有機・生物化学

研究成果 1979 2019

1998
16 引用 (Scopus)
Serine
Peptide Hydrolases
Peptides
Arginine
Substrates

Loss of the product-inhibition for phosphatidylserine biosynthesis in cho cells with a point-mutation in phosphatidylserine synthase

Nistujima, I. M., Kuge, O., Hasegawa, K. & Saito, K., 12 1 1998, : : FASEB Journal. 12, 8

研究成果: ジャーナルへの寄稿記事

CDPdiacylglycerol-Serine O-Phosphatidyltransferase
phosphatidylserines
Phosphatidylserines
Biosynthesis
point mutation
80 引用 (Scopus)

Purification and characterization of a novel ceramidase from pseudomonas aeruginosa

Okino, N., Tani, M., Imayama, S. & Ito, M., 6 5 1998, : : Journal of Biological Chemistry. 273, 23, p. 14368-14373 6 p.

研究成果: ジャーナルへの寄稿記事

Ceramidases
Pseudomonas aeruginosa
Ceramides
Purification
Enzymes
37 引用 (Scopus)

Role of α-subunit of mitochondrial processing peptidase in substrate recognition

Shimokata, K., Kitada, S., Ogishima, T. & Ito, A., 9 25 1998, : : Journal of Biological Chemistry. 273, 39, p. 25158-25163 6 p.

研究成果: ジャーナルへの寄稿記事

Substrates
Processing
Adrenodoxin
Acidic Amino Acids
Peptides
62 引用 (Scopus)
ethylenediamine
Epoxidation
Manganese
Epoxy Compounds
Ions
1999
8 引用 (Scopus)
Arginine
Amino Acids
Protein Precursors
Mitochondrial Proteins
Peptide Hydrolases
203 引用 (Scopus)

Asymmetric catalysis of new generation chiral metallosalen complexes

Ito, Y. & Katsuki, T., 4 1 1999, : : Bulletin of the Chemical Society of Japan. 72, 4, p. 603-619 17 p.

研究成果: ジャーナルへの寄稿記事

Catalysis
Epoxidation
Manganese
Derivatives
Styrene
31 引用 (Scopus)

cis-selective aziridination of cis- or trans-α,β-unsaturated amides using diaziridine

Hori, K., Sugihara, H., Ito, Y. & Katsuki, T., 7 9 1999, : : Tetrahedron Letters. 40, 28, p. 5207-5210 4 p.

研究成果: ジャーナルへの寄稿記事

Amides
Nitrogen
Atoms
Geometry
Substrates
32 引用 (Scopus)

Designed hapten aimed at anti-ciguatoxin monoclonal antibody: Synthesis, immunization and discrimination of the C2 configuration

Oguri, H., Tanaka, S. I., Hishiyama, S., Oishi, T., Hirama, M., Tumuraya, T., Tomioka, Y. & Mizugaki, M., 1 1 1999, : : Synthesis. SPEC. ISS., p. 1431-1436 6 p.

研究成果: ジャーナルへの寄稿記事

Ciguatoxins
Immunization
Monoclonal antibodies
Haptens
Monoclonal Antibodies
38 引用 (Scopus)

Enantioselective synthesis of the medium ring ethers, tetrahydrooxepin, oxocane and hexahydrooxonin, of ciguatoxin. Extensive ring-expansion and chemoenzymatic desymmetrization strategy

Oishi, T., Maruyama, M., Shoji, M., Maeda, K., Kumahara, N., Tanaka, S. I. & Hirama, M., 6 11 1999, : : Tetrahedron. 55, 24, p. 7471-7498 28 p.

研究成果: ジャーナルへの寄稿記事

Ciguatoxins
Acylation
Ethers
Lipase
Alcohols
72 引用 (Scopus)

Expeditious tandem-metathesis route to the AB-ring fragment of ciguatoxin

Oguri, H., Sasaki, S. Y., Oishi, T. & Hirama, M., 7 16 1999, : : Tetrahedron Letters. 40, 29, p. 5405-5408 4 p.

研究成果: ジャーナルへの寄稿記事

Ciguatoxins
Calcium Gluconate

Importance of ligand Phe-phenyl group for activation of thrombin receptor

Fujita, T., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., 1999, Peptide Science 1998. p. 33-36

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

46 引用 (Scopus)

Isolation of a Chinese hamster ovary cell mutant defective in intramitochondrial transport of phosphatidylserine

Emoto, K., Kuge, O., Nishijima, M. & Umeda, M., 10 26 1999, : : Proceedings of the National Academy of Sciences of the United States of America. 96, 22, p. 12400-12405 6 p.

研究成果: ジャーナルへの寄稿記事

Phosphatidylserines
Cricetulus
Ovary
Mitochondrial Membranes
Mitochondria
1 引用 (Scopus)

Phosphatidylserine metabolism and biosynthetic regulation in mammalian cells

Kuge, O., 12 1 1999, : : Seikagaku. 71, 1, p. 1-15 15 p.

研究成果: ジャーナルへの寄稿記事

Molecular Sequence Data
Phosphatidylethanolamines
Carboxy-Lyases
CHO Cells
Phosphatidylserines
22 引用 (Scopus)
Sphingolipids
Sphingomyelins
Hydrolysis
Assays
Carrier Proteins
37 引用 (Scopus)

Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide

Tani, M., Okino, N., Mitsutake, S. & Ito, M., 1999, : : Journal of Biochemistry. 125, 4, p. 746-749 4 p.

研究成果: ジャーナルへの寄稿記事

Alkaline Ceramidase
Neutral Ceramidase
Assays
Ceramides
Enzymes
2000
37 引用 (Scopus)

A very short route to the functionalized A-ring moiety of ciguatoxin

Oguri, H., Tanaka, S. I., Oishi, T. & Hirama, M., 2 5 2000, : : Tetrahedron Letters. 41, 6, p. 975-978 4 p.

研究成果: ジャーナルへの寄稿記事

Ciguatoxins
Catalysis
Transition metals
Metals

Chemical syntheses of phenylalanine derivatives containing halogenated benzene ring as structural explorers for elucidation of molecular mechanisms of receptor interactions

Matsushima, A., Fujita, T., Okada, K., Yamauchi, Y., Nose, T. & Shimohigashi, Y., 2000, Peptide Science 1999. p. 141-142

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

24 引用 (Scopus)

Edge-to-face CH/π interaction between ligand Phe-phenyl and receptor aromatic group in the thrombin receptor activation

Matsushima, A., Fujita, T., Nose, T. & Shimohigashi, Y., 1 1 2000, : : Journal of biochemistry. 128, 2, p. 225-232 8 p.

研究成果: ジャーナルへの寄稿記事

Thrombin Receptors
Phenylalanine
Chemical activation
Ligands
Hydrogen
28 引用 (Scopus)

Enthalpy- and/or entropy-controlled asymmetric oxidation: Stereocontrolling factors in Mn-salen-catalyzed oxidation

Nishida, T., Miyafuji, A., Ito, Y. & Katsuki, T., 9 2 2000, : : Tetrahedron Letters. 41, 36, p. 7053-7058 6 p.

研究成果: ジャーナルへの寄稿記事

Entropy
Enthalpy
Oxidation
Alkenes
Conformations
11 引用 (Scopus)

Enzymatic synthesis of [14C]ceramide, [14C]glycosphingolipids, and ω-aminoceramide

Ito, M., Mitsutake, S., Tani, M. & Kita, K., 1 1 2000, : : Methods in enzymology. 311, p. 682-689 8 p.

研究成果: ジャーナルへの寄稿記事

Carbon Radioisotopes
Amidohydrolases
Isotope Labeling
Glycosphingolipids
Ceramides
5 引用 (Scopus)

Exploration of the role of phenylalanine in the thrombin receptor tethered-ligand peptide by substitution with a series of trifluorophenylalanines

Matsushima, A., Fujita, T., Okada, K., Shirasu, N., Nose, T. & Shimohigashi, Y., 11 1 2000, : : Bulletin of the Chemical Society of Japan. 73, 11, p. 2531-2538 8 p.

研究成果: ジャーナルへの寄稿記事

thrombin receptor peptide SFLLRNP
Thrombin Receptors
Phenylalanine
Hydrogen
Substitution reactions
36 引用 (Scopus)

Glycine-rich region of mitochondrial processing peptidase α-subunit is essential for binding and cleavage of the precursor proteins

Nagao, Y., Kitada, S., Kojima, K., Toh, H., Kuhara, S., Ogishima, T. & Ito, A., 11 3 2000, : : Journal of Biological Chemistry. 275, 44, p. 34552-34556 5 p.

研究成果: ジャーナルへの寄稿記事

Protein Precursors
Glycine
Mutation
Enzymes
Peptides

Highly potent peptide ligands for thrombin receptor

Fujita, T., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., 2000, Peptide Science 1999. p. 421-424

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

92 引用 (Scopus)

Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases

Tani, M., Okino, N., Mori, K., Tanigawa, T., Izu, H. & Ito, M., 4 14 2000, : : Journal of Biological Chemistry. 275, 15, p. 11229-11234 6 p.

研究成果: ジャーナルへの寄稿記事

Alkaline Ceramidase
Neutral Ceramidase
Ceramidases
Cloning
Molecular Cloning
41 引用 (Scopus)

Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells

Romiti, E., Meacci, E., Tani, M., Nuti, F., Farnararo, M., Ito, M. & Bruni, P., 9 7 2000, : : Biochemical and Biophysical Research Communications. 275, 3, p. 746-751 6 p.

研究成果: ジャーナルへの寄稿記事

Alkaline Ceramidase
Neutral Ceramidase
Acid Ceramidase
Endothelial cells
Endothelial Cells
71 引用 (Scopus)
Neutral Ceramidase
Ceramides
Liver
Purification
Ceramidases
16 引用 (Scopus)

Synthesis of a complete set of L-difluorophenylalanines, L-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor

Fujita, T., Nose, T., Matsushima, A., Okada, K., Asai, D., Yamauchi, Y., Shirasu, N., Honda, T., Shigehiro, D. & Shimohigashi, Y., 2 5 2000, : : Tetrahedron Letters. 41, 6, p. 923-927 5 p.

研究成果: ジャーナルへの寄稿記事

thrombin receptor peptide SFLLRNP
Thrombin Receptors
Peptide Receptors
Hydrogen
Ligands
2001

Activity Enhancement by Introduction of two different halogen atoms into Phe-2-phenyl group of thrombin receptor tetherd-ligand analogs.

Fujita, T., Inoue, N., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2001, Peptide Science 2000. p. 135-138

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

23 引用 (Scopus)

A proposed common structure of substrates bound to mitochondrial processing peptidase

Kojima, K., Kitada, S., Ogishima, T. & Ito, A., 1 19 2001, : : Journal of Biological Chemistry. 276, 3, p. 2115-2121 7 p.

研究成果: ジャーナルへの寄稿記事

Introns
Substrates
Fluorescence Resonance Energy Transfer
Peptides
ethylenediamine

cDNA cloning of a circadian rhythm pacemaker hormone PDF of the house fly Musca domestica

Matsushima, A., Chuman, Y., Sato, S., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2001, Comparative Biochemistry and Physiology. p. 876

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

cDNA Cloning of circadian rhythm pacemaker neuropeptide PDF in Gryllus bimaculatus and its neuclear localization

Chuman, Y., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 2001, Peptide Science 2000. p. 59-62

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

26 引用 (Scopus)

Convenient route to both enantiomerically pure forms of trans-4,5-dihydroxy-2-cyclopenten-1-one: Efficient synthesis of the neocarzinostatin chromophore core

Toyama, K., Iguchi, S., Sakazaki, H., Oishi, T. & Hirama, M., 6 1 2001, : : Bulletin of the Chemical Society of Japan. 74, 6, p. 997-1008 12 p.

研究成果: ジャーナルへの寄稿記事

Cyclopentanes
Alkynes
Palladium
Derivatives
cyclopentenone
36 引用 (Scopus)

Convergent strategy for synthesizing polycyclic ether marine toxins: Synthesis of the ABCDE ring fragment of ciguatoxin CTX3C

Maruyama, M., Maeda, K., Oishi, T., Oguri, H. & Hirama, M., 1 1 2001, : : Heterocycles. 54, 1, p. 93-99 7 p.

研究成果: ジャーナルへの寄稿記事

Ciguatoxins
Marine Toxins
Alkenes
Ether
ciguatoxin 3C
50 引用 (Scopus)

Convergent synthesis of the EFGH ring fragment of ciguatoxin CTX3C

Imai, H., Uehara, H., Inoue, M., Oguri, H., Oishi, T. & Hirama, M., 8 27 2001, : : Tetrahedron Letters. 42, 35, p. 6219-6222 4 p.

研究成果: ジャーナルへの寄稿記事

Acetals
Cyclization
ciguatoxin 3C
25 引用 (Scopus)

Enhancement of Transport-dependent Decarboxylation of Phosphatidylserine by S100B Protein in Permeabilized Chinese Hamster Ovary Cells

Kuge, O., Yamakawa, Y. & Nishijima, M., 6 29 2001, : : Journal of Biological Chemistry. 276, 26, p. 23700-23706 7 p.

研究成果: ジャーナルへの寄稿記事

Decarboxylation
Phosphatidylserines
Cricetulus
Ovary
Cells

Gene expression of a circadian pacemaker hormone peptide PDF in cricket Gryllus bimaculatus

Matsushima, A., Chuman, Y., Onoue, H., Ito, Y., Tomioka, K., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2001, Peptide Science 2000. p. 63-66

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

13 引用 (Scopus)

Highly diastereoselective aziridination of α,β-unsaturated amides using diaziridine

Ishihara, H., Ito, Y. & Katsuki, T., 1 1 2001, : : Chemistry Letters. 10, p. 984-985 2 p.

研究成果: ジャーナルへの寄稿記事

Aziridines
Stereochemistry
Amides
Substrates

PERIOD clock protein of the summer cicada Meimuna opalifera: cDNA cloning and structural analysis

Sato, S., Chuman, Y., Matsushima, A., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2001, Comparative Biochemistry and Physiology. 巻 130. p. 876

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

92 引用 (Scopus)

Purification, Characterization, Molecular Cloning, and Subcellular Distribution of Neutral Ceramidase of Rat Kidney

Mitsutake, S., Tani, M., Okino, N., Mori, K., Ichinose, S., Omori, A., Iida, H., Nakamura, T. & Ito, M., 7 13 2001, : : Journal of Biological Chemistry. 276, 28, p. 26249-26259 11 p.

研究成果: ジャーナルへの寄稿記事

Neutral Ceramidase
Ceramidases
Cloning
Molecular Cloning
Purification
12 引用 (Scopus)

Purification of phosphatidylglycerophosphate synthase from Chinese hamster ovary cells

Kawasaki, K., Kuge, O., Yamakawa, Y. & Nishijima, M., 2 15 2001, : : Biochemical Journal. 354, 1, p. 9-15 7 p.

研究成果: ジャーナルへの寄稿記事

CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Cricetulus
Purification
Ovary
Cells
5 引用 (Scopus)

Recognition of mitochondrial protein precursor lacking arginine at position -2 by Mitochondrial Processing Peptidase: Processing of bovine cytochrome p450(SCC) precursor

Kojima, K., Yamasaki, E., Kitada, S., Ogishima, T. & Ito, A., 1 1 2001, : : Journal of biochemistry. 130, 4, p. 497-502 6 p.

研究成果: ジャーナルへの寄稿記事

Protein Precursors
Mitochondrial Proteins
Cytochrome P-450 Enzyme System
Arginine
Processing
225 引用 (Scopus)

Total synthesis of ciguatoxin CTX3C

Hirama, M., Oishi, T., Uehara, H., Inoue, M., Maruyama, M., Oguri, H. & Satake, M., 11 30 2001, : : Science. 294, 5548, p. 1904-1907 4 p.

研究成果: ジャーナルへの寄稿記事

Ciguatoxins
Ciguatera Poisoning
Seafood
Neurotoxins
Molecular Structure
2002
24 引用 (Scopus)

A circadian neuropeptide, pigment-dispersing factor-PDF, in the last-summer cicada Meimuna opalifera: cDNA cloning and immunocytochemistry

Sato, S., Chuman, Y., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 8 1 2002, : : Zoological science. 19, 8, p. 821-828 8 p.

研究成果: ジャーナルへの寄稿記事

Cicadidae
neuropeptides
immunocytochemistry
molecular cloning
pigments
58 引用 (Scopus)

Amphotericin B covalent dimers forming sterol-dependent ion-permeable membrane channels

Matsumori, N., Yamaji, N., Matsuoka, S., Oishi, T. & Murata, M., 4 24 2002, : : Journal of the American Chemical Society. 124, 16, p. 4180-4181 2 p.

研究成果: ジャーナルへの寄稿記事

Amphotericin B
Sterols
Ion Channels
Dimers
Ions
21 引用 (Scopus)

cDNA cloning and nuclear localization of the circadian neuropeptide designated as pigment-dispersing factor PDF in the cricket Gryllus bimaculatus

Chuman, Y., Matsushima, A., Sato, S., Tomioka, K., Tominaga, Y., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., 1 1 2002, : : Journal of Biochemistry. 131, 6, p. 895-903 9 p.

研究成果: ジャーナルへの寄稿記事

Gryllidae
Cloning
Neuropeptides
Pigments
Insects

cDNA cloning of PDF peptide precursors in housefly and last summer cicada

Sato, S., Matsushima, A., Chuman, Y., Tominaga, K., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 139-142

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Circadian rhythm pacemaker neuropeptide 'PDF' in nocturnal insect cricket gryllus bimaculatus: cDNA cloning, mRNA expression, and nuclear localization

Chuman, Y., Matsushima, A., Nose, T., Shimohigashi, Y. & Shimohigashi, M., 2002, American Peptide Society 2001. p. 797-798

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Contractile activity of Drosophila FMRFamide-related peptides in the Meretrix Lusoria heart muscle.

Tokunaga, T., Ohtani, M., Matsushima, A., Chuman, Y., Nose, T. & Shimohigashi, Y., 2002, Peptide Science 2001. p. 167-170

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

59 引用 (Scopus)

Convergent synthesis of the ABCDE ring system of ciguatoxin CTX3C

Maruyama, M., Inoue, M., Oishi, T., Oguri, H., Ogasawara, Y., Shindo, Y. & Hirama, M., 3 4 2002, : : Tetrahedron. 58, 10, p. 1835-1851 17 p.

研究成果: ジャーナルへの寄稿記事

Ciguatoxins
Ciguatera Poisoning
Seafood
Alkenes
Ether