有機・生物化学

研究成果 1979 2019

2011
1 引用 (Scopus)

The mucin box and signal/anchor sequence of rat neutral ceramidase recruit bacterial sphingomyelinase to the plasma membrane

Nakagawa, T., Tani, M., Sueyoshi, N. & Ito, M., 6 6 2011, : : Bioscience, Biotechnology and Biochemistry. 75, 5, p. 987-990 4 p.

研究成果: ジャーナルへの寄稿記事

Neutral Ceramidase
Sphingomyelin Phosphodiesterase
Mucins
Cell membranes
Protein Sorting Signals

The Trp Residue of Opioid Receptor TM5 is Present at the Cell Membrane Interface as a Molecular Anchor for Full Activation

Nishimura, H., Li, J., Inokuchi, N., Koikawa, S., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., 3 2011, Peptide Science 2010. p. 175 1 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

13 引用 (Scopus)

Total synthesis of (-)-brevenal: A streamlined strategy for practical synthesis of polycyclic ethers

Ebine, M., Fuwa, H. & Sasaki, M., 12 2 2011, : : Chemistry - A European Journal. 17, 49, p. 13754-13761 8 p.

研究成果: ジャーナルへの寄稿記事

Ethers
Polyethers
Lactones
Bioactivity
Biological Products

基幹教育シリーズ 化学 「有機物質化学」

Suenaga, M., Ishida, T., Tokunaga, M., Ito, Y., Uchida, T., Oishi, T. & Kawato, T., 2011, 学術図書出版社.

研究成果: 著書/レポートタイプ著書

2010
148 引用 (Scopus)

Adrenocortical zonation in humans under normal and pathological conditions

Nishimoto, K., Nakagawa, K., Li, D., Kosaka, T., Oya, M., Mikami, S., Shibata, H., Itoh, H., Mitani, F., Yamazaki, T., Ogishima, T., Suematsu, M. & Mukai, K., 1 1 2010, : : Journal of Clinical Endocrinology and Metabolism. 95, 5, p. 2296-2305 10 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Steroid 11-beta-Hydroxylase
Aldosterone
Adenoma
Enzymes
105 引用 (Scopus)

Bisphenol AF is a full agonist for the estrogen receptor ERα but a highly specific antagonist for ERβ

Matsushima, A., Liu, X., Okada, H., Shimohigashi, M. & Shimohigashi, Y., 9 1 2010, : : Environmental Health Perspectives. 118, 9, p. 1267-1272 6 p.

研究成果: ジャーナルへの寄稿記事

Estrogens
Reporter Genes
Estradiol
4,4'-hexafluorisopropylidene diphenol
Physiological Phenomena
14 引用 (Scopus)
Acid resistance
Ceramides
Inositol
Yeast
Saccharomyces cerevisiae
10 引用 (Scopus)

Detection of Rap1A as a yessotoxin binding protein from blood cell membranes

Ujihara, S., Oishi, T., Mouri, R., Tamate, R., Konoki, K., Matsumori, N., Murata, M., Oshima, Y., Sugiyama, N., Tomita, M. & Ishihama, Y., 11 15 2010, : : Bioorganic and Medicinal Chemistry Letters. 20, 22, p. 6443-6446 4 p.

研究成果: ジャーナルへの寄稿記事

Cell membranes
Blood Cells
Carrier Proteins
Blood
Polyethers
16 引用 (Scopus)

Distinction of the binding modes for human nuclear receptor ERRγ between bisphenol A and 4-hydroxytamoxifen

Liu, X., Matsushima, A., Okada, H. & Shimohigashi, Y., 8 1 2010, : : Journal of Biochemistry. 148, 2, p. 247-254 8 p.

研究成果: ジャーナルへの寄稿記事

Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estrogens
Phenol
Hydrogen Bonding

Functional role of the C-terminal Helix 12 peptide in the receptor activation mechanism of estrogen-related receptor γ (ERRγ)

Liu, X., Matsushima, A., Nose, T., Okada, H. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 435–436

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

23 引用 (Scopus)

Highly efficient synthesis of medium-sized lactones via oxidative lactonization: Concise total synthesis of isolaurepanf

Ebine, M., Suga, Y., Fuwa, H. & Sasaki, M., 2 23 2010, : : Organic and Biomolecular Chemistry. 8, 1, p. 39-42 4 p.

研究成果: ジャーナルへの寄稿記事

Lactones
synthesis
TEMPO

Identification of circadian neuropeptide PDF mRNA isoforms in the housefly Musca domestica

Kawanaka, C., Matsushima, A., Takeda, Y., Shimohigashi, M. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 145–146

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

33 引用 (Scopus)

Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma-membrane proteins in Schizosaccharomyces pombe

Nakase, M., Tani, M., Morita, T., Kitamoto, H. K., Kashiwazaki, J., Nakamura, T., Hosomi, A., Tanaka, N. & Takegawa, K., 5 1 2010, : : Journal of Cell Science. 123, 9, p. 1578-1587 10 p.

研究成果: ジャーナルへの寄稿記事

Sphingolipids
Schizosaccharomyces
Blood Proteins
Membrane Proteins
Cell Membrane
17 引用 (Scopus)
Sphingolipids
Saccharomyces cerevisiae
Yeasts
Enzymes
Growth
2 引用 (Scopus)

Second-generation synthesis of endogenous sperm-activating and attracting factor (SAAF) isolated from the ascidian Ciona intestinalis

Oishi, T., Ootou, K., Shibata, H. & Murata, M., 5 12 2010, : : Tetrahedron Letters. 51, 19, p. 2600-2602 3 p.

研究成果: ジャーナルへの寄稿記事

Ciona intestinalis
Urochordata
Spermatozoa
Molecular Probes
Epoxy Compounds
17 引用 (Scopus)

Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance

Swasono, R. T., Mouri, R., Morsy, N., Matsumori, N., Oishi, T. & Murata, M., 4 1 2010, : : Bioorganic and Medicinal Chemistry Letters. 20, 7, p. 2215-2218 4 p.

研究成果: ジャーナルへの寄稿記事

Surface Plasmon Resonance
Surface plasmon resonance
Sterols
Membranes
Ergosterol
10 引用 (Scopus)

Structural reevaluations of amphidinol 3, a potent antifungal compound from dinoflagellate

Swasono, R. T., Kanemoto, M., Matsumori, N., Oishi, T. & Murata, M., 2 28 2010, : : Heterocycles. 82, 2, p. 1359-1369 11 p.

研究成果: ジャーナルへの寄稿記事

Dinoflagellida
Organic solvents
Nuclear magnetic resonance
Membranes
amphidinol 3

Structure-function analysis of nociceptin receptor ORL1 by the site-directed mutagenesis

Li, J., Isozaki, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 219–220

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

5 引用 (Scopus)

Synthesis and properties of fullerene (C70) complexes of 2,6-bis(porphyrin)-substituted pyrazine derivatives bound to a Pd(II) ion

Eda, Y., Itoh, K., Ito, Y., Fujitsuka, M., Majima, T. & Kawato, T., 9 1 2010, : : Supramolecular Chemistry. 22, 9, p. 517-523 7 p.

研究成果: ジャーナルへの寄稿記事

Pyrazines
Porphyrins
Ions
Derivatives
Association reactions
61 引用 (Scopus)

The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes

Gilquin, B., Taillebourg, E., Cherradi, N., Hubstenberger, A., Gay, O., Merle, N., Assard, N., Fauvarque, M. O., Tomohiro, S., Kuge, O. & Baudier, J., 1 1 2010, : : Molecular and cellular biology. 30, 8, p. 1984-1996 13 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Dynamics
Adenosine Triphosphatases
Membranes
Eukaryota
Drosophila

The direct measure of intermolecular interaction of prion protein N-terminal octapeptide repeats by the quarts crystal microbalance (QCM)

Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 207–208

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

The functional role of Trp present at the cell membrane interface in the opioid receptor activation

Nishimura, H., Li, J., Inokuchi, N., Koikawa, A., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 23–24

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

The preparation and purification of prion protein N-terminal domain with fluctuations in the number of octapeptide repeat

Sato, K., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 219–220

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

The role of the peptide PAP coded in pdf gene

Shimohigashi, M., Ito, T., Honda, T., Saito, M., Koga, K., Takahashi, K., Matsushima, A., Ueda, R., Tanimura, T., Shimohigashi, Y. & Matsumoto, A., 2010, Peptide Science 2009. p. 207–208

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2009
7 引用 (Scopus)

2,6-Bis(porphyrin)-substituted pyrazine: a new class of supramolecular synthon binding to a transition-metal ion and fullerene (C60)

Eda, Y., Itoh, K., Ito, Y. & Kawato, T., 1 3 2009, : : Tetrahedron. 65, 1, p. 282-288 7 p.

研究成果: ジャーナルへの寄稿記事

Pyrazines
Porphyrins
Transition metals
Metal ions
Metals

Bisphenol A-specific nuclear receptor ERRγ: structure-function analysis of the two novel isoforms lacking vital peptide fragment in the ligand binding domain

Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, Y. & Shimohigashi, M., 2009, Peptide Science 2008. p. 517-518

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

5 引用 (Scopus)

Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)14, (Arg/Lys)15]nociceptin on ORL1 receptor binding and activation

Nishimura, H., Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 8 1 2009, : : Bioorganic and Medicinal Chemistry. 17, 15, p. 5683-5687 5 p.

研究成果: ジャーナルへの寄稿記事

Substitution reactions
Chemical activation
nociceptin
nociceptin receptor
Arg(14)-Lys(15)-nociceptin

ERα/ERRα nuclear receptor heterodimer directly linked by a flag peptide

Ikeda, S., Matsushima, A. & Shimohigashi, Y., 2009, Peptide Science 2008. p. 511-512

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Induced-fit type ligand binding guided by free-rotatory Leu residue present in the 7th α-helix peptide in the estrogen-related receptor γ (ERRγ)

Matsushima, A., Okada, H., Liu, X., Tokunaga, T., Teramoto, T., Kakuta, Y. & Shimohigashi, Y., 2009, Peptide Science 2008. p. 521-522

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

23 引用 (Scopus)

In vitro import of peroxisome-targeting signal type 2 (PTS2) receptor Pex7p into peroxisomes

Miyata, N., Hosoi, K. I., Mukai, S. & Fujiki, Y., 5 1 2009, : : Biochimica et Biophysica Acta - Molecular Cell Research. 1793, 5, p. 860-870 11 p.

研究成果: ジャーナルへの寄稿記事

Peroxisomes
Adenosine Triphosphate
Ethylmaleimide
In Vitro Techniques
peroxisomal targeting signal 2 receptor
13 引用 (Scopus)

Ion channel complex of antibiotics as viewed by NMR

Murata, M., Kasai, Y., Umegawa, Y., Matsushita, N., Tsuchikawa, H., Matsumori, N. & Oishi, T., 7 24 2009, : : Pure and Applied Chemistry. 81, 6, p. 1123-1129 7 p.

研究成果: ジャーナルへの寄稿記事

Amphotericin B
Antibiotics
Ion Channels
Nuclear magnetic resonance
Ergosterol
22 引用 (Scopus)

Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase

Inoue, T., Okino, N., Kakuta, Y., Hijikata, A., Okano, H., Goda, H. M., Tani, M., Sueyoshi, N., Kambayashi, K., Matsumura, H., Kai, Y. & Ito, M., 4 3 2009, : : Journal of Biological Chemistry. 284, 14, p. 9566-9577 12 p.

研究成果: ジャーナルへの寄稿記事

Neutral Ceramidase
Ceramides
Exotoxins
Hydrolysis
Ceramidases

Molecular recognition of prion protein via its N-terminal octapeptide repeat Structure

Horiuchi, Y., Hattori, E., Yokotani, S., Matsushima, A. & Shimohigashi, Y., 2009, Peptide Science 2008. p. 513-516

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

60 引用 (Scopus)

Placenta expressing the greatest quantity of bisphenol A receptor ERRγ among the human reproductive tissues: Predominant expression of type-1 ERRγ isoform

Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 7 1 2009, : : Journal of biochemistry. 146, 1, p. 113-122 10 p.

研究成果: ジャーナルへの寄稿記事

Estrogen Receptors
Placenta
Protein Isoforms
Estrogens
Tissue
21 引用 (Scopus)

Purification and characterization of human phosphatidylserine synthases 1 and 2

Tomohiro, S., Kawaguti, A., Kawabe, Y., Kitada, S. & Kuge, O., 3 1 2009, : : Biochemical Journal. 418, 2, p. 421-429 9 p.

研究成果: ジャーナルへの寄稿記事

CDPdiacylglycerol-Serine O-Phosphatidyltransferase
Phosphatidylserines
Purification
Phosphatidylcholines
Mouse Ptdss2 protein
4 引用 (Scopus)

Spare interactions of highly potent [Arg14,Lys15]nociceptin for cooperative induction of ORL1 receptor activation

Isozaki, K., Li, J., Okada, K., Nishimura, H., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 12 1 2009, : : Bioorganic and Medicinal Chemistry. 17, 23, p. 7904-7908 5 p.

研究成果: ジャーナルへの寄稿記事

Chemical activation
Bioactivity
Acidic Amino Acids
nociceptin
nociceptin receptor
23 引用 (Scopus)
Cell membranes
Cysteine
Cell Membrane
Enzymes
Lipoylation
2008
57 引用 (Scopus)

Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase

Briggs, L. C., Baldwin, G. S., Miyata, N., Kondo, H., Zhang, X. & Freemont, P. S., 5 16 2008, : : Journal of Biological Chemistry. 283, 20, p. 13745-13752 8 p.

研究成果: ジャーナルへの寄稿記事

Adenosine Triphosphatases
Nucleotides
Adenosine Diphosphate
Endoplasmic Reticulum-Associated Degradation
Organelle Biogenesis
10 引用 (Scopus)

Cytochrome P-45017α in β-cells of rat pancreas and its local steroidogenesis

Ogishima, T., Mitani, F. & Suematsu, M., 7 1 2008, : : Journal of Steroid Biochemistry and Molecular Biology. 111, 1-2, p. 80-86 7 p.

研究成果: ジャーナルへの寄稿記事

Cytochromes
Lyases
Androstenedione
Rats
Pancreas
14 引用 (Scopus)

Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist

Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 3 1 2008, : : Bioorganic and Medicinal Chemistry. 16, 5, p. 2635-2644 10 p.

研究成果: ジャーナルへの寄稿記事

Opioid Receptors
Peptide Library
Peptides
Carbon Monoxide
Analgesics
267 引用 (Scopus)

Direct evidence revealing structural elements essential for the high binding ability of bisphenol a to human estrogen-related receptor-γ

Okada, H., Tokunaga, T., Liu, X., Takayanagi, S., Matsushima, A. & Shimohigashi, Y., 1 1 2008, : : Environmental Health Perspectives. 116, 1, p. 32-38 7 p.

研究成果: ジャーナルへの寄稿記事

Estrogen Receptors
Endocrine Disruptors
Phenol
Luciferases
Reporter Genes
20 引用 (Scopus)
Peroxisomes
Oligomers
Adenosine Triphosphate
Membranes
Adenosine Triphosphatases
54 引用 (Scopus)

ERRγ tethers strongly bisphenol A and 4-α-cumylphenol in an induced-fit manner

Matsushima, A., Teramoto, T., Okada, H., Liu, X., Tokunaga, T., Kakuta, Y. & Shimohigashi, Y., 8 29 2008, : : Biochemical and Biophysical Research Communications. 373, 3, p. 408-413 6 p.

研究成果: ジャーナルへの寄稿記事

Estrogen Receptors
Estrogens
Phenol
Hydroxyl Radical
Crystal structure

Optimization of the N-terminal group of Ac-RYYRIK-NH2 as ORL1 receptor antagonist

Li, J., Isozaki, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 257-260

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

1 引用 (Scopus)
Radar
Tandem Repeat Sequences
Amino Acids
Aromatic Amino Acids
Prion Diseases
20 引用 (Scopus)

Scope of the thermal cyclization of nonconjugated ene-yne-nitrile system: A facile synthesis of cyanofluorenol derivatives

Kimura, H., Torikai, K., Miyawaki, K. & Ueda, I., 6 5 2008, : : Chemistry Letters. 37, 6, p. 662-663 2 p.

研究成果: ジャーナルへの寄稿記事

Nitriles
Cyclization
Derivatives
Hot Temperature

Structural requirement of housefly FMRFamide peptides in its receptor activation

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 313-314

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

8 引用 (Scopus)

Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation

Okada, K., Isozaki, K., Li, J., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 10 15 2008, : : Bioorganic and Medicinal Chemistry. 16, 20, p. 9261-9267 7 p.

研究成果: ジャーナルへの寄稿記事

Chemical activation
Dipeptides
arginyllysine
Assays
Peptides
4 引用 (Scopus)

Synthesis of pyrazine acetals by the biased reaction of symmetric 2,5-bis(chloromethyl) or 2,3,5,6-tetrakis(chloromethyl) substituents on pyrazine ring with sodium alkoxides

Eda, Y., Odazaki, Y., Mizutani, A., Ito, Y. & Kawato, T., 4 14 2008, : : Tetrahedron Letters. 49, 16, p. 2519-2522 4 p.

研究成果: ジャーナルへの寄稿記事

Pyrazines
Acetals
Sodium
Substitution reactions

The Conformation Change-sensing Antibodies for Retinoid-related Orphan Receptor Family

Nose, T., Nishigori, M., Liu, X., Tokunaga, T. & Shimohigashi, Y., 3 2008, Peptide Science 2007. p. 497-492 2 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)