有機・生物化学

研究成果 1983 2019

2007
65 引用 (Scopus)

Klotho-related protein is a novel cytosolic neutral β- glycosylceramidase

Hayashi, Y., Okino, N., Kakuta, Y., Shikanai, T., Tani, M., Narimatsu, H. & Ito, M., 10 19 2007, : : Journal of Biological Chemistry. 282, 42, p. 30889-30900 12 p.

研究成果: ジャーナルへの寄稿記事

Lactase-Phlorizin Hydrolase
Glucosylceramides
Proteins
Enzymes
Substrates
87 引用 (Scopus)

Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis

Chida, D., Nakagawa, S., Nagai, S., Sagara, H., Katsumata, H., Imaki, T., Suzuki, H., Mitani, F., Ogishima, T., Shimizu, C., Kotaki, H., Kakuta, S., Sudo, K., Koike, T., Kubo, M. & Iwakura, Y., 11 13 2007, : : Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18205-18210 6 p.

研究成果: ジャーナルへの寄稿記事

Receptor, Melanocortin, Type 2
Gluconeogenesis
Adrenal Glands
Knockout Mice
Adrenocorticotropic Hormone
51 引用 (Scopus)

Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues: Role of palmitoylation in subcellular localization

Tani, M. & Hannun, Y. A., 3 30 2007, : : Journal of Biological Chemistry. 282, 13, p. 10047-10056 10 p.

研究成果: ジャーナルへの寄稿記事

Lipoylation
Sphingomyelin Phosphodiesterase
Cell membranes
Cysteine
Cell Membrane
27 引用 (Scopus)
Endocrine Disruptors
Phenol
Estrogen Receptors
Hydroxyl Radical
Hydrogen
4 引用 (Scopus)

Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer

Nishino, T. G., Kitano, K., Kojima, K., Ogishima, T., Ito, A. & Kitada, S., 6 1 2007, : : Journal of biochemistry. 141, 6, p. 889-895 7 p.

研究成果: ジャーナルへの寄稿記事

Fluorescence Resonance Energy Transfer
Yeast
Yeasts
Glycine
mitochondrial processing peptidase
141 引用 (Scopus)

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ

Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S-I., Kimura, M. & Shimohigashi, Y., 10 1 2007, : : Journal of biochemistry. 142, 4, p. 517-524 8 p.

研究成果: ジャーナルへの寄稿記事

Endocrine Disruptors
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estrogens
Ligands
26 引用 (Scopus)

Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary

Taketoh, J., Mutoh, J., Takeda, T., Ogishima, T., Takeda, S., Ishii, Y., Ishida, T. & Yamada, H., 3 13 2007, : : Life Sciences. 80, 14, p. 1259-1267 9 p.

研究成果: ジャーナルへの寄稿記事

Maternal Exposure
Gonadotropins
Cytochrome P-450 Enzyme System
Luteinizing Hormone
Multifetal Pregnancy Reduction
2006

a-helix peptides for bio-panning in the phage display method to obtain the antibodies specific for conformation-change nuclear receptors

Okada, H., Tokunaga, T., Shirasu, N., Matsushima, A., Nose, T. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Conformation change of α-helix peptide for sensing of deactivation of nuclear peceptor: Immunoassay using polyclonal antibody specific for the C-terminal a-helix 12 of estrogen-related receptor γ (ERRγ)

Tokunaga, T., Liu, X., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 176

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

42 引用 (Scopus)

Cytocidal actions of parasporin-2, an anti-tumor crystal toxin from Bacillus thuringiensis

Kitada, S., Abe, Y., Shimada, H., Kusaka, Y., Matsuo, Y., Katayama, H., Okumura, S., Akao, T., Mizuki, E., Kuge, O., Sasaguri, Y., Ohba, M. & Ito, A., 9 8 2006, : : Journal of Biological Chemistry. 281, 36, p. 26350-26360 11 p.

研究成果: ジャーナルへの寄稿記事

Bacillus thuringiensis
Bacilli
Tumors
Cells
Crystals

Design and synthesis of a-helix peptide binding to prion protein N-terminal octarepeat domain

Koga, K., Sato, S., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

225 引用 (Scopus)

Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor γ (ERRγ) with high constitutive activity

Takayanagi, S., Tokunaga, T., Liu, X., Okada, H., Matsushima, A. & Shimohigashi, Y., 12 1 2006, : : Toxicology Letters. 167, 2, p. 95-105 11 p.

研究成果: ジャーナルへの寄稿記事

Endocrine Disruptors
Estrogen Receptors
Estrogens
Cytoplasmic and Nuclear Receptors
Assays

Identification of novel isoforms of the circadian neuropeptide PDF in the silk moth Bombyx mori and their expression in brain

Sato, S., Jonathan, C., Takeda, Y., Kaneki, A., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 99-100

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Immunological confirmation of circadian-related neuropeptide PDF-isoform peptide in the cricket Gryllus bimaculatus

Koga, K., Hiramura, D., Takeda, Y., Kaneki, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 262

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Molecular cloning and in situ hybridization of circadian neuropeptide PDF receptor in the fruit fly Drosophila melanogaster

Kaneki, A., Yoshida, T., Isozaki, K., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 263

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Monoclonal antibody sensing assay for conformation change induced by metal binding to prion protein N-terminal octarepear domain

Yokotani, S., Honda, T., Kawano, M., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 455-456

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Multiple post-transcriptional regulations in circadian pacemaker neuropeptide pdf gene

Takeda, Y., Sumiyoshi, M., Koga, K., Ito, M., Matsushima, A., Shimohigashi, Y. & Shimohigashi, M., 2006, Peptide Science 2006. p. 260

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

32 引用 (Scopus)
Infantile Refsum's Disease
Zellweger Syndrome
Mutation
Peroxisomes
Genes
2 引用 (Scopus)

Neutral ceramidase as an integral modulator for the generation of S1P and S1P-mediated signaling

Ito, M., Tani, M. & Yoshimura, Y., 2006, Sphingolipid Biology. Springer Japan, p. 183-196 14 p.

研究成果: 著書/レポートタイプへの貢献

Neutral Ceramidase
Modulators
Ceramides
Enzymes
Bacteria
3 引用 (Scopus)

Phosphatidylserine is involved in gene expression from Sindbis virus subgenomic promoter

Saito, K., Nishijima, M. & Kuge, O., 6 30 2006, : : Biochemical and Biophysical Research Communications. 345, 2, p. 878-885 8 p.

研究成果: ジャーナルへの寄稿記事

Sindbis Virus
Phosphatidylserines
Viruses
Gene expression
RNA
4 引用 (Scopus)

Requirement of an IκB-β COOH terminal region protein for acidic-adaptation in CHO cells

Lao, Q., Fukamachi, T., Saito, H., Kuge, O., Nishijima, M. & Kobayashi, H., 4 1 2006, : : Journal of cellular physiology. 207, 1, p. 238-243 6 p.

研究成果: ジャーナルへの寄稿記事

CHO Cells
Transcription
Genes
p38 Mitogen-Activated Protein Kinases
Proteins

Specific dimerization of prion protein N-terminal domain

Matsushima, A., Horiuchi, Y., Yokotani, S., Kawano, M. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

17 引用 (Scopus)

Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: Immunocytochemical evidence from specific monoclonal antibodies

Honda, T., Matsushima, A., Sumida, K., Chuman, Y., Sakaguchi, K., Onoue, H., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., 11 20 2006, : : Journal of Comparative Neurology. 499, 3, p. 404-421 18 p.

研究成果: ジャーナルへの寄稿記事

Gryllidae
Neuropeptides
Protein Isoforms
Monoclonal Antibodies
Peptides

Structure-activity studies of FMRFamide-related peptides in activating the specific receptor present in the housefly Musca domestica

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 174

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

51 引用 (Scopus)

Structures of new amphidinols with truncated polyhydroxyl chain and their membrane-permeabilizing activities

Morsy, N., Houdai, T., Matsuoka, S., Matsumori, N., Adachi, S., Oishi, T., Murata, M., Iwashita, T. & Fujita, T., 10 1 2006, : : Bioorganic and Medicinal Chemistry. 14, 19, p. 6548-6554 7 p.

研究成果: ジャーナルへの寄稿記事

Polyenes
Dinoflagellida
Structure-Activity Relationship
Bioactivity
Chain length
106 引用 (Scopus)

Total synthesis, structure revision, and absolute configuration of (-)-brevenal

Fuwa, H., Ebine, M., Bourdelais, A. J., Baden, D. G. & Sasaki, M., 12 27 2006, : : Journal of the American Chemical Society. 128, 51, p. 16989-16999 11 p.

研究成果: ジャーナルへの寄稿記事

Biological Products
Polyethers
Tides
Harmful Algal Bloom
Ethers
51 引用 (Scopus)

Total synthesis of the proposed structure of brevenal

Fuwa, H., Ebine, M. & Sasaki, M., 8 2 2006, : : Journal of the American Chemical Society. 128, 30, p. 9648-9650 3 p.

研究成果: ジャーナルへの寄稿記事

Biological Products
Skeleton
Ether
Polyethers
Ethers
2005
6 引用 (Scopus)

An IκB-β COOH terminal region protein is essential for the proliferation of CHO cells under acidic stress

Lao, Q., Kuge, O., Fukamachi, T., Kakegawa, T., Saito, H., Nishijima, M. & Kobayashi, H., 4 1 2005, : : Journal of cellular physiology. 203, 1, p. 186-192 7 p.

研究成果: ジャーナルへの寄稿記事

CHO Cells
Symporters
Proton-Translocating ATPases
Homeostasis
Protons
5 引用 (Scopus)

Ascorbate stimulates monooxygenase-dependent steroidogenesis in adrenal zona glomerulosa

Mitani, F., Ogishima, T., Mukai, K. & Suematsu, M., 12 9 2005, : : Biochemical and Biophysical Research Communications. 338, 1, p. 483-490 8 p.

研究成果: ジャーナルへの寄稿記事

Zona Glomerulosa
Mixed Function Oxygenases
Ascorbic Acid
Aldosterone
Adrenal Cortex

Bioactive conformation of a D-Trp-containing cardioexcitatory tripeptide isolated from the sea hare Aplysia

Yokotani, S., Matsushima, A., Nose, T., Morishita, F. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 539-540

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

8 引用 (Scopus)

C18:3-GM1a induces apoptosis in Neuro2a cells: Enzymatic remodeling of fatty acyl chains of glycosphingolipids

Nakagawa, T., Morotomi, A., Tani, M., Sueyoshi, N., Komori, H. & Ito, M., 12 1 2005, : : Journal of Lipid Research. 46, 6, p. 1103-1112 10 p.

研究成果: ジャーナルへの寄稿記事

Glycosphingolipids
Gangliosides
Apoptosis
Chemical activation
Lipids

cDNA cloning and mRNA expression of the circadian neuropeptide PDF in the silk moth Bombyx mori

Sato, S., Sumida, K., Hiramura, D., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 197-200

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Conformation change-senseing assay using monoclonal antibody for N-terminal octapeptide repreat region of prion protein

Kawano, M., Honda, T., Horiuchi, Y., Yokotani, S., Matsushima, A., Nose, T. & Shimohigashi, Y., 2005, Peptide Science 2004.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

83 引用 (Scopus)

Convergent total synthesis of gymnocin-A and evaluation of synthetic analogues

Tsukano, C., Ebine, M. & Sasaki, M., 3 30 2005, : : Journal of the American Chemical Society. 127, 12, p. 4326-4335 10 p.

研究成果: ジャーナルへの寄稿記事

Structure-Activity Relationship
Skeleton
Polyethers
Harmful Algal Bloom
Dinoflagellida

FMRFamide-related peptides in the nervous system of the housefly Musca domestica: cDNA cloning and actions on clam heart contraction.

Matsushima, A., Yokotani, S., Koretsune, Y., Meinertzhagen, I. A., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 157-160

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Immunocytochemical identification of mature peptide formation for the circadian neuromodulator PDF in the housefly Musca domestica

Sumida, K., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Immunocytochemical studies on the circadian neuropeptide PDF in the Cricket Gryllus bimaculatus

Shimohigashi, M., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 339-342

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

41 引用 (Scopus)

Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu

Tani, M., Igarashi, Y. & Ito, M., 11 4 2005, : : Journal of Biological Chemistry. 280, 44, p. 36592-36600 9 p.

研究成果: ジャーナルへの寄稿記事

Neutral Ceramidase
Ceramides
Cell membranes
Sphingosine
Metabolism
7 引用 (Scopus)

Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase

Oshima, T., Yamasaki, E., Ogishima, T., Kadowaki, K. I., Ito, A. & Kitada, S., 2 1 2005, : : Biochemical Journal. 385, 3, p. 755-761 7 p.

研究成果: ジャーナルへの寄稿記事

Polyproteins
Processing
Mitochondria
Succinate Dehydrogenase
mitochondrial processing peptidase
148 引用 (Scopus)

Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export

Miyata, N. & Fujiki, Y., 12 1 2005, : : Molecular and Cellular Biology. 25, 24, p. 10822-10832 11 p.

研究成果: ジャーナルへの寄稿記事

Peroxisomes
Adenosine Triphosphate
CHO Cells
Native Polyacrylamide Gel Electrophoresis
Cytosol

Structural characteristics of Drosophila estrogen-related receptor ligand binding domain to capture the peptide and non-peptide ligands

Liu, X., Matsushima, A., Shirasu, N., Tominaga, Y., Shimohigashi, M., Shimohigashi, Y. & Nose, T., 2005, Peptide Science 2004. p. 303-304

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structural characteristics of the N-Terminal octapeptide repeat region of Prion protein in self-polymerization

Horiuchi, Y., Kawano, M., Yokotani, S., Honda, T., Matsushima, A., Nose, T. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 317-318

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

51 引用 (Scopus)

Subcellular localization of human neutral ceramidase expressed in HEK293 cells

Hwang, Y. H., Tani, M., Nakagawa, T., Okino, N. & Ito, M., 5 27 2005, : : Biochemical and Biophysical Research Communications. 331, 1, p. 37-42 6 p.

研究成果: ジャーナルへの寄稿記事

HEK293 Cells
Cell membranes
Neutral Ceramidase
Ceramidases
Mitochondria

Triplicate alternative splicings that produce multiple variants of the PERIOD protein in the silk moth Bombyx mori by deletion/Insertion of peptides

Takeda, Y., Shirasu, N., Sato, S., Matsushima, A., Chuman, Y., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 203-206

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2004
19 引用 (Scopus)

cDNA cloning of the housefly pigment-dispersing factor (PDF) precursor protein and its peptides comparison among the insect circadian neuropeptides

Matsushima, A., Sato, S., Chuman, Y., Takeda, Y., Yokotani, S., Nose, T., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., 2 1 2004, : : Journal of Peptide Science. 10, 2, p. 82-91 10 p.

研究成果: ジャーナルへの寄稿記事

Houseflies
Protein Precursors
Cloning
Neuropeptides
Pigments
7 引用 (Scopus)
Neutral Ceramidase
Enzyme activity
Tail
Amino Acids
Enzymes

Effect of the Phe-Phenyl H-F subsutitution in the sea hare Aplysia neuropeptide H-Asn-d-Phe-NH2 on the conformation and contraction activity

Kaneki, A., Matsushima, A., Takeda, Y., Yokotani, S., Ozaki, M., Shimohigashi, M. & Shimohigashi, Y., 2004, Peptide Science 2003. p. 459-462

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Effects of the Phe-Phenyl H→F Substitutions in the Sea Hare Aplysia Neuropeptide H-Asn-D-Trp-Phe-NH2 on the Conformation and Contractile Activity

Yokotani, S., Matsushima, A., Nose, T., Shimohigashi, Y. & Morishita, F., 3 2004, Peptide Science 2003. p. 263-266 4 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

10 引用 (Scopus)

Functional analysis of Chinese hamster phosphatidylserine synthase 1 through systematic alanine mutagenesis

Ohsawa, T., Nishijima, M. & Kuge, O., 8 1 2004, : : Biochemical Journal. 381, 3, p. 853-859 7 p.

研究成果: ジャーナルへの寄稿記事

CDPdiacylglycerol-Serine O-Phosphatidyltransferase
Mutagenesis
Functional analysis
Cricetulus
Alanine

Localization profiles of circadian neuropeptide PDF in brain of the cricket Gryllus bimaculatus

Honda, T., Chuman, Y., Matsushima, A., Nose, T., Sakaguchi, K., Onoue, H., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2004, Peptide Science 2003. p. 483-486

研究成果: 著書/レポートタイプへの貢献章 (査読済み)