研究成果 1976 2019

2000
27 引用 (Scopus)

Constituents of holothuroidea.9. Isolation and structure of a new ganglioside molecular species from the sea cucumber Holothuria pervicax

Yamada, K., Harada, Y., Miyamoto, T., Isobi, R. & Higuchi, R., 1 2000, : : Chemical and Pharmaceutical Bulletin. 48, 1, p. 157-159 3 p.

研究成果: ジャーナルへの寄稿記事

Holothuria
Sea Cucumbers
Gangliosides
PC12 Cells
Chloroform
7 引用 (Scopus)

Cross-reactivity of various tetrahydrocannabinol metabolites with a monoclonal antibody against tetrahydrocannabinolic acid

Watanabe, K., Matsuda, M., Tateoka, Y., Kimura, T., Matsunaga, T., Tanaka, H., Shoyama, Y. & Yamamoto, I., 1 1 2000, : : Journal of Health Science. 46, 4, p. 310-313 4 p.

研究成果: ジャーナルへの寄稿記事

Dronabinol
Metabolites
Monoclonal Antibodies
Acids
Cannabinoids
105 引用 (Scopus)

Cytotoxic lavandulyl flavanones from Sophora flavescens

Kang, T. H., Jeong, S. J., Ko, W. G., Kim, N. Y., Lee, B. H., Inagaki, M., Miyamoto, T., Higuchi, R. & Kim, Y. C., 5 1 2000, : : Journal of Natural Products. 63, 5, p. 680-681 2 p.

研究成果: ジャーナルへの寄稿記事

Sophora
Flavanones
Optical rotation
Optical Rotation
Myeloid Leukemia
9 引用 (Scopus)

Determination of 1,5-anhydro-glucitol-carrier protein conjugates matrix-assisted laser desorption/ionization tof mass spectrometry and antibody formation

Xuan, L. J., Tanaka, H., Morimoto, S., Shoyama, Y., Akanuma, H. & Muraoka, K., 1 1 2000, : : Spectroscopy. 14, 3, p. 85-92 8 p.

研究成果: ジャーナルへの寄稿記事

Sorbitol
Succinic Acid
Ionization
Mass spectrometry
Desorption

Determination of hybrids in Papaver species by RAPD, HPLC and ELISA

Shoyama, Y., Tanaka, H., Morimoto, S. & Taura, F., 2000, : : Japanese Journal of Forensic Toxicology. 18, 2, p. 160-161 2 p.

研究成果: ジャーナルへの寄稿記事

Thebaine
Papaver
Enzyme-Linked Immunosorbent Assay
High Pressure Liquid Chromatography
Oligonucleotides
119 引用 (Scopus)

Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4

Ohnishi, A., Matsuo, H., Yamada, S., Takanaga, H., Morimoto, S., Shoyama, Y., Ohtani, H. & Sawada, Y., 1 1 2000, : : British Journal of Pharmacology. 130, 6, p. 1369-1377 9 p.

研究成果: ジャーナルへの寄稿記事

Citrus paradisi
Cytochrome P-450 CYP3A
Caco-2 Cells
Vinblastine
P-Glycoprotein
2 引用 (Scopus)

ELISA, western blotting, immunocytolocalization and immunoaffinity column for naturally occuring bioactive compounds using monoclonal antibodies

Shan, S. J., Putalun, W., Fukuda, N., Morinaga, O., Tanaka, H. & Shoyama, Y., 12 1 2000, : : Journal of Food and Drug Analysis. 8, 4, p. 258-269 12 p.

研究成果: ジャーナルへの寄稿評論記事

glycyrrhizin
Glycyrrhizic Acid
monoclonal antibodies
Western blotting
Western Blotting
7 引用 (Scopus)

Expression and characterization of human rheumatoid factor single-chain Fv

Hashimoto, Y., Ikenaga, T., Tanigawa, K., Ueda, T., Ezaki, I. & Imoto, T., 1 1 2000, : : Biological and Pharmaceutical Bulletin. 23, 8, p. 941-945 5 p.

研究成果: ジャーナルへの寄稿記事

Single-Chain Antibodies
Rheumatoid Factor
Urea
Escherichia coli
Genetic Engineering
48 引用 (Scopus)

Formation of monoclonal antibody against a major ginseng component, ginsenoside Rg1 and its characterization: Monoclonal antibody for a ginseng saponin

Fukuda, N., Tanaka, H. & Shoyama, Y., 1 1 2000, : : Cytotechnology. 34, 3, p. 197-204 8 p.

研究成果: ジャーナルへの寄稿記事

Panax
Monoclonal antibodies
Saponins
Antigens
Ionization
1 引用 (Scopus)

Formation of monoclonal antibody against naturally occurring biologically active compounds and their application

Tanaka, H., 6 1 2000, : : Natural Medicines. 54, 3, p. 123-128 6 p.

研究成果: ジャーナルへの寄稿記事

Glycyrrhetinic Acid
Cannabinoids
Glucuronides
Cross Reactions
Colforsin
370 引用 (Scopus)

Genetic variants of IL-13 signalling and human asthma and atopy

Heinzmann, A., Mao, X. Q., Akaiwa, M., Kreomer, R. T., Gao, P. S., Ohshima, K., Umeshita, R., Abe, Y., Braun, S., Yamashita, T., Roberts, M. H., Sugimoto, R., Arima, K., Arinobu, Y., Yu, B., Kruse, S., Enomoto, T., Dake, Y., Kawai, M., Shimazu, S. および12人, Sasaki, S., Adra, C. N., Kitaichi, M., Inoue, H., Yamauchi, K., Tomichi, N., Kurimoto, F., Hamasaki, N., Hopkin, J. M., Izuhara, K., Shirakawa, T. & Deichmann, K. A., 3 1 2000, : : Human Molecular Genetics. 9, 4, p. 549-559 11 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-13
Asthma
Immunoglobulin E
Smooth Muscle
Chromosomes
14 引用 (Scopus)

Heterooligomer of type 1 and type 2 inositol 1, 4, 5-trisphosphate receptor expressed in rat liver membrane fraction exists as tetrameric complex

Onoue, H., Tanaka, H., Tanaka, K., Doira, N. & Ito, Y., 1 27 2000, : : Biochemical and Biophysical Research Communications. 267, 3, p. 928-933 6 p.

研究成果: ジャーナルへの寄稿記事

Inositol 1,4,5-Trisphosphate Receptors
Liver
Rats
Monomers
Membranes
3 引用 (Scopus)

Histochemical investigation of β-glucuronidase in culture cells and regenerated plants of Scutellaria baicalensis Georgi

Matsuda, T., Hatano, K., Harioka, T., Taura, F., Tanaka, H., Tateishi, N., Shan, S., Morimoto, S. & Shoyama, Y., 3 2000, : : Plant Cell Reports. 19, 4, p. 390-394 5 p.

研究成果: ジャーナルへの寄稿記事

Scutellaria baicalensis
cell culture
trichomes
cells
leaf primordia
34 引用 (Scopus)

Hyaluronidase inhibitory active 6H-dibenzo[b,d]pyran-6-ones from the feces of Trogopterus xanthipes

Jeong, S. J., Kim, N. Y., Kim, D. H., Kang, T. H., Ahn, N. H., Miyamoto, T., Higuchi, R. & Kim, Y. C., 2 26 2000, : : Planta medica. 66, 1, p. 76-77 2 p.

研究成果: ジャーナルへの寄稿記事

Hyaluronoglucosaminidase
Feces
Bioassay
Fractionation
Biological Assay
90 引用 (Scopus)

Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells

Ikegawa, T., Ushigome, F., Koyabu, N., Morimoto, S., Shoyama, Y., Naito, M., Tsuruo, T., Ohtani, H. & Sawada, Y., 11 10 2000, : : Cancer Letters. 160, 1, p. 21-28 8 p.

研究成果: ジャーナルへの寄稿記事

Myeloid Leukemia
K562 Cells
P-Glycoprotein
Doxorubicin
Citrus paradisi
42 引用 (Scopus)

Interaction between cytochrome P450 and other drug-metabolizing enzymes: Evidence for an association of CYP1A1 with microsomal epoxide hydrolase and UDP-glucuronosyltransferase

Taura, K. I., Yamada, H., Hagino, Y., Ishii, Y., Mori, M. A. & Oguri, K., 7 14 2000, : : Biochemical and Biophysical Research Communications. 273, 3, p. 1048-1052 5 p.

研究成果: ジャーナルへの寄稿記事

Epoxide Hydrolases
Glucuronosyltransferase
Cytochrome P-450 CYP1A1
Cytochrome P-450 Enzyme System
Association reactions
36 引用 (Scopus)

Isolation of the pharmacologically active saponin ginsenoside Rb1 from ginseng by immunoaffinity column chromatography

Fukuda, N., Tanaka, H. & Shoyama, Y., 2 1 2000, : : Journal of Natural Products. 63, 2, p. 283-285 3 p.

研究成果: ジャーナルへの寄稿記事

Column chromatography
Panax
Saponins
saponins
Chromatography
2 引用 (Scopus)

Letter to the editor: Assignment of 1H and 15N resonances of mouse lysozyme M [1]

Obita, T., Ueda, T., Tanaka, Y., Hashimoto, Y. & Imoto, T., 12 1 2000, : : Journal of Biomolecular NMR. 18, 4, p. 361-362 2 p.

研究成果: ジャーナルへの寄稿レター

Nitrogen Isotopes
Biomolecular Nuclear Magnetic Resonance
Secondary Protein Structure
Muramidase
Protons
24 引用 (Scopus)
Cathepsin B
Phosphorylation
Cysteine Proteases
Lysosomes
Oligosaccharides
17 引用 (Scopus)
Cathepsin H
Cysteine Proteases
Lysosomes
Hepatocytes
Methionine
33 引用 (Scopus)

Molecular characterization of a novel β-glucuronidase from Scutellaria baicalensis Georgi

Sasaki, K., Taura, F., Shoyama, Y. & Morimoto, S., 9 1 2000, : : Journal of Biological Chemistry. 275, 35, p. 27466-27472 7 p.

研究成果: ジャーナルへの寄稿記事

Scutellaria baicalensis
Glucuronidase
Scutellaria
Mutagenesis
Site-Directed Mutagenesis
13 引用 (Scopus)

Mutant DnaA proteins defective in duplex opening of oriC, the origin of chromosomal DNA replication in Escherichia coli

Takata, M., Guo, L., Katayama, T., Hase, M., Seyama, Y., Miki, T. & Sekimizu, K., 1 31 2000, : : Molecular Microbiology. 35, 2, p. 454-462 9 p.

研究成果: ジャーナルへの寄稿記事

Mutant Proteins
DNA Replication
Escherichia coli
Proteins
Complex Mixtures
10 引用 (Scopus)

Mutant mouse lysozyme carrying a minimal T cell epitope of hen egg lysozyme evokes high autoantibody response

Tsujihata, Y., So, T., Chijiiwa, Y., Hashimoto, Y., Hirata, M., Ueda, T. & Imoto, T., 10 1 2000, : : Journal of Immunology. 165, 7, p. 3606-3611 6 p.

研究成果: ジャーナルへの寄稿記事

T-Lymphocyte Epitopes
Muramidase
Autoantibodies
Egg White
hen egg lysozyme
74 引用 (Scopus)

Octamer transcription factor-1 enhances hepatic nuclear factor-1α- mediated activation of the human UDP glucuronosyltransferase 2B7 promoter

Ishii, Y., Hansen, A. J. & Mackenzie, P. I., 5 22 2000, : : Molecular Pharmacology. 57, 5, p. 940-947 8 p.

研究成果: ジャーナルへの寄稿記事

Octamer Transcription Factor-1
Hepatocyte Nuclear Factor 1
AT Rich Sequence
Genes
human UGT2B7 protein
122 引用 (Scopus)

Polymethoxylated flavones in orange juice are inhibitors of P- glycoprotein but not cytochrome P450 3A4

Takanaga, H., Ohnishi, A., Yamada, S., Matsuo, H., Morimoto, S., Shoyama, Y., Ohtani, H. & Sawada, Y., 4 1 2000, : : Journal of Pharmacology and Experimental Therapeutics. 293, 1, p. 230-236 7 p.

研究成果: ジャーナルへの寄稿記事

Flavones
Cytochrome P-450 CYP3A
Vinblastine
P-Glycoprotein
Caco-2 Cells
32 引用 (Scopus)

Production of monoclonal antibody against a major purgative component, sennoside A, its characterization and ELISA

Morinaga, O., Tanaka, H. & Shoyama, Y., 7 1 2000, : : Analyst. 125, 6, p. 1109-1113 5 p.

研究成果: ジャーナルへの寄稿記事

Cathartics
Immunization
Monoclonal antibodies
Antigens
Isomers
25 引用 (Scopus)

Relationship between local structure and stability in hen egg white lysozyme mutant with alanine substituted for glycine

Masumoto, K., Ueda, T., Motoshima, H. & Imoto, T., 12 1 2000, : : Protein Engineering. 13, 10, p. 691-695 5 p.

研究成果: ジャーナルへの寄稿記事

Egg White
Dihedral angle
Muramidase
Alanine
Glycine
18 引用 (Scopus)

Remarkable thermal stability of doubly intramolecularly cross-linked hen lysozyme

Ueda, T., Masumoto, K., Ishibashi, R., So, T. & Imoto, T., 5 15 2000, : : Protein Engineering. 13, 3, p. 193-196 4 p.

研究成果: ジャーナルへの寄稿記事

Muramidase
Thermodynamic stability
Enzymes
Hot Temperature
Denaturation
54 引用 (Scopus)

Rotundines A-C, three novel sesquiterpene alkaloids from Cyperus rotundus

Jeong, S. J., Miyamoto, T., Inagaki, M., Kim, Y. C. & Higuchi, R., 5 1 2000, : : Journal of Natural Products. 63, 5, p. 673-675 3 p.

研究成果: ジャーナルへの寄稿記事

Cyperus
Cyperus rotundus
Rhizome
Sesquiterpenes
Alkaloids
3 引用 (Scopus)

Sequence analyses of CYP2B genes and catalytic profiles for P450s in Qdj: Sprague-Dawley rats that lack response to the phenobarbital-mediated induction of CYP2B2

Yamada, H., Matsunaga, H., Tsuji, K., Matsumoto, S., Yamamoto, M., Ishii, Y., Omiecinski, C. J. & Oguri, K., 12 7 2000, : : Journal of Pharmacology and Experimental Therapeutics. 295, 3, p. 986-993 8 p.

研究成果: ジャーナルへの寄稿記事

Phenobarbital
Sequence Analysis
Sprague Dawley Rats
Cytochrome P-450 CYP2B1
Exons
16 引用 (Scopus)

Small guanosine triphosphatase Rho/Rho-associated kinase as a novel regulator of intracellular redistribution of lysosomes in invasive tumor cells

Nishimura, Y., Itoh, K., Yoshioka, K., Uehata, M. & Himeno, M., 1 1 2000, : : Cell and tissue research. 301, 3, p. 341-351 11 p.

研究成果: ジャーナルへの寄稿記事

rho-Associated Kinases
Cathepsin D
Guanosine
Lysosomes
Microtubules
30 引用 (Scopus)

Squid nerve sphingomyelin containing an unusual sphingoid base

Ohashi, Y., Tanaka, T., Akashi, S., Morimoto, S., Kishimoto, Y. & Nagai, Y., 7 1 2000, : : Journal of Lipid Research. 41, 7, p. 1118-1124 7 p.

研究成果: ジャーナルへの寄稿記事

Decapodiformes
Sphingomyelins
Starfish
Ions
Mass spectrometry
356 引用 (Scopus)

Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20

Abe, Y., Shodai, T., Muto, T., Mihara, K., Torii, H., Nishikawa, S. I., Endo, T. & Kohda, D., 3 3 2000, : : Cell. 100, 5, p. 551-560 10 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Proteins
Rats
Aldehyde Dehydrogenase
Peptides
Mitochondria
14 引用 (Scopus)

Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl

Ikeda, M., Ishii, Y., Kato, H., Akazawa, D., Hatsumura, M., Ishida, T., Matsusue, K., Yamada, H. & Oguri, K., 8 1 2000, : : Archives of Biochemistry and Biophysics. 380, 1, p. 159-164 6 p.

研究成果: ジャーナルへの寄稿記事

3,4,5,3',4'-pentachlorobiphenyl
Carbonic Anhydrase III
Dioxins
Poisons
Polychlorinated Biphenyls
11 引用 (Scopus)

Survey of solasodine-type glycoalkaloids by western blotting and ELISA using anti-solamargine monoclonal antibody

Putalun, W., Tanaka, H., Yahara, S., Lhieochaiphan, S. & Shoyama, Y., 1 2000, : : Biological and Pharmaceutical Bulletin. 23, 1, p. 72-75 4 p.

研究成果: ジャーナルへの寄稿記事

Glycosides
Solanum
Western Blotting
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
18 引用 (Scopus)

Synthesis and absolute stereochemistry of the acyl moiety of quillajasaponins

Zhu, X., Yu, B., Hui, Y., Higuchi, R., Kusano, T. & Miyamoto, T., 1 29 2000, : : Tetrahedron Letters. 41, 5, p. 717-719 3 p.

研究成果: ジャーナルへの寄稿記事

Immunologic Adjuvants
Stereochemistry
octanoic acid
21 引用 (Scopus)

Thermodynamic consequences of grafting enhanced affinity toward the mutated antigen onto an antibody. The case of anti-lysozyme antibody HyHEL-10

Nishimiya, Y., Tsumoto, K., Shiroishi, M., Yutani, K. & Kumagai, I., 4 28 2000, : : Journal of Biological Chemistry. 275, 17, p. 12813-12820 8 p.

研究成果: ジャーナルへの寄稿記事

Muramidase
Thermodynamics
Anti-Idiotypic Antibodies
Antigens
Antibodies
26 引用 (Scopus)

Two new biologically active triterpene saponins from Acanthophyllum squarrosum

Gaidi, G., Miyamoto, T., Rustaiyan, A., Laurens, V. & Lacaille-Dubois, M. A., 12 10 2000, : : Journal of Natural Products. 63, 11, p. 1497-1502 6 p.

研究成果: ジャーナルへの寄稿記事

Triterpenes
Lymphocytes
Saponins
Assays
Nuclear magnetic resonance
1999
26 引用 (Scopus)
Biphenyl Compounds
Poisons
Polychlorinated Biphenyls
Unsaturated Fatty Acids
Arachidonic Acid
47 引用 (Scopus)

Analysis of the relationship between enzyme activity and its internal motion using nuclear magnetic resonance: 15N relaxation studies of wild-type and mutant lysozyme

Mine, S., Tate, S. I., Ueda, T., Kainosho, M. & Imoto, T., 3 12 1999, : : Journal of Molecular Biology. 286, 5, p. 1547-1565 19 p.

研究成果: ジャーナルへの寄稿記事

Glucosamine
Muramidase
Magnetic Resonance Spectroscopy
Enzymes
Catalytic Domain
2 引用 (Scopus)

An improved method for the purification and characterization of a 54 kDa protein in rat liver which has recently been identified as a selenium-binding protein

Ishida, T., Fukuda, A., Yoshioka, Y., Maji, D., Ishii, Y. & Oguri, K., 1 1 1999, : : Journal of Health Science. 45, 4, p. 203-208 6 p.

研究成果: ジャーナルへの寄稿記事

Selenium-Binding Proteins
Liver
Purification
Rats
Selenium
28 引用 (Scopus)

Assembly of the Epstein-Barr virus BBLF4, BSLF1 and BBLF2/3 proteins and their interactive properties

Yokoyama, N., Fujii, K., Hirata, M., Tamai, K., Kiyono, T., Kuzushima, K., Nishiyama, Y., Fujita, M. & Tsurumi, T., 1 1 1999, : : Journal of General Virology. 80, 11, p. 2879-2887 9 p.

研究成果: ジャーナルへの寄稿記事

Human Herpesvirus 4
Proteins
DNA Primase
Insects
Baculoviridae
25 引用 (Scopus)
G(M3) Ganglioside
Glycosphingolipids
glucosides
Gangliosides
Glycosides
22 引用 (Scopus)

Biosynthesis of drimane terpenoids in dorid molluscs: Pivotal role of 7- deacetoxyolepupuane in two species of Dendrodoris nudibranchs

Fontana, A., Ciavatta, M. L., Miyamoto, T., Spinella, A. & Cimino, G., 4 30 1999, : : Tetrahedron. 55, 18, p. 5937-5946 10 p.

研究成果: ジャーナルへの寄稿記事

Molluscs
Mollusca
Biosynthesis
Terpenes
Nuclear magnetic resonance spectroscopy
28 引用 (Scopus)

Constituents of holothuroidea, 8([≠]). - Structure of neuritogenic active ganglioside from the sea cucumber Stichopus japonicus

Kaneko, M., Kisa, F., Yamada, K., Miyamoto, T. & Higuchi, R., 11 1 1999, : : European Journal of Organic Chemistry. 11, p. 3171-3174 4 p.

研究成果: ジャーナルへの寄稿記事

phytosphingosine
Gangliosides
acids
Ceramides
N-Acetylneuraminic Acid
6 引用 (Scopus)

Construction of the single-chain Fv from 196-14 antibody toward ovarian cancer-associated antigen CA125

Hashimoto, Y., Tanigawa, K., Nakashima, M., Sonoda, K., Ueda, T., Watanabe, T. & Imoto, T., 1 1 1999, : : Biological and Pharmaceutical Bulletin. 22, 10, p. 1068-1072 5 p.

研究成果: ジャーナルへの寄稿記事

CA-125 Antigen
Single-Chain Antibodies
Inclusion Bodies
Histidine
Ovarian Neoplasms
62 引用 (Scopus)
Egg White
Muramidase
Crystal structure
Complementarity Determining Regions
Light
1 引用 (Scopus)

Effect of Dioxins on Molecular Chaperones HSP70 and HSP90 in Rat Leydig Cells

Fukuda, A., Kurogi, R., Tasaki, K., Ishida, T., Ishii, Y. & Oguri, K., 1 1 1999, : : Journal of Health Science. 45, 1, 1 p.

研究成果: ジャーナルへの寄稿記事

Molecular Chaperones
Dioxins
Rats
12 引用 (Scopus)

Extended blood half-life of monomethoxypolyethylene glycol-conjugated hen lysozyme is a key parameter controlling immunological tolerogenicity

So, T., Ito, H. O., Hirata, M., Ueda, T. & Imoto, T., 8 11 1999, : : Cellular and Molecular Life Sciences. 55, 8-9, p. 1187-1194 8 p.

研究成果: ジャーナルへの寄稿記事

Half-Life
Blood
Proteins
T-cells
Antibody Formation

Formation of ginsenoside-protein conjugates

Park, H., Shoyama, Y., Xuan, L. J. & Tanaka, H., 12 1 1999, : : Studies in Plant Science. 6, C, p. 83-86 4 p.

研究成果: ジャーナルへの寄稿記事

haptens
proteins
antibody formation
bovine serum albumin
solubility