有機・生物化学

研究成果 1979 2019

2006

Structure-activity studies of FMRFamide-related peptides in activating the specific receptor present in the housefly Musca domestica

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 174

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

51 引用 (Scopus)

Structures of new amphidinols with truncated polyhydroxyl chain and their membrane-permeabilizing activities

Morsy, N., Houdai, T., Matsuoka, S., Matsumori, N., Adachi, S., Oishi, T., Murata, M., Iwashita, T. & Fujita, T., 10 1 2006, : : Bioorganic and Medicinal Chemistry. 14, 19, p. 6548-6554 7 p.

研究成果: ジャーナルへの寄稿記事

Polyenes
Dinoflagellida
Structure-Activity Relationship
Bioactivity
Chain length
112 引用 (Scopus)

The extended family of neutral sphingomyelinases

Clarke, C. J., Snook, C. F., Tani, M., Matmati, N., Marchesini, N. & Hannun, Y. A., 9 26 2006, : : Biochemistry. 45, 38, p. 11247-11256 10 p.

研究成果: ジャーナルへの寄稿記事

Sphingomyelin Phosphodiesterase
Yeast
Bacteria
Enzymes
Yeasts
107 引用 (Scopus)

Total synthesis, structure revision, and absolute configuration of (-)-brevenal

Fuwa, H., Ebine, M., Bourdelais, A. J., Baden, D. G. & Sasaki, M., 12 27 2006, : : Journal of the American Chemical Society. 128, 51, p. 16989-16999 11 p.

研究成果: ジャーナルへの寄稿記事

Biological Products
Polyethers
Tides
Harmful Algal Bloom
Ethers
51 引用 (Scopus)

Total synthesis of the proposed structure of brevenal

Fuwa, H., Ebine, M. & Sasaki, M., 8 2 2006, : : Journal of the American Chemical Society. 128, 30, p. 9648-9650 3 p.

研究成果: ジャーナルへの寄稿記事

Biological Products
Skeleton
Ether
Polyethers
Ethers
2005
6 引用 (Scopus)

An IκB-β COOH terminal region protein is essential for the proliferation of CHO cells under acidic stress

Lao, Q., Kuge, O., Fukamachi, T., Kakegawa, T., Saito, H., Nishijima, M. & Kobayashi, H., 4 1 2005, : : Journal of cellular physiology. 203, 1, p. 186-192 7 p.

研究成果: ジャーナルへの寄稿記事

CHO Cells
Symporters
Proton-Translocating ATPases
Homeostasis
Protons
5 引用 (Scopus)

Ascorbate stimulates monooxygenase-dependent steroidogenesis in adrenal zona glomerulosa

Mitani, F., Ogishima, T., Mukai, K. & Suematsu, M., 12 9 2005, : : Biochemical and Biophysical Research Communications. 338, 1, p. 483-490 8 p.

研究成果: ジャーナルへの寄稿記事

Zona Glomerulosa
Mixed Function Oxygenases
Ascorbic Acid
Aldosterone
Adrenal Cortex

Bioactive conformation of a D-Trp-containing cardioexcitatory tripeptide isolated from the sea hare Aplysia

Yokotani, S., Matsushima, A., Nose, T., Morishita, F. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 539-540

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

8 引用 (Scopus)

C18:3-GM1a induces apoptosis in Neuro2a cells: Enzymatic remodeling of fatty acyl chains of glycosphingolipids

Nakagawa, T., Morotomi, A., Tani, M., Sueyoshi, N., Komori, H. & Ito, M., 12 1 2005, : : Journal of Lipid Research. 46, 6, p. 1103-1112 10 p.

研究成果: ジャーナルへの寄稿記事

Glycosphingolipids
Gangliosides
Apoptosis
Chemical activation
Lipids

cDNA cloning and mRNA expression of the circadian neuropeptide PDF in the silk moth Bombyx mori

Sato, S., Sumida, K., Hiramura, D., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 197-200

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Conformation change-senseing assay using monoclonal antibody for N-terminal octapeptide repreat region of prion protein

Kawano, M., Honda, T., Horiuchi, Y., Yokotani, S., Matsushima, A., Nose, T. & Shimohigashi, Y., 2005, Peptide Science 2004.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

32 引用 (Scopus)

Convergent synthesis of the FGHI ring system of yessotoxin: Stereoselective construction of the G ring

Watanabe, K., Suzuki, M., Murata, M. & Oishi, T., 6 6 2005, : : Tetrahedron Letters. 46, 23, p. 3991-3995 5 p.

研究成果: ジャーナルへの寄稿記事

Acetals
Ethers
Polyethers
Alkylation
Ladders
87 引用 (Scopus)

Convergent total synthesis of gymnocin-A and evaluation of synthetic analogues

Tsukano, C., Ebine, M. & Sasaki, M., 3 30 2005, : : Journal of the American Chemical Society. 127, 12, p. 4326-4335 10 p.

研究成果: ジャーナルへの寄稿記事

Structure-Activity Relationship
Skeleton
Polyethers
Harmful Algal Bloom
Dinoflagellida

FMRFamide-related peptides in the nervous system of the housefly Musca domestica: cDNA cloning and actions on clam heart contraction.

Matsushima, A., Yokotani, S., Koretsune, Y., Meinertzhagen, I. A., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 157-160

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Immunocytochemical identification of mature peptide formation for the circadian neuromodulator PDF in the housefly Musca domestica

Sumida, K., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Immunocytochemical studies on the circadian neuropeptide PDF in the Cricket Gryllus bimaculatus

Shimohigashi, M., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 339-342

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

41 引用 (Scopus)

Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu

Tani, M., Igarashi, Y. & Ito, M., 11 4 2005, : : Journal of Biological Chemistry. 280, 44, p. 36592-36600 9 p.

研究成果: ジャーナルへの寄稿記事

Neutral Ceramidase
Ceramides
Cell membranes
Sphingosine
Metabolism
7 引用 (Scopus)

Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase

Oshima, T., Yamasaki, E., Ogishima, T., Kadowaki, K. I., Ito, A. & Kitada, S., 2 1 2005, : : Biochemical Journal. 385, 3, p. 755-761 7 p.

研究成果: ジャーナルへの寄稿記事

Polyproteins
Processing
Mitochondria
Succinate Dehydrogenase
mitochondrial processing peptidase
148 引用 (Scopus)

Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export

Miyata, N. & Fujiki, Y., 12 1 2005, : : Molecular and cellular biology. 25, 24, p. 10822-10832 11 p.

研究成果: ジャーナルへの寄稿記事

Peroxisomes
Adenosine Triphosphate
CHO Cells
Native Polyacrylamide Gel Electrophoresis
Cytosol

Structural characteristics of Drosophila estrogen-related receptor ligand binding domain to capture the peptide and non-peptide ligands

Liu, X., Matsushima, A., Shirasu, N., Tominaga, Y., Shimohigashi, M., Shimohigashi, Y. & Nose, T., 2005, Peptide Science 2004. p. 303-304

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structural characteristics of the N-Terminal octapeptide repeat region of Prion protein in self-polymerization

Horiuchi, Y., Kawano, M., Yokotani, S., Honda, T., Matsushima, A., Nose, T. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 317-318

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

51 引用 (Scopus)

Subcellular localization of human neutral ceramidase expressed in HEK293 cells

Hwang, Y. H., Tani, M., Nakagawa, T., Okino, N. & Ito, M., 5 27 2005, : : Biochemical and Biophysical Research Communications. 331, 1, p. 37-42 6 p.

研究成果: ジャーナルへの寄稿記事

HEK293 Cells
Cell membranes
Neutral Ceramidase
Ceramidases
Mitochondria

Triplicate alternative splicings that produce multiple variants of the PERIOD protein in the silk moth Bombyx mori by deletion/Insertion of peptides

Takeda, Y., Shirasu, N., Sato, S., Matsushima, A., Chuman, Y., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 203-206

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2004
33 引用 (Scopus)

An amphotericin B-ergosterol covalent conjugate with powerful membrane permeabilizing activity

Matsumori, N., Eiraku, N., Matsuoka, S., Oishi, T., Murata, M., Aoki, T. & Ide, T., 5 1 2004, : : Chemistry and Biology. 11, 5, p. 673-679 7 p.

研究成果: ジャーナルへの寄稿記事

Ergosterol
Amphotericin B
Membranes
Cholesterol
Bearings (structural)
19 引用 (Scopus)

cDNA cloning of the housefly pigment-dispersing factor (PDF) precursor protein and its peptides comparison among the insect circadian neuropeptides

Matsushima, A., Sato, S., Chuman, Y., Takeda, Y., Yokotani, S., Nose, T., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., 2 1 2004, : : Journal of Peptide Science. 10, 2, p. 82-91 10 p.

研究成果: ジャーナルへの寄稿記事

Houseflies
Protein Precursors
Cloning
Neuropeptides
Pigments
7 引用 (Scopus)
Neutral Ceramidase
Enzyme activity
Tail
Amino Acids
Enzymes

Effect of the Phe-Phenyl H-F subsutitution in the sea hare Aplysia neuropeptide H-Asn-d-Phe-NH2 on the conformation and contraction activity

Kaneki, A., Matsushima, A., Takeda, Y., Yokotani, S., Ozaki, M., Shimohigashi, M. & Shimohigashi, Y., 2004, Peptide Science 2003. p. 459-462

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Effects of the Phe-Phenyl H→F Substitutions in the Sea Hare Aplysia Neuropeptide H-Asn-D-Trp-Phe-NH2 on the Conformation and Contractile Activity

Yokotani, S., Matsushima, A., Nose, T., Shimohigashi, Y. & Morishita, F., 3 2004, Peptide Science 2003. p. 263-266 4 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

10 引用 (Scopus)

Functional analysis of Chinese hamster phosphatidylserine synthase 1 through systematic alanine mutagenesis

Ohsawa, T., Nishijima, M. & Kuge, O., 8 1 2004, : : Biochemical Journal. 381, 3, p. 853-859 7 p.

研究成果: ジャーナルへの寄稿記事

CDPdiacylglycerol-Serine O-Phosphatidyltransferase
Mutagenesis
Functional analysis
Cricetulus
Alanine
10 引用 (Scopus)

Intact glycation end products containing carboxymethyl-lysine and glyoxal lysine dimer obtained from synthetic collagen model peptide

Yamada, H., Sasaki, T., Niwa, S., Oishi, T., Murata, M., Kawakami, T. & Aimoto, S., 11 15 2004, : : Bioorganic and Medicinal Chemistry Letters. 14, 22, p. 5677-5680 4 p.

研究成果: ジャーナルへの寄稿記事

Glyoxal
Dimers
Lysine
Collagen
Peptides

Localization profiles of circadian neuropeptide PDF in brain of the cricket Gryllus bimaculatus

Honda, T., Chuman, Y., Matsushima, A., Nose, T., Sakaguchi, K., Onoue, H., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2004, Peptide Science 2003. p. 483-486

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

45 引用 (Scopus)

Molecular cloning and functional analysis of zebrafish neutral ceramidase

Yoshimura, Y., Tani, M., Okino, N., Iida, H. & Ito, M., 10 15 2004, : : Journal of Biological Chemistry. 279, 42, p. 44012-44022 11 p.

研究成果: ジャーナルへの寄稿記事

Functional analysis
Cloning
Molecular Cloning
Morpholinos
Antisense Oligonucleotides
3 引用 (Scopus)

Possible participation of outer mitochondrial membrane cytochrome B 5 in steroidogenesis in zona glomerulosa of rat adrenal cortex

Mitani, F., Ogishima, T., Mukai, K., Hoshino, R., Watanabe, K. & Suematsu, M., 12 1 2004, : : Endocrine Research. 30, 4, p. 639-644 6 p.

研究成果: ジャーナルへの寄稿記事

Zona Glomerulosa
Adrenal Cortex
Mitochondrial Membranes
Cytochromes
monodehydroascorbate reductase (NADH)
37 引用 (Scopus)

Stereocontrolled synthesis of the ABCDE ring moiety of ciguatoxin CTX3C

Kobayashi, S., Takahashi, Y., Komano, K., Alizadeh, B. H., Kawada, Y., Oishi, T., Tanaka, S. I., Ogasawara, Y., Sasaki, S. Y. & Hirama, M., 9 13 2004, : : Tetrahedron. 60, 38, p. 8375-8396 22 p.

研究成果: ジャーナルへの寄稿記事

Ciguatoxins
Ciguatera Poisoning
Alkylation
Condensation
3-hydroxybutanal
10 引用 (Scopus)

Structural analysis and identification of novel isoforms of the circadian clock gene period in the silk moth Bombyx mori

Takeda, Y., Chuman, Y., Shirasu, N., Sato, S., Matsushima, A., Kaneki, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 9 1 2004, : : Zoological science. 21, 9, p. 903-915 13 p.

研究成果: ジャーナルへの寄稿記事

Bombyx mori
silk
circadian rhythm
moths
alternative splicing

Structural requirements of the N-terminal octapeptide repeat of prion protein

Kawano, M., Horiuchi, Y., Honda, T., Yokotani, S., Matsushima, A., Nose, T. & Shimohigashi, Y., 2004, Peptide Science 2003. p. 483-486

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

21 引用 (Scopus)

Synthesis of the CDE/FG ring models of prymnesins: Reassignment of the relative configuration of the E/F ring juncture

Sasaki, M., Ebine, M., Takagi, H., Takakura, H., Shida, T., Satake, M., Oshima, Y., Igarashi, T. & Yasumoto, T., 4 29 2004, : : Organic Letters. 6, 9, p. 1501-1504 4 p.

研究成果: ジャーナルへの寄稿記事

red tide
Haptophyta
rings
Tides
synthesis

Two distinctly different isoforms with/without pentapeptide fragment in the silk moth clock protein peptide

Takeda, Y., Shirasu, N., Sato, S., Matsushima, A., Chuman, Y., Shimohigashi, M. & Shimohigashi, Y., 2004, Peptide Science 2003. p. 473-476

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2003
20 引用 (Scopus)

A neutral ceramidase homologue from Dictyostelium discoideum exhibits an acidic pH optimum

Monjusho, H., Okino, N., Tani, M., Maeda, M., Yoshida, M. & Ito, M., 12 1 2003, : : Biochemical Journal. 376, 2, p. 473-479 7 p.

研究成果: ジャーナルへの寄稿記事

Neutral Ceramidase
Dictyostelium
Fungi
Alkaline Ceramidase
Acid Ceramidase
33 引用 (Scopus)

Biosynthetic regulation and intracellular transport of phosphatidylserine in mammalian cells

Kuge, O. & Nishijima, M., 4 1 2003, : : Journal of biochemistry. 133, 4, p. 397-403 7 p.

研究成果: ジャーナルへの寄稿評論記事

Phosphatidylserines
Cells
Decarboxylation
Mitochondria
Endoplasmic Reticulum
35 引用 (Scopus)

Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells

Ogishima, T., Kinoshita, J. Y., Mitani, F., Suematsu, M. & Ito, A., 6 6 2003, : : Journal of Biological Chemistry. 278, 23, p. 21204-21211 8 p.

研究成果: ジャーナルへの寄稿記事

Cytochromes b5
Leydig Cells
Mitochondrial Membranes
Modulators
Androgens

Localization profiles of the precursor protein of circadian rhythm pacemaker hormone PDF in Gryllus brain

Honda, T., Chuman, Y., Matsushima, A., Asai, D., Nose, T., Sakaguchi, K., Onoue, H., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2003, Peptide Science 2002. p. 433-436

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

7 引用 (Scopus)

Molecular cloning and circadian expression profile of insect neuropeptide PDF in black blowfly, Phormia regina

Matsushima, A., Yokotani, S., Lui, X., Sumida, K., Honda, T., Sato, S., Kaneki, A., Takeda, Y., Chuman, Y., Ozaki, M., Asai, D., Nose, T., Onoue, H., Ito, Y., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 11 1 2003, : : Letters in Peptide Science. 10, 5-6, p. 419-430 12 p.

研究成果: ジャーナルへの寄稿記事

Cloning
Molecular Cloning
Neuropeptides
Peptides
Protein Precursors
54 引用 (Scopus)

Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation

Matsumoto, N., Tamura, S., Furuki, S., Miyata, N., Moser, A., Shimozawa, N., Moser, H. W., Suzuki, Y., Kondo, N. & Fujiki, Y., 8 1 2003, : : American journal of human genetics. 73, 2, p. 233-246 14 p.

研究成果: ジャーナルへの寄稿記事

Genetic Association Studies
Zellweger Syndrome
Infantile Refsum's Disease
Phenotype
Peroxisomal Disorders
52 引用 (Scopus)
Neutral Ceramidase
Glycosylation
Mucins
Cell membranes
Membrane Proteins
12 引用 (Scopus)

Purification and Characterization of Chinese Hamster Phosphatidylserine Synthase 2

Kuge, O., Hasegawa, K., Ohsawa, T., Saito, K. & Nishijima, M., 10 24 2003, : : Journal of Biological Chemistry. 278, 43, p. 42692-42698 7 p.

研究成果: ジャーナルへの寄稿記事

Phosphatidylserines
Cricetulus
Purification
CDPdiacylglycerol-Serine O-Phosphatidyltransferase
Phosphatidylcholines
Neutral Ceramidase
Amidohydrolases
Species Specificity
Organ Specificity
Molecular Evolution

Structural analysis of PERIOD-PAS domain binding regions in insect clock protein TIMELESS

Sato, S., Oka, H., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2003, Peptide Science 2002. p. 429-432

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structural characterization of the house fly PDF, a circadian rhythm pacemaker hormone

Matsushima, A., Nose, T., Tomioka, K., Shimohigashi, M. & Shimohigashi, Y., 2003, Peptide Science 2002. p. 333-336

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

The Structure-activity studies of Drosophila FMRFamide-related peptides

Tokunaga, T., Ohtahi, M., Matsushima, A., Nose, T., Aimoto, S. & Shimohigashi, Y., 2003, Peptide Science 2002. p. 265-268

研究成果: 著書/レポートタイプへの貢献章 (査読済み)