研究成果 1976 2019

2015
4 引用 (Scopus)

A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo

Ohira, M., Iwasaki, Y., Tanaka, C., Kuroki, M., Matsuo, N., Kitamura, T., Yukuhiro, M., Morimoto, H., Pang, N., Liu, B., Kiyono, T., Amemiya, M., Tanaka, K., Yoshida, K., Sugimoto, N., Ohshima, T. & Fujita, M., 5 19 2015, : : Biochimica et Biophysica Acta - General Subjects. 1850, 9, p. 1676-1684 9 p.

研究成果: ジャーナルへの寄稿記事

Cell growth
Microtubules
Tumors
Cells
Growth
21 引用 (Scopus)

A pore-forming toxin requires a specific residue for its activity in membranes with particular physicochemical properties

Morante, K., Martinez Caaveiro, J. M., Tanaka, K., González-Mañas, J. M. & Tsumoto, K., 4 24 2015, : : Journal of Biological Chemistry. 290, 17, p. 10850-10861 12 p.

研究成果: ジャーナルへの寄稿記事

Membranes
Sea Anemones
Cholesterol
Lipids
Sphingomyelins
7 引用 (Scopus)

Basic and aromatic residues in the C-terminal domain of PriC are involved in ssDNA and SSB binding

Aramaki, T., Abe, Y., Furutani, K., Katayama, T. & Ueda, T., 1 1 2015, : : Journal of Biochemistry. 157, 6, p. 529-537 9 p.

研究成果: ジャーナルへの寄稿記事

Single-Stranded DNA
DNA-Binding Proteins
Protein Binding
Basic Amino Acids
Aromatic Amino Acids
7 引用 (Scopus)

Bioconjugation of Oligodeoxynucleotides Carrying 1,4-Dicarbonyl Groups via Reductive Amination with Lysine Residues

Yang, B., Jinnouchi, A., Usui, K., Katayama, T., Fujii, M., Suemune, H. & Aso, M., 8 19 2015, : : Bioconjugate Chemistry. 26, 8, p. 1830-1838 9 p.

研究成果: ジャーナルへの寄稿記事

Amination
Oligodeoxyribonucleotides
Lysine
Aldehydes
Amines
19 引用 (Scopus)

Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture

Sugimoto, N., Maehara, K., Yoshida, K., Yasukouchi, S., Osano, S., Watanabe, S., Aizawa, M., Yugawa, T., Kiyono, T., Kurumizaka, H., Ohkawa, Y. & Fujita, M., 1 1 2015, : : Nucleic acids research. 43, 12, p. 5898-5911 14 p.

研究成果: ジャーナルへの寄稿記事

Histones
Chromatin
Glutamic Acid
Carrier Proteins
Replication Origin
82 引用 (Scopus)

Crystal structure of the anion exchanger domain of human erythrocyte band 3

Arakawa, T., Kobayashi-Yurugi, T., Alguel, Y., Iwanari, H., Hatae, H., Iwata, M., Abe, Y., Hino, T., Ikeda-Suno, C., Kuma, H., Kang, D., Murata, T., Hamakubo, T., Cameron, A. D., Kobayashi, T., Hamasaki, N. & Iwata, S., 11 6 2015, : : Science. 350, 6261, p. 680-684 5 p.

研究成果: ジャーナルへの寄稿記事

Erythrocyte Anion Exchange Protein 1
Anions
Erythrocytes
Congenital Hemolytic Anemia
Chloride-Bicarbonate Antiporters
78 引用 (Scopus)

Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication

Lori, C., Ozaki, S., Steiner, S., Böhm, R., Abel, S., Dubey, B. N., Schirmer, T., Hiller, S. & Jenal, U., 7 9 2015, : : Nature. 523, 7559, p. 236-239 4 p.

研究成果: ジャーナルへの寄稿記事

Cell Cycle
Chromosomes
Bacteria
Cyclins
Phosphotransferases
6 引用 (Scopus)

Development of a Rapid Immunochromatographic Strip Test for the Detection of Mulberroside A

Inyai, C., Komaikul, J., Kitisripanya, T., Tanaka, H., Sritularak, B. & Putalun, W., 11 1 2015, : : Phytochemical Analysis. 26, 6, p. 423-427 5 p.

研究成果: ジャーナルへの寄稿記事

immunoaffinity chromatography
cosmetics
polyclonal antibodies
testing
sampling
9 引用 (Scopus)

Development of indirect competitive ELISA for quantification of mitragynine in Kratom (Mitragyna speciosa (Roxb.) Korth.)

Limsuwanchote, S., Wungsintaweekul, J., Keawpradub, N., Putalun, W., Morimoto, S. & Tanaka, H., 1 1 2015, : : Forensic Science International. 244, p. 70-77 8 p.

研究成果: ジャーナルへの寄稿記事

Mitragyna
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
Ethyldimethylaminopropyl Carbodiimide
Indole Alkaloids
5 引用 (Scopus)

Dioxin-produced alteration in the profiles of fecal and urinary metabolomes: A change in bile acids and its relevance to toxicity

Kakizuka, S., Takeda, T., Komiya, Y., Koba, A., Hiroshi, U., Yamamoto, M., Furue, M., Ishii, Y. & Yamada, H., 10 1 2015, : : Biological and Pharmaceutical Bulletin. 38, 10, p. 1484-1495 12 p.

研究成果: ジャーナルへの寄稿記事

Dioxins
Metabolome
Bile Acids and Salts
Chenodeoxycholic Acid
Cholic Acid
11 引用 (Scopus)

Discovery and characterization of natural tropolones as inhibitors of the antibacterial target CapF from Staphylococcus aureus

Nakano, K., Chigira, T., Miyafusa, T., Nagatoishi, S., Caaveiro, J. M. M. & Tsumoto, K., 10 16 2015, : : Scientific reports. 5, 15337.

研究成果: ジャーナルへの寄稿記事

公開
Tropolone
Staphylococcus aureus
Polysaccharides
Enzyme Inhibitors
Bacteria
2 引用 (Scopus)

Effect of Cynaropicrin on 2,3,4,7,8-Pentachlorodibenzofuran-induced Wasting Syndrome and Oxidative Stress

Yamada, K. I., Ishii, Y., Takeda, T., Kuroki, H., Mitoma, C., Hiroshi, U., Furue, M. & Yamada, H., 5 1 2015, : : Fukuoka igaku zasshi = Hukuoka acta medica. 106, 5, p. 169-175 7 p.

研究成果: ジャーナルへの寄稿記事

Wasting Syndrome
Oxidative Stress
Cynara scolymus
cynaropicrin
2,3,4,7,8-pentachlorodibenzofuran
6 引用 (Scopus)

Effect of glycyrrhetinic acid on lipid raft model at the air/water interface

Sakamoto, S., Uto, T. & Shoyama, Y., 1 1 2015, : : Biochimica et Biophysica Acta - Biomembranes. 1848, 2, p. 434-443 10 p.

研究成果: ジャーナルへの寄稿記事

Glycyrrhetinic Acid
Air
Glycyrrhizic Acid
Lipids
Water
6 引用 (Scopus)

Effect of in utero exposure to endocrine disruptors on fetal steroidogenesis governed by the pituitary-gonad axis: A study in rats using different ways of administration

Kariyazono, Y., Taura, J., Hattori, Y., Ishii, Y., Narimatsu, S., Fujimura, M., Takeda, T. & Yamada, H., 11 10 2015, : : Journal of Toxicological Sciences. 40, 6, p. 909-916 8 p.

研究成果: ジャーナルへの寄稿レター

Endocrine Disruptors
Gonads
Rats
Luteinizing Hormone
Pituitary Hormones
12 引用 (Scopus)

EGF-stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib-resistant human lung cancer cell line

Nishimura, Y., Takiguchi, S., Ito, S. & Itoh, K., 4 1 2015, : : International journal of oncology. 46, 4, p. 1721-1729 9 p.

研究成果: ジャーナルへの寄稿記事

Sorting Nexins
Recycling
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Lung Neoplasms
5 引用 (Scopus)

Enhanced mulberroside a production from cell suspension and root cultures of morus alba using elicitation

Komaikul, J., Kitisripanya, T., Tanaka, H., Sritularak, B. & Putalun, W., 1 1 2015, : : Natural product communications. 10, 7, p. 1253-1256 4 p.

研究成果: ジャーナルへの寄稿記事

Morus
Morus alba
cell suspension culture
Suspensions
exposure duration
25 引用 (Scopus)

Entamoeba mitosomes play an important role in encystation by association with cholesteryl sulfate synthesis

Mi-ichi, F., Miyamoto, T., Takao, S., Jeelani, G., Hashimoto, T., Hara, H., Nozaki, T. & Yoshida, H., 6 2 2015, : : Proceedings of the National Academy of Sciences of the United States of America. 112, 22, p. E2884-E2890

研究成果: ジャーナルへの寄稿記事

Entamoeba
Sulfates
Mitochondria
Entamoeba histolytica
Organelles
13 引用 (Scopus)

Enzyme-linked immunosorbent assay by enhanced chemiluminescence detection for the standardization of estrogenic miroestrol in Pueraria candollei Graham ex Benth

Yusakul, G., Udomsin, O., Tanaka, H., Morimoto, S., Juengwatanatrakul, T. & Putalun, W., 2015, : : Luminescence. 30, 5, p. 568-575 8 p.

研究成果: ジャーナルへの寄稿記事

Pueraria
Immunosorbents
Chemiluminescence
Luminescence
Standardization
3 引用 (Scopus)

Functional analysis of CedA based on its structure: Residues important in binding of DNA and RNA polymerase and in the cell division regulation

Abe, Y., Fujisaki, N., Miyoshi, T., Watanabe, N., Katayama, T. & Ueda, T., 5 13 2015, : : Journal of biochemistry. 159, 2, p. 217-223 7 p.

研究成果: ジャーナルへの寄稿記事

Functional analysis
DNA-Directed DNA Polymerase
DNA-Directed RNA Polymerases
Cell Division
Cells
13 引用 (Scopus)

Functional characterization of Val60, a key residue involved in the membrane-oligomerization of fragaceatoxin C, an actinoporin from Actinia fragacea

Morante, K., Caaveiro, J. M. M., Viguera, A. R., Tsumoto, K. & González-Mañas, J. M., 2015, : : FEBS Letters. 589, p. 1840-1846 7 p.

研究成果: ジャーナルへの寄稿記事

Actinium
Oligomerization
Sea Anemones
Membranes
Point Mutation

Helicase and its interacting factors: Regulation mechanism, characterization, structure, and application for drug design

Huang, C. Y., Abe, Y., Ding, H. & Chung, I. F., 1 1 2015, : : BioMed Research International. 2015, 909047.

研究成果: ジャーナルへの寄稿編集

50 引用 (Scopus)

Human mincle binds to cholesterol crystals and triggers innate immune responses

Kiyotake, R., Oh-Hora, M., Ishikawa, E., Miyamoto, T., Ishibashi, T. & Yamasaki, S., 10 16 2015, : : Journal of Biological Chemistry. 290, 42, p. 25322-25332 11 p.

研究成果: ジャーナルへの寄稿記事

C-Type Lectins
Innate Immunity
Macrophages
Cholesterol
Crystals
4 引用 (Scopus)

Identification of okadaic acid binding protein 2 in reconstituted sponge cell clusters from Halichondria okadai and its contribution to the detoxification of okadaic acid

Konoki, K., Okada, K., Kohama, M., Matsuura, H., Saito, K., Cho, Y., Nishitani, G., Miyamoto, T., Fukuzawa, S., Tachibana, K. & Yotsu-Yamashita, M., 12 15 2015, : : Toxicon. 108, p. 38-45 8 p.

研究成果: ジャーナルへの寄稿記事

Okadaic Acid
Detoxification
Porifera
Carrier Proteins
Protein Phosphatase 2
23 引用 (Scopus)
Glucans
Innate Immunity
Insects
Peptide Hydrolases
Hemolymph
9 引用 (Scopus)

Intracellular dynamics and fate of a humanized anti-interleukin-6 receptor monoclonal antibody, Tocilizumab

Fujimoto, K., Ida, H., Hirota, Y., Ishigai, M., Amano, J. & Tanaka, Y., 10 1 2015, : : Molecular Pharmacology. 88, 4, p. 660-675 16 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-6 Receptors
Monoclonal Antibodies
Endosomes
Lysosomes
Endocytosis
58 引用 (Scopus)

Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14 signaling pathways

Hirota, Y., Yamashita, S. I., Kurihara, Y., Jin, X., Aihara, M., Saigusa, T., Kang, D. & Kanki, T., 1 1 2015, : : Autophagy. 11, 2, p. 332-343 12 p.

研究成果: ジャーナルへの寄稿記事

Mitogen-Activated Protein Kinase 14
Mitochondrial Degradation
Autophagy
Starvation
Mitochondria
3 引用 (Scopus)

Role of the osmolyte taurine on the folding of a model protein, hen egg white lysozyme, under a crowding condition

Abe, Y., Ohkuri, T., Yoshitomi, S., Murakami, S. & Ueda, T., 5 1 2015, : : Amino Acids. 47, 5, p. 909-915 7 p.

研究成果: ジャーナルへの寄稿記事

Taurine
Muramidase
Proteins
Protein Folding
Alanine
7 引用 (Scopus)

Sappanin-type homoisoflavonoids from Sansevieria trifasciata Prain

Tchegnitegni, B. T., Teponno, R. B., Tanaka, C., Gabriel, A. F., Tapondjou, L. A. & Miyamoto, T., 6 16 2015, : : Phytochemistry Letters. 12, p. 262-266 5 p., 936.

研究成果: ジャーナルへの寄稿記事

Sansevieria
Sansevieria trifasciata
fluorouracil
glycols
Cameroon
2 引用 (Scopus)

Screening of stable G-protein-coupled receptor variants in Saccharomyces cerevisiae

Shiroishi, M. & Kobayashi, T., 1 1 2015, : : Methods in molecular biology (Clifton, N.J.). 1261, p. 159-170 12 p.

研究成果: ジャーナルへの寄稿記事

G-Protein-Coupled Receptors
Saccharomyces cerevisiae
Green Fluorescent Proteins
Membrane Proteins
Saccharomycetales
2 引用 (Scopus)

Short CCG repeat in huntingtin gene is an obstacle for replicative DNA polymerases, potentially hampering progression of replication fork

Le, H. P., Masuda, Y., Tsurimoto, T., Maki, S., Katayama, T., Furukohri, A. & Maki, H., 10 1 2015, : : Genes to Cells. 20, 10, p. 817-833 17 p.

研究成果: ジャーナルへの寄稿記事

Trinucleotide Repeats
DNA-Directed DNA Polymerase
DNA Polymerase III
DNA Replication
Trinucleotide Repeat Expansion
Aldehyde Oxidase
Oxygenases
Esterases
Drug Discovery
Transferases
20 引用 (Scopus)

Simultaneous determination of soy isoflavone glycosides, daidzin and genistin by monoclonal antibody-based highly sensitive indirect competitive enzyme-linked immunosorbent assay

Sakamoto, S., Yusakul, G., Pongkitwitoon, B., Paudel, M. K., Tanaka, H. & Morimoto, S., 2 15 2015, : : Food Chemistry. 169, p. 127-133 7 p.

研究成果: ジャーナルへの寄稿記事

daidzin
genistin
Immunosorbents
Isoflavones
isoflavones
4 引用 (Scopus)

Six New Polyacetylenic Alcohols from the Marine Sponges Petrosia sp. and Halichondria sp.

Gabriel, A. F., Li, Z., Kusuda, R., Tanaka, C. & Miyamoto, T., 6 1 2015, : : Chemical and Pharmaceutical Bulletin. 63, 6, p. 469-475 7 p.

研究成果: ジャーナルへの寄稿記事

Petrosia
Porifera
Alcohols
Stereochemistry
K562 Cells
8 引用 (Scopus)

Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding

Igawa, T., Abe, Y., Makoto, T., Inoue, K. & Ueda, T., 3 12 2015, : : FEBS Letters. 589, 6, p. 680-686 7 p.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Rats
Metals
Head
Cations
8 引用 (Scopus)

Specific binding of eukaryotic ORC to DNA replication origins depends on highly conserved basic residues

Kawakami, H., Ohashi, E., Kanamoto, S., Tsurimoto, T. & Katayama, T., 10 12 2015, : : Scientific reports. 5, 14929.

研究成果: ジャーナルへの寄稿記事

Origin Recognition Complex
Replication Origin
DNA Replication
DNA
Eukaryota
1 引用 (Scopus)

Spirostane-Type Saponins from Dracaena fragrans Yellow Coast

Rezgui, A., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C. & Lacaille-Dubois, M. A., 1 1 2015, : : Natural Product Communications. 10, 1, p. 37-38 2 p.

研究成果: ジャーナルへの寄稿記事

Dracaena
Dracaena fragrans
Saponins
Glycosides
saponins
17 引用 (Scopus)

Sterylglucoside catabolism in cryptococcus neoformans with endoglycoceramidase-related protein 2 (EGCrP2), the first steryl-β-glucosidase identified in fungi

Watanabe, T., Ito, T., Goda, H. M., Ishibashi, Y., Miyamoto, T., Ikeda, K., Taguchi, R., Okino, N. & Ito, M., 9 9 2015, : : Journal of Biological Chemistry. 290, 2, p. 1005-1019 15 p.

研究成果: ジャーナルへの寄稿記事

endoglycoceramidase
Glucosidases
Cryptococcus neoformans
Fungi
Glucosides
28 引用 (Scopus)

Structural analysis of Fc/FcγR complexes: A blueprint for antibody design

Caaveiro, J. M. M., Kiyoshi, M. & Tsumoto, K., 11 2015, : : Immunological Reviews. 268, 1, p. 201-221 21 p.

研究成果: ジャーナルへの寄稿評論記事

Fc Receptors
Antibodies
Immunoglobulin G
Immunoglobulin Fc Fragments
IgG Receptors
14 引用 (Scopus)

Structural and thermodynamic basis of epitope binding by neutralizing and nonneutralizing forms of the anti-HIV-1 antibody 4E10

Rujas, E., Gulzar, N., Morante, K., Tsumoto, K., Scott, J. K., Nieva, J. L. & Caaveiro, J. M. M., 1 1 2015, : : Journal of virology. 89, 23, p. 11975-11989 15 p.

研究成果: ジャーナルへの寄稿記事

公開
Complementarity Determining Regions
HIV Antibodies
Human immunodeficiency virus 1
Thermodynamics
neutralization
54 引用 (Scopus)

Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI

Kiyoshi, M., Caaveiro, J. M. M., Kawai, T., Tashiro, S., Ide, T., Asaoka, Y., Hatayama, K. & Tsumoto, K., 4 30 2015, : : Nature communications. 6, 6866.

研究成果: ジャーナルへの寄稿記事

公開
Fc Receptors
affinity
Immunoglobulin G
Cell Surface Receptors
Adaptive Immunity
88 引用 (Scopus)

Structural basis for self-assembly of a cytolytic pore lined by protein and lipid

Tanaka, K., Caaveiro, J. M. M., Morante, K., González-Manãs, J. M. & Tsumoto, K., 2 25 2015, : : Nature communications. 6, 6337.

研究成果: ジャーナルへの寄稿記事

公開
Porins
Self assembly
lipids
self assembly
proteins
12 引用 (Scopus)
Cytochrome P-450 CYP3A
Glucuronosyltransferase
Proteins
Calnexin
NADPH-Ferrihemoprotein Reductase
15 引用 (Scopus)

The Arg fingers of key DnaA protomers are oriented inward within the replication origin oriC and stimulate DnaA subcomplexes in the initiation complex

Noguchi, Y., Sakiyama, Y., Kawakami, H. & Katayama, T., 8 14 2015, : : Journal of Biological Chemistry. 290, 33, p. 20295-20312 18 p.

研究成果: ジャーナルへの寄稿記事

Replication Origin
Protein Subunits
Fingers
DnaB Helicases
Adenosine Triphosphate
28 引用 (Scopus)

The atomic structure of the HIV-1 gp41 transmembrane domain and its connection to the immunogenic membrane-proximal external region

Apellaniz, B., Rujas, E., Serrano, S., Morante, K., Tsumoto, K., Caaveiro, J. M. M., Jimenez, M. A. & Nieva, J. L., 2015, : : Journal of Biological Chemistry. p. 12999-13015 17 p.

研究成果: ジャーナルへの寄稿記事

HIV-1
Membranes
Fusion reactions
Anchors
Vaccines

The Effect of Maternal Exposure to Dioxins on the Level of Thyroid Hormone in Developing Pups

Hattori, Y., Takeda, T., Taura, J., Kuroki, H., Ishii, Y. & Yamada, H., 5 1 2015, : : Fukuoka igaku zasshi = Hukuoka acta medica. 106, 5, p. 127-134 8 p.

研究成果: ジャーナルへの寄稿記事

Maternal Exposure
Dioxins
Thyroid Hormones
Thyroxine
Thyrotropin
6 引用 (Scopus)
Therapeutic Uses
Neutralizing Antibodies
Monoclonal Antibodies
Middle East Respiratory Syndrome Coronavirus
6 引用 (Scopus)

Triterpene saponins from Eryngium kotschyi

Aslan Erdem, S., Mitaine-Offer, A. C., Miyamoto, T., Kartal, M. & Lacaille-Dubois, M. A., 1 1 2015, : : Phytochemistry. 110, p. 160-165 6 p.

研究成果: ジャーナルへの寄稿記事

Eryngium
Triterpenes
triterpenoid saponins
Saponins
saponins
5 引用 (Scopus)

Two new triterpene saponins from Acanthophyllum laxiusculum

Pertuit, D., Baghery Lotfabad, T., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C. & Lacaille-Dubois, M. A., 5 1 2015, : : Helvetica Chimica Acta. 98, 5, p. 611-617 7 p.

研究成果: ジャーナルへの寄稿記事

Triterpenes
Saponins
esters
Esters
Glycosides
2014
4 引用 (Scopus)

2,3,4,7,8-Pentachlorodibenzofuran is far less potent than 2,3,7,8-tetrachlorodibenzo-p-dioxin in disrupting the pituitary-gonad axis of the rat fetus

Taura, J., Takeda, T., Fujii, M., Hattori, Y., Ishii, Y., Kuroki, H., Tsukimori, K., Hiroshi, U., Furue, M. & Yamada, H., 11 5 2014, : : Toxicology and Applied Pharmacology. 281, 1, p. 48-57 10 p.

研究成果: ジャーナルへの寄稿記事

Gonads
Rats
Fetus
Fetal Development
Dioxins
24 引用 (Scopus)

Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control

Ozaki, S., Schalch-Moser, A., Zumthor, L., Manfredi, P., Ebbensgaard, A., Schirmer, T. & Jenal, U., 11 1 2014, : : Molecular Microbiology. 94, 3, p. 580-594 15 p.

研究成果: ジャーナルへの寄稿記事

Caulobacter crescentus
Cell Cycle Checkpoints
S Phase
Proteins
Peptide Hydrolases