有機・生物化学

研究成果 1979 2019

2008
14 引用 (Scopus)

Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist

Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 3 1 2008, : : Bioorganic and Medicinal Chemistry. 16, 5, p. 2635-2644 10 p.

研究成果: ジャーナルへの寄稿記事

Opioid Receptors
Peptide Library
Peptides
Carbon Monoxide
Analgesics
269 引用 (Scopus)

Direct evidence revealing structural elements essential for the high binding ability of bisphenol a to human estrogen-related receptor-γ

Okada, H., Tokunaga, T., Liu, X., Takayanagi, S., Matsushima, A. & Shimohigashi, Y., 1 1 2008, : : Environmental Health Perspectives. 116, 1, p. 32-38 7 p.

研究成果: ジャーナルへの寄稿記事

Estrogen Receptors
Endocrine Disruptors
Phenol
Luciferases
Reporter Genes
20 引用 (Scopus)
Peroxisomes
Oligomers
Adenosine Triphosphate
Membranes
Adenosine Triphosphatases
54 引用 (Scopus)

ERRγ tethers strongly bisphenol A and 4-α-cumylphenol in an induced-fit manner

Matsushima, A., Teramoto, T., Okada, H., Liu, X., Tokunaga, T., Kakuta, Y. & Shimohigashi, Y., 8 29 2008, : : Biochemical and Biophysical Research Communications. 373, 3, p. 408-413 6 p.

研究成果: ジャーナルへの寄稿記事

Estrogen Receptors
Estrogens
Phenol
Hydroxyl Radical
Crystal structure
13 引用 (Scopus)

Interaction of ladder-shaped polyethers with transmembrane α-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonance

Ujihara, S., Oishi, T., Torikai, K., Konoki, K., Matsumori, N., Murata, M., Oshima, Y. & Aimoto, S., 12 1 2008, : : Bioorganic and Medicinal Chemistry Letters. 18, 23, p. 6115-6118 4 p.

研究成果: ジャーナルへの寄稿記事

Glycophorin
Surface Plasmon Resonance
Polyethers
Ladders
Surface plasmon resonance

Optimization of the N-terminal group of Ac-RYYRIK-NH2 as ORL1 receptor antagonist

Li, J., Isozaki, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 257-260

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

15 引用 (Scopus)

Orientation of fluorinated cholesterol in lipid bilayers analyzed by 19F tensor calculation and solid-state NMR

Matsumori, N., Kasai, Y., Oishi, T., Murata, M. & Nomura, K., 4 9 2008, : : Journal of the American Chemical Society. 130, 14, p. 4757-4766 10 p.

研究成果: ジャーナルへの寄稿記事

Lipid bilayers
Cholesterol
Lipid Bilayers
Tensors
Nuclear magnetic resonance
1 引用 (Scopus)

Radar chart deviation analysis of prion protein amino acid composition defines characteristic structural abnormalities of the N-terminal octapeptide tandem repeat

Yokotani, S., Nose, T., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 9 1 2008, : : Protein and Peptide Letters. 15, 9, p. 949-955 7 p.

研究成果: ジャーナルへの寄稿記事

Radar
Tandem Repeat Sequences
Amino Acids
Aromatic Amino Acids
Prion Diseases
10 引用 (Scopus)

Roles of integral protein in membrane permeabilization by amphidinols

Morsy, N., Konoki, K., Houdai, T., Matsumori, N., Oishi, T., Murata, M. & Aimoto, S., 6 1 2008, : : Biochimica et Biophysica Acta - Biomembranes. 1778, 6, p. 1453-1459 7 p.

研究成果: ジャーナルへの寄稿記事

Glycophorin
Membrane Proteins
Membranes
Lipid bilayers
Surface Plasmon Resonance
20 引用 (Scopus)

Scope of the thermal cyclization of nonconjugated ene-yne-nitrile system: A facile synthesis of cyanofluorenol derivatives

Kimura, H., Torikai, K., Miyawaki, K. & Ueda, I., 6 5 2008, : : Chemistry Letters. 37, 6, p. 662-663 2 p.

研究成果: ジャーナルへの寄稿記事

Nitriles
Cyclization
Derivatives
Hot Temperature
36 引用 (Scopus)

Self-assembled amphotericin B is probably surrounded by ergosterol: Bimolecular interactions as evidenced by solid-state NMR and CD spectra

Kasai, Y., Matsumori, N., Umegawa, Y., Matsuoka, S., Ueno, H., Ikeuchi, H., Oishi, T. & Murata, M., 2 11 2008, : : Chemistry - A European Journal. 14, 4, p. 1178-1185 8 p.

研究成果: ジャーナルへの寄稿記事

Ergosterol
Amphotericin B
Cholesterol
Nuclear magnetic resonance
Membranes
18 引用 (Scopus)

Structural features of dinoflagellate toxins underlying biological activity as viewed by NMR

Murata, M., Matsumori, N., Konoki, K. & Oishi, T., 12 1 2008, : : Bulletin of the Chemical Society of Japan. 81, 3, p. 307-319 13 p.

研究成果: ジャーナルへの寄稿評論記事

Bioactivity
Biological Products
Nuclear magnetic resonance
Metabolites
Toxicity

Structural requirement of housefly FMRFamide peptides in its receptor activation

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 313-314

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

8 引用 (Scopus)

Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation

Okada, K., Isozaki, K., Li, J., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 10 15 2008, : : Bioorganic and Medicinal Chemistry. 16, 20, p. 9261-9267 7 p.

研究成果: ジャーナルへの寄稿記事

Chemical activation
Dipeptides
arginyllysine
Assays
Peptides
4 引用 (Scopus)

Synthesis of pyrazine acetals by the biased reaction of symmetric 2,5-bis(chloromethyl) or 2,3,5,6-tetrakis(chloromethyl) substituents on pyrazine ring with sodium alkoxides

Eda, Y., Odazaki, Y., Mizutani, A., Ito, Y. & Kawato, T., 4 14 2008, : : Tetrahedron Letters. 49, 16, p. 2519-2522 4 p.

研究成果: ジャーナルへの寄稿記事

Pyrazines
Acetals
Sodium
Substitution reactions

The Conformation Change-sensing Antibodies for Retinoid-related Orphan Receptor Family

Nose, T., Nishigori, M., Liu, X., Tokunaga, T. & Shimohigashi, Y., 3 2008, Peptide Science 2007. p. 497-492 2 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

The effect of amino acid substitution on oligomerization of octapeptide repeat structure in prion protein

Hattori, E., Yokotani, S., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 239-242

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

The output mechanism of circadian pacemaker neuropeptide PDF in the regulation of bimodal locomotor distribution

Takeda, Y., Koga, K., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 65-68

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

39 引用 (Scopus)

Total synthesis of (-)-brevenal: A concise synthetic entry to the pentacyclic polyether core

Ebine, M., Fuwa, H. & Sasaki, M., 6 5 2008, : : Organic Letters. 10, 11, p. 2275-2278 4 p.

研究成果: ジャーナルへの寄稿記事

Ribose
Polyethers
Alkenes
Biological Products
entry
8 引用 (Scopus)

Valosin-containing protein/p97 interacts with sperm-activating and sperm-attracting factor (SAAF) in the ascidian egg and modulates sperm-attracting activity

Kondoh, E., Konno, A., Inaba, K., Oishi, T., Murata, M. & Yoshida, M., 10 1 2008, : : Development Growth and Differentiation. 50, 8, p. 665-673 9 p.

研究成果: ジャーナルへの寄稿記事

Urochordata
Ovum
Spermatozoa
Oocytes
Proteasome Endopeptidase Complex
2007
39 引用 (Scopus)

Analysis of membrane topology of neutral sphingomyelinase 2

Tani, M. & Hannun, Y. A., 4 3 2007, : : FEBS Letters. 581, 7, p. 1323-1328 6 p.

研究成果: ジャーナルへの寄稿記事

Sphingomyelin Phosphodiesterase
Topology
Membranes
Cell membranes
Cell Membrane
21 引用 (Scopus)

A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria

Kitada, S., Uchiyama, T., Funatsu, T., Kitada, Y., Ogishima, T. & Ito, A., 2 1 2007, : : Journal of bacteriology. 189, 3, p. 844-850 7 p.

研究成果: ジャーナルへの寄稿記事

Rickettsia prowazekii
Protein Transport
Protein Sorting Signals
Mitochondria
Peptide Hydrolases
103 引用 (Scopus)

Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space

Tani, M., Ito, M. & Igarashi, Y., 2 1 2007, : : Cellular Signalling. 19, 2, p. 229-237 9 p.

研究成果: ジャーナルへの寄稿評論記事

Sphingolipids
Sphingosine
Ceramides
Extracellular Space
Neutral Ceramidase
4 引用 (Scopus)

Double-labelled in situ hybridization reveals the lack of co-localization of mRNAs for the circadian neuropeptide PDF and FMRFamide in brains of the flies Musca domestica and Drosophila melanogaster

Matsushima, A., Takano, K., Yoshida, T., Takeda, Y., Yokotani, S., Shimohigashi, Y. & Shimohigashi, M., 6 1 2007, : : Journal of biochemistry. 141, 6, p. 867-877 11 p.

研究成果: ジャーナルへの寄稿記事

FMRFamide
Houseflies
Neuropeptides
Drosophila melanogaster
Pigments
15 引用 (Scopus)

Haeme-regulated degradation of δ-aminolevulinate synthase 1 in rat liver mitochondria

Yoshino, K., Munakata, H., Kuge, O., Ito, A. & Ogishima, T., 10 1 2007, : : Journal of biochemistry. 142, 4, p. 453-458 6 p.

研究成果: ジャーナルへの寄稿記事

Mitochondria
Liver Mitochondrion
Heme
Liver
Rats
65 引用 (Scopus)

Klotho-related protein is a novel cytosolic neutral β- glycosylceramidase

Hayashi, Y., Okino, N., Kakuta, Y., Shikanai, T., Tani, M., Narimatsu, H. & Ito, M., 10 19 2007, : : Journal of Biological Chemistry. 282, 42, p. 30889-30900 12 p.

研究成果: ジャーナルへの寄稿記事

Lactase-Phlorizin Hydrolase
Glucosylceramides
Proteins
Enzymes
Substrates
89 引用 (Scopus)

Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis

Chida, D., Nakagawa, S., Nagai, S., Sagara, H., Katsumata, H., Imaki, T., Suzuki, H., Mitani, F., Ogishima, T., Shimizu, C., Kotaki, H., Kakuta, S., Sudo, K., Koike, T., Kubo, M. & Iwakura, Y., 11 13 2007, : : Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18205-18210 6 p.

研究成果: ジャーナルへの寄稿記事

Receptor, Melanocortin, Type 2
Gluconeogenesis
Adrenal Glands
Knockout Mice
Adrenocorticotropic Hormone
51 引用 (Scopus)

Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues: Role of palmitoylation in subcellular localization

Tani, M. & Hannun, Y. A., 3 30 2007, : : Journal of Biological Chemistry. 282, 13, p. 10047-10056 10 p.

研究成果: ジャーナルへの寄稿記事

Lipoylation
Sphingomyelin Phosphodiesterase
Cell membranes
Cysteine
Cell Membrane
27 引用 (Scopus)
Endocrine Disruptors
Phenol
Estrogen Receptors
Hydroxyl Radical
Hydrogen
4 引用 (Scopus)

Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer

Nishino, T. G., Kitano, K., Kojima, K., Ogishima, T., Ito, A. & Kitada, S., 6 1 2007, : : Journal of biochemistry. 141, 6, p. 889-895 7 p.

研究成果: ジャーナルへの寄稿記事

Fluorescence Resonance Energy Transfer
Yeast
Yeasts
Glycine
mitochondrial processing peptidase
143 引用 (Scopus)

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ

Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S-I., Kimura, M. & Shimohigashi, Y., 10 1 2007, : : Journal of biochemistry. 142, 4, p. 517-524 8 p.

研究成果: ジャーナルへの寄稿記事

Endocrine Disruptors
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estrogens
Ligands
26 引用 (Scopus)

Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary

Taketoh, J., Mutoh, J., Takeda, T., Ogishima, T., Takeda, S., Ishii, Y., Ishida, T. & Yamada, H., 3 13 2007, : : Life Sciences. 80, 14, p. 1259-1267 9 p.

研究成果: ジャーナルへの寄稿記事

Maternal Exposure
Gonadotropins
Cytochrome P-450 Enzyme System
Luteinizing Hormone
Multifetal Pregnancy Reduction
14 引用 (Scopus)

Synthesis of the JK ring fragments of yessotoxin and 42,43,44,45,46,47,55-heptanor-41-oxoyessotoxin

Watanabe, K., Minato, H., Murata, M. & Oishi, T., 4 13 2007, : : Heterocycles. 72, p. 207-212 6 p.

研究成果: ジャーナルへの寄稿記事

Cyclization
Epoxy Compounds
yessotoxin
42,43,44,45,46,47,55-heptanor-41-oxohomoyessotoxin
2006

a-helix peptides for bio-panning in the phage display method to obtain the antibodies specific for conformation-change nuclear receptors

Okada, H., Tokunaga, T., Shirasu, N., Matsushima, A., Nose, T. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Conformation change of α-helix peptide for sensing of deactivation of nuclear peceptor: Immunoassay using polyclonal antibody specific for the C-terminal a-helix 12 of estrogen-related receptor γ (ERRγ)

Tokunaga, T., Liu, X., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 176

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

42 引用 (Scopus)

Cytocidal actions of parasporin-2, an anti-tumor crystal toxin from Bacillus thuringiensis

Kitada, S., Abe, Y., Shimada, H., Kusaka, Y., Matsuo, Y., Katayama, H., Okumura, S., Akao, T., Mizuki, E., Kuge, O., Sasaguri, Y., Ohba, M. & Ito, A., 9 8 2006, : : Journal of Biological Chemistry. 281, 36, p. 26350-26360 11 p.

研究成果: ジャーナルへの寄稿記事

Bacillus thuringiensis
Bacilli
Tumors
Cells
Crystals

Design and synthesis of a-helix peptide binding to prion protein N-terminal octarepeat domain

Koga, K., Sato, S., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

21 引用 (Scopus)

Design and synthesis of an artificial ladder-shaped polyether that interacts with glycophorin A

Torikai, K., Yari, H., Mori, M., Ujihara, S., Matsumori, N., Murata, M. & Oishi, T., 12 15 2006, : : Bioorganic and Medicinal Chemistry Letters. 16, 24, p. 6355-6359 5 p.

研究成果: ジャーナルへの寄稿記事

Glycophorin
Polyethers
Ladders
Ether
Ciguatoxins
235 引用 (Scopus)

Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor γ (ERRγ) with high constitutive activity

Takayanagi, S., Tokunaga, T., Liu, X., Okada, H., Matsushima, A. & Shimohigashi, Y., 12 1 2006, : : Toxicology Letters. 167, 2, p. 95-105 11 p.

研究成果: ジャーナルへの寄稿記事

Endocrine Disruptors
Estrogen Receptors
Estrogens
Cytoplasmic and Nuclear Receptors
Assays

Identification of novel isoforms of the circadian neuropeptide PDF in the silk moth Bombyx mori and their expression in brain

Sato, S., Jonathan, C., Takeda, Y., Kaneki, A., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 99-100

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Molecular cloning and in situ hybridization of circadian neuropeptide PDF receptor in the fruit fly Drosophila melanogaster

Kaneki, A., Yoshida, T., Isozaki, K., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 263

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Monoclonal antibody sensing assay for conformation change induced by metal binding to prion protein N-terminal octarepear domain

Yokotani, S., Honda, T., Kawano, M., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 455-456

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Multiple post-transcriptional regulations in circadian pacemaker neuropeptide pdf gene

Takeda, Y., Sumiyoshi, M., Koga, K., Ito, M., Matsushima, A., Shimohigashi, Y. & Shimohigashi, M., 2006, Peptide Science 2006. p. 260

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

32 引用 (Scopus)
Infantile Refsum's Disease
Zellweger Syndrome
Mutation
Peroxisomes
Genes
2 引用 (Scopus)

Neutral ceramidase as an integral modulator for the generation of S1P and S1P-mediated signaling

Ito, M., Tani, M. & Yoshimura, Y., 2006, Sphingolipid Biology. Springer Japan, p. 183-196 14 p.

研究成果: 著書/レポートタイプへの貢献

Neutral Ceramidase
Modulators
Ceramides
Enzymes
Bacteria
3 引用 (Scopus)

Phosphatidylserine is involved in gene expression from Sindbis virus subgenomic promoter

Saito, K., Nishijima, M. & Kuge, O., 6 30 2006, : : Biochemical and Biophysical Research Communications. 345, 2, p. 878-885 8 p.

研究成果: ジャーナルへの寄稿記事

Sindbis Virus
Phosphatidylserines
Viruses
Gene expression
RNA
4 引用 (Scopus)

Requirement of an IκB-β COOH terminal region protein for acidic-adaptation in CHO cells

Lao, Q., Fukamachi, T., Saito, H., Kuge, O., Nishijima, M. & Kobayashi, H., 4 1 2006, : : Journal of cellular physiology. 207, 1, p. 238-243 6 p.

研究成果: ジャーナルへの寄稿記事

CHO Cells
Transcription
Genes
p38 Mitogen-Activated Protein Kinases
Proteins
21 引用 (Scopus)

Rescue of cell growth by sphingosine with disruption of lipid microdomain formation in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis

Tani, M., Kihara, A. & Igarashi, Y., 2 15 2006, : : Biochemical Journal. 394, 1, p. 237-242 6 p.

研究成果: ジャーナルへの寄稿記事

Sphingolipids
Sphingosine
Biosynthesis
Cell growth
Yeast

Specific dimerization of prion protein N-terminal domain

Matsushima, A., Horiuchi, Y., Yokotani, S., Kawano, M. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

17 引用 (Scopus)

Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: Immunocytochemical evidence from specific monoclonal antibodies

Honda, T., Matsushima, A., Sumida, K., Chuman, Y., Sakaguchi, K., Onoue, H., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., 11 20 2006, : : Journal of Comparative Neurology. 499, 3, p. 404-421 18 p.

研究成果: ジャーナルへの寄稿記事

Gryllidae
Neuropeptides
Protein Isoforms
Monoclonal Antibodies
Peptides