研究成果 1976 2019

2000
13 引用 (Scopus)

Mutant DnaA proteins defective in duplex opening of oriC, the origin of chromosomal DNA replication in Escherichia coli

Takata, M., Guo, L., Katayama, T., Hase, M., Seyama, Y., Miki, T. & Sekimizu, K., 1 31 2000, : : Molecular Microbiology. 35, 2, p. 454-462 9 p.

研究成果: ジャーナルへの寄稿記事

Mutant Proteins
DNA Replication
Escherichia coli
Proteins
Complex Mixtures
10 引用 (Scopus)

Mutant mouse lysozyme carrying a minimal T cell epitope of hen egg lysozyme evokes high autoantibody response

Tsujihata, Y., So, T., Chijiiwa, Y., Hashimoto, Y., Hirata, M., Ueda, T. & Imoto, T., 10 1 2000, : : Journal of Immunology. 165, 7, p. 3606-3611 6 p.

研究成果: ジャーナルへの寄稿記事

T-Lymphocyte Epitopes
Muramidase
Autoantibodies
Egg White
hen egg lysozyme
74 引用 (Scopus)

Octamer transcription factor-1 enhances hepatic nuclear factor-1α- mediated activation of the human UDP glucuronosyltransferase 2B7 promoter

Ishii, Y., Hansen, A. J. & Mackenzie, P. I., 5 22 2000, : : Molecular Pharmacology. 57, 5, p. 940-947 8 p.

研究成果: ジャーナルへの寄稿記事

Octamer Transcription Factor-1
Hepatocyte Nuclear Factor 1
AT Rich Sequence
Genes
human UGT2B7 protein
122 引用 (Scopus)

Polymethoxylated flavones in orange juice are inhibitors of P- glycoprotein but not cytochrome P450 3A4

Takanaga, H., Ohnishi, A., Yamada, S., Matsuo, H., Morimoto, S., Shoyama, Y., Ohtani, H. & Sawada, Y., 4 1 2000, : : Journal of Pharmacology and Experimental Therapeutics. 293, 1, p. 230-236 7 p.

研究成果: ジャーナルへの寄稿記事

Flavones
Cytochrome P-450 CYP3A
Vinblastine
P-Glycoprotein
Caco-2 Cells
32 引用 (Scopus)

Production of monoclonal antibody against a major purgative component, sennoside A, its characterization and ELISA

Morinaga, O., Tanaka, H. & Shoyama, Y., 7 1 2000, : : Analyst. 125, 6, p. 1109-1113 5 p.

研究成果: ジャーナルへの寄稿記事

Cathartics
Immunization
Monoclonal antibodies
Antigens
Isomers
25 引用 (Scopus)

Relationship between local structure and stability in hen egg white lysozyme mutant with alanine substituted for glycine

Masumoto, K., Ueda, T., Motoshima, H. & Imoto, T., 12 1 2000, : : Protein Engineering. 13, 10, p. 691-695 5 p.

研究成果: ジャーナルへの寄稿記事

Egg White
Dihedral angle
Muramidase
Alanine
Glycine
18 引用 (Scopus)

Remarkable thermal stability of doubly intramolecularly cross-linked hen lysozyme

Ueda, T., Masumoto, K., Ishibashi, R., So, T. & Imoto, T., 5 15 2000, : : Protein Engineering. 13, 3, p. 193-196 4 p.

研究成果: ジャーナルへの寄稿記事

Muramidase
Thermodynamic stability
Enzymes
Hot Temperature
Denaturation
54 引用 (Scopus)

Rotundines A-C, three novel sesquiterpene alkaloids from Cyperus rotundus

Jeong, S. J., Miyamoto, T., Inagaki, M., Kim, Y. C. & Higuchi, R., 5 1 2000, : : Journal of Natural Products. 63, 5, p. 673-675 3 p.

研究成果: ジャーナルへの寄稿記事

Cyperus
Cyperus rotundus
Rhizome
Sesquiterpenes
Alkaloids
3 引用 (Scopus)

Sequence analyses of CYP2B genes and catalytic profiles for P450s in Qdj: Sprague-Dawley rats that lack response to the phenobarbital-mediated induction of CYP2B2

Yamada, H., Matsunaga, H., Tsuji, K., Matsumoto, S., Yamamoto, M., Ishii, Y., Omiecinski, C. J. & Oguri, K., 12 7 2000, : : Journal of Pharmacology and Experimental Therapeutics. 295, 3, p. 986-993 8 p.

研究成果: ジャーナルへの寄稿記事

Phenobarbital
Sequence Analysis
Sprague Dawley Rats
Cytochrome P-450 CYP2B1
Exons
16 引用 (Scopus)

Small guanosine triphosphatase Rho/Rho-associated kinase as a novel regulator of intracellular redistribution of lysosomes in invasive tumor cells

Nishimura, Y., Itoh, K., Yoshioka, K., Uehata, M. & Himeno, M., 1 1 2000, : : Cell and tissue research. 301, 3, p. 341-351 11 p.

研究成果: ジャーナルへの寄稿記事

rho-Associated Kinases
Cathepsin D
Guanosine
Lysosomes
Microtubules
30 引用 (Scopus)

Squid nerve sphingomyelin containing an unusual sphingoid base

Ohashi, Y., Tanaka, T., Akashi, S., Morimoto, S., Kishimoto, Y. & Nagai, Y., 7 1 2000, : : Journal of Lipid Research. 41, 7, p. 1118-1124 7 p.

研究成果: ジャーナルへの寄稿記事

Decapodiformes
Sphingomyelins
Starfish
Ions
Mass spectrometry
356 引用 (Scopus)

Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20

Abe, Y., Shodai, T., Muto, T., Mihara, K., Torii, H., Nishikawa, S. I., Endo, T. & Kohda, D., 3 3 2000, : : Cell. 100, 5, p. 551-560 10 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Proteins
Rats
Aldehyde Dehydrogenase
Peptides
Mitochondria
14 引用 (Scopus)

Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl

Ikeda, M., Ishii, Y., Kato, H., Akazawa, D., Hatsumura, M., Ishida, T., Matsusue, K., Yamada, H. & Oguri, K., 8 1 2000, : : Archives of Biochemistry and Biophysics. 380, 1, p. 159-164 6 p.

研究成果: ジャーナルへの寄稿記事

3,4,5,3',4'-pentachlorobiphenyl
Carbonic Anhydrase III
Dioxins
Poisons
Polychlorinated Biphenyls
11 引用 (Scopus)

Survey of solasodine-type glycoalkaloids by western blotting and ELISA using anti-solamargine monoclonal antibody

Putalun, W., Tanaka, H., Yahara, S., Lhieochaiphan, S. & Shoyama, Y., 1 2000, : : Biological and Pharmaceutical Bulletin. 23, 1, p. 72-75 4 p.

研究成果: ジャーナルへの寄稿記事

Glycosides
Solanum
Western Blotting
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
18 引用 (Scopus)

Synthesis and absolute stereochemistry of the acyl moiety of quillajasaponins

Zhu, X., Yu, B., Hui, Y., Higuchi, R., Kusano, T. & Miyamoto, T., 1 29 2000, : : Tetrahedron Letters. 41, 5, p. 717-719 3 p.

研究成果: ジャーナルへの寄稿記事

Immunologic Adjuvants
Stereochemistry
octanoic acid
21 引用 (Scopus)

Thermodynamic consequences of grafting enhanced affinity toward the mutated antigen onto an antibody. The case of anti-lysozyme antibody HyHEL-10

Nishimiya, Y., Tsumoto, K., Shiroishi, M., Yutani, K. & Kumagai, I., 4 28 2000, : : Journal of Biological Chemistry. 275, 17, p. 12813-12820 8 p.

研究成果: ジャーナルへの寄稿記事

Muramidase
Thermodynamics
Anti-Idiotypic Antibodies
Antigens
Antibodies
26 引用 (Scopus)

Two new biologically active triterpene saponins from Acanthophyllum squarrosum

Gaidi, G., Miyamoto, T., Rustaiyan, A., Laurens, V. & Lacaille-Dubois, M. A., 12 10 2000, : : Journal of Natural Products. 63, 11, p. 1497-1502 6 p.

研究成果: ジャーナルへの寄稿記事

Triterpenes
Lymphocytes
Saponins
Assays
Nuclear magnetic resonance
2001
37 引用 (Scopus)

Aggregation and chemical reaction in hen lysozyme caused by heating at pH 6 are depressed by osmolytes, sucrose and trehalose

Ueda, T., Nagata, M. & Imoto, T., 1 1 2001, : : Journal of Biochemistry. 130, 4, p. 491-496 6 p.

研究成果: ジャーナルへの寄稿記事

Trehalose
Muramidase
Heating
Sucrose
Chemical reactions
20 引用 (Scopus)

Arrest of cell division and nucleoid partition by genetic alterations in the sliding clamp of the replicase and in DnaA

Kawakami, H., Iwura, T., Takata, M., Sekimizu, K., Hiraga, S. & Katayama, T., 10 16 2001, : : Molecular Genetics and Genomics. 266, 2, p. 167-179 13 p.

研究成果: ジャーナルへの寄稿記事

Cell Division
DNA Polymerase III
Protein Subunits
Cell Size
Immunoblotting
8 引用 (Scopus)

A single amino acid substitution in a self protein is sufficient to trigger autoantibody response

Tsujihata, Y., So, T., Hashimoto, Y., Ueda, T. & Imoto, T., 11 7 2001, : : Molecular Immunology. 38, 5, p. 375-381 7 p.

研究成果: ジャーナルへの寄稿記事

Amino Acid Substitution
Muramidase
Autoantibodies
Proteins
T-Lymphocytes
53 引用 (Scopus)

Constituents of holothuroidea. 10. Isolation and structure of a biologically active ganglioside molecular species from the sea cucumber Holothuria leucospilota

Yamada, K., Matsubara, R., Kaneko, M., Miyamoto, T. & Higuchi, R., 5 5 2001, : : Chemical and Pharmaceutical Bulletin. 49, 4, p. 447-452 6 p.

研究成果: ジャーナルへの寄稿記事

Holothuria
Sea Cucumbers
Gangliosides
Ceramides
phytosphingosine
30 引用 (Scopus)

Contribution of conformational stability of hen lysozyme to induction of type 2 T-helper immune responses

So, T., Ito, H. O., Hirata, M., Ueda, T. & Imoto, T., 11 26 2001, : : Immunology. 104, 3, p. 259-268 10 p.

研究成果: ジャーナルへの寄稿記事

Muramidase
T-Lymphocytes
Interleukin-4
Proteins
Th2 Cells
122 引用 (Scopus)

Crocin suppresses tumor necrosis factor-α-induced cell death of neuronally differentiated PC-12 cells

Soeda, S., Ochiai, T., Paopong, L., Tanaka, H., Shoyama, Y. & Shimeno, H., 11 2 2001, : : Life Sciences. 69, 24, p. 2887-2898 12 p.

研究成果: ジャーナルへの寄稿記事

Cell death
Cell Death
Tumor Necrosis Factor-alpha
Daunorubicin
Cytochromes c
64 引用 (Scopus)

Differential interaction of equinatoxin II with model membranes in response to lipid composition

Caaveiro, J. M. M., Echabe, I., Gutiérrez-Aguirre, I., Nieva, J. L., Arrondo, J. L. R. & González-Mañas, J. M., 1 1 2001, : : Biophysical Journal. 80, 3, p. 1343-1353 11 p.

研究成果: ジャーナルへの寄稿記事

Unilamellar Liposomes
Sphingomyelins
Phosphatidylcholines
Lipids
Membranes
7 引用 (Scopus)

Direct determination of naturally occurring biologically active compound-serum albumin conjugate by matrix-assisted laser desorption/ionization mass spectrometry

Tanaka, H., Xuan, L. J., Morimoto, S., Shoyama, Y., Isobe, R. & Nojima, K., 1 1 2001, : : Spectroscopy. 15, 1, p. 1-18 18 p.

研究成果: ジャーナルへの寄稿記事

Bovine Serum Albumin
Serum Albumin
Ionization
Mass spectrometry
Desorption
74 引用 (Scopus)

Disease model: LAMP-2 enlightens Danon disease

Saftig, P., Von Figura, K., Tanaka, Y. & Lüllmann-Rauch, R., 1 1 2001, : : Trends in Molecular Medicine. 7, 1, p. 37-39 3 p.

研究成果: ジャーナルへの寄稿評論記事

Lysosomal-Associated Membrane Protein 2
Glycogen Storage Disease Type IIb
Protein Deficiency
Autophagy
Muscular Diseases
1 引用 (Scopus)

Distribution of Solasodine glycosides in solanum khasianum fruiting stage determined by ELISA and western blotting

Putalun, W., Tanaka, H., Ikenaka, T. & Shoyama, Y., 1 1 2001, : : Natural Medicines. 55, 5, p. 243-246 4 p.

研究成果: ジャーナルへの寄稿記事

Solanum
Glycosides
Fruits
Western Blotting
Enzyme-Linked Immunosorbent Assay
4 引用 (Scopus)

DnaA protein Lys-415 is close to the ATP-binding site: ATP-pyridoxal affinity labeling

Kubota, T., Ito, Y., Sekimizu, K., Tagaya, M. & Katayama, T., 11 16 2001, : : Biochemical and Biophysical Research Communications. 288, 5, p. 1141-1148 8 p.

研究成果: ジャーナルへの寄稿記事

Pyridoxal
Labeling
Adenosine Triphosphate
Binding Sites
Proteins
29 引用 (Scopus)

DNA replication-coupled inactivation of DnaA protein in vitro: A role for DnaA arginine-334 of the AAA+ Box VIII motif in ATP hydrolysis

Su'Etsugu, M., Kawakami, H., Kurokawa, K., Kubota, T., Takata, M. & Katayama, T., 5 12 2001, : : Molecular Microbiology. 40, 2, p. 376-386 11 p.

研究成果: ジャーナルへの寄稿記事

DNA Replication
Arginine
Hydrolysis
Adenosine Triphosphate
Proteins
24 引用 (Scopus)

Double staining of ginsenosides by western blotting using anti-ginsenoside Rb1 and Rg1 monoclonal antibodies

Fukuda, N., Tanaka, H. & Shoyama, Y., 11 21 2001, : : Biological and Pharmaceutical Bulletin. 24, 10, p. 1157-1160 4 p.

研究成果: ジャーナルへの寄稿記事

Ginsenosides
Western Blotting
Monoclonal Antibodies
Staining and Labeling
Bovine Serum Albumin
8 引用 (Scopus)

Effects of a highly toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl on intermediary metabolism: reduced triose phosphate content in rat liver cytosol.

Ishii, Y., Kato, H., Hatsumura, M., Ishida, T., Ariyoshi, N., Yamada, H. & Oguri, K., 1 1 2001, : : Fukuoka igaku zasshi = Hukuoka acta medica. 92, 5, p. 190-200 11 p.

研究成果: ジャーナルへの寄稿記事

3,4,5,3',4'-pentachlorobiphenyl
Trioses
Alcohol Dehydrogenase
Poisons
Polychlorinated Biphenyls
1 引用 (Scopus)

Effects of ethanol extract of Crocus sativus L. and its components on learning behavior and long-term potentiation

Saito, H., Sugiura, M., Abe, K., Tanaka, H., Morimoto, S., Taura, F. & Shoyama, Y., 12 1 2001, : : Studies in Natural Products Chemistry. 25, PART F, p. 955-969 15 p.

研究成果: ジャーナルへの寄稿記事

Long-Term Potentiation
Ethanol
Learning
Glucose
Neurology
49 引用 (Scopus)

Electron emission properties of carbon nanotubes

Hirakawa, M., Sonoda, S., Tanaka, C., Murakami, H. & Yamakawa, H., 1 15 2001, : : Applied Surface Science. 169, 170, p. 662-665 4 p.

研究成果: ジャーナルへの寄稿記事

Carbon Nanotubes
Electron emission
Carbon nanotubes
Quartz
Gases
64 引用 (Scopus)

Endogenous cannabinoid, 2-arachidonoylglycerol, attenuates naloxone-precipitated withdrawal signs in morphine-dependent mice

Yamaguchi, T., Hagiwara, Y., Tanaka, H., Sugiura, T., Waku, K., Shoyama, Y., Watanabe, S. & Yamamoto, T., 8 3 2001, : : Brain Research. 909, 1-2, p. 121-126 6 p.

研究成果: ジャーナルへの寄稿記事

Cannabinoids
Naloxone
Morphine
Dronabinol
Cannabinoid Receptor Agonists
81 引用 (Scopus)

Enzyme-linked immunosorbent assay for glycyrrhizin using anti-glycyrrhizin monoclonal antibody and an eastern blotting technique for glucuronides of glycyrrhetic acid

Shan, S., Tanaka, H. & Shoyama, Y., 12 15 2001, : : Analytical Chemistry. 73, 24, p. 5784-5790 7 p.

研究成果: ジャーナルへの寄稿記事

Glycyrrhetinic Acid
Glycyrrhizic Acid
Immunosorbents
Glucuronides
Assays
9 引用 (Scopus)

Evidence for an initiation site for hen lysozyme folding from the reduced form using its dissected peptide fragments

Ohkuri, T., Ueda, T., Tsurumaru, M. & Imoto, T., 12 1 2001, : : Protein Engineering. 14, 11, p. 829-833 5 p.

研究成果: ジャーナルへの寄稿記事

Peptide Fragments
Muramidase
Homoserine
Peptides
Enzymes
65 引用 (Scopus)

Feedback controls restrain the initiation of Escherichia coli chromosomal replication

Katayama, T., 7 30 2001, : : Molecular Microbiology. 41, 1, p. 9-17 9 p.

研究成果: ジャーナルへの寄稿小調査

Escherichia coli
DNA
DNA Polymerase III
Proteins
Replication Origin
195 引用 (Scopus)

Hda, a novel DnaA-related protein, regulates the replication cycle in Escherichia coli

Kato, J. I. & Katayama, T., 8 1 2001, : : EMBO Journal. 20, 15, p. 4253-4262 10 p.

研究成果: ジャーナルへの寄稿記事

Escherichia coli
DNA Polymerase III
Replication Origin
Bacterial Proteins
Clamping devices
20 引用 (Scopus)

Isolation and structures of two new compounds from the essential oil of Brazilian propolis

Kusumoto, T., Miyamoto, T., Higuchi, R., Doi, S., Sugimoto, H. & Yamada, H., 9 26 2001, : : Chemical and Pharmaceutical Bulletin. 49, 9, p. 1207-1209 3 p.

研究成果: ジャーナルへの寄稿記事

Propolis
Aromatic compounds
Terpenes
Volatile Oils
2,6-diprenyl-4-vinylphenol
19 引用 (Scopus)

Junceosides A-C, new triterpene saponins from Arenaria juncea

Gaidi, G., Miyamoto, T. & Lacaille-Dubois, M. A., 12 1 2001, : : Journal of Natural Products. 64, 12, p. 1533-1537 5 p.

研究成果: ジャーナルへの寄稿記事

Triterpenes
Saponins
Biomolecular Nuclear Magnetic Resonance
Nuclear magnetic resonance
junceoside A
33 引用 (Scopus)

Morphine metabolism in the opium poppy and its possible physiological function. Biochemical characterization of the morphine metabolite, bismorphine

Morimoto, S., Suemori, K., Moriwaki, J., Taura, F., Tanaka, H., Aso, M., Tanaka, M., Suemune, H., Shimohigashi, Y. & Shoyama, Y., 10 12 2001, : : Journal of Biological Chemistry. 276, 41, p. 38179-38184 6 p.

研究成果: ジャーナルへの寄稿記事

Papaver
Opium
Pectins
Metabolites
Metabolism
30 引用 (Scopus)

Multiple pathways regulating DnaA function in Escherichia coli: Distinct roles for DnaA titration by the datA locus and the regulatory inactivation of DnaA

Katayama, T., Fujimitsu, K. & Ogawa, T., 1 1 2001, : : Biochimie. 83, 1, p. 13-17 5 p.

研究成果: ジャーナルへの寄稿記事

Titration
Escherichia coli
Adenosine Triphosphate
DNA Polymerase III
Holoenzymes
74 引用 (Scopus)

NMR identification of the Tom20 binding segment in mitochondrial presequences

Muto, T., Obita, T., Abe, Y., Shodai, T., Endo, T. & Kohda, D., 2 16 2001, : : Journal of Molecular Biology. 306, 2, p. 137-143 7 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Proteins
Spin Labels
Peptides
Cytosol
Amino Acid Sequence
37 引用 (Scopus)

Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis

Miyamoto, T., Kodama, K., Aramaki, Y., Higuchi, R. & Van Soest, R. W. M., 9 3 2001, : : Tetrahedron Letters. 42, 36, p. 6349-6351 3 p.

研究成果: ジャーナルへの寄稿記事

Porifera
Sterols
Leukemia
Apoptosis
Spectroscopic analysis
28 引用 (Scopus)

Production of monoclonal antibodies against a major purgative component, sennoside B, their characterization and use in ELISA

Morinaga, O., Nakajima, S., Tanaka, H. & Shoyama, Y., 8 25 2001, : : Analyst. 126, 8, p. 1372-1376 5 p.

研究成果: ジャーナルへの寄稿記事

Cathartics
Immunization
Monoclonal antibodies
immunization
Antigens
4 引用 (Scopus)

Role of the dioxin-like toxic compound coplanar polychlorinated biphenyl,3,3′,4,4′,5-pentachlorobiphenyl in reducing hepatic alcohol dehydrogenase levels in rats in vivo

Ishii, Y., Kato, H., Hatsumura, M., Ishida, T., Ariyoshi, N., Yamada, H. & Oguri, K., 12 21 2001, : : Journal of Health Science. 47, 6, p. 575-578 4 p.

研究成果: ジャーナルへの寄稿記事

Dioxins
Alcohol Dehydrogenase
Poisons
Polychlorinated Biphenyls
Rats
56 引用 (Scopus)

Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation

Ishii, Y., Miyoshi, A., Watanabe, R., Tsuruda, K., Tsuda, M., Yamaguchi-Nagamatsu, Y., Yoshisue, K., Tanaka, M., Maji, D., Ohgiya, S. & Oguri, K., 1 1 2001, : : Molecular Pharmacology. 60, 5, p. 1040-1048 9 p.

研究成果: ジャーナルへの寄稿記事

COS Cells
Guinea Pigs
Glucuronosyltransferase
Morphine
Complementary DNA
44 引用 (Scopus)

Stabilization of hen egg white lysozyme by a cavity-filling mutation

Ohmura, T., Ueda, T., Ootsuka, K., Saito, M. & Imoto, T., 3 31 2001, : : Protein Science. 10, 2, p. 313-320 8 p.

研究成果: ジャーナルへの寄稿記事

Egg White
Muramidase
Stabilization
Mutation
Proteins
27 引用 (Scopus)

Structural evidence for entropic contribution of salt bridge formation to a protein antigen-antibody interaction. The case of hen lysozyme-HyHEL-10 Fv complex

Shiroishi, M., Yokota, A., Tsumoto, K., Kondo, H., Nishimiya, Y., Horii, K., Matsushima, M., Ogasahara, K., Yutani, K. & Kumagai, I., 6 22 2001, : : Journal of Biological Chemistry. 276, 25, p. 23042-23050 9 p.

研究成果: ジャーナルへの寄稿記事

Egg White
Muramidase
Salts
Antigens
Antibodies
19 引用 (Scopus)

Structure of a novel multidrug resistance modulator, irciniasulfonic acid, isolated from a marine sponge, Ircinia sp.

Kawakami, A., Miyamoto, T., Higuchi, R., Uchiumi, T., Kuwano, M. & Van Soest, R. W. M., 5 7 2001, : : Tetrahedron Letters. 42, 19, p. 3335-3337 3 p.

研究成果: ジャーナルへの寄稿記事

Porifera
Multiple Drug Resistance
Modulators
Acids
Isethionic Acid