有機・生物化学

研究成果 1983 2019

2013
4 引用 (Scopus)

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro

Vecchiola, A., Lagos, C. F., Fuentes, C. A., Allende, F., Campino, C., Valdivia, C., Tapia-Castillo, A., Ogishima, T., Mukai, K., Owen, G., Solari, S., Carvajal, C. A. & Fardella, C. E., 8 13 2013, : : Reproductive Biology and Endocrinology. 11, 1, 76.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Progesterone
Estradiol
Aldosterone
Steroid 11-beta-Hydroxylase

Exploration of pharmacological chaperone for rescue of misfolded and/or unfolded ORL1 nociceptin receptor proteins

Nishimura, H., Inamine, S., Li, J., Matsushima, A. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 115-118

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

3 引用 (Scopus)

Guest responsivity of a two-dimensional coordination polymer incorporating a cholesterol-based co-ligand

Kajitani, K., Koshiyama, T., Hori, A., Otani, R., Mishima, A., Torikai, K., Ebine, M., Oishi, T., Takata, M., Kitagawa, S. & Ohba, M., 12 7 2013, : : Dalton Transactions. 42, 45, p. 15893-15897 5 p.

研究成果: ジャーナルへの寄稿記事

Polymers
Cholesterol
Ligands

Halogenated Phe-containing endomorphin-2 analogs with mixed agonist and antagonist activities

Nishio, K., Nishimura, H., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 25-26

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

High-precision binding assay procedure of tachykinin receptor NK-1 for highly potent Substance P analogs

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 213-214

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Identification of affinity binding site of Cys(Npys)-elongated RYYRIK peptide antagonist by means of Cys→Ala mutated ORL1 nociceptin receptors

Matsushima, A., Nishimura, H., Inamine, S. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 207-208

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

19 引用 (Scopus)

Immunohistochemistry improves histopathologic diagnosis in primary aldosteronism

Volpe, C., Höög, A., Ogishima, T., Mukai, K., Lu, M., Thorén, M. & Hamberger, B., 4 2013, : : Journal of Clinical Pathology - Clinical Molecular Pathology. 66, 4, p. 351-354 4 p.

研究成果: ジャーナルへの寄稿記事

Hyperaldosteronism
Aldosterone
Immunohistochemistry
Adenoma
Hyperplasia
16 引用 (Scopus)

Synthesis and structure revision of the C43-C67 part of amphidinol 3

Ebine, M., Kanemoto, M., Manabe, Y., Konno, Y., Sakai, K., Matsumori, N., Murata, M. & Oishi, T., 6 26 2013, : : Organic Letters. 15, 11, p. 2846-2849 4 p.

研究成果: ジャーナルへの寄稿記事

nuclear magnetic resonance
oxidation
synthesis
configurations
Nuclear magnetic resonance
77 引用 (Scopus)

Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria

Tamura, Y., Harada, Y., Nishikawa, S. I., Yamano, K., Kamiya, M., Shiota, T., Kuroda, T., Kuge, O., Sesaki, H., Imai, K., Tomii, K. & Endo, T., 5 7 2013, : : Cell metabolism. 17, 5, p. 709-718 10 p.

研究成果: ジャーナルへの寄稿記事

Cytidine Diphosphate Diglycerides
Diacylglycerol Cholinephosphotransferase
Cardiolipins
Mitochondria
Phosphatidic Acids

The impact of bisphenol A-feeding on the Drosophila neuropeptide PDF mRNA structure

Matsuo, A., Nakamura, M., Takeda, Y., Matsuyama, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 75-76

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

5 引用 (Scopus)

Triazoyl-phenyl linker system enhancing the aqueous solubility of a molecular probe and its efficiency in affinity labeling of a target protein for jasmonate glucoside

Tamura, S., Inomata, S., Ebine, M., Genji, T., Iwakura, I., Mukai, M., Shoji, M., Sugai, T. & Ueda, M., 1 1 2013, : : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 188-193 6 p.

研究成果: ジャーナルへの寄稿記事

Molecular Probes
Glucosides
Solubility
Labeling
Proteins

Two different binding modes of peptide library-based antagonist acyl-RYYRIK amide in the orl1 nociceptin receptor

Inamine, S., Nishimura, H., Li, J., Matsushima, A., Costa, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 229-230

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2012

Affinity labeling of the ORL1 nociceptin receptor by Cys(Npys)-elongated RYYRIK peptide antagonist

Matsushima, A., Nishimura, H., Uemura, S., Li, J., Inamine, S. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 179-180

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

7 引用 (Scopus)

Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells

Oishi, T., Konoki, K., Tamate, R., Torikai, K., Hasegawa, F., Matsumori, N. & Murata, M., 6 1 2012, : : Bioorganic and Medicinal Chemistry Letters. 22, 11, p. 3619-3622 4 p.

研究成果: ジャーナルへの寄稿記事

Dinoflagellida
Polyethers
Ladders
Glioma
Rats
41 引用 (Scopus)

AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase

Miyata, N., Okumoto, K., Mukai, S., Noguchi, M. & Fujiki, Y., 1 2012, : : Traffic. 13, 1, p. 168-183 16 p.

研究成果: ジャーナルへの寄稿記事

Peroxisomes
Adenosine Triphosphatases
Assays
Fibroblasts
Fractionation
35 引用 (Scopus)

Comprehensive molecular motion capture for sphingomyelin by site-specific deuterium labeling

Matsumori, N., Yasuda, T., Okazaki, H., Suzuki, T., Yamaguchi, T., Tsuchikawa, H., Doi, M., Oishi, T. & Murata, M., 10 23 2012, : : Biochemistry. 51, 42, p. 8363-8370 8 p.

研究成果: ジャーナルへの寄稿記事

Sphingomyelins
Deuterium
Labeling
Cholesterol
Sphingosine
14 引用 (Scopus)

Confirmation of the absolute configuration at C45 of amphidinol 3

Manabe, Y., Ebine, M., Matsumori, N., Murata, M. & Oishi, T., 12 3 2012, : : Journal of Natural Products. 75, 11, p. 2003-2006 4 p.

研究成果: ジャーナルへの寄稿記事

Dinoflagellida
Biological Products
Degradation
Esters
Carbon
3 引用 (Scopus)
Ethers
Polyethers
Ladders
Ether
Cyclic Ethers

Effects of the halogenation of Phe-phenyl group of two consecutive residues in endomorphin-2 on the interaction with the μ–opioid receptors

Nishio, K., Nishimura, H., Suyama, K., Abe, Y., Matsushima, A., Nose, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 171-172

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

5 引用 (Scopus)

Expression of budding yeast IPT1 produces mannosyldiinositol phosphorylceramide in fission yeast and inhibits cell growth

Nakase, M., Tani, M. & Takegawa, K., 5 1 2012, : : Microbiology. 158, 5, p. 1219-1228 10 p.

研究成果: ジャーナルへの寄稿記事

Saccharomycetales
Schizosaccharomyces
Growth
Sphingolipids
Poisons
10 引用 (Scopus)

Fine spatial assembly for construction of the phenol-binding pocket to capture bisphenol a in the human nuclear receptor estrogen-related receptor γ

Liu, X., Matsushima, A., Nakamura, M., Costa, T., Nose, T. & Shimohigashi, Y., 4 1 2012, : : Journal of biochemistry. 151, 4, p. 403-415 13 p.

研究成果: ジャーナルへの寄稿記事

Cytoplasmic and Nuclear Receptors
Phenol
Estrogen Receptors
Estrogens
Benzene
22 引用 (Scopus)

Head-to-tail interaction between amphotericin b and ergosterol occurs in hydrated phospholipid membrane

Umegawa, Y., Nakagawa, Y., Tahara, K., Tsuchikawa, H., Matsumori, N., Oishi, T. & Murata, M., 1 10 2012, : : Biochemistry. 51, 1, p. 83-89 7 p.

研究成果: ジャーナルへの寄稿記事

Ergosterol
Amphotericin B
Phospholipids
Head
Membranes
13 引用 (Scopus)
Hydroxylation
Sphingolipids
Yeast
Ceramides
Saccharomyces cerevisiae
23 引用 (Scopus)

Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis

Lee, S., Uchida, Y., Emoto, K., Umeda, M., Kuge, O., Taguchi, T. & Arai, H., 8 1 2012, : : Genes to Cells. 17, 8, p. 728-736 9 p.

研究成果: ジャーナルへの寄稿記事

CHO Cells
Endosomes
Phosphatidylserines
Membranes
Cell Membrane
10 引用 (Scopus)
Sphingolipids
Phosphatidylserines
Saccharomyces cerevisiae
Yeasts
Endosomes
28 引用 (Scopus)
Peroxisomes
Membranes
Adenosine Triphosphatases
peroxisome-targeting signal 1 receptor
Hydrolysis
29 引用 (Scopus)

NMR-based conformational analysis of sphingomyelin in bicelles

Yamaguchi, T., Suzuki, T., Yasuda, T., Oishi, T., Matsumori, N. & Murata, M., 1 1 2012, : : Bioorganic and Medicinal Chemistry. 20, 1, p. 270-278 9 p.

研究成果: ジャーナルへの寄稿記事

Sphingomyelins
Nuclear magnetic resonance
Conformations
Lipid bilayers
Membranes

Receptor Binding Characteristics of Tritium-labeled Pure antagonist Peptide for Hyperalgesic nociceptin ORL1 receptor

Inamine, S., Nishimura, H., Li, J., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 183-184

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

26 引用 (Scopus)

Selenium Compound Protects Corneal Epithelium against Oxidative Stress

Higuchi, A., Inoue, H., Kawakita, T., Ogishima, T. & Tsubota, K., 9 25 2012, : : PloS one. 7, 9, e45612.

研究成果: ジャーナルへの寄稿記事

Selenium Compounds
Corneal Epithelium
Lactoferrin
Oxidative stress
selenium

Structural Analysis of Delta Opioid Receptor Dimer by Bivalent Deltorphin II Analogs

Ito, N., Nishimura, H., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 3 2012, Peptide Science 2011. p. 173-174 2 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structural Characteristics of Thr-Gly Dipeptide Repeat in the Drosophila Clock Protein PERIOD

Matsuo, A., Nishimura, H., Masayuki, N., Koga, K., Sumiyoshi, M., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 3 2012, Peptide Science 2011. p. 351-352 2 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structural Essentials of Hyperalgesic Nociceptin ORL1 Receptor for Ligand Binding and Receptor Activation

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 33-34

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2011
2 引用 (Scopus)

Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor

Matsushima, A., Nishimura, H., Inamine, S., Uemura, S. & Shimohigashi, Y., 12 15 2011, : : Bioorganic and Medicinal Chemistry. 19, 24, p. 7597-7602 6 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Ethylmaleimide
Cysteine
Binding Sites
Sulfhydryl Compounds
19 引用 (Scopus)

"Click-made" biaryl-linker improving efficiency in protein labelling for the membrane target protein of a bioactive compound

Nakamura, Y., Inomata, S., Ebine, M., Manabe, Y., Iwakura, I. & Ueda, M., 1 1 2011, : : Organic and Biomolecular Chemistry. 9, 1, p. 83-85 3 p.

研究成果: ジャーナルへの寄稿記事

activity (biology)
Labeling
marking
Membrane Proteins
membranes
72 引用 (Scopus)

Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recycling

Okumoto, K., Misono, S., Miyata, N., Matsumoto, Y., Mukai, S. & Fujiki, Y., 8 2011, : : Traffic. 12, 8, p. 1067-1083 17 p.

研究成果: ジャーナルへの寄稿記事

Peroxisomes
Ubiquitination
Recycling
Cysteine
Dithiothreitol
54 引用 (Scopus)

Endocrine disrupter bisphenol a increases in situ estrogen production in the mouse urogenital sinus

Arase, S., Ishii, K., Igarashi, K., Aisaki, K., Yoshio, Y., Matsushima, A., Shimohigashi, Y., Arima, K., Kanno, J. & Sugimura, Y., 4 1 2011, : : Biology of Reproduction. 84, 4, p. 734-742 9 p.

研究成果: ジャーナルへの寄稿記事

Estrogens
Aromatase
Messenger RNA
Prostate
Up-Regulation

Exploration of the binding site of ORL1 nociceptin receptor antagonist

Inamine, S., Nishimura, H., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 167

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

22 引用 (Scopus)

FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis

Kuroda, T., Tani, M., Moriguchi, A., Tokunaga, S., Higuchi, T., Kitada, S. & Kuge, O., 4 1 2011, : : Molecular Microbiology. 80, 1, p. 248-265 18 p.

研究成果: ジャーナルへの寄稿記事

Cardiolipins
Maintenance
Mitochondrial Genes
Growth
Genes

Metabolic machinery of sphingolipid signaling molecules

Tani, M., 2011, : : Seikagaku. The Journal of Japanese Biochemical Society. 83, 7, p. 623-627 5 p.

研究成果: ジャーナルへの寄稿記事

Signal transduction
Sphingolipids
Machinery
Animals
Molecules
15 引用 (Scopus)

Pigment-dispersing factor affects nocturnal activity rhythms, photic entrainment, and the free-running period of the circadian clock in the cricket gryllus bimaculatus

Hassaneen, E., El-Din Sallam, A., Abo-Ghalia, A., Moriyama, Y., Karpova, S. G., Abdelsalam, S., Matsushima, A., Shimohigashi, Y. & Tomioka, K., 2 1 2011, : : Journal of Biological Rhythms. 26, 1, p. 3-13 11 p.

研究成果: ジャーナルへの寄稿記事

Gryllidae
Circadian Clocks
Photoperiod
Light
Double-Stranded RNA
2 引用 (Scopus)

Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743

Torikai, K., Saruwatari, T., Kitano, T., Sano, T., Nakane, A., Noguchi, H. & Watanabe, K., 12 1 2011, : : Letters in Organic Chemistry. 8, 10, p. 686-689 4 p.

研究成果: ジャーナルへの寄稿記事

trabectedin
Biological Products
Purification
Crystallization
High Pressure Liquid Chromatography

QCM-analyses of the intermolecular interaction between prion protein N-terminal domains having increased number of octapeptide repeat.

Sato, K., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 128

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2 引用 (Scopus)

Recent applications of the suzuki-miyaura cross-coupling to complex polycyclic ether synthesis

Fuwa, H., Ebine, M. & Sasaki, M., 1 1 2011, : : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 69, 11, p. 1251-1262 12 p.

研究成果: ジャーナルへの寄稿記事

Biological Products
Ether
Ladders
Palladium
Bioactivity

Structural essentials of hyperalgesic nococeptin ORL1 receptor for ligand binding and receptor activation

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 128

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

5 引用 (Scopus)

Synthesis of 6-F-ergosterol and its influence on membrane-permeabilization of amphotericin B and amphidinol 3

Kasai, Y., Matsumori, N., Ueno, H., Nonomura, K., Yano, S., Michio, M. & Oishi, T., 3 1 2011, : : Organic and Biomolecular Chemistry. 9, 5, p. 1437-1442 6 p.

研究成果: ジャーナルへの寄稿記事

Amphotericin B
Ergosterol
membranes
Membranes
Sterols
1 引用 (Scopus)

The mucin box and signal/anchor sequence of rat neutral ceramidase recruit bacterial sphingomyelinase to the plasma membrane

Nakagawa, T., Tani, M., Sueyoshi, N. & Ito, M., 6 6 2011, : : Bioscience, Biotechnology and Biochemistry. 75, 5, p. 987-990 4 p.

研究成果: ジャーナルへの寄稿記事

Neutral Ceramidase
Sphingomyelin Phosphodiesterase
Mucins
Cell membranes
Protein Sorting Signals

The Trp Residue of Opioid Receptor TM5 is Present at the Cell Membrane Interface as a Molecular Anchor for Full Activation

Nishimura, H., Li, J., Inokuchi, N., Koikawa, S., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., 3 2011, Peptide Science 2010. p. 175 1 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

13 引用 (Scopus)

Total synthesis of (-)-brevenal: A streamlined strategy for practical synthesis of polycyclic ethers

Ebine, M., Fuwa, H. & Sasaki, M., 12 2 2011, : : Chemistry - A European Journal. 17, 49, p. 13754-13761 8 p.

研究成果: ジャーナルへの寄稿記事

Ethers
Polyethers
Lactones
Bioactivity
Biological Products

基幹教育シリーズ 化学 「有機物質化学」

Suenaga, M., Ishida, T., Tokunaga, M., Ito, Y., Uchida, T., Oishi, T. & Kawato, T., 2011, 学術図書出版社.

研究成果: 著書/レポートタイプ著書