

Matsushima, A., Koyanagi, K. O., Nishimura, H., Inamine, S., Motomatsu, Y. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 281-282

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

A novel method identify and quantify the coactivator proteins that couple with human nuclear receptor: the use of interacting interface a-helix peptide for quantitative inhibition

Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Bisphenol A-induced substantial peak decay of Drosophila circadian neuropeptide hugin mRNA expression

Shotaro, U., Matsuo, A., Matsuyama, Y., Nakamura, M., Koga, K., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 41-42

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

4 引用 (Scopus)

COX assembly factor ccdc56 regulates mitochondrial morphology by affecting mitochondrial recruitment of Drp1

Ban-Ishihara, R., Tomohiro-Takamiya, S., Tani, M., Baudier, J., Ishihara, N. & Kuge, O., 10 7 2015, : : FEBS Letters. 589, 20, p. 3126-3132 7 p., 37349.

研究成果: ジャーナルへの寄稿記事

Electron Transport Complex IV
Mitochondria
Personnel Selection
Mitochondrial Dynamics
Cell signaling
6 引用 (Scopus)

Ergosteryl-β-glucosidase (Egh1) involved in sterylglucoside catabolism and vacuole formation in Saccharomyces cerevisiae

Watanabe, T., Tani, M., Ishibashi, Y., Endo, I., Okino, N. & Ito, M., 4 14 2015, : : Glycobiology. 25, 10, p. 1079-1089 11 p.

研究成果: ジャーナルへの寄稿記事

Glucosidases
Glucosides
Vacuoles
Yeast
Saccharomyces cerevisiae

GPCR functional role of Phe-269 and Phe-221 in the molecular switching of ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

12 引用 (Scopus)

Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling

Sakakibara, K., Eiyama, A., Suzuki, S. W., Sakoh-Nakatogawa, M., Okumura, N., Tani, M., Hashimoto, A., Nagumo, S., Kondo-Okamoto, N., Kondo-Kakuta, C., Asai, E., Kirisako, H., Nakatogawa, H., Kuge, O., Takao, T., Ohsumi, Y. & Okamoto, K., 11 3 2015, : : EMBO Journal. 34, 21, p. 2703-2719 17 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Degradation
Mitochondria
Methylation
Recycling
Phospholipids

Receptor selectivity and specificity of a series of opioid peptides latent in the proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Kuramitsu, Y., Inamine, S., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 201-202

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

15 引用 (Scopus)

Stereoselective synthesis of the C1-C29 part of amphidinol 3

Tsuruda, T., Ebine, M., Umeda, A. & Oishi, T., 1 16 2015, : : Journal of Organic Chemistry. 80, 2, p. 859-871 13 p.

研究成果: ジャーナルへの寄稿記事

Lithium
Amides
amphidinol 3

Structural and molecular evolutionary analysis of the ligand-binding domain of forty-eight human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 347-348

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structure-activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, M., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 319-320

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

8 引用 (Scopus)

Synthesis of mannosylinositol phosphorylceramides is involved in maintenance of cell integrity of yeast Saccharomyces cerevisiae

Morimoto, Y. & Tani, M., 1 1 2015, : : Molecular Microbiology. 95, 4, p. 706-722 17 p.

研究成果: ジャーナルへの寄稿記事

Saccharomyces cerevisiae
Yeasts
Maintenance
Mannans
Polysaccharides

The molecular switching of ORL1 nociceptin receptor in activation/inactivation

Nishimura, H., Li, J., Isozaki, K., yuuki, T., Matsushima, A., Liu, X., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 201-202

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

1 引用 (Scopus)

Tuned Classical Thermal Aromatization Furnishing an Estrogenic Benzoacridine

Koga, R., Oishi, T. & Torikai, K., 12 17 2015, : : Synlett. 26, 20, p. 2801-2805 5 p., st-2015-s0585-c.

研究成果: ジャーナルへの寄稿記事

Aromatization
Estrogens
Derivatives
Pharmaceutical Preparations
Hot Temperature
1 引用 (Scopus)

VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae

Miyata, N., Miyoshi, T., Yamaguchi, T., Nakazono, T., Tani, M. & Kuge, O., 12 15 2015, : : Biochemical Journal. 472, 3, p. 319-328 10 p.

研究成果: ジャーナルへの寄稿記事

Yeast
Transcriptional Activation
Saccharomyces cerevisiae
Genes
Yeasts
2 引用 (Scopus)

Voltammetric study of the boric acid-salicylaldehyde-H-acid ternary system and its application to the voltammetric determination of boron

Kajiwara, M., Ito, Y. N., Miyazaki, Y., Fujimori, T., Takehara, K. & Yoshimura, K., 2 14 2015, : : Physical Chemistry Chemical Physics. 17, 6, p. 4578-4588 11 p.

研究成果: ジャーナルへの寄稿記事

boric acids
Boron
Ternary systems
ternary systems
boron
2014
14 引用 (Scopus)

A characteristic back support structure in the bisphenol A-binding pocket in the human nuclear receptor ERRγ

Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 6 30 2014, : : PloS one. 9, 6, e101252.

研究成果: ジャーナルへの寄稿記事

bisphenol A
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
receptors
estrogens
69 引用 (Scopus)

Adrenal nodularity and somatic mutations in primary aldosteronism: One node is the culprit?

Dekkers, T., Ter Meer, M., Lenders, J. W. M., Hermus, A. R. M., Schultze Kool, L., Langenhuijsen, J. F., Nishimoto, K., Ogishima, T., Mukai, K., Azizan, E. A. B., Tops, B., Deinum, J. & Küsters, B., 7 2014, : : Journal of Clinical Endocrinology and Metabolism. 99, 7, p. E1341-1351

研究成果: ジャーナルへの寄稿記事

Hyperaldosteronism
Aldosterone
Adenoma
Mutation
Genes
8 引用 (Scopus)

AlCl3-mediated aldol cyclocondensation of 1,6- and 1,7-diones to cyclopentene and cyclohexene derivatives

Miyahara, Y. & Ito, Y., 1 1 2014, : : Journal of Organic Chemistry. 79, 15, p. 6801-6807 7 p.

研究成果: ジャーナルへの寄稿記事

Cyclopentanes
Condensation
Derivatives
Water
Temperature

Bisphenol A-induced Epigenetic Mutations in Circadian Pacemaker Neuropeptide mRNAs of Hyperactive Drosophila Fruit Flies

Matsuo, A., Umeno, S., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 457-458

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

8 引用 (Scopus)

Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae

Toume, M. & Tani, M., 1 1 2014, : : FEMS microbiology letters. 358, 1, p. 64-71 8 p.

研究成果: ジャーナルへの寄稿記事

Serine C-Palmitoyltransferase
Sphingolipids
Saccharomyces cerevisiae
Yeasts
Pseudomonas syringae

Constitutive α-Helix-peptides Required for Functional Dimerization of Estrogen-related Receptor γ (ERRγ).

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 429-430

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Expression and Mutation Analyses of Brain Neuropeptide Genes of Rndocrine-disrupting Bisphenol A-exposed Hypoactive Mouse

Sugiyama, M., Matsuo, A., Saito, T., Uchimura, E., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 453-454

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Functionally Essential Amino Acid Residues in ORL1 Nociceptin Receptor for Ligand-stimulated Receptor Activation

Nishimura, H., Li, J., abe, Y., Isozaki, K., Matsushima, A., Inamine, S., Costa, T. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 333-334

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Influence Analysis of the Circadian Evening Pacemaker Neuropeptide hugγ Gene in the Bisphenol A-exposed Fruit Fly Drosophila Brain

Umeno, S., Matsuo, A., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 455-456

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

8 引用 (Scopus)
Phosphatidylserines
Phosphatases
Phosphatidylinositols
Phosphoric Monoester Hydrolases
Metabolism
12 引用 (Scopus)

Loss of hydroxyl groups from the ceramide moiety can modify the lateral diffusion of membrane proteins in S. cerevisiae

Uemura, S., Shishido, F., Tani, M., Mochizuki, T., Abe, F. & Inokuchi, J. I., 7 2014, : : Journal of Lipid Research. 55, 7, p. 1343-1356 14 p.

研究成果: ジャーナルへの寄稿記事

Ceramides
Protein S
Inositol
Hydroxyl Radical
Yeast

Multiple and Simultaneous Cys→Ala Mutations of ORL1 Nociceptin Receptor to Identify the Affinity Binding site of Cys(Npys)-Elongated RYYRIK Peptide Antagonist

Matsushima, A., Nishimura, H., Inamine, S. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 413-414

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

17 引用 (Scopus)
Neutral Ceramidase
Ceramides
Enzymes
Vertebrates
Zinc
3 引用 (Scopus)

N-methylthioacetylation of RYYRIK-NH2 with enhanced specific binding affinity and high antagonist activity for nociceptin ORL1 receptor

Li, J., Nishimura, H., Matsushima, A. & Shimohigashi, Y., 11 1 2014, : : Bioorganic and Medicinal Chemistry. 22, 21, p. 5721-5726 6 p.

研究成果: ジャーナルへの寄稿記事

Peptide Library
Atoms
Peptides
Peptide Receptors
Neuropeptides
29 引用 (Scopus)

Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1

Miyata, N., Steffen, J., Johnson, M. E., Fargue, S., Danpure, C. J. & Koehler, C. M., 10 7 2014, : : Proceedings of the National Academy of Sciences of the United States of America. 111, 40, p. 14406-14411 6 p.

研究成果: ジャーナルへの寄稿記事

Peroxisomes
Oxalates
Mitochondria
Enzymes
Pyridoxine

Specific Role of Phe Residues in Opioid Peptide Met-enkephalin- Arg-Phe in Binding to All Three Opioid Receptors

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Inamine, S., Kuramitsu, Y., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 317-318

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structure-Activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 3 2014, Peptide Science 2013. p. 319-320 2 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

11 引用 (Scopus)

Synthesis and biological activity of the C'D'E'F' ring system of maitotoxin

Kunitake, M., Oshima, T., Konoki, K., Ebine, M., Torikai, K., Murata, M. & Oishi, T., 6 6 2014, : : Journal of Organic Chemistry. 79, 11, p. 4948-4962 15 p.

研究成果: ジャーナルへの寄稿記事

Cyclization
Bioactivity
Rats
maitotoxin
allyl alcohol
8 引用 (Scopus)

Synthesis and biological activity of the QRS ring system of maitotoxin

Onoue, H., Baba, T., Konoki, K., Torikai, K., Ebine, M. & Oishi, T., 1 1 2014, : : Chemistry Letters. 43, 12, p. 1904-1906 3 p.

研究成果: ジャーナルへの寄稿記事

Bioactivity
Acetals
Methylation
Polyethers
Ladders

Three-dimensional Docking Modeling to Human Nuclear Receptors for Exploration of Bisphenol-A Targeting Receptors

Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 459-460

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

25 引用 (Scopus)

TMEM14C is required for erythroid mitochondrial heme metabolism

Yien, Y. Y., Robledo, R. F., Schultz, I. J., Takahashi-Makise, N., Gwynn, B., Bauer, D. E., Dass, A., Yi, G., Li, L., Hildick-Smith, G. J., Cooney, J. D., Pierce, E. L., Mohler, K., Dailey, T. A., Miyata, N., Kingsley, P. D., Garone, C., Hattangadi, S. M., Huang, H., Chen, W. および15人, Keenan, E. M., Shah, D. I., Schlaeger, T. M., Dimauro, S., Orkin, S. H., Cantor, A. B., Palis, J., Koehler, C. M., Lodish, H. F., Kaplan, J., Ward, D. M., Dailey, H. A., Phillips, J. D., Peters, L. L. & Paw, B. H., 10 1 2014, : : Journal of Clinical Investigation. 124, 10, p. 4294-4304 11 p.

研究成果: ジャーナルへの寄稿記事

Heme
Erythroid Cells
Erythropoiesis
Porphyrins
Anemia