研究成果

2000

Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4

Ohnishi, A., Matsuo, H., Yamada, S., Takanaga, H., Morimoto, S., Shoyama, Y., Ohtani, H. & Sawada, Y., 1 1 2000, : : British Journal of Pharmacology. 130, 6, p. 1369-1377 9 p.

研究成果: ジャーナルへの寄稿記事

124 引用 (Scopus)

ELISA, western blotting, immunocytolocalization and immunoaffinity column for naturally occuring bioactive compounds using monoclonal antibodies

Shan, S. J., Putalun, W., Fukuda, N., Morinaga, O., Tanaka, H. & Shoyama, Y., 12 1 2000, : : Journal of Food and Drug Analysis. 8, 4, p. 258-269 12 p.

研究成果: ジャーナルへの寄稿評論記事

2 引用 (Scopus)

Expression and characterization of human rheumatoid factor single-chain Fv

Hashimoto, Y., Ikenaga, T., Tanigawa, K., Ueda, T., Ezaki, I. & Imoto, T., 1 1 2000, : : Biological and Pharmaceutical Bulletin. 23, 8, p. 941-945 5 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

Formation of monoclonal antibody against a major ginseng component, ginsenoside Rg1 and its characterization: Monoclonal antibody for a ginseng saponin

Fukuda, N., Tanaka, H. & Shoyama, Y., 1 1 2000, : : Cytotechnology. 34, 3, p. 197-204 8 p.

研究成果: ジャーナルへの寄稿記事

50 引用 (Scopus)

Formation of monoclonal antibody against naturally occurring biologically active compounds and their application

Tanaka, H., 6 1 2000, : : Natural Medicines. 54, 3, p. 123-128 6 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Genetic variants of IL-13 signalling and human asthma and atopy

Heinzmann, A., Mao, X. Q., Akaiwa, M., Kreomer, R. T., Gao, P. S., Ohshima, K., Umeshita, R., Abe, Y., Braun, S., Yamashita, T., Roberts, M. H., Sugimoto, R., Arima, K., Arinobu, Y., Yu, B., Kruse, S., Enomoto, T., Dake, Y., Kawai, M., Shimazu, S. および12人, Sasaki, S., Adra, C. N., Kitaichi, M., Inoue, H., Yamauchi, K., Tomichi, N., Kurimoto, F., Hamasaki, N., Hopkin, J. M., Izuhara, K., Shirakawa, T. & Deichmann, K. A., 3 1 2000, : : Human Molecular Genetics. 9, 4, p. 549-559 11 p.

研究成果: ジャーナルへの寄稿記事

372 引用 (Scopus)

Heterooligomer of type 1 and type 2 inositol 1, 4, 5-trisphosphate receptor expressed in rat liver membrane fraction exists as tetrameric complex

Onoue, H., Tanaka, H., Tanaka, K., Doira, N. & Ito, Y., 1 27 2000, : : Biochemical and Biophysical Research Communications. 267, 3, p. 928-933 6 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Histochemical investigation of β-glucuronidase in culture cells and regenerated plants of Scutellaria baicalensis Georgi

Matsuda, T., Hatano, K., Harioka, T., Taura, F., Tanaka, H., Tateishi, N., Shan, S., Morimoto, S. & Shoyama, Y., 3 2000, : : Plant Cell Reports. 19, 4, p. 390-394 5 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Hyaluronidase inhibitory active 6H-dibenzo[b,d]pyran-6-ones from the feces of Trogopterus xanthipes

Jeong, S. J., Kim, N. Y., Kim, D. H., Kang, T. H., Ahn, N. H., Miyamoto, T., Higuchi, R. & Kim, Y. C., 2 26 2000, : : Planta medica. 66, 1, p. 76-77 2 p.

研究成果: ジャーナルへの寄稿記事

34 引用 (Scopus)

Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells

Ikegawa, T., Ushigome, F., Koyabu, N., Morimoto, S., Shoyama, Y., Naito, M., Tsuruo, T., Ohtani, H. & Sawada, Y., 11 10 2000, : : Cancer Letters. 160, 1, p. 21-28 8 p.

研究成果: ジャーナルへの寄稿記事

91 引用 (Scopus)

Interaction between cytochrome P450 and other drug-metabolizing enzymes: Evidence for an association of CYP1A1 with microsomal epoxide hydrolase and UDP-glucuronosyltransferase

Taura, K. I., Yamada, H., Hagino, Y., Ishii, Y., Mori, M. A. & Oguri, K., 7 14 2000, : : Biochemical and Biophysical Research Communications. 273, 3, p. 1048-1052 5 p.

研究成果: ジャーナルへの寄稿記事

43 引用 (Scopus)

Isolation of the pharmacologically active saponin ginsenoside Rb1 from ginseng by immunoaffinity column chromatography

Fukuda, N., Tanaka, H. & Shoyama, Y., 2 1 2000, : : Journal of Natural Products. 63, 2, p. 283-285 3 p.

研究成果: ジャーナルへの寄稿記事

37 引用 (Scopus)

Letter to the editor: Assignment of 1H and 15N resonances of mouse lysozyme M [1]

Obita, T., Ueda, T., Tanaka, Y., Hashimoto, Y. & Imoto, T., 12 1 2000, : : Journal of Biomolecular NMR. 18, 4, p. 361-362 2 p.

研究成果: ジャーナルへの寄稿レター

2 引用 (Scopus)
24 引用 (Scopus)
17 引用 (Scopus)

Molecular characterization of a novel β-glucuronidase from Scutellaria baicalensis Georgi

Sasaki, K., Taura, F., Shoyama, Y. & Morimoto, S., 9 1 2000, : : Journal of Biological Chemistry. 275, 35, p. 27466-27472 7 p.

研究成果: ジャーナルへの寄稿記事

32 引用 (Scopus)

Mutant DnaA proteins defective in duplex opening of oriC, the origin of chromosomal DNA replication in Escherichia coli

Takata, M., Guo, L., Katayama, T., Hase, M., Seyama, Y., Miki, T. & Sekimizu, K., 1 31 2000, : : Molecular Microbiology. 35, 2, p. 454-462 9 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Mutant mouse lysozyme carrying a minimal T cell epitope of hen egg lysozyme evokes high autoantibody response

Tsujihata, Y., So, T., Chijiiwa, Y., Hashimoto, Y., Hirata, M., Ueda, T. & Imoto, T., 10 1 2000, : : Journal of Immunology. 165, 7, p. 3606-3611 6 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

Octamer transcription factor-1 enhances hepatic nuclear factor-1α- mediated activation of the human UDP glucuronosyltransferase 2B7 promoter

Ishii, Y., Hansen, A. J. & Mackenzie, P. I., 5 22 2000, : : Molecular Pharmacology. 57, 5, p. 940-947 8 p.

研究成果: ジャーナルへの寄稿記事

74 引用 (Scopus)

Polymethoxylated flavones in orange juice are inhibitors of P- glycoprotein but not cytochrome P450 3A4

Takanaga, H., Ohnishi, A., Yamada, S., Matsuo, H., Morimoto, S., Shoyama, Y., Ohtani, H. & Sawada, Y., 4 1 2000, : : Journal of Pharmacology and Experimental Therapeutics. 293, 1, p. 230-236 7 p.

研究成果: ジャーナルへの寄稿記事

124 引用 (Scopus)

Production of monoclonal antibody against a major purgative component, sennoside A, its characterization and ELISA

Morinaga, O., Tanaka, H. & Shoyama, Y., 1 1 2000, : : Analyst. 125, 6, p. 1109-1113 5 p.

研究成果: ジャーナルへの寄稿記事

32 引用 (Scopus)

Relationship between local structure and stability in hen egg white lysozyme mutant with alanine substituted for glycine

Masumoto, K., Ueda, T., Motoshima, H. & Imoto, T., 12 1 2000, : : Protein Engineering. 13, 10, p. 691-695 5 p.

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

Remarkable thermal stability of doubly intramolecularly cross-linked hen lysozyme

Ueda, T., Masumoto, K., Ishibashi, R., So, T. & Imoto, T., 5 15 2000, : : Protein Engineering. 13, 3, p. 193-196 4 p.

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

Rotundines A-C, three novel sesquiterpene alkaloids from Cyperus rotundus

Jeong, S. J., Miyamoto, T., Inagaki, M., Kim, Y. C. & Higuchi, R., 5 1 2000, : : Journal of Natural Products. 63, 5, p. 673-675 3 p.

研究成果: ジャーナルへの寄稿記事

54 引用 (Scopus)

Sequence analyses of CYP2B genes and catalytic profiles for P450s in Qdj: Sprague-Dawley rats that lack response to the phenobarbital-mediated induction of CYP2B2

Yamada, H., Matsunaga, H., Tsuji, K., Matsumoto, S., Yamamoto, M., Ishii, Y., Omiecinski, C. J. & Oguri, K., 12 7 2000, : : Journal of Pharmacology and Experimental Therapeutics. 295, 3, p. 986-993 8 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Small guanosine triphosphatase Rho/Rho-associated kinase as a novel regulator of intracellular redistribution of lysosomes in invasive tumor cells

Nishimura, Y., Itoh, K., Yoshioka, K., Uehata, M. & Himeno, M., 1 1 2000, : : Cell and tissue research. 301, 3, p. 341-351 11 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

Squid nerve sphingomyelin containing an unusual sphingoid base

Ohashi, Y., Tanaka, T., Akashi, S., Morimoto, S., Kishimoto, Y. & Nagai, Y., 7 1 2000, : : Journal of Lipid Research. 41, 7, p. 1118-1124 7 p.

研究成果: ジャーナルへの寄稿記事

30 引用 (Scopus)

Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl

Ikeda, M., Ishii, Y., Kato, H., Akazawa, D., Hatsumura, M., Ishida, T., Matsusue, K., Yamada, H. & Oguri, K., 8 1 2000, : : Archives of Biochemistry and Biophysics. 380, 1, p. 159-164 6 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Survey of solasodine-type glycoalkaloids by western blotting and ELISA using anti-solamargine monoclonal antibody

Putalun, W., Tanaka, H., Yahara, S., Lhieochaiphan, S. & Shoyama, Y., 1 2000, : : Biological and Pharmaceutical Bulletin. 23, 1, p. 72-75 4 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Synthesis and absolute stereochemistry of the acyl moiety of quillajasaponins

Zhu, X., Yu, B., Hui, Y., Higuchi, R., Kusano, T. & Miyamoto, T., 1 29 2000, : : Tetrahedron Letters. 41, 5, p. 717-719 3 p.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

Thermodynamic consequences of grafting enhanced affinity toward the mutated antigen onto an antibody. The case of anti-lysozyme antibody HyHEL-10

Nishimiya, Y., Tsumoto, K., Shiroishi, M., Yutani, K. & Kumagai, I., 4 28 2000, : : Journal of Biological Chemistry. 275, 17, p. 12813-12820 8 p.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

Two new biologically active triterpene saponins from Acanthophyllum squarrosum

Gaidi, G., Miyamoto, T., Rustaiyan, A., Laurens, V. & Lacaille-Dubois, M. A., 12 10 2000, : : Journal of Natural Products. 63, 11, p. 1497-1502 6 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)
1999
26 引用 (Scopus)

Analysis of the relationship between enzyme activity and its internal motion using nuclear magnetic resonance: 15N relaxation studies of wild-type and mutant lysozyme

Mine, S., Tate, S. I., Ueda, T., Kainosho, M. & Imoto, T., 3 12 1999, : : Journal of Molecular Biology. 286, 5, p. 1547-1565 19 p.

研究成果: ジャーナルへの寄稿記事

47 引用 (Scopus)

An improved method for the purification and characterization of a 54 kDa protein in rat liver which has recently been identified as a selenium-binding protein

Ishida, T., Fukuda, A., Yoshioka, Y., Maji, D., Ishii, Y. & Oguri, K., 1 1 1999, : : Journal of Health Science. 45, 4, p. 203-208 6 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)
25 引用 (Scopus)

Biosynthesis of drimane terpenoids in dorid molluscs: Pivotal role of 7- deacetoxyolepupuane in two species of Dendrodoris nudibranchs

Fontana, A., Ciavatta, M. L., Miyamoto, T., Spinella, A. & Cimino, G., 4 30 1999, : : Tetrahedron. 55, 18, p. 5937-5946 10 p.

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

Constituents of holothuroidea, 8([≠]). - Structure of neuritogenic active ganglioside from the sea cucumber Stichopus japonicus

Kaneko, M., Kisa, F., Yamada, K., Miyamoto, T. & Higuchi, R., 11 1 1999, : : European Journal of Organic Chemistry. 11, p. 3171-3174 4 p.

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

Construction of the single-chain Fv from 196-14 antibody toward ovarian cancer-associated antigen CA125

Hashimoto, Y., Tanigawa, K., Nakashima, M., Sonoda, K., Ueda, T., Watanabe, T. & Imoto, T., 1 1 1999, : : Biological and Pharmaceutical Bulletin. 22, 10, p. 1068-1072 5 p.

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)
63 引用 (Scopus)

Effect of Dioxins on Molecular Chaperones HSP70 and HSP90 in Rat Leydig Cells

Fukuda, A., Kurogi, R., Tasaki, K., Ishida, T., Ishii, Y. & Oguri, K., 1 1 1999, : : Journal of Health Science. 45, 1, 1 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Extended blood half-life of monomethoxypolyethylene glycol-conjugated hen lysozyme is a key parameter controlling immunological tolerogenicity

So, T., Ito, H. O., Hirata, M., Ueda, T. & Imoto, T., 8 11 1999, : : Cellular and Molecular Life Sciences. 55, 8-9, p. 1187-1194 8 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Formation of ginsenoside-protein conjugates

Park, H., Shoyama, Y., Xuan, L. J. & Tanaka, H., 12 1 1999, : : Studies in Plant Science. 6, C, p. 83-86 4 p.

研究成果: ジャーナルへの寄稿記事

Formation of monoclonal antibody against a major ginseng component, ginsenoside Rb1 and its characterization

Tanaka, H., Fukuda, N. & Shoyama, Y., 1 1 1999, : : Cytotechnology. 29, 2, p. 115-120 6 p.

研究成果: ジャーナルへの寄稿記事

56 引用 (Scopus)

High-level expression of uniformly 15N-labeled hen lysozyme in Pichia pastoris and identification of the site in hen lysozyme where phosphate ion binds using NMR measurements

Mine, S., Ueda, T., Hashimoto, Y., Tanaka, Y. & Imoto, T., 4 2 1999, : : FEBS Letters. 448, 1, p. 33-37 5 p.

研究成果: ジャーナルへの寄稿記事

44 引用 (Scopus)

Identification and molecular characterization of novel peroxidase with structural protein-like properties

Morimoto, S., Tateishi, N., Inuyama, M., Taura, F., Tanaka, H. & Shoyama, Y., 9 10 1999, : : Journal of Biological Chemistry. 274, 37, p. 26192-26198 7 p.

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

Inactivation of Escherichia coli DnaA protein by DNA polymerase III and negative regulations for initiation of chromosomal replication

Katayama, T. & Sekimizu, K., 1 1 1999, : : Biochimie. 81, 8-9, p. 835-840 6 p.

研究成果: ジャーナルへの寄稿記事

32 引用 (Scopus)

Induction of molecular chaperones HSP70 and HSP90 in rat liver cytosol by a highly toxic coplanar PCB

Fukuda, A., Ishii, Y., Tasaki, K., Matsusue, K., Ishida, T. & Oguri, K., 1999, : : Fukuoka Acta Medica. 90, 5, p. 259-271 13 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

In vitro binding study of adaptor protein complex (AP-1) to lysosomal targeting motif (LI-motif)

Fujita, H., Saeki, M., Yasunaga, K., Ueda, T., Imoto, T. & Himeno, M., 2 5 1999, : : Biochemical and Biophysical Research Communications. 255, 1, p. 54-58 5 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

Isolation and characterization of novel cold-sensitive dnaA mutants of Escherichia coli

Guo, L., Katayama, T., Seyama, Y., Sekimizu, K. & Miki, T., 7 15 1999, : : FEMS microbiology letters. 176, 2, p. 357-366 10 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)