研究成果 1976 2019

記事
14 引用 (Scopus)

Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships

Okubo, S., Uto, T., Goto, A., Tanaka, H., Nishioku, T., Yamada, K. & Shoyama, Y., 1 1 2017, : : American Journal of Chinese Medicine. 45, 7, p. 1497-1511 15 p.

研究成果: ジャーナルへの寄稿記事

Berberine
Caspase 8
Structure-Activity Relationship
Caspase 3
Leukemia
21 引用 (Scopus)

Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP)·Cdk2·cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2

Chinami, M., Yano, Y., Yang, X., Salahuddin, S., Moriyama, K., Shiroishi, M., Turner, H., Shirakawa, T. & Adra, C. N., 4 29 2005, : : Journal of Biological Chemistry. 280, 17, p. 17235-17242 8 p.

研究成果: ジャーナルへの寄稿記事

Cyclin A
Cyclin-Dependent Kinases
Phosphoric Monoester Hydrolases
Cyclin-Dependent Kinase 2
Phosphorylation
18 引用 (Scopus)

Bioactive diterpenoids from octocorallia, 2. deoxyxeniolide B, a novel ichthyotoxic diterpenoid from the soft coral xenia elongata

Miyamoto, T., Takenaka, Y., Yamada, K. & Higuchi, R., 6 1995, : : Journal of Natural Products. 58, 6, p. 924-928 5 p.

研究成果: ジャーナルへの寄稿記事

Anthozoa
Diterpenes
Spectrum analysis
Oxidation
deoxyxeniolide B
14 引用 (Scopus)

Bioactive steroidal saponins from Smilax medica

Sautour, M., Miyamoto, T. & Lacaille-Dubois, M. A., 6 1 2006, : : Planta medica. 72, 7, p. 667-670 4 p.

研究成果: ジャーナルへの寄稿記事

Smilax
Spirostans
steroid saponins
Candida glabrata
Candida tropicalis
48 引用 (Scopus)

Bioactive terpenoids from Octocorallia, I. Bioactive diterpenoids: Litophynols A and B from the mucus of the soft coral Litophyton sp.

Miyamoto, T., Yamada, K., Ikeda, N., Komori, T. & Higuchi, R., 9 1 1994, : : Journal of Natural Products. 57, 9, p. 1212-1219 8 p.

研究成果: ジャーナルへの寄稿記事

Anthozoa
Diterpenes
Terpenes
Mucus
X-Rays
49 引用 (Scopus)

Bioactive terpenoids from octocorallia. 3. A new eunicellin-based diterpenoid from the soft coral Cladiella sphaeroides

Yamada, K., Ogata, N., Ryu, K., Miyamoto, T., Komori, T. & Higuchi, R., 1 1 1997, : : Journal of Natural Products. 60, 4, p. 393-396 4 p.

研究成果: ジャーナルへの寄稿記事

Anthozoa
Diterpenes
Terpenes
diterpenoids
terpenoids
37 引用 (Scopus)

Bioactive terpenoids from octocorallia. 4. Three new cembrane-type diterpenoids from the soft coral Lobophytum schoedei

Yamada, K., Ryu, K., Miyamoto, T. & Higuchi, R., 1 1 1997, : : Journal of Natural Products. 60, 8, p. 798-801 4 p.

研究成果: ジャーナルへの寄稿記事

Gambusia
Cyprinodontiformes
Oryzias
Artemia
Oryzias latipes
8 引用 (Scopus)

Bioactivity of American ginseng by knockout extract preparation using monoclonal antibody

Yuan, C. S. & Tanaka, H., 3 1 2011, : : Current Drug Discovery Technologies. 8, 1, p. 32-41 10 p.

研究成果: ジャーナルへの寄稿記事

Panax
Fruit
Monoclonal Antibodies
Blood Glucose
Fasting
37 引用 (Scopus)

Biochemical analysis of the movement of a major lysosomal membrane glycoprotein in the endocytic membrane system

Furuno, K., Yano, S., Akasaki, K., Tanaka, Y., Yamaguchi, Y., Tsuji, H., Himeno, M. & Kato, K., 1 1 1989, : : Journal of biochemistry. 106, 4, p. 717-722 6 p.

研究成果: ジャーナルへの寄稿記事

Lysosome-Associated Membrane Glycoproteins
Membranes
Immunoglobulin G
Lysosomes
Antibodies
4 引用 (Scopus)

Biochemical characterization of liver microsomal, golgi, lysosomal, and serum β-glucuronidases in dibuty1 phosphate-treated rats

Nishimura, Y., Kato, K. & Himeno, M., 1 1 1995, : : Journal of biochemistry. 118, 1, p. 56-66 11 p.

研究成果: ジャーナルへの寄稿記事

Glucuronidase
Liver
Rats
Phosphates
Serum
6 引用 (Scopus)

Biochemical Properties and Intracellular Processing of Lysosomal Cathepsins B and H

Nishimura, Y., Tsuji, H., Kato, K., Sato, H., Amano, J., Himeno, M. & Tsuji, H., 1 1 1995, : : Biological and Pharmaceutical Bulletin. 18, 6, p. 829-836 8 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin H
Cathepsin B
Radioactivity
yeast proteinase B
Lysosomes
7 引用 (Scopus)

Bioconjugation of Oligodeoxynucleotides Carrying 1,4-Dicarbonyl Groups via Reductive Amination with Lysine Residues

Yang, B., Jinnouchi, A., Usui, K., Katayama, T., Fujii, M., Suemune, H. & Aso, M., 8 19 2015, : : Bioconjugate Chemistry. 26, 8, p. 1830-1838 9 p.

研究成果: ジャーナルへの寄稿記事

Amination
Oligodeoxyribonucleotides
Lysine
Aldehydes
Amines
28 引用 (Scopus)

Biologically active glycosides from asteroida, XXXIV: Isolation and structure of cerebrosides from the starfish Stellaster equestris

Higuchi, R., Harano, Y., Mitsuyuki, M., Isobe, R., Yamada, K., Miyamoto, T. & Komori, T., 4 1 1996, : : Liebigs Annales. 4, p. 593-599 7 p.

研究成果: ジャーナルへの寄稿記事

Cerebrosides
Glycosides
Chloroform
Methanol
10 引用 (Scopus)

Biologically active glycosides from asteroidea, 35: Isolation and structure of four new steroid glycoside di-O-sulfates from the starfish Asteropecten latespinosus

Higuchi, R., Fujita, M., Matsumoto, S., Yamada, K., Miyamoto, T. & Sasaki, T., 5 1 1996, : : Liebigs Annales. 5, p. 837-840 4 p.

研究成果: ジャーナルへの寄稿記事

Trientine
Glycosides
Chloroform
Sulfates
Methanol
23 引用 (Scopus)

Biologically active glycosides from asteroidea, 36: Re-examination of the structure of acanthaganglioside C, and the identification of three minor acanthagangliosides F, G and H

Miyamoto, T., Inagaki, M., Isobe, R., Tanaka, Y., Higuchi, R., Iha, M. & Teruya, K., 1 1 1997, : : Liebigs Annales. 5, p. 931-936 6 p.

研究成果: ジャーナルへの寄稿記事

Neuraminic Acids
Gangliosides
Glycosides
Galactose
Experiments
16 引用 (Scopus)

Biologically active glycosides from asteroidea, 37. Glycosphingolipids from the starfish Luidia maculata, 1: Structure of a new sulfatide molecular species

Kawatake, S., Inagaki, M., Isobe, R., Miyamoto, T. & Higuchi, R., 1 1 1997, : : Liebigs Annales. 8, p. 1797-1800 4 p.

研究成果: ジャーナルへの寄稿記事

Sulfoglycosphingolipids
Glycosphingolipids
Glycosides
Molecular mass
Chloroform
25 引用 (Scopus)
G(M3) Ganglioside
Glycosphingolipids
glucosides
Gangliosides
Glycosides
25 引用 (Scopus)

Biologically active glycosides from asteroidea, 40 two new gangliosides, acanthagangliosides I and J from the starfish Acanthaster planci

Miyamoto, T., Yamamoto, A., Wakabayashi, M., Nagaregawa, Y., Inagaki, M., Higuchi, R., Iha, M. & Teruya, K., 6 1 2000, : : European Journal of Organic Chemistry. 12, p. 2295-2301 7 p.

研究成果: ジャーナルへの寄稿記事

glucosides
Gangliosides
Glycosides
hydrolysis
Enzymatic hydrolysis
25 引用 (Scopus)

Biologically active glycosides from asteroidea, 42. Isolation and structure of a new biologically active ganglioside molecular species from the starfish Asterina pectinifera

Higuchi, R., Inoue, S., Inagaki, K., Sakai, M., Miyamoto, T., Komori, T., Inagaki, M. & Isobe, R., 3 1 2006, : : Chemical and Pharmaceutical Bulletin. 54, 3, p. 287-291 5 p.

研究成果: ジャーナルへの寄稿記事

Asterina
Starfish
Gangliosides
Glycosides
endoglycoceramidase
21 引用 (Scopus)
Starfish
Gangliosides
Glycosides
Molecular mass
Pheochromocytoma
10 引用 (Scopus)

Biologically active quinolone alkaloids from Evodia rutaecarpa on Artemia salina

Kim, Y. C., Kim, N. Y., Jeong, S. J., Sohn, D. H., Miyamoto, T. & Higuchi, R., 7 13 1998, : : Planta Medica. 64, 5, 1 p.

研究成果: ジャーナルへの寄稿記事

Evodia
Quinolones
Alkaloids
Salinum
8 引用 (Scopus)

Biosynthesis and Processing of Lysosomal Cathepsin D in Primary Cultures of Rat Hepatocytes

Nishimura, Y., Kato, K., Himeno, M. & Koji, F., 1 1 1995, : : Biological and Pharmaceutical Bulletin. 18, 6, p. 825-828 4 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin D
Enzyme Precursors
Hepatocytes
Tunicamycin
Chloroquine
55 引用 (Scopus)

Biosynthesis and processing of lysosomal cathepsin L in primary cultures of rat hepatocytes

Nishimura, Y., Furuno, K. & Kato, K., 5 15 1988, : : Archives of Biochemistry and Biophysics. 263, 1, p. 107-116 10 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin L
Biosynthesis
Enzyme Precursors
Rats
Hepatocytes
22 引用 (Scopus)

Biosynthesis of drimane terpenoids in dorid molluscs: Pivotal role of 7- deacetoxyolepupuane in two species of Dendrodoris nudibranchs

Fontana, A., Ciavatta, M. L., Miyamoto, T., Spinella, A. & Cimino, G., 4 30 1999, : : Tetrahedron. 55, 18, p. 5937-5946 10 p.

研究成果: ジャーナルへの寄稿記事

Molluscs
Mollusca
Biosynthesis
Terpenes
Nuclear magnetic resonance spectroscopy
45 引用 (Scopus)

Biosynthesis of lysosomal cathepsins B and H in cultured rat hepatocytes

Nishimura, Y., Amano, J., Sato, H., Tsuji, H. & Kato, K., 4 1988, : : Archives of Biochemistry and Biophysics. 262, 1, p. 159-170 12 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin H
Cathepsin B
Enzyme Precursors
Biosynthesis
Rats
22 引用 (Scopus)

Biosythesis processing, and intracellular transport of lysosomal acid phosphatase in rat hepatocytes

Tanaka, Y., Harada, R., Himeno, M. & Kato, K., 1 1 1990, : : Journal of biochemistry. 108, 2, p. 278-286 9 p.

研究成果: ジャーナルへの寄稿記事

Acid Phosphatase
Rats
Hepatocytes
Lysosomes
Processing
18 引用 (Scopus)

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

Tashima, R., Mikuriya, S., Tomiyama, D., Shiratori-Hayashi, M., Yamashita, T., Kohro, Y., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., 3 23 2016, : : Scientific reports. 6, 23701.

研究成果: ジャーナルへの寄稿記事

Peripheral Nerve Injuries
Microglia
Bone Marrow Cells
Population
Spinal Cord
11 引用 (Scopus)

Brefeldin A inhibits the targeting of cathepsin D and cathepsin H to lysosomes in rat hepatocytes

Oda, K. & Nishimura, Y., 8 30 1989, : : Biochemical and Biophysical Research Communications. 163, 1, p. 220-225 6 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin H
Brefeldin A
Cathepsin D
Lysosomes
Rats
32 引用 (Scopus)

Bryoanthrathiophene, a new antiangiogenic constituent from the bryozoan Watersipora subtorquata (d'Orbigny, 1852)

Jeong, S. J., Higuchi, R., Miyamoto, T., Ono, M., Kuwano, M. & Mawatari, S. F., 9 1 2002, : : Journal of Natural Products. 65, 9, p. 1344-1345 2 p.

研究成果: ジャーナルへの寄稿記事

Bioassay
Endothelial cells
Cell proliferation
Fractionation
Biological Assay
13 引用 (Scopus)

Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin

Ito, K., Sugawara, T., Koizumi, A., Nakajima, K. I., Shimizu-Ibuka, A., Shiroishi, M., Asada, H., Yurugi-Kobayashi, T., Shimamura, T., Asakura, T., Masuda, K., Ishiguro, M., Misaka, T., Iwata, S., Kobayashi, T. & Abe, K., 9 1 2010, : : Biochimica et Biophysica Acta - General Subjects. 1800, 9, p. 986-992 7 p.

研究成果: ジャーナルへの寄稿記事

Mannose
Yeast
Polysaccharides
Protein Sorting Signals
Recombinant Proteins
83 引用 (Scopus)

Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa

Taura, F., Sirikantaramas, S., Shoyama, Y., Yoshikai, K., Shoyama, Y. & Morimoto, S., 6 26 2007, : : FEBS Letters. 581, 16, p. 2929-2934 6 p.

研究成果: ジャーナルへの寄稿記事

Cannabis
Cannabinoids
Fibers
Enzymes
Acids
19 引用 (Scopus)

Cannabinerolic acid, a cannabinoid from Cannabis sativa

Taura, F., Morimoto, S. & Shoyama, Y., 1 1 1995, : : Phytochemistry. 39, 2, p. 457-458 2 p.

研究成果: ジャーナルへの寄稿記事

cannabinoids
Cannabis sativa
Cannabinoids
Cannabis
Acids
5 引用 (Scopus)

Cannabinoids act as necrosis-inducing factors in Cannabis sativa

Shoyama, Y., Sugawa, C., Tanaka, H. & Morimoto, S., 12 2008, : : Plant Signaling and Behavior. 3, 12, p. 1111-1112 2 p.

研究成果: ジャーナルへの寄稿記事

cannabinoids
Cannabis sativa
necrosis
permeability
Cannabis
14 引用 (Scopus)

Cannabis, 21. Biotransformation of cannabinol to its glycosides by in vitro plant tissue

Tanaka, H., Morimoto, S. & Shoyama, Y., 12 1993, : : Journal of Natural Products. 56, 12, p. 2068-2072 5 p.

研究成果: ジャーナルへの寄稿記事

Cannabinol
Cannabis
Glycosides
Biotransformation
Metabolites
11 引用 (Scopus)

Cannabis. XIV. Two New Propyl Cannabinoids, Cannabicyclovarin and Δ7-cis-Iso-tetrahydrocannabivarin, from Thai Cannabis

Shoyama, Y., Morimoto, S. & Nishioka, I., 1 1 1981, : : Chemical and Pharmaceutical Bulletin. 29, 12, p. 3720-3723 4 p.

研究成果: ジャーナルへの寄稿記事

Cannabinoids
Cannabis
Skeleton
4 引用 (Scopus)

Cannabis. XV. preparation and stability of Δ9-tetrahydrocannabinol-β-cyclodextrin inclusion complex

Shoyama, Y., Morimoto, S. & Nishioka, I., 1 1 1983, : : Journal of Natural Products. 46, 5, p. 633-637 5 p.

研究成果: ジャーナルへの寄稿記事

Dronabinol
Cyclodextrins
Cannabis
Drug Delivery Systems
Oxygen
8 引用 (Scopus)

Cannabis 25, biotransformation of cannabidiol and cannabidiolic acid by Pinellia ternata tissue segments

Tanaka, H., Takahashi, R., Morimoto, S. & Shoyama, Y., 1 1 1996, : : Plant Cell Reports. 15, 11, p. 819-823 5 p.

研究成果: ジャーナルへの寄稿記事

Pinellia ternata
cannabidiol
Cannabis
biotransformation
metabolites
8 引用 (Scopus)

Cathepsin B in the Growth of Colorectal Cancer: Increased Activity of Cathepsin B in Human Colorectal Cancer

Satoh, Y., Higashi, T., Nouso, K., Shiota, T., Kinugasa, N., Yoshida, K., Uematsu, S., Nakatsukasa, H., Nishimura, Y. & Tsuji, T., 12 1 1996, : : Acta medica Okayama. 50, 6, p. 305-311 7 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin B
Tumors
Colorectal Neoplasms
Growth
Bearings (structural)
5 引用 (Scopus)

Cathepsin B in the Growth of Colorectal Cancer: Suppressive Effect of Leupeptin on the Growth of DMH-induced Rat Colon Neoplasm

Satoh, Y., Higashi, T., Nouso, K., Shiota, T., Kinugasa, N., Yoshida, K., Uematsu, S., Nakatsukasa, H., Nishimura, Y. & Tsuji, T., 12 1 1996, : : Acta medica Okayama. 50, 6, p. 299-303 5 p.

研究成果: ジャーナルへの寄稿記事

1,2-Dimethylhydrazine
Cathepsin B
Colonic Neoplasms
Rats
Tumors
5 引用 (Scopus)

Cathepsin D associates with lysosomal membranous protein

Nishimura, Y. & Himeno, M., 1 1 1995, : : Biological and Pharmaceutical Bulletin. 18, 10, p. 1340-1346 7 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin D
Membranes
Lysosome-Associated Membrane Glycoproteins
IGF Type 2 Receptor
lysosomal proteins
53 引用 (Scopus)

CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia

Toyomitsu, E., Tsuda, M., Yamashita, T., Tozaki-Saitoh, H., Tanaka, Y. & Inoue, K., 6 1 2012, : : Purinergic Signalling. 8, 2, p. 301-310 10 p.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Microglia
Lysosomes
Exocytosis
Green Fluorescent Proteins
47 引用 (Scopus)

Cdc6-induced conformational changes in ORC bound to origin DNA revealed by cryo-electron microscopy

Sun, J., Kawakami, H., Zech, J., Speck, C., Stillman, B. & Li, H., 3 7 2012, : : Structure. 20, 3, p. 534-544 11 p.

研究成果: ジャーナルへの寄稿記事

Origin Recognition Complex
Cryoelectron Microscopy
DNA
Peptide Initiation Factors
Replication Origin
20 引用 (Scopus)

CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells

Yoshida, K., Sugimoto, N., Iwahori, S., Yugawa, T., Narisawa-Saito, M., Kiyono, T. & Fujita, M., 1 15 2010, : : Journal of cell science. 123, 2, p. 225-235 11 p.

研究成果: ジャーナルへの寄稿記事

Eukaryotic Cells
Xenopus
Phosphorylation
S Phase
Chromatin
19 引用 (Scopus)

Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture

Sugimoto, N., Maehara, K., Yoshida, K., Yasukouchi, S., Osano, S., Watanabe, S., Aizawa, M., Yugawa, T., Kiyono, T., Kurumizaka, H., Ohkawa, Y. & Fujita, M., 1 1 2015, : : Nucleic acids research. 43, 12, p. 5898-5911 14 p.

研究成果: ジャーナルへの寄稿記事

Histones
Chromatin
Glutamic Acid
Carrier Proteins
Replication Origin
33 引用 (Scopus)

CedA is a novel Escherichia coli protein that activates the cell division inhibited by chromosomal DNA over-replication

Katayama, T., Takata, M. & Sekimizu, K., 1997, : : Molecular Microbiology. 26, 4, p. 687-697 11 p.

研究成果: ジャーナルへの寄稿記事

Escherichia coli Proteins
DNA Replication
Cell Division
Genes
Chromosomes
165 引用 (Scopus)

Cell size and nucleoid organization of engineered Escherichia coli cells with a reduced genome

Hashimoto, M., Ichimura, T., Mizoguchi, H., Tanaka, K., Fujimitsu, K., Keyamura, K., Ote, T., Yamakawa, T., Yamazaki, Y., Mori, H., Katayama, T. & Kato, J. I., 1 1 2005, : : Molecular Microbiology. 55, 1, p. 137-149 13 p.

研究成果: ジャーナルへの寄稿記事

Cell Size
Genome
Escherichia coli
Chromosomes
Genetic Techniques
8 引用 (Scopus)

Characterization and diagnostic use of a recombinant single-chain antibody specific for the gp116 envelop glycoprotein of Yellow head virus

Intorasoot, S., Tanaka, H., Shoyama, Y. & Leelamanit, W., 8 1 2007, : : Journal of Virological Methods. 143, 2, p. 186-193 8 p.

研究成果: ジャーナルへの寄稿記事

Roniviridae
Single-Chain Antibodies
Glycoproteins
Enzyme-Linked Immunosorbent Assay
Nidovirales
13 引用 (Scopus)

Characterization and regulation of expression of an antifungal peptide from hemolymph of an insect, Manduca sexta

Al Souhail, Q., Hiromasa, Y., Rahnamaeian, M., Giraldo, M. C., Takahashi, D., Valent, B., Vilcinskas, A. & Kanost, M. R., 8 1 2016, : : Developmental and Comparative Immunology. 61, p. 258-268 11 p.

研究成果: ジャーナルへの寄稿記事

Manduca
Hemolymph
Insects
Fat Body
Peptides
103 引用 (Scopus)

Characterization of a mutation in a family with saposin B deficiency: a glycosylation site defect

Kretz, K. A., Carson, G. S., Morimoto, S., Kishimoto, Y., Fluharty, A. L. & O'Brien, J. S., 4 1990, : : Proceedings of the National Academy of Sciences of the United States of America. 87, 7, p. 2541-4 4 p.

研究成果: ジャーナルへの寄稿記事

Saposins
Glycosylation
Mutation
Metachromatic Leukodystrophy
Isoleucine
4 引用 (Scopus)

Characterization of deamidation at Asn138 in L-chain of recombinant humanized Fab expressed from Pichia pastoris

Ohkuri, T., Murase, E., Sun, S. L., Sugitani, J. & Ueda, T., 10 1 2013, : : Journal of biochemistry. 154, 4, p. 333-340 8 p.

研究成果: ジャーナルへの寄稿記事

Pichia
Antigens
endoproteinase Asp-N
Circular Dichroism
Yeast