有機・生物化学

研究成果 1983 2019

1999

Importance of ligand Phe-phenyl group for activation of thrombin receptor

Fujita, T., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., 1999, Peptide Science 1998. p. 33-36

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

22 引用 (Scopus)
Sphingolipids
Sphingomyelins
Hydrolysis
Assays
Carrier Proteins
37 引用 (Scopus)

Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide

Tani, M., Okino, N., Mitsutake, S. & Ito, M., 1999, : : Journal of Biochemistry. 125, 4, p. 746-749 4 p.

研究成果: ジャーナルへの寄稿記事

Alkaline Ceramidase
Neutral Ceramidase
Assays
Ceramides
Enzymes
1998
21 引用 (Scopus)

Cooperative formation of a substrate binding pocket by α- and β- subunits of mitochondrial processing peptidase

Kojima, K., Kitada, S., Shimokata, K., Ogishima, T. & Ito, A., 12 4 1998, : : Journal of Biological Chemistry. 273, 49, p. 32542-32546 5 p.

研究成果: ジャーナルへの寄稿記事

Substrates
Peptides
Arginine
Protein Precursors
mitochondrial processing peptidase
38 引用 (Scopus)

Enzymatic synthesis of ω-amino-ceramide: Preparation of a sensitive fluorescent substrate for ceramidase

Tani, M., Kita, K., Komori, H., Nakagawa, T. & Ito, M., 10 15 1998, : : Analytical Biochemistry. 263, 2, p. 183-188 6 p.

研究成果: ジャーナルへの寄稿記事

Ceramidases
Ceramides
Trifluoroacetic Acid
Substrates
Enzymes
31 引用 (Scopus)

Glutamate residues required for substrate binding and cleavage activity in mitochondrial processing peptidase

Kitada, S., Kojima, K., Shimokata, K., Ogishima, T. & Ito, A., 12 4 1998, : : Journal of Biological Chemistry. 273, 49, p. 32547-32553 7 p.

研究成果: ジャーナルへの寄稿記事

Glutamic Acid
Substrates
Peptides
Glutamates
Mutation
16 引用 (Scopus)
Serine
Peptide Hydrolases
Peptides
Arginine
Substrates
78 引用 (Scopus)

Purification and characterization of a novel ceramidase from pseudomonas aeruginosa

Okino, N., Tani, M., Imayama, S. & Ito, M., 6 5 1998, : : Journal of Biological Chemistry. 273, 23, p. 14368-14373 6 p.

研究成果: ジャーナルへの寄稿記事

Ceramidases
Pseudomonas aeruginosa
Ceramides
Purification
Enzymes
37 引用 (Scopus)

Role of α-subunit of mitochondrial processing peptidase in substrate recognition

Shimokata, K., Kitada, S., Ogishima, T. & Ito, A., 9 25 1998, : : Journal of Biological Chemistry. 273, 39, p. 25158-25163 6 p.

研究成果: ジャーナルへの寄稿記事

Substrates
Processing
Adrenodoxin
Acidic Amino Acids
Peptides
62 引用 (Scopus)
ethylenediamine
Epoxidation
Manganese
Epoxy Compounds
Ions
1997

Processing of mitochondrial protein precursors

Ito, A., Ogishima, T. & Kitada, S., 1 1 1997, : : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 42, 14 Suppl, p. 2362-2367 6 p.

研究成果: ジャーナルへの寄稿評論記事

Metalloendopeptidases
Protein Precursors
Mitochondrial Proteins
Mitochondria
17 引用 (Scopus)

Remarkable solvent effect on the enantioface selectivity in the Diels- Alder reaction catalyzed by an aluminum complex of a newly prepared chiral menthol derivative

Naraku, G., Hori, K., Ito, Y. & Katsuki, T., 11 24 1997, : : Tetrahedron Letters. 38, 47, p. 8231-8232 2 p.

研究成果: ジャーナルへの寄稿記事

Menthol
Enantiomers
Cycloaddition Reaction
Aluminum
Reaction products
22 引用 (Scopus)

Substrate recognition by mitochondrial processing peptidase toward the malate dehydrogenase precursor

Shimokata, K., Nishio, T., Song, M. C., Kitada, S., Ogishima, T. & Ito, A., 1 1 1997, : : Journal of biochemistry. 122, 5, p. 1019-1023 5 p.

研究成果: ジャーナルへの寄稿記事

Malate Dehydrogenase
Arginine
Peptides
Substrates
Protein Precursors
95 引用 (Scopus)

The first asymmetric epoxidation using a combination of achiral (salen)manganese(III) complex and chiral amine

Hashihayata, T., Ito, Y. & Katsuki, T., 7 14 1997, : : Tetrahedron. 53, 28, p. 9541-9552 12 p.

研究成果: ジャーナルへの寄稿記事

sulfoxide
Epoxidation
Manganese
Amines
Sparteine
1996
60 引用 (Scopus)

Enantioselective Epoxidation of 2,2-Dimethylchromenes Using Achiral Mn-Salen Complex as a Catalyst in the Presence of Chiral Amine

Hashihayata, T., Ito, Y. & Katsuki, T., 1996, : : Synlett. 1996, 11, p. 1079-1081 3 p.

研究成果: ジャーナルへの寄稿記事

Sparteine
Epoxidation
Manganese
Amines
Derivatives
42 引用 (Scopus)

Extensive Ring-Expansion Strategy for the Enantioselective Synthesis of the Medium Ring Ethers, Oxepene, Oxocane, and Oxonene, of Ciguatoxin

Oishi, T., Shoji, M., Maeda, K., Kumahara, N. & Hirama, M., 1 1 1996, : : Synlett. 1996, 12, p. 1165-1167 3 p.

研究成果: ジャーナルへの寄稿記事

Oxepins
Ciguatoxins
Acylation
Ethers
Lipase
31 引用 (Scopus)

Role of basic amino acids in the cleavage of synthetic peptide substrates by mitochondrial processing peptidase

Song, M. C., Shimokata, K., Kitada, S., Ogishima, T. & Ito, A., 1 1 1996, : : Journal of biochemistry. 120, 6, p. 1163-1166 4 p.

研究成果: ジャーナルへの寄稿記事

Basic Amino Acids
Ornithine-Oxo-Acid Transaminase
Peptides
Substrates
Processing
1995
46 引用 (Scopus)

Analysis of elements in the substrate required for processing by mitochondrial processing peptidase

Ogishima, T., Niidome, T., Shimokata, K., Kitada, S. & Ito, A., 12 22 1995, : : Journal of Biological Chemistry. 270, 51, p. 30322-30326 5 p.

研究成果: ジャーナルへの寄稿記事

Arginine
Peptide Hydrolases
Proline
Glycine
Substrates
1994
128 引用 (Scopus)

A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: Histochemical detection and possible physiological role

Mitani, F., Suzuki, H., Hata, J. I., Ogishima, T., Shimada, H. & Ishimura, Y., 1 1 1994, : : Endocrinology. 135, 1, p. 431-438 8 p.

研究成果: ジャーナルへの寄稿記事

Adrenal Cortex
Adrenal Cortex Hormones
Enzymes
Cytochrome P-450 CYP11B2
Zona Fasciculata
59 引用 (Scopus)

Arginine residues in the extension peptide are required for cleavage of a precursor by mitochondrial processing peptidase. Demonstration using synthetic peptide as a substrate

Niidome, T., Kitada, S., Shimokata, K., Ogishima, T. & Ito, A., 1 1 1994, : : Journal of Biological Chemistry. 269, 40, p. 24719-24722 4 p.

研究成果: ジャーナルへの寄稿記事

Arginine
Demonstrations
Peptides
Substrates
Amino Acids
1993
26 引用 (Scopus)

A formal synthesis of aplysiatoxin: enantioselective synthesis of kishi's aldehyde

Okamura, H., Kuroda, S., Ikegami, S., Tomita, K., Sugimoto, Y. I., Sakaguchi, S. I., Ito, Y., Katsuki, T. & Yamaguchi, M., 1 1 1993, : : Tetrahedron. 49, 46, p. 10531-10554 24 p.

研究成果: ジャーナルへの寄稿記事

Aldehydes
Neoplasms
aplysiatoxin
14 引用 (Scopus)

Molecular Cloning of the Smaller Subunit (P52) of Rat Liver Mitochondrial Processing Protease

Kitada, S., Niidome, T., Nagano, T., Ogishima, T. & Ito, A., 1 1 1993, : : Biochemical and Biophysical Research Communications. 190, 1, p. 289-293 5 p.

研究成果: ジャーナルへの寄稿記事

Cloning
Molecular Cloning
Liver
Yeast
Rats
1992
28 引用 (Scopus)

Effect of dietary sodium restriction on mrna for aldosterone synthase cytochrome P-450 in rat adrenals

Imai, M., Ogishima, T., Shimada, H. & Ishimura, Y., 1 1 1992, : : Journal of biochemistry. 111, 4, p. 440-443 4 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Dietary Sodium
Cytochromes
Rats
Sodium
1991
9 引用 (Scopus)

A formal total synthesis of aplysiatoxin

Okamura, H., Kuroda, S., Ikegami, S., Ito, Y., Katsuki, T. & Yamaguchi, M., 9 16 1991, : : Tetrahedron Letters. 32, 38, p. 5141-5142 2 p.

研究成果: ジャーナルへの寄稿記事

Stereochemistry
Communication
aplysiatoxin
18 引用 (Scopus)

A Highly Stereoselective Synthesis of (3A,4iS)-Statine and (SS^AJ-Cyclohexylstatine^

Takemoto, Y., Matsumoto, T., Ito, Y. & Terashima, S., 1 1 1991, : : Chemical and Pharmaceutical Bulletin. 39, 9, p. 2425-2428 4 p.

研究成果: ジャーナルへの寄稿記事

Acetals
Titanium
Phenylalanine
Renin
Aldehydes
175 引用 (Scopus)

Catalytic asymmetric epoxidation of unfunctionalized olefins using chiral (salen)manganese(III) complexes

Irie, R., Noda, K., Ito, Y., Matsumoto, N. & Katsuki, T., 1 1 1991, : : Tetrahedron: Asymmetry. 2, 7, p. 481-494 14 p.

研究成果: ジャーナルへの寄稿記事

epoxidation
Epoxidation
Alkenes
Manganese
alkenes
45 引用 (Scopus)

Catalytic epoxidation with molecular oxygen using nickel complex

Irie, R., Ito, Y. & Katsuki, T., 11 18 1991, : : Tetrahedron Letters. 32, 47, p. 6891-6894 4 p.

研究成果: ジャーナルへの寄稿記事

Epoxidation
Molecular oxygen
Alkenes
Nickel
Oxygen
145 引用 (Scopus)

Enantioselective epoxidation of unfunctionalized olefins using chiral (salen)manganese(III) complexes

Irie, R., Noda, K., Ito, Y. & Katsuki, T., 2 18 1991, : : Tetrahedron Letters. 32, 8, p. 1055-1058 4 p.

研究成果: ジャーナルへの寄稿記事

Stilbenes
Epoxidation
Enantioselectivity
Alkenes
Manganese
56 引用 (Scopus)

Regulation of aldosterone synthase cytochrome P-450 in rat adrenals by angiotensin II and potassium

Shibata, H., Ogishima, T., Mitani, F., Suzuki, H., Murakami, M., Saruta, T. & Ishimura, Y., 5 1 1991, : : Endocrinology. 128, 5, p. 2534-2539 6 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Angiotensin II
Potassium
Diet
Aldosterone
26 引用 (Scopus)

Structural differences in 5′-flanking regions of rat cytochrome P-450aldo and P-45011β genes

Mukai, K., Imai, M., Shimada, H., Okada, Y., Ogishima, T. & Ishimura, Y., 11 14 1991, : : Biochemical and Biophysical Research Communications. 180, 3, p. 1187-1193 7 p.

研究成果: ジャーナルへの寄稿記事

5' Flanking Region
Cytochromes
Rats
Genes
Nuclease Protection Assays
1990
22 引用 (Scopus)

An efficient synthesis of methyl N-[2-(R)-(1-napthylmethyl)-3-(morpholinocarbonyl)propionyl]-(S)-histidinate, the key synthetic intermediate of renin inhibitors

Ito, Y., Kamijo, T., Harada, H., Matsuda, F. & Terashima, S., 1 1 1990, : : Tetrahedron Letters. 31, 19, p. 2731-2734 4 p.

研究成果: ジャーナルへの寄稿記事

Succinic Acid
Renin
phosphine
Rhodium
Enantiomers
49 引用 (Scopus)

An expeditious synthesis of (3S,4S)-statine and (3S,4S)cyclohexylstatine

Takemoto, Y., Matsumoto, T., Ito, Y. & Terashima, S., 1 1 1990, : : Tetrahedron Letters. 31, 2, p. 217-218 2 p.

研究成果: ジャーナルへの寄稿記事

Acetals
Titanium
Aldehydes
Chlorides
statine
612 引用 (Scopus)

Catalytic asymmetric epoxidation of unfunctionalized olefins

Irie, R., Noda, K., Ito, Y., Matsumoto, N. & Katsuki, T., 1 1 1990, : : Tetrahedron Letters. 31, 50, p. 7345-7348 4 p.

研究成果: ジャーナルへの寄稿記事

Epoxidation
Enantioselectivity
Alkenes
Manganese
Ligands
87 引用 (Scopus)

Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P-450 in rat adrenal cortex

Imai, M., Shimada, H., Okada, Y., Matsushima-Hibiya, Y., Ogishima, T. & Ishimura, Y., 4 24 1990, : : FEBS Letters. 263, 2, p. 299-302 4 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Cloning
Adrenal Cortex
Molecular Cloning
Rats
24 引用 (Scopus)

Novel Synthesis of Three Types of C-Terminal Components of Renin Inhibitors from Unnatural (2S,3S)-Tartaric Acid

Kobayashi, Y., Matsumoto, T., Takemoto, Y., Terashima, S., Nakatani, K., Ito, Y., Kamijo, T. & Harada, H., 1 1 1990, : : Chemical and Pharmaceutical Bulletin. 39, 10, p. 2550-2555 6 p.

研究成果: ジャーナルへの寄稿記事

Addition reactions
Epoxy Compounds
Renin
Nucleophiles
Imines
1985
56 引用 (Scopus)

A highly effective asymmetric synthesis of α-hydroxy acids by alkylation of chiral n-(benzyloxyacetyl)-trans-2,5-bis(methoxymethoxymethyl)pyrrolidine

Enomoto, M., Ito, Y., Katsuki, T. & Yamaguchi, M., 1 1 1985, : : Tetrahedron Letters. 26, 10, p. 1343-1344 2 p.

研究成果: ジャーナルへの寄稿記事

Stereoselectivity
Hydroxy Acids
Alkylation
Acids
pyrrolidine
48 引用 (Scopus)

Effects of synthetic model peptides resembling the extension peptides of mitochondrial enzyme precursors on import of the precursors into mitochondria

Ito, A., Ogishima, T., Ou, W., Omura, T., Aoyagi, H., Lee, S., Mihara, H. & Izumiya, N., 1 1 1985, : : Journal of Biochemistry. 98, 6, p. 1571-1582 12 p.

研究成果: ジャーナルへの寄稿記事

Enzyme Precursors
Mitochondria
Peptides
Basic Amino Acids
Membranes
44 引用 (Scopus)

Highly anti-diastereoselective reduction of 2-alkyl-3-oxo amides by potassium triethylborohydride

Ito, Y., Katsuki, T. & Yamaguchi, M., 1 1 1985, : : Tetrahedron Letters. 26, 38, p. 4643-4646 4 p.

研究成果: ジャーナルへの寄稿記事

Amides
Potassium
Acylation
Hydroxy Acids
35 引用 (Scopus)

Import and processing of the precursor of cytochrome P-450(SCC) by bovine adrenal cortex mitochondria

Ogishima, T., Okada, Y. & Omura, T., 1 1 1985, : : Journal of biochemistry. 98, 3, p. 781-791 11 p.

研究成果: ジャーナルへの寄稿記事

Mitochondria
Adrenal Cortex
Cytochrome P-450 Enzyme System
Membranes
Processing
1984
58 引用 (Scopus)
Acylation
Amides
pyrrolidine
oxoamide
3-hydroxybutanal
6 引用 (Scopus)

Fractionation of mammalian tissue mRNAs by high-performance gel filtration chromatography

Ogishima, T., Okada, Y. & Omura, T., 5 1 1984, : : Analytical Biochemistry. 138, 2, p. 309-313 5 p.

研究成果: ジャーナルへの寄稿記事

Fractionation
Chromatography
Gel Chromatography
Gels
Tissue
4 引用 (Scopus)

Presence of a prepiece at the NH2-terminai end of pre-cytochrome P-450(SCC) peptide

Ogishima, T., Okada, Y. & Omura, T., 1 1 1984, : : Journal of biochemistry. 95, 5, p. 1525-1528 4 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 Enzyme System
Peptides
Radio
Amino Acids
Acids
1983
18 引用 (Scopus)

Partial amino acid sequences of two mitochondrial and two microsomal cytochrome p-450's from adrenal cortex

Ogishima, T., Okada, Y., Kominami, S., Takemori, S. & Omura, T., 11 1983, : : Journal of Biochemistry. 94, 5, p. 1711-1714 4 p.

研究成果: ジャーナルへの寄稿記事

Adrenal Cortex
Cytochromes
Cytochrome P-450 Enzyme System
Amino Acid Sequence
Amino Acids
30 引用 (Scopus)

Stereoselective reduction of 3-oxo amides with zinc borohydride

Ito, Y. & Yamaguchi, M., 1983, : : Tetrahedron Letters. 24, 48, p. 5385-5386 2 p.

研究成果: ジャーナルへの寄稿記事

Borohydrides
Amides
Zinc
Stereoselectivity