有機・生物化学

研究成果 1983 2019

2004
45 引用 (Scopus)

Molecular cloning and functional analysis of zebrafish neutral ceramidase

Yoshimura, Y., Tani, M., Okino, N., Iida, H. & Ito, M., 10 15 2004, : : Journal of Biological Chemistry. 279, 42, p. 44012-44022 11 p.

研究成果: ジャーナルへの寄稿記事

Functional analysis
Cloning
Molecular Cloning
Morpholinos
Antisense Oligonucleotides
3 引用 (Scopus)

Possible participation of outer mitochondrial membrane cytochrome B 5 in steroidogenesis in zona glomerulosa of rat adrenal cortex

Mitani, F., Ogishima, T., Mukai, K., Hoshino, R., Watanabe, K. & Suematsu, M., 12 1 2004, : : Endocrine Research. 30, 4, p. 639-644 6 p.

研究成果: ジャーナルへの寄稿記事

Zona Glomerulosa
Adrenal Cortex
Mitochondrial Membranes
Cytochromes
monodehydroascorbate reductase (NADH)
9 引用 (Scopus)

Structural analysis and identification of novel isoforms of the circadian clock gene period in the silk moth Bombyx mori

Takeda, Y., Chuman, Y., Shirasu, N., Sato, S., Matsushima, A., Kaneki, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 9 1 2004, : : Zoological science. 21, 9, p. 903-915 13 p.

研究成果: ジャーナルへの寄稿記事

Bombyx mori
silk
circadian rhythm
moths
alternative splicing

Structural requirements of the N-terminal octapeptide repeat of prion protein

Kawano, M., Horiuchi, Y., Honda, T., Yokotani, S., Matsushima, A., Nose, T. & Shimohigashi, Y., 2004, Peptide Science 2003. p. 483-486

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

21 引用 (Scopus)

Synthesis of the CDE/FG ring models of prymnesins: Reassignment of the relative configuration of the E/F ring juncture

Sasaki, M., Ebine, M., Takagi, H., Takakura, H., Shida, T., Satake, M., Oshima, Y., Igarashi, T. & Yasumoto, T., 4 29 2004, : : Organic Letters. 6, 9, p. 1501-1504 4 p.

研究成果: ジャーナルへの寄稿記事

red tide
Haptophyta
rings
Tides
synthesis

Two distinctly different isoforms with/without pentapeptide fragment in the silk moth clock protein peptide

Takeda, Y., Shirasu, N., Sato, S., Matsushima, A., Chuman, Y., Shimohigashi, M. & Shimohigashi, Y., 2004, Peptide Science 2003. p. 473-476

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2003
20 引用 (Scopus)

A neutral ceramidase homologue from Dictyostelium discoideum exhibits an acidic pH optimum

Monjusho, H., Okino, N., Tani, M., Maeda, M., Yoshida, M. & Ito, M., 12 1 2003, : : Biochemical Journal. 376, 2, p. 473-479 7 p.

研究成果: ジャーナルへの寄稿記事

Neutral Ceramidase
Dictyostelium
Fungi
Alkaline Ceramidase
Acid Ceramidase
34 引用 (Scopus)

Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells

Ogishima, T., Kinoshita, J. Y., Mitani, F., Suematsu, M. & Ito, A., 6 6 2003, : : Journal of Biological Chemistry. 278, 23, p. 21204-21211 8 p.

研究成果: ジャーナルへの寄稿記事

Cytochromes b5
Leydig Cells
Mitochondrial Membranes
Modulators
Androgens

Localization profiles of the precursor protein of circadian rhythm pacemaker hormone PDF in Gryllus brain

Honda, T., Chuman, Y., Matsushima, A., Asai, D., Nose, T., Sakaguchi, K., Onoue, H., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2003, Peptide Science 2002. p. 433-436

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

7 引用 (Scopus)

Molecular cloning and circadian expression profile of insect neuropeptide PDF in black blowfly, Phormia regina

Matsushima, A., Yokotani, S., Lui, X., Sumida, K., Honda, T., Sato, S., Kaneki, A., Takeda, Y., Chuman, Y., Ozaki, M., Asai, D., Nose, T., Onoue, H., Ito, Y., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 11 1 2003, : : Letters in Peptide Science. 10, 5-6, p. 419-430 12 p.

研究成果: ジャーナルへの寄稿記事

Cloning
Molecular Cloning
Neuropeptides
Peptides
Protein Precursors
54 引用 (Scopus)

Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation

Matsumoto, N., Tamura, S., Furuki, S., Miyata, N., Moser, A., Shimozawa, N., Moser, H. W., Suzuki, Y., Kondo, N. & Fujiki, Y., 8 1 2003, : : American journal of human genetics. 73, 2, p. 233-246 14 p.

研究成果: ジャーナルへの寄稿記事

Genetic Association Studies
Zellweger Syndrome
Infantile Refsum's Disease
Phenotype
Peroxisomal Disorders
52 引用 (Scopus)
Neutral Ceramidase
Glycosylation
Mucins
Cell membranes
Membrane Proteins
12 引用 (Scopus)

Purification and Characterization of Chinese Hamster Phosphatidylserine Synthase 2

Kuge, O., Hasegawa, K., Ohsawa, T., Saito, K. & Nishijima, M., 10 24 2003, : : Journal of Biological Chemistry. 278, 43, p. 42692-42698 7 p.

研究成果: ジャーナルへの寄稿記事

Phosphatidylserines
Cricetulus
Purification
CDPdiacylglycerol-Serine O-Phosphatidyltransferase
Phosphatidylcholines

Structural analysis of PERIOD-PAS domain binding regions in insect clock protein TIMELESS

Sato, S., Oka, H., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2003, Peptide Science 2002. p. 429-432

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structural characterization of the house fly PDF, a circadian rhythm pacemaker hormone

Matsushima, A., Nose, T., Tomioka, K., Shimohigashi, M. & Shimohigashi, Y., 2003, Peptide Science 2002. p. 333-336

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

The Structure-activity studies of Drosophila FMRFamide-related peptides

Tokunaga, T., Ohtahi, M., Matsushima, A., Nose, T., Aimoto, S. & Shimohigashi, Y., 2003, Peptide Science 2002. p. 265-268

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2002
24 引用 (Scopus)

A circadian neuropeptide, pigment-dispersing factor-PDF, in the last-summer cicada Meimuna opalifera: cDNA cloning and immunocytochemistry

Sato, S., Chuman, Y., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 8 1 2002, : : Zoological Science. 19, 8, p. 821-828 8 p.

研究成果: ジャーナルへの寄稿記事

Cicadidae
neuropeptides
immunocytochemistry
molecular cloning
pigments
21 引用 (Scopus)

cDNA cloning and nuclear localization of the circadian neuropeptide designated as pigment-dispersing factor PDF in the cricket Gryllus bimaculatus

Chuman, Y., Matsushima, A., Sato, S., Tomioka, K., Tominaga, Y., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., 1 1 2002, : : Journal of Biochemistry. 131, 6, p. 895-903 9 p.

研究成果: ジャーナルへの寄稿記事

Gryllidae
Cloning
Neuropeptides
Pigments
Insects

cDNA cloning of PDF peptide precursors in housefly and last summer cicada

Sato, S., Matsushima, A., Chuman, Y., Tominaga, K., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 139-142

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Circadian rhythm pacemaker neuropeptide 'PDF' in nocturnal insect cricket gryllus bimaculatus: cDNA cloning, mRNA expression, and nuclear localization

Chuman, Y., Matsushima, A., Nose, T., Shimohigashi, Y. & Shimohigashi, M., 2002, American Peptide Society 2001. p. 797-798

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Contractile activity of Drosophila FMRFamide-related peptides in the Meretrix Lusoria heart muscle.

Tokunaga, T., Ohtani, M., Matsushima, A., Chuman, Y., Nose, T. & Shimohigashi, Y., 2002, Peptide Science 2001. p. 167-170

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Design and preparation of universal anti-PERIOD antibodies and their immunoresponses.

Asai, D., Tokunaga, T., Matsushima, A., Sato, S., Chuman, Y., Nose, T., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 399-402

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

26 引用 (Scopus)

Highly diastereo- and enantioselective aziridination of α,β-unsaturated amides with diaziridine and mechanistic consideration on its stereochemistry

Ishihara, H., Hori, K., Sugihara, H., Ito, Y. & Katsuki, T., 12 1 2002, : : Helvetica Chimica Acta. 85, 12, p. 4272-4286 15 p.

研究成果: ジャーナルへの寄稿記事

Stereochemistry
Enantioselectivity
stereochemistry
Amides
amides
47 引用 (Scopus)

Molecular cloning and characterization of a secretory neutral ceramidase of Drosophila melanogaster

Yoshimura, Y., Okino, N., Tani, M. & Ito, M., 8 2002, : : Journal of Biochemistry. 132, 2, p. 229-236 8 p.

研究成果: ジャーナルへの寄稿記事

Neutral Ceramidase
Ceramidases
Cloning
Molecular Cloning
Drosophila melanogaster

Structure and function of nuclear localization signal peptide present in circadian rhythm hormone peptide precursor

Matsushima, A., Chuman, Y., Sato, S., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 159-162

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2001

Activity Enhancement by Introduction of two different halogen atoms into Phe-2-phenyl group of thrombin receptor tetherd-ligand analogs.

Fujita, T., Inoue, N., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2001, Peptide Science 2000. p. 135-138

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

23 引用 (Scopus)

A proposed common structure of substrates bound to mitochondrial processing peptidase

Kojima, K., Kitada, S., Ogishima, T. & Ito, A., 1 19 2001, : : Journal of Biological Chemistry. 276, 3, p. 2115-2121 7 p.

研究成果: ジャーナルへの寄稿記事

Introns
Substrates
Fluorescence Resonance Energy Transfer
Peptides
ethylenediamine

cDNA cloning of a circadian rhythm pacemaker hormone PDF of the house fly Musca domestica

Matsushima, A., Chuman, Y., Sato, S., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2001, Comparative Biochemistry and Physiology. p. 876

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

cDNA Cloning of circadian rhythm pacemaker neuropeptide PDF in Gryllus bimaculatus and its neuclear localization

Chuman, Y., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 2001, Peptide Science 2000. p. 59-62

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

25 引用 (Scopus)

Enhancement of Transport-dependent Decarboxylation of Phosphatidylserine by S100B Protein in Permeabilized Chinese Hamster Ovary Cells

Kuge, O., Yamakawa, Y. & Nishijima, M., 6 29 2001, : : Journal of Biological Chemistry. 276, 26, p. 23700-23706 7 p.

研究成果: ジャーナルへの寄稿記事

Decarboxylation
Phosphatidylserines
Cricetulus
Ovary
Cells

Gene expression of a circadian pacemaker hormone peptide PDF in cricket Gryllus bimaculatus

Matsushima, A., Chuman, Y., Onoue, H., Ito, Y., Tomioka, K., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2001, Peptide Science 2000. p. 63-66

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

13 引用 (Scopus)

Highly diastereoselective aziridination of α,β-unsaturated amides using diaziridine

Ishihara, H., Ito, Y. & Katsuki, T., 1 1 2001, : : Chemistry Letters. 10, p. 984-985 2 p.

研究成果: ジャーナルへの寄稿記事

Aziridines
Stereochemistry
Amides
Substrates

PERIOD clock protein of the summer cicada Meimuna opalifera: cDNA cloning and structural analysis

Sato, S., Chuman, Y., Matsushima, A., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2001, Comparative Biochemistry and Physiology. 巻 130. p. 876

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

92 引用 (Scopus)

Purification, Characterization, Molecular Cloning, and Subcellular Distribution of Neutral Ceramidase of Rat Kidney

Mitsutake, S., Tani, M., Okino, N., Mori, K., Ichinose, S., Omori, A., Iida, H., Nakamura, T. & Ito, M., 7 13 2001, : : Journal of Biological Chemistry. 276, 28, p. 26249-26259 11 p.

研究成果: ジャーナルへの寄稿記事

Neutral Ceramidase
Ceramidases
Cloning
Molecular Cloning
Purification
12 引用 (Scopus)

Purification of phosphatidylglycerophosphate synthase from Chinese hamster ovary cells

Kawasaki, K., Kuge, O., Yamakawa, Y. & Nishijima, M., 2 15 2001, : : Biochemical Journal. 354, 1, p. 9-15 7 p.

研究成果: ジャーナルへの寄稿記事

CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Cricetulus
Purification
Ovary
Cells
5 引用 (Scopus)

Recognition of mitochondrial protein precursor lacking arginine at position -2 by Mitochondrial Processing Peptidase: Processing of bovine cytochrome p450(SCC) precursor

Kojima, K., Yamasaki, E., Kitada, S., Ogishima, T. & Ito, A., 1 1 2001, : : Journal of biochemistry. 130, 4, p. 497-502 6 p.

研究成果: ジャーナルへの寄稿記事

Protein Precursors
Mitochondrial Proteins
Cytochrome P-450 Enzyme System
Arginine
Processing
2000

Chemical syntheses of phenylalanine derivatives containing halogenated benzene ring as structural explorers for elucidation of molecular mechanisms of receptor interactions

Matsushima, A., Fujita, T., Okada, K., Yamauchi, Y., Nose, T. & Shimohigashi, Y., 2000, Peptide Science 1999. p. 141-142

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

24 引用 (Scopus)

Edge-to-face CH/π interaction between ligand Phe-phenyl and receptor aromatic group in the thrombin receptor activation

Matsushima, A., Fujita, T., Nose, T. & Shimohigashi, Y., 1 1 2000, : : Journal of biochemistry. 128, 2, p. 225-232 8 p.

研究成果: ジャーナルへの寄稿記事

Thrombin Receptors
Phenylalanine
Chemical activation
Ligands
Hydrogen
28 引用 (Scopus)

Enthalpy- and/or entropy-controlled asymmetric oxidation: Stereocontrolling factors in Mn-salen-catalyzed oxidation

Nishida, T., Miyafuji, A., Ito, Y. & Katsuki, T., 9 2 2000, : : Tetrahedron Letters. 41, 36, p. 7053-7058 6 p.

研究成果: ジャーナルへの寄稿記事

Entropy
Enthalpy
Oxidation
Alkenes
Conformations
5 引用 (Scopus)

Exploration of the role of phenylalanine in the thrombin receptor tethered-ligand peptide by substitution with a series of trifluorophenylalanines

Matsushima, A., Fujita, T., Okada, K., Shirasu, N., Nose, T. & Shimohigashi, Y., 11 1 2000, : : Bulletin of the Chemical Society of Japan. 73, 11, p. 2531-2538 8 p.

研究成果: ジャーナルへの寄稿記事

thrombin receptor peptide SFLLRNP
Thrombin Receptors
Phenylalanine
Hydrogen
Substitution reactions
36 引用 (Scopus)

Glycine-rich region of mitochondrial processing peptidase α-subunit is essential for binding and cleavage of the precursor proteins

Nagao, Y., Kitada, S., Kojima, K., Toh, H., Kuhara, S., Ogishima, T. & Ito, A., 11 3 2000, : : Journal of Biological Chemistry. 275, 44, p. 34552-34556 5 p.

研究成果: ジャーナルへの寄稿記事

Protein Precursors
Glycine
Mutation
Enzymes
Peptides

Highly potent peptide ligands for thrombin receptor

Fujita, T., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., 2000, Peptide Science 1999. p. 421-424

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

92 引用 (Scopus)

Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases

Tani, M., Okino, N., Mori, K., Tanigawa, T., Izu, H. & Ito, M., 4 14 2000, : : Journal of Biological Chemistry. 275, 15, p. 11229-11234 6 p.

研究成果: ジャーナルへの寄稿記事

Alkaline Ceramidase
Neutral Ceramidase
Ceramidases
Cloning
Molecular Cloning
41 引用 (Scopus)

Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells

Romiti, E., Meacci, E., Tani, M., Nuti, F., Farnararo, M., Ito, M. & Bruni, P., 9 7 2000, : : Biochemical and Biophysical Research Communications. 275, 3, p. 746-751 6 p.

研究成果: ジャーナルへの寄稿記事

Alkaline Ceramidase
Neutral Ceramidase
Acid Ceramidase
Endothelial cells
Endothelial Cells
71 引用 (Scopus)
Neutral Ceramidase
Ceramides
Liver
Purification
Ceramidases
16 引用 (Scopus)

Synthesis of a complete set of L-difluorophenylalanines, L-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor

Fujita, T., Nose, T., Matsushima, A., Okada, K., Asai, D., Yamauchi, Y., Shirasu, N., Honda, T., Shigehiro, D. & Shimohigashi, Y., 2 5 2000, : : Tetrahedron Letters. 41, 6, p. 923-927 5 p.

研究成果: ジャーナルへの寄稿記事

thrombin receptor peptide SFLLRNP
Thrombin Receptors
Peptide Receptors
Hydrogen
Ligands
1999
8 引用 (Scopus)
Arginine
Amino Acids
Protein Precursors
Mitochondrial Proteins
Peptide Hydrolases
202 引用 (Scopus)

Asymmetric catalysis of new generation chiral metallosalen complexes

Ito, Y. & Katsuki, T., 4 1 1999, : : Bulletin of the Chemical Society of Japan. 72, 4, p. 603-619 17 p.

研究成果: ジャーナルへの寄稿記事

Catalysis
Epoxidation
Manganese
Derivatives
Styrene
31 引用 (Scopus)

cis-selective aziridination of cis- or trans-α,β-unsaturated amides using diaziridine

Hori, K., Sugihara, H., Ito, Y. & Katsuki, T., 7 9 1999, : : Tetrahedron Letters. 40, 28, p. 5207-5210 4 p.

研究成果: ジャーナルへの寄稿記事

Amides
Nitrogen
Atoms
Geometry
Substrates
38 引用 (Scopus)

Enantioselective synthesis of the medium ring ethers, tetrahydrooxepin, oxocane and hexahydrooxonin, of ciguatoxin. Extensive ring-expansion and chemoenzymatic desymmetrization strategy

Oishi, T., Maruyama, M., Shoji, M., Maeda, K., Kumahara, N., Tanaka, S. I. & Hirama, M., 6 11 1999, : : Tetrahedron. 55, 24, p. 7471-7498 28 p.

研究成果: ジャーナルへの寄稿記事

Ciguatoxins
Acylation
Ethers
Lipase
Alcohols