研究成果 1976 2019

2003
84 引用 (Scopus)

LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice

Gamp, A. C., Tanaka, Y., Lüllmann-Rauch, R., Wittke, D., D'Hooge, R., De Deyn, P. P., Moser, T., Maier, H., Hartmann, D., Reiss, K., Illert, A. L., von Figura, K. & Saftig, P., 3 15 2003, : : Human Molecular Genetics. 12, 6, p. 631-646 16 p.

研究成果: ジャーナルへの寄稿記事

Deafness
Peripheral Nervous System Diseases
Stria Vascularis
Outer Auditory Hair Cells
Inner Auditory Hair Cells
9 引用 (Scopus)

New acylated preatroxigenin saponins from Atroxima congolana

Elbandy, M., Miyamoto, T., Delaude, C. & Lacaille-Dubois, M. A., 4 1 2003, : : Helvetica Chimica Acta. 86, 2, p. 522-531 10 p.

研究成果: ジャーナルへの寄稿記事

Saponins
Isomers
esters
Esters
isomers
12 引用 (Scopus)

New acylated saponins from Polygala myrtifolia

Haddad, M., Miyamoto, T., Delaude, C. & Lacaille-Dubois, M. A., 10 22 2003, : : Helvetica Chimica Acta. 86, 9, p. 3055-3065 11 p.

研究成果: ジャーナルへの寄稿記事

Polygala
Saponins
Isomers
esters
Esters
12 引用 (Scopus)

New acylated triterpene saponins from Polygala arenaria

Mitaine-Offer, A. C., Miyamoto, T., Laurens, V., Delaude, C. & Lacaille-Dubois, M. A., 8 29 2003, : : Helvetica Chimica Acta. 86, 7, p. 2404-2413 10 p.

研究成果: ジャーナルへの寄稿記事

Polygala
Triterpenes
Saponins
Isomers
esters
15 引用 (Scopus)

New dimeric morphine from opium poppy (Papaver somuniferum) and its physiological function

Morimoto, S., Suemori, K., Taura, F. & Shoyama, Y., 7 1 2003, : : Journal of Natural Products. 66, 7, p. 987-989 3 p.

研究成果: ジャーナルへの寄稿記事

Papaver
Opium
Papaver somniferum
morphine
Morphine
35 引用 (Scopus)

Overexpression of ROCK in human breast cancer cells: Evidence that ROCK activity mediates intracellular membrane traffic of lysosomes

Nishimura, Y., Itoh, K., Yoshioka, K., Tokuda, K. & Himeno, M., 1 1 2003, : : Pathology and Oncology Research. 9, 2, p. 83-95 13 p.

研究成果: ジャーナルへの寄稿記事

Intracellular Membranes
Lysosomes
Transferrin
Breast Neoplasms
Endocytosis
11 引用 (Scopus)

Preparation of anti-2,4-dichlorophenol and 2,4-dichlorophenoxyacetic acid monoclonal antibodies

Tanaka, H., Yan, S., Miura, N. & Shoyama, Y., 12 1 2003, : : Cytotechnology. 42, 2, p. 101-107 7 p.

研究成果: ジャーナルへの寄稿記事

2,4-Dichlorophenoxyacetic Acid
Monoclonal antibodies
Antigens
Ionization
Mass spectrometry
2 引用 (Scopus)

Promising pharmacological actions of croon in crocus sativus on the central nervous system

Soeda, S., Ochiai, T., Shimeno, H., Saito, H., Abe, K., Sugiura, M., Tanaka, H., Taura, F., Morimoto, S. & Shoyama, Y., 1 1 2003, Studies in Natural Products Chemistry. PART I 版 Elsevier, p. 313-329 17 p. (Studies in Natural Products Chemistry; 巻数 28, 番号 PART I).

研究成果: 著書/レポートタイプへの貢献

Neurology
Central Nervous System
Pharmacology
Ethanol
D-Aspartic Acid
23 引用 (Scopus)

Prostaglandin E2 attenuates SR141716A-precipitated withdrawal in tetrahydrocannabinol-dependent mice

Anggadiredja, K., Yamaguchi, T., Tanaka, H., Shoyama, Y., Watanabe, S. & Yamamoto, T., 3 14 2003, : : Brain Research. 966, 1, p. 47-53 7 p.

研究成果: ジャーナルへの寄稿記事

rimonabant
Grooming
Dronabinol
Dinoprostone
Tremor
11 引用 (Scopus)

Solution structure and activity of mouse lysozyme M

Obita, T., Ueda, T. & Imoto, T., 1 1 2003, : : Cellular and Molecular Life Sciences. 60, 1, p. 176-184 9 p.

研究成果: ジャーナルへの寄稿記事

Muramidase
Biomolecular Nuclear Magnetic Resonance
Rubiaceae
Glycoside Hydrolases
Substrates
127 引用 (Scopus)

Structural basis of replication origin recognition by the DnaA protein

Fujikawa, N., Kurumizaka, H., Nureki, O., Terada, T., Shirouzu, M., Katayama, T. & Yokoyama, S., 4 15 2003, : : Nucleic acids research. 31, 8, p. 2077-2086 10 p.

研究成果: ジャーナルへの寄稿記事

Replication Origin
Helix-Turn-Helix Motifs
Hydrogen
DNA
Proteins
32 引用 (Scopus)

Structure of a new neuritogenic-active ganglioside from the sea cucumber Stichopus japonicus

Kaneko, M., Kisa, F., Yamada, K., Miyamoto, T. & Higuchi, R., 1 1 2003, : : European Journal of Organic Chemistry. 6, p. 1004-1008 5 p.

研究成果: ジャーナルへの寄稿記事

Gangliosides
carbohydrates
sugars
chloroform
acetic acid

The molecular mechanism for lysosome biogenesis

Fujita, H., Tanaka, Y. & Himeno, M., 1 1 2003, : : Fukuoka igaku zasshi = Hukuoka acta medica. 94, 9, p. 259-266 8 p.

研究成果: ジャーナルへの寄稿評論記事

CD Antigens
Vesicular Transport Adaptor Proteins
Lysosome-Associated Membrane Glycoproteins
rab GTP-Binding Proteins
CD36 Antigens
49 引用 (Scopus)

The role of hydrogen bonding via interfacial water molecules in antigen-antibody complexation: The HyHEL-10-HEL interaction

Yokota, A., Tsumoto, K., Shiroishi, M., Kondo, H. & Kumagai, I., 2 14 2003, : : Journal of Biological Chemistry. 278, 7, p. 5410-5418 9 p.

研究成果: ジャーナルへの寄稿記事

Egg White
Hydrogen Bonding
Muramidase
Complexation
Hydrogen bonds
25 引用 (Scopus)

Transcriptional control for initiation of chromosomal replication in Escherichia coli: Fluctuation of the level of origin transcription ensures timely initiation

Su'etsugu, M., Emoto, A., Fujimitsu, K., Keyamura, K. & Katayama, T., 9 1 2003, : : Genes to Cells. 8, 9, p. 731-745 15 p.

研究成果: ジャーナルへの寄稿記事

Cell Cycle
Escherichia coli
Mutation
Replication Origin
Growth
15 引用 (Scopus)

Two lysosomal membrane proteins, LGP85 and LGP107, are delivered to late endosomes/lysosomes through different intracellular routes after exiting from the trans-Golgi network

Niwa, K., Tanaka, R., Murase, H., Ishikawa, T., Fujita, H., Himeno, M. & Tanaka, Y., 2 21 2003, : : Biochemical and Biophysical Research Communications. 301, 4, p. 833-840 8 p.

研究成果: ジャーナルへの寄稿記事

Lysosome-Associated Membrane Glycoproteins
trans-Golgi Network
Endosomes
Lysosomes
Horseradish Peroxidase
71 引用 (Scopus)

Two new biologically active triterpenoidal saponins acylated with salicylic acid from Albizia adianthifolia

Haddad, M., Miyamoto, T., Laurens, V. & Lacaille-Dubois, M. A., 3 1 2003, : : Journal of Natural Products. 66, 3, p. 372-377 6 p.

研究成果: ジャーナルへの寄稿記事

Albizzia
Salicylic Acid
Saponins
Oleanolic Acid
Jurkat Cells
2002

A metal binding in the polypeptide chain improves the folding efficiency of a denatured and reduced protein

Ohkuri, T., Ueda, T., Yoshida, Y., Abe, Y., Hamasaki, N. & Imoto, T., 7 5 2002, : : Biopolymers. 64, 2, p. 106-114 9 p.

研究成果: ジャーナルへの寄稿記事

Polypeptides
Muramidase
Enzymes
Metals
Proteins
30 引用 (Scopus)

Amyloid-β-protein (Aβ) (25-35)-associated free radical generation is strongly influenced by the aggregational state of the peptides

Monji, A., Utsumi, H., Ueda, T., Imoto, T., Yoshida, I., Hashioka, S., Tashiro, K. I. & Tashiro, N., 1 4 2002, : : Life Sciences. 70, 7, p. 833-841 9 p.

研究成果: ジャーナルへの寄稿記事

Serum Amyloid A Protein
Free Radicals
Phosphates
Peptides
Buffers
100 引用 (Scopus)
Escherichia coli Proteins
Mutant Proteins
Escherichia coli
Hydrolysis
Nucleotides
15 引用 (Scopus)

A role for small GTPase RhoA in regulating intracellular membrane traffic of lysosomes in invasive rat hepatoma cells

Nishimura, Y., Itoh, K., Yoshioka, K., Ikeda, K. & Himeno, M., 5 1 2002, : : Histochemical Journal. 34, 5, p. 189-213 25 p.

研究成果: ジャーナルへの寄稿記事

Intracellular Membranes
Monomeric GTP-Binding Proteins
Lysosomes
Hepatocellular Carcinoma
Transferrin Receptors
105 引用 (Scopus)

A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphophology

Kuronita, T., Eskelinen, E. L., Fujita, H., Saftig, P., Himeno, M. & Tanaka, Y., 11 1 2002, : : Journal of Cell Science. 115, 21, p. 4117-4131 15 p.

研究成果: ジャーナルへの寄稿評論記事

Lysosome-Associated Membrane Glycoproteins
Endosomes
Lysosomes
Maintenance
Membranes
2 引用 (Scopus)

B-cell repertoire specific for an unfolded self-determinant of mouse lysozyme escape tolerance and dominantly participate in the autoantibody response

Tsujihata, Y., Mizukami, Y., Ueda, T., So, T. & Imoto, T., 12 1 2002, : : Immunology. 107, 4, p. 394-402 9 p.

研究成果: ジャーナルへの寄稿記事

Muramidase
Autoantibodies
B-Lymphocytes
Monoclonal Antibodies
Immunoglobulin G
32 引用 (Scopus)

Bryoanthrathiophene, a new antiangiogenic constituent from the bryozoan Watersipora subtorquata (d'Orbigny, 1852)

Jeong, S. J., Higuchi, R., Miyamoto, T., Ono, M., Kuwano, M. & Mawatari, S. F., 9 1 2002, : : Journal of Natural Products. 65, 9, p. 1344-1345 2 p.

研究成果: ジャーナルへの寄稿記事

Bioassay
Endothelial cells
Cell proliferation
Fractionation
Biological Assay
60 引用 (Scopus)

Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway

Jeong, S. J., Itokawa, T., Shibuya, M., Kuwano, M., Ono, M., Higuchi, R. & Miyamoto, T., 12 10 2002, : : Cancer Letters. 187, 1-2, p. 129-133 5 p.

研究成果: ジャーナルへの寄稿記事

Saussurea
Sesquiterpenes
Lactones
Vascular Endothelial Growth Factor A
Asteraceae
16 引用 (Scopus)

Determination of aculeatisides based on immunoassay using a polyclonal antibody against aculeatiside A

Putalun, W., Tanaka, H., Muranaka, T. & Shoyama, Y., 1 1 2002, : : Analyst. 127, 10, p. 1328-1332 5 p.

研究成果: ジャーナルへの寄稿記事

Immunosorbents
immunoassay
Immunoassay
Antibodies
antibody
17 引用 (Scopus)

Determination of the secondary structure in solution of the Escherichia coli DnaA DNA-binding domain

Obita, T., Iwura, T., Su'etsugu, M., Yoshida, Y., Tanaka, Y., Katayama, T., Ueda, T. & Imoto, T., 12 2 2002, : : Biochemical and Biophysical Research Communications. 299, 1, p. 42-48 7 p.

研究成果: ジャーナルへの寄稿記事

Escherichia coli
DNA
Proteins
Replication Origin
Chemical shift
8 引用 (Scopus)

Differential expression of MHC class II antigens and cathepsin L by subtypes of cortical epithelial cells in the rat thymus: An immunoelectron microscopic study

Arudchelvan, Y., Nishimura, Y., Tokuda, N., Sawada, T., Shinozaki, F. & Fukumoto, T., 7 8 2002, : : Journal of Electron Microscopy. 51, 3, p. 173-181 9 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin L
Thymus
Histocompatibility Antigens Class II
antigens
Antigens
10 引用 (Scopus)

Effect of sucrose on formation of the β-amyloid fibrils and D-aspartic acids in Aβ1-42

Ueda, T., Nagata, M., Monji, A., Yoshida, I., Tashiro, N. & Imoto, T., 3 1 2002, : : Biological and Pharmaceutical Bulletin. 25, 3, p. 375-378 4 p.

研究成果: ジャーナルへの寄稿記事

D-Aspartic Acid
Amyloid
Sucrose
Peptides
Viscosity
2 引用 (Scopus)

Effects of stereochemistry of sugars on protein stabilities

Masumoto, K., Ueda, T., Nagata, M., Yamada, Y., Yoshida, Y., Hashimoto, Y. & Imoto, T., 9 28 2002, : : Protein and Peptide Letters. 9, 5, p. 435-439 5 p.

研究成果: ジャーナルへの寄稿記事

Stereochemistry
Protein Stability
Sugars
Stabilization
Proteins
9 引用 (Scopus)

Five new medicagenic acid saponins from Muraltia ononidifolia

Elbandy, M., Miyamoto, T., Delaude, C. & Lacaille-Dubois, M. A., 10 29 2002, : : Helvetica Chimica Acta. 85, 9, p. 2721-2728 8 p.

研究成果: ジャーナルへの寄稿記事

Saponins
Esters
acids
Acids
esters
19 引用 (Scopus)

Flexible regions within the membrane-embedded portions of polytopic membrane proteins

Hamasaki, N., Abe, Y. & Tanner, M. J. A., 3 26 2002, : : Biochemistry. 41, 12, p. 3852-3854 3 p.

研究成果: ジャーナルへの寄稿小調査

Membrane Proteins
Membranes
Membrane Transport Proteins
Ion Channels
Peptides
5 引用 (Scopus)

Fluctuations in free or substrate-complexed lysozyme and a mutant of it detected on x-ray crystallography and comparison with those detected on NMR

Ohmura, T., Motoshima, H., Ueda, T. & Imoto, T., 1 1 2002, : : Journal of Biochemistry. 131, 5, p. 701-704 4 p.

研究成果: ジャーナルへの寄稿記事

Crystallography
Muramidase
Nuclear magnetic resonance
X-Rays
X rays

Genetic background of Japanese thrombophilia

Hamasaki, N., Kinoshita, S. & Abe, Y., 1 1 2002, : : Rinsho byori. The Japanese journal of clinical pathology. Suppl 123, p. 104-111 8 p.

研究成果: ジャーナルへの寄稿評論記事

Thrombophilia
Thrombosis
Factor V
Population
Genes
1 引用 (Scopus)

Immunoaffinity column for isolation of bioactive compounds using monoclonal antibodies

Putalun, W., Fukuda, N., Tanaka, H. & Shoyama, Y., 10 10 2002, : : Journal of Liquid Chromatography and Related Technologies. 25, 13-15, p. 2387-2398 12 p.

研究成果: ジャーナルへの寄稿評論記事

Panax
Glycosides
Complex Mixtures
Monoclonal Antibodies
Solanum
17 引用 (Scopus)

Isolation and structure of monomethylated GM3-Type ganglioside molecular species from the starfish Luidia maculata

Kawatake, S., Inagaki, M., Isobe, R., Miyamoto, T. & Higuchi, R., 10 1 2002, : : Chemical and Pharmaceutical Bulletin. 50, 10, p. 1386-1389 4 p.

研究成果: ジャーナルへの寄稿記事

G(M3) Ganglioside
Starfish
Gangliosides
Ceramides
phytosphingosine
39 引用 (Scopus)

Molecular basis and functional consequences of the dominant effects of the mutant band 3 on the structure of normal band 3 in Southeast Asian ovalocytosis

Kuma, H., Abe, Y., Askin, D., Bruce, L. J., Hamasaki, T., Tanner, M. J. A. & Hamasaki, N., 3 12 2002, : : Biochemistry. 41, 10, p. 3311-3320 10 p.

研究成果: ジャーナルへの寄稿記事

Membranes
Biotinylation
Molecules
Chemical modification
Cell membranes
40 引用 (Scopus)

New acylated triterpene saponins from Silene fortunei that modulate lymphocyte proliferation

Gaidi, G., Miyamoto, T., Laurens, V. & Lacaille-Dubois, M. A., 11 1 2002, : : Journal of Natural Products. 65, 11, p. 1568-1572 5 p.

研究成果: ジャーナルへの寄稿記事

Silene
Triterpenes
triterpenoid saponins
Lymphocytes
Saponins
21 引用 (Scopus)

Novel acylated triterpene glycosides from Muraltia heisteria

Elbandy, M., Miyamoto, T., Chauffert, B., Delaude, C. & Lacaille-Dubois, M. A., 3 6 2002, : : Journal of Natural Products. 65, 2, p. 193-197 5 p.

研究成果: ジャーナルへの寄稿記事

Triterpenes
cisplatin
Cytotoxicity
Glycosides
colorectal neoplasms
148 引用 (Scopus)

Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein

Takamatsu, C., Umeda, S., Ohsato, T., Ohno, T., Abe, Y., Fukuoh, A., Shinagawa, H., Hamasaki, N. & Kang, D., 1 1 2002, : : EMBO Reports. 3, 5, p. 451-456 6 p.

研究成果: ジャーナルへの寄稿記事

DNA-Binding Proteins
Mitochondrial DNA
Transcription Factors
Transcription
HeLa Cells
11 引用 (Scopus)

Simple assay for antitumour immunoactive glycoprotein derived from Chlorella vulgaris strain CK22 using eLISA

Noda, K., Tanaka, K., Yamada, A., Ogata, J., Tanaka, H. & Shoyama, Y., 1 1 2002, : : Phytotherapy Research. 16, 6, p. 581-585 5 p.

研究成果: ジャーナルへの寄稿記事

Chlorella vulgaris
Glycoproteins
Cross Reactions
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
6 引用 (Scopus)

The active constituents from Gualou-xiebai-baijiu-tang part I: Active saponins

He, X. J., Qiu, F., Shoyama, Y., Tanaka, H. & Yao, X. S., 2002, : : Journal of Asian Natural Products Research. 4, 3, p. 189-196 8 p.

研究成果: ジャーナルへの寄稿記事

steroid saponins
Saponins
saponins
Galactose
glycols
10 引用 (Scopus)

The induction of hepatic selenium-binding protein by aryl hydrocarbon (Ah)-receptor ligands in rats

Ishida, T., Ishii, Y., Yamada, H. & Oguri, K., 2 1 2002, : : Journal of Health Science. 48, 1, p. 62-68 7 p.

研究成果: ジャーナルへの寄稿記事

Selenium-Binding Proteins
Aryl Hydrocarbon Receptors
Rats
Ligands
Liver
29 引用 (Scopus)

Three new triterpene saponins from two species of Carpolobia

Mitaine-Offer, A. C., Miyamoto, T., Khan, I. A., Delaude, C. & Lacaille-Dubois, M. A., 5 11 2002, : : Journal of Natural Products. 65, 4, p. 553-557 5 p.

研究成果: ジャーナルへの寄稿記事

Triterpenes
Saponins
Esters
Nuclear magnetic resonance
8 引用 (Scopus)

Two new steroidal saponins from "Gualou-xiebai-baijiu-tang" consisting of Fructus trichosanthis and Bulbus allii macrostemi

Xiangjiu, H. E., Qiu, F., Shoyama, Y., Tanaka, H. & Yao, X., 5 1 2002, : : Chemical and Pharmaceutical Bulletin. 50, 5, p. 653-655 3 p.

研究成果: ジャーナルへの寄稿記事

Saponins
Galactose
Traditional Medicine
Spectrum analysis
Medicine
11 引用 (Scopus)

Unexpectedly enhanced stereoselectivity of peroxidase-catalyzed sulfoxidation in branched alcohols

Yuchun, X., Das, P. K., Caaveiro, J. M. M. & Klibanov, A. M., 2002, : : Biotechnology and Bioengineering. 79, 1, p. 105-111 7 p.

研究成果: ジャーナルへの寄稿記事

Stereoselectivity
Peroxidase
Alcohols
Enzymes
Horseradish Peroxidase
2001
37 引用 (Scopus)

Aggregation and chemical reaction in hen lysozyme caused by heating at pH 6 are depressed by osmolytes, sucrose and trehalose

Ueda, T., Nagata, M. & Imoto, T., 1 1 2001, : : Journal of Biochemistry. 130, 4, p. 491-496 6 p.

研究成果: ジャーナルへの寄稿記事

Trehalose
Muramidase
Heating
Sucrose
Chemical reactions
20 引用 (Scopus)

Arrest of cell division and nucleoid partition by genetic alterations in the sliding clamp of the replicase and in DnaA

Kawakami, H., Iwura, T., Takata, M., Sekimizu, K., Hiraga, S. & Katayama, T., 10 16 2001, : : Molecular Genetics and Genomics. 266, 2, p. 167-179 13 p.

研究成果: ジャーナルへの寄稿記事

Cell Division
DNA Polymerase III
Protein Subunits
Cell Size
Immunoblotting
8 引用 (Scopus)

A single amino acid substitution in a self protein is sufficient to trigger autoantibody response

Tsujihata, Y., So, T., Hashimoto, Y., Ueda, T. & Imoto, T., 11 7 2001, : : Molecular Immunology. 38, 5, p. 375-381 7 p.

研究成果: ジャーナルへの寄稿記事

Amino Acid Substitution
Muramidase
Autoantibodies
Proteins
T-Lymphocytes
53 引用 (Scopus)

Constituents of holothuroidea. 10. Isolation and structure of a biologically active ganglioside molecular species from the sea cucumber Holothuria leucospilota

Yamada, K., Matsubara, R., Kaneko, M., Miyamoto, T. & Higuchi, R., 5 5 2001, : : Chemical and Pharmaceutical Bulletin. 49, 4, p. 447-452 6 p.

研究成果: ジャーナルへの寄稿記事

Holothuria
Sea Cucumbers
Gangliosides
Ceramides
phytosphingosine