有機・生物化学

研究成果 1983 2019

フィルター
記事
2019
Glycosylation
Stereoselectivity
Oligosaccharides
linkages
reactivity

Design and synthesis of artificial ladder-shaped polyethers for exploring biological functions

Oishi, T., 1 1 2019, : : Heterocycles. 99, 1, p. 21-53 33 p.

研究成果: ジャーナルへの寄稿記事

Dinoflagellida
Polyethers
Ladders
Molecular Structure
Biological Products

Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors

Masuya, T., Iwamoto, M., Liu, X. & Matsushima, A., 12 1 2019, : : Scientific reports. 9, 1, 9954.

研究成果: ジャーナルへの寄稿記事

公開
Cytoplasmic and Nuclear Receptors
Estrogens
Estrogen Receptors
Epoxy Resins
Endocrine Disruptors
4 引用 (Scopus)

Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

Sakaue, H., Shiota, T., Ishizaka, N., Kawano, S., Tamura, Y., Tan, K. S., Imai, K., Motono, C., Hirokawa, T., Taki, K., Miyata, N., Kuge, O., Lithgow, T. & Endo, T., 3 7 2019, : : Molecular Cell. 73, 5, p. 1044-1055.e8

研究成果: ジャーナルへの寄稿記事

Porins
Mitochondrial Proteins
TOM translocase

Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors

Liu, X., Sakai, H., Nishigori, M., Suyama, K., Nawaji, T., Ikeda, S., Nishigouchi, M., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 8 15 2019, : : Toxicology and Applied Pharmacology. 377, 114610.

研究成果: ジャーナルへの寄稿記事

Cytoplasmic and Nuclear Receptors
Assays
Endocrine Disruptors
Peroxisome Proliferator-Activated Receptors
Competitive Binding
2018
Amphotericin B
Nuclear magnetic resonance
Anti-Bacterial Agents
Membranes
Ergosterol
3 引用 (Scopus)

Convergent syntheses of the WXYZ ring of maitotoxin and the HIJK ring of brevisulcenal-F

Osato, N., Onoue, H., Toma, Y., Torikai, K., Ebine, M., Satake, M. & Oishi, T., 1 1 2018, : : Chemistry Letters. 47, 3, p. 265-268 4 p.

研究成果: ジャーナルへの寄稿記事

Ketones
Stereochemistry
Methylation
Lithium
Aldehydes

Flow synthesis of (3R)- and (3S)-(E)-1-iodohexa-1,5-dien-3-ol: Chiral building blocks for natural product synthesis

Katayama, S., Koge, T., Katsuragi, S., Akai, S. & Oishi, T., 1 1 2018, : : Chemistry Letters. 47, 9, p. 1116-1118 3 p.

研究成果: ジャーナルへの寄稿記事

Ion Exchange Resins
Biological Products
Lipase
Evaporation
Acetates

Overexpression of PDR16 confers resistance to complex sphingolipid biosynthesis inhibitor aureobasidin A in yeast Saccharomyces cerevisiae

Katsuki, Y., Yamaguchi, Y. & Tani, M., 2 1 2018, : : FEMS microbiology letters. 365, 3, fnx255.

研究成果: ジャーナルへの寄稿記事

Sphingolipids
Saccharomyces cerevisiae
Yeasts
Tetracycline
Growth
2 引用 (Scopus)

Porin proteins have critical functions in mitochondrial phospholipid metabolism in yeast

Miyata, N., Fujii, S. & Kuge, O., 11 9 2018, : : The Journal of biological chemistry. 293, 45, p. 17593-17605 13 p.

研究成果: ジャーナルへの寄稿記事

Porins
Cardiolipins
Metabolism
Yeast
Phospholipids
5 引用 (Scopus)

Protective role of the HOG pathway against the growth defect caused by impaired biosynthesis of complex sphingolipids in yeast Saccharomyces cerevisiae

Yamaguchi, Y., Katsuki, Y., Tanaka, S., Kawaguchi, R., Denda, H., Ikeda, T., Funato, K. & Tani, M., 2 1 2018, : : Molecular Microbiology. 107, 3, p. 363-386 24 p.

研究成果: ジャーナルへの寄稿記事

Sphingolipids
Osmolar Concentration
Glycerol
Saccharomyces cerevisiae
Yeasts
1 引用 (Scopus)

Synthesis and complete structure determination of a sperm-activating and -attracting factor isolated from the ascidian ascidia sydneiensis

Watanabe, T., Shibata, H., Ebine, M., Tsuchikawa, H., Matsumori, N., Murata, M., Yoshida, M., Morisawa, M., Lin, S., Yamauchi, K., Sakai, K. & Oishi, T., 4 27 2018, : : Journal of Natural Products. 81, 4, p. 985-997 13 p.

研究成果: ジャーナルへの寄稿記事

Ergosterol
Urochordata
Biological Products
Ketones
Eggs
2 引用 (Scopus)

Synthesis and Stereochemical Revision of the C31–C67 Fragment of Amphidinol 3

Wakamiya, Y., Ebine, M., Murayama, M., Omizu, H., Matsumori, N., Murata, M. & Oishi, T., 5 22 2018, : : Angewandte Chemie - International Edition. 57, 21, p. 6060-6064 5 p.

研究成果: ジャーナルへの寄稿記事

Degradation
Biological Products
Carbon
Nuclear magnetic resonance
Availability

Synthesis of 6/6/6-tricyclic ether system via Achmatowicz and intramolecular oxa-michael reactions

Yamamoto, H., Torikai, K., Ebine, M. & Oishi, T., 1 1 2018, : : Heterocycles. 97, 1, p. 158-162 5 p.

研究成果: ジャーナルへの寄稿記事

Ethers
Aldehydes
Isomers
Ether
Alcohols

Synthesis of an analog of amphidinol 3 corresponding to the c31-c67 section

Koge, T., Wakamiya, Y., Ebine, M. & Oishi, T., 1 1 2018, : : Heterocycles. 96, 7, p. 1197-1202 6 p.

研究成果: ジャーナルへの寄稿記事

Structure-Activity Relationship
Derivatives
amphidinol 3
polyol
2 引用 (Scopus)

Synthesis of anti-tubercular marine alkaloids denigrins A and B

Karak, M., Oishi, T. & Torikai, K., 7 18 2018, : : Tetrahedron Letters. 59, 29, p. 2800-2803 4 p.

研究成果: ジャーナルへの寄稿記事

Maleic Anhydrides
Alkaloids
Cross Reactions
Palladium
Salts
2017
1 引用 (Scopus)

1-Naphthylmethyl and 1-naphthylmethoxymethyl protecting groups: New members of the benzyl- and benzyloxymethyl-type family

Sato, T., Joh, Y., Oishi, T. & Torikai, K., 1 1 2017, : : Tetrahedron Letters. 58, 23, p. 2178-2181 4 p.

研究成果: ジャーナルへの寄稿記事

Oxidation
Hydrogenolysis
Nucleophiles
Temperature
Acids
2 引用 (Scopus)

Adaptation of a genetic screen reveals an inhibitor for mitochondrial protein import component Tim44

Miyata, N., Tang, Z., Conti, M. A., Johnson, M. E., Douglas, C. J., Hasson, S. A., Damoiseaux, R., Chang, C. E. A. & Koehler, C. M., 3 31 2017, : : Journal of Biological Chemistry. 292, 13, p. 5429-5442 14 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Proteins
Membranes
Mitochondria
Proteins
Molecules
5 引用 (Scopus)

BAK regulates catalase release from peroxisomes

Fujiki, Y., Miyata, N., Mukai, S., Okumoto, K. & Cheng, E. H., 3 17 2017, : : Molecular & Cellular Oncology . 4, 3, e1306610.

研究成果: ジャーナルへの寄稿記事

Voltage-Dependent Anion Channel 2
Peroxisomes
Catalase
Permeability
Mitochondria
3 引用 (Scopus)

Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae

Miyata, N., Goda, N., Matsuo, K., Hoketsu, T. & Kuge, O., 12 1 2017, : : Scientific reports. 7, 1, 16447.

研究成果: ジャーナルへの寄稿記事

Cardiolipins
Saccharomyces cerevisiae
Mitochondrial Membranes
Yeasts
Phosphatidic Acids
4 引用 (Scopus)

Design and synthesis of benzoacridines as estrogenic and anti-estrogenic agents

Torikai, K., Koga, R., Liu, X., Umehara, K., Kitano, T., Watanabe, K., Oishi, T., Noguchi, H. & Shimohigashi, Y., 1 1 2017, : : Bioorganic and Medicinal Chemistry. 25, 20, p. 5216-5237 22 p.

研究成果: ジャーナルへの寄稿記事

Estrogens
Estrogen Receptors
Orphan Nuclear Receptors
Selective Estrogen Receptor Modulators
Inhibitory Concentration 50
2 引用 (Scopus)

Syntheses and Biological Activities of the LMNO, ent-LMNO, and NOPQR(S) Ring Systems of Maitotoxin

Onoue, H., Marubayashi, R., Ishikawa, E., Konoki, K., Torikai, K., Ebine, M., Murata, M. & Oishi, T., 1 1 2017, : : Journal of Organic Chemistry. 82, 18, p. 9595-9618 24 p.

研究成果: ジャーナルへの寄稿記事

Bioactivity
Enantiomers
Aldehydes
Alkynes
Biological Products
3 引用 (Scopus)

Synthesis of a truncated analog of amphidinol 3 corresponding to the C21C39/C52C67 section

Ebine, M., Takada, Y., Yanai, N. & Oishi, T., 1 1 2017, : : Chemistry Letters. 46, 5, p. 662-664 3 p.

研究成果: ジャーナルへの寄稿記事

Polyenes
amphidinol 3
20 引用 (Scopus)

The VDAC2-BAK axis regulates peroxisomal membrane permeability

Hosoi, K., Miyata, N., Mukai, S., Furuki, S., Okumoto, K., Cheng, E. H. & Fujiki, Y., 3 6 2017, : : Journal of Cell Biology. 216, 3, p. 709-722

研究成果: ジャーナルへの寄稿記事

Peroxisomes
Permeability
Membranes
Peroxisomal Disorders
Inborn Genetic Diseases
2016
62 引用 (Scopus)

Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling

Otera, H., Miyata, N., Kuge, O. & Mihara, K., 1 1 2016, : : Journal of Cell Biology. 212, 5, p. 531-544 14 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Dynamics
Cytochromes c
Apoptosis
Cytoplasm
Phenotype
26 引用 (Scopus)

Phosphatidylserine transport by Ups2-Mdm35 in respiration-active mitochondria

Miyata, N., Watanabe, Y., Tamura, Y., Endo, T. & Kuge, O., 7 1 2016, : : Journal of Cell Biology. 214, 1, p. 77-88 12 p.

研究成果: ジャーナルへの寄稿記事

Phosphatidylserines
Mitochondria
Respiration
Mitochondrial Membranes
Endoplasmic Reticulum
3 引用 (Scopus)

Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X., Costa, T. & Shimohigashi, Y., 11 4 2016, : : Biopolymers. p. 460-469 10 p.

研究成果: ジャーナルへの寄稿記事

Sulfhydryl Compounds
Labeling
Peptides
Ligands
Binding sites
11 引用 (Scopus)

The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores

Nakagawa, Y., Umegawa, Y., Matsushita, N., Yamamoto, T., Tsuchikawa, H., Hanashima, S., Oishi, T., Matsumori, N. & Murata, M., 6 21 2016, : : Biochemistry. 55, 24, p. 3392-3402 11 p.

研究成果: ジャーナルへの寄稿記事

Ergosterol
Amphotericin B
Membranes
Macrolides
Polyenes
4 引用 (Scopus)

Yeast lacking the amphiphysin family protein Rvs167 is sensitive to disruptions in sphingolipid levels

Toume, M. & Tani, M., 8 1 2016, : : FEBS Journal. p. 2911-2928 18 p.

研究成果: ジャーナルへの寄稿記事

Serine C-Palmitoyltransferase
Sphingolipids
Yeast
Yeasts
Biosynthesis
1 引用 (Scopus)

α-Helix-peptides comprising the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 11 4 2016, : : Biopolymers. p. 547-554 8 p.

研究成果: ジャーナルへの寄稿記事

Dimerization
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Peptides
Estrogens

核内受容体が示す有害化学物質ビスフェノール応答

Matsushima, A., 12 2016, : : Seikagaku. The Journal of Japanese Biochemical Society. 88, 6, p. 733-43 11 p.

研究成果: ジャーナルへの寄稿記事

2015
2 引用 (Scopus)

2-Naphthylmethoxymethyl as a Mildly Introducible and Oxidatively Removable Benzyloxymethyl-Type Protecting Group

Sato, T., Oishi, T. & Torikai, K., 6 19 2015, : : Organic Letters. 17, 12, p. 3110-3113 4 p.

研究成果: ジャーナルへの寄稿記事

Chlorides
Temperature
compatibility
chlorides
2,6-lutidine
8 引用 (Scopus)
Vacuolar Proton-Translocating ATPases
Sphingolipids
Saccharomyces cerevisiae
Yeasts
Ceramides
4 引用 (Scopus)

COX assembly factor ccdc56 regulates mitochondrial morphology by affecting mitochondrial recruitment of Drp1

Ban-Ishihara, R., Tomohiro-Takamiya, S., Tani, M., Baudier, J., Ishihara, N. & Kuge, O., 10 7 2015, : : FEBS Letters. 589, 20, p. 3126-3132 7 p., 37349.

研究成果: ジャーナルへの寄稿記事

Electron Transport Complex IV
Mitochondria
Personnel Selection
Mitochondrial Dynamics
Cell signaling
6 引用 (Scopus)

Ergosteryl-β-glucosidase (Egh1) involved in sterylglucoside catabolism and vacuole formation in Saccharomyces cerevisiae

Watanabe, T., Tani, M., Ishibashi, Y., Endo, I., Okino, N. & Ito, M., 4 14 2015, : : Glycobiology. 25, 10, p. 1079-1089 11 p.

研究成果: ジャーナルへの寄稿記事

Glucosidases
Glucosides
Vacuoles
Yeast
Saccharomyces cerevisiae
12 引用 (Scopus)

Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling

Sakakibara, K., Eiyama, A., Suzuki, S. W., Sakoh-Nakatogawa, M., Okumura, N., Tani, M., Hashimoto, A., Nagumo, S., Kondo-Okamoto, N., Kondo-Kakuta, C., Asai, E., Kirisako, H., Nakatogawa, H., Kuge, O., Takao, T., Ohsumi, Y. & Okamoto, K., 11 3 2015, : : EMBO Journal. 34, 21, p. 2703-2719 17 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Degradation
Mitochondria
Methylation
Recycling
Phospholipids
14 引用 (Scopus)

Stereoselective synthesis of the C1-C29 part of amphidinol 3

Tsuruda, T., Ebine, M., Umeda, A. & Oishi, T., 1 16 2015, : : Journal of Organic Chemistry. 80, 2, p. 859-871 13 p.

研究成果: ジャーナルへの寄稿記事

Lithium
Amides
amphidinol 3
8 引用 (Scopus)

Synthesis of mannosylinositol phosphorylceramides is involved in maintenance of cell integrity of yeast Saccharomyces cerevisiae

Morimoto, Y. & Tani, M., 1 1 2015, : : Molecular Microbiology. 95, 4, p. 706-722 17 p.

研究成果: ジャーナルへの寄稿記事

Saccharomyces cerevisiae
Yeasts
Maintenance
Mannans
Polysaccharides
1 引用 (Scopus)

Tuned Classical Thermal Aromatization Furnishing an Estrogenic Benzoacridine

Koga, R., Oishi, T. & Torikai, K., 12 17 2015, : : Synlett. 26, 20, p. 2801-2805 5 p., st-2015-s0585-c.

研究成果: ジャーナルへの寄稿記事

Aromatization
Estrogens
Derivatives
Pharmaceutical Preparations
Hot Temperature
1 引用 (Scopus)

VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae

Miyata, N., Miyoshi, T., Yamaguchi, T., Nakazono, T., Tani, M. & Kuge, O., 12 15 2015, : : Biochemical Journal. 472, 3, p. 319-328 10 p.

研究成果: ジャーナルへの寄稿記事

Yeast
Transcriptional Activation
Saccharomyces cerevisiae
Genes
Yeasts
2 引用 (Scopus)

Voltammetric study of the boric acid-salicylaldehyde-H-acid ternary system and its application to the voltammetric determination of boron

Kajiwara, M., Ito, Y., Miyazaki, Y., Fujimori, T., Takehara, K. & Yoshimura, K., 2 14 2015, : : Physical Chemistry Chemical Physics. 17, 6, p. 4578-4588 11 p.

研究成果: ジャーナルへの寄稿記事

boric acids
Boron
Ternary systems
ternary systems
boron
2014
11 引用 (Scopus)

A characteristic back support structure in the bisphenol A-binding pocket in the human nuclear receptor ERRγ

Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 6 30 2014, : : PLoS One. 9, 6, e101252.

研究成果: ジャーナルへの寄稿記事

bisphenol A
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
receptors
estrogens
63 引用 (Scopus)

Adrenal nodularity and somatic mutations in primary aldosteronism: One node is the culprit?

Dekkers, T., Ter Meer, M., Lenders, J. W. M., Hermus, A. R. M., Schultze Kool, L., Langenhuijsen, J. F., Nishimoto, K., Ogishima, T., Mukai, K., Azizan, E. A. B., Tops, B., Deinum, J. & Küsters, B., 1 1 2014, : : Journal of Clinical Endocrinology and Metabolism. 99, 7

研究成果: ジャーナルへの寄稿記事

Hyperaldosteronism
Aldosterone
Adenoma
Mutation
Genes
6 引用 (Scopus)

AlCl3-mediated aldol cyclocondensation of 1,6- and 1,7-diones to cyclopentene and cyclohexene derivatives

Miyahara, Y. & Ito, Y., 1 1 2014, : : Journal of Organic Chemistry. 79, 15, p. 6801-6807 7 p.

研究成果: ジャーナルへの寄稿記事

Cyclopentanes
Condensation
Derivatives
Water
Temperature
8 引用 (Scopus)

Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae

Toume, M. & Tani, M., 1 1 2014, : : FEMS microbiology letters. 358, 1, p. 64-71 8 p.

研究成果: ジャーナルへの寄稿記事

Serine C-Palmitoyltransferase
Sphingolipids
Saccharomyces cerevisiae
Yeasts
Pseudomonas syringae
8 引用 (Scopus)
Phosphatidylserines
Phosphatases
Phosphatidylinositols
Phosphoric Monoester Hydrolases
Metabolism
11 引用 (Scopus)

Loss of hydroxyl groups from the ceramide moiety can modify the lateral diffusion of membrane proteins in S. cerevisiae

Uemura, S., Shishido, F., Tani, M., Mochizuki, T., Abe, F. & Inokuchi, J. I., 1 1 2014, : : Journal of Lipid Research. 55, 7, p. 1343-1356 14 p.

研究成果: ジャーナルへの寄稿記事

Ceramides
Protein S
Inositol
Hydroxyl Radical
Yeast
3 引用 (Scopus)

N-methylthioacetylation of RYYRIK-NH2 with enhanced specific binding affinity and high antagonist activity for nociceptin ORL1 receptor

Li, J., Nishimura, H., Matsushima, A. & Shimohigashi, Y., 11 1 2014, : : Bioorganic and Medicinal Chemistry. 22, 21, p. 5721-5726 6 p.

研究成果: ジャーナルへの寄稿記事

Peptide Library
Atoms
Peptides
Peptide Receptors
Neuropeptides
10 引用 (Scopus)

Synthesis and biological activity of the C'D'E'F' ring system of maitotoxin

Kunitake, M., Oshima, T., Konoki, K., Ebine, M., Torikai, K., Murata, M. & Oishi, T., 6 6 2014, : : Journal of Organic Chemistry. 79, 11, p. 4948-4962 15 p.

研究成果: ジャーナルへの寄稿記事

Cyclization
Bioactivity
Rats
maitotoxin
allyl alcohol
6 引用 (Scopus)

Synthesis and biological activity of the QRS ring system of maitotoxin

Onoue, H., Baba, T., Konoki, K., Torikai, K., Ebine, M. & Oishi, T., 1 1 2014, : : Chemistry Letters. 43, 12, p. 1904-1906 3 p.

研究成果: ジャーナルへの寄稿記事

Bioactivity
Acetals
Methylation
Polyethers
Ladders