研究成果

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Article
1991

Studies on Pharmacoepidemiology of Antiepileptic Adverse Reactions (2)

Hirata, K., Ieiri, I., Kajiwara, M., Kuroda, T., Kojima, K., Ikeda, M., Higuchi, S., Yamada, H. & Aoyama, T., 6 1991, : : Psychiatry and clinical neurosciences. 45, 2, p. 464-467 4 p.

研究成果: Contribution to journalArticle

1 引用 (Scopus)
1992

Pharmacoepidemiological Study on Adverse Reactions of Antiepileptic Drugs

Ieiri, I., Higuchi, S., Toshinobu, A., Hirata, K., Kojima, K. & Ikeda, M., 1992, : : Chemical and Pharmaceutical Bulletin. 40, 5, p. 1280-1288 9 p.

研究成果: Contribution to journalArticle

14 引用 (Scopus)
1996

Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney

Salto, H., Masuda, S. & Inui, K. I., 9 5 1996, : : Journal of Biological Chemistry. 271, 34, p. 20719-20725 7 p.

研究成果: Contribution to journalArticle

187 引用 (Scopus)
1997

mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules

Masuda, S., Saito, H., Nonoguchi, H., Tomita, K. & Inui, K. I., 4 28 1997, : : FEBS Letters. 407, 2, p. 127-131 5 p.

研究成果: Contribution to journalArticle

88 引用 (Scopus)

Stereoselective 4'-hydroxylation of phenytoin: Relationship to (S)-mephenytoin polymorphism in Japanese

Ieiri, I., Mamiya, K., Urae, A., Wada, Y., Kimura, M., Irie, S., Amamoto, T., Kubota, T., Yoshioka, S., Nakamura, K., Nakano, S., Tashiro, N. & Higuchi, S., 1997, : : British journal of clinical pharmacology. 43, 4, p. 441-445 5 p.

研究成果: Contribution to journalArticle

28 引用 (Scopus)
1998

Association of polymorphisms in the cytochrome P450 (CYP) 2C19 and 2C18 genes in Japanese epileptic patients

Mamiya, K., Ieiri, I., Miyahara, S., Imai, J., Furuumi, H., Fukumaki, Y., Ninomiya, H., Tashiro, N., Yamada, H. & Higuchi, S., 1998, : : Pharmacogenetics. 8, 1, p. 87-90 4 p.

研究成果: Contribution to journalArticle

11 引用 (Scopus)

Pharmacogenetics of CYP2C subfamily in a Japanese population

Ieiri, I. & Higuchi, S., 7 1998, : : Journal of Toxicological Sciences. 23, SUPPL. 2, p. 129-131 3 p.

研究成果: Contribution to journalArticle

公開
1999

Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney

Masuda, S., Ibaramoto, K., Takeuchi, A., Saito, H., Hashimoto, Y. & Inui, K. I., 4 19 1999, : : Molecular Pharmacology. 55, 4, p. 743-752 10 p.

研究成果: Contribution to journalArticle

127 引用 (Scopus)

Functional analysis of rat renal organic anion transporter OAT-K1: Bidirectional methotrexate transport in apical membrane

Masuda, S., Takeuchi, A., Saito, H., Hashimoto, Y. & Inui, K. I., 10 1 1999, : : FEBS Letters. 459, 1, p. 128-132 5 p.

研究成果: Contribution to journalArticle

35 引用 (Scopus)

Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping: Possible effect of age, liver disease and length of therapy

Kimura, M., Ieiri, I., Wada, Y., Mamiya, K., Urae, A., Iimori, E., Sakai, T., Otsubo, K. & Higuchi, S., 1999, : : British journal of clinical pharmacology. 47, 1, p. 115-119 5 p.

研究成果: Contribution to journalArticle

37 引用 (Scopus)
2000

Cellular and molecular aspects of drug transport in the kidney

Inui, K., Masuda, S. & Saito, H., 1 1 2000, : : Kidney International. 58, 3, p. 944-958 15 p.

研究成果: Contribution to journalArticle

371 引用 (Scopus)

CYP2C19 polymorphism effect on phenobarbitone. Pharmacokineties in Japanese patients with epilepsy: Analysis by population pharmacokinetics

Mamiya, K., Hadama, A., Yukawa, E., Ieiri, I., Otsubo, K., Ninomiya, H., Tashiro, N. & Higuchi, S., 2000, : : European Journal of Clinical Pharmacology. 55, 11-12, p. 821-825 5 p.

研究成果: Contribution to journalArticle

58 引用 (Scopus)

Differential localization of organic cation transporters rOCT1 and rOCT2 in the basolateral membrane of rat kidney proximal tubules

Sugawara-Yokoo, M., Urakami, Y., Koyama, H., Fujikura, K., Masuda, S., Saito, H., Naruse, T., Inui, K. I. & Takata, K., 2000, : : Histochemistry and Cell Biology. 114, 3, p. 175-180 6 p.

研究成果: Contribution to journalArticle

68 引用 (Scopus)

Effect of intestinal P-glycoprotein on daily tacrolimus trough level in a living-donor small bowel recipient

Masuda, S., Uemoto, S., Hashida, T., Inomata, Y., Tanaka, K. & Inui, K. I., 2000, : : Clinical Pharmacology and Therapeutics. 68, 1, p. 98-103 6 p.

研究成果: Contribution to journalArticle

100 引用 (Scopus)

Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2

Inui, K. I., Terada, T., Masuda, S. & Saito, H., 2000, : : Nephrology Dialysis Transplantation. 15, SUPPL. 6, p. 11-13 3 p.

研究成果: Contribution to journalArticle

公開
57 引用 (Scopus)

Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: Genetic analysis of the CYP2C9 locus

Imai, J., Ieiri, I., Mamiya, K., Miyahara, S., Furuumi, H., Nanba, E., Yamane, M., Fukumaki, Y., Ninomiya, H., Tashiro, N., Otsubo, K. & Higuchi, S., 2000, : : Pharmacogenetics. 10, 1, p. 85-89 5 p.

研究成果: Contribution to journalArticle

131 引用 (Scopus)

Trans-stimulation effects of folic acid derivatives on methotrexate transport by rat renal organic anion transporter, OAT-K1

Takeuchi, A., Masuda, S., Saito, H., Hashimoto, Y. & Inui, K. I., 6 1 2000, : : Journal of Pharmacology and Experimental Therapeutics. 293, 3, p. 1034-1039 6 p.

研究成果: Contribution to journalArticle

18 引用 (Scopus)
2001

Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules

Urakami, Y., Okuda, M., Masuda, S., Akazawa, M., Saito, H. & Inui, K. I., 11 12 2001, : : Pharmaceutical Research. 18, 11, p. 1528-1534 7 p.

研究成果: Contribution to journalArticle

54 引用 (Scopus)

Expression of peptide transporter following intestinal transplantation in the rat

Motohashi, H., Masuda, S., Katsura, T., Saito, H., Sakamoto, S., Uemoto, S., Tanaka, K. & Inui, K. I., 2001, : : Journal of Surgical Research. 99, 2, p. 294-300 7 p.

研究成果: Contribution to journalArticle

13 引用 (Scopus)

Genetic polymorphisms and functional characterization of the 5′-flanking region of the human CYP2C9 gene: In vitro and in vivo studies

Shintani, M., Ieiri, I., Inoue, K., Mamiya, K., Ninomiya, H., Tashiro, N., Higuchi, S. & Otsubo, K., 9 3 2001, : : Clinical Pharmacology and Therapeutics. 70, 2, p. 175-182 8 p.

研究成果: Contribution to journalArticle

85 引用 (Scopus)

Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2

Takeuchi, A., Masuda, S., Saito, H., Abe, T. & Inui, K. I., 2001, : : Journal of Pharmacology and Experimental Therapeutics. 299, 1, p. 261-267 7 p.

研究成果: Contribution to journalArticle

39 引用 (Scopus)

Pharmacokinetic and prognostic significance of intestinal MDR1 expression in recipients of living-donor liver transplantation

Hashida, T., Masuda, S., Uemoto, S., Saito, H., Tanaka, K. & Inui, K. I., 5 2001, : : Clinical Pharmacology and Therapeutics. 69, 5, p. 308-316 9 p.

研究成果: Contribution to journalArticle

111 引用 (Scopus)

Phenytoin intoxication induced by fluvoxamine

Mamiya, K., Kojima, K., Yukawa, E., Higuchi, S., Ieiri, I., Ninomiya, H. & Tashiro, N., 2001, : : Therapeutic drug monitoring. 23, 1, p. 75-77 3 p.

研究成果: Contribution to journalArticle

28 引用 (Scopus)

P-hydroxylation of phenobarbital: Relationship to (s)-mephenytoin hydroxylation (CYP2C19) polymorphism

Hadama, A., Ieiri, I., Morita, T., Kimura, M., Urae, A., Irie, S., Kaneda, T., Mamiya, K., Tashiro, N., Higuchi, S. & Otsubo, K., 4 5 2001, : : Therapeutic drug monitoring. 23, 2, p. 115-118 4 p.

研究成果: Contribution to journalArticle

28 引用 (Scopus)

Role of kidney-specific organic anion transporters in the urinary excretion of methotrexate

Takeuchi, A., Masuda, S., Saito, H., Doi, T. & Inui, K. I., 1 1 2001, : : Kidney International. 60, 3, p. 1058-1068 11 p.

研究成果: Contribution to journalArticle

33 引用 (Scopus)

Upregulation of H+-peptide cotransporter PEPT2 in rat remnant kidney

Takahashi, K., Masuda, S., Nakamura, N., Saito, H., Futami, T., Doi, T. & Inui, K. I., 2001, : : American Journal of Physiology - Renal Physiology. 281, 6 50-6, p. F1109-F1116

研究成果: Contribution to journalArticle

33 引用 (Scopus)
2002

C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation

Goto, M., Masuda, S., Saito, H., Uemoto, S., Kiuchi, T., Tanaka, K. & Inui, K. I., 8 2002, : : Pharmacogenetics. 12, 6, p. 451-457 7 p.

研究成果: Contribution to journalArticle

176 引用 (Scopus)

Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy

Ji, L., Masuda, S., Saito, H. & Inui, K. I., 2002, : : Kidney International. 62, 2, p. 514-524 11 p.

研究成果: Contribution to journalArticle

109 引用 (Scopus)

Organic anion transporter oatp2-mediated interaction between digoxin and amiodarone in the rat liver

Kodawara, T., Masuda, S., Wakasugi, H., Uwai, Y., Futami, T., Saito, H., Abe, T. & Inui, K. I., 1 1 2002, : : Pharmaceutical Research. 19, 6, p. 738-743 6 p.

研究成果: Contribution to journalArticle

48 引用 (Scopus)

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein

Kurata, Y., Ieiri, I., Kimura, M., Morita, T., Irie, S., Urae, A., Ohdo, S., Ohtani, H., Sawada, Y., Higuchi, S. & Otsubo, K., 8 1 2002, : : Clinical Pharmacology and Therapeutics. 72, 2, p. 209-219 11 p.

研究成果: Contribution to journalArticle

251 引用 (Scopus)

Roles of the jejunum and ileum in the first-pass effect as absorptive barriers for orally administered tacrolimus

Shimomura, M., Masuda, S., Saito, H., Sakamoto, S., Uemoto, S., Tanaka, K. & Inui, K. I., 2002, : : Journal of Surgical Research. 103, 2, p. 215-222 8 p.

研究成果: Contribution to journalArticle

37 引用 (Scopus)
2003

Cloning and characterization of a novel Na+-dependent glucose transporter (NaGLT1) in rat kidney

Horiba, N., Masuda, S., Takeuchi, A., Takeuchi, D., Okuda, M. & Inui, K. I., 4 25 2003, : : Journal of Biological Chemistry. 278, 17, p. 14669-14676 8 p.

研究成果: Contribution to journalArticle

38 引用 (Scopus)

Decreased expression of P-glycoprotein during differentiation in the human intestinal cell line Caco-2

Goto, M., Masuda, S., Saito, H. & Inui, K. I., 7 1 2003, : : Biochemical Pharmacology. 66, 1, p. 163-170 8 p.

研究成果: Contribution to journalArticle

34 引用 (Scopus)

Enhanced expression of enterocyte P-glycoprotein depresses cyclosporine bioavailability in a recipient of living donor liver transplantation

Masuda, S., Goto, M., Kiuchi, T., Uemoto, S., Kodawara, T., Saito, H., Tanaka, K. & Inui, K. I., 10 2003, : : Liver Transplantation. 9, 10, p. 1108-1113 6 p.

研究成果: Contribution to journalArticle

25 引用 (Scopus)

Formation of highly analgesic morphine-6-glucuronide following physiologic concentration of morphine in human brain

Yamada, H., Ishii, K., Ishii, Y., Ieiri, I., Nishio, S., Morioka, T. & Oguri, K., 12 2003, : : Journal of Toxicological Sciences. 28, 5, p. 395-401 7 p.

研究成果: Contribution to journalArticle

39 引用 (Scopus)

Na+-dependent fructose transport via rNaGLT1 in rat kidney

Horiba, N., Masuda, S., Ohnishi, C., Takeuchi, D., Okuda, M. & Inui, K. I., 7 10 2003, : : FEBS Letters. 546, 2-3, p. 276-280 5 p.

研究成果: Contribution to journalArticle

16 引用 (Scopus)

Polymorphisms of Two Anion Transporters (OATP-C and MRP2) Genes - Consequences for Pravastatin Pharmacokinetics

Ieiri, I., Otsubo, K., Kusuhara, H., Suzuki, H., Sugiyama, Y., Higuchi, S., Kimura, M., Irie, S., Urae, A. & Kawabata, K., 2003, : : Japanese Pharmacology and Therapeutics. 31, SUPPL. 1, p. S95-S100+S107

研究成果: Contribution to journalArticle

2004

Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients

Uwai, Y., Masuda, S., Goto, M., Motohashi, H., Saito, H., Okuda, M., Nakamura, E., Ito, N., Ogawa, O. & Inui, K. I., 2 19 2004, : : Journal of Human Genetics. 49, 1, p. 40-45 6 p.

研究成果: Contribution to journalArticle

28 引用 (Scopus)

CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation

Goto, M., Masuda, S., Kiuchi, T., Ogura, Y., Oike, F., Okuda, M., Tanaka, K. & Inui, K. I., 7 2004, : : Pharmacogenetics. 14, 7, p. 471-478 8 p.

研究成果: Contribution to journalArticle

163 引用 (Scopus)

Decreased expression of glucose and peptide transporters in rat remnant kidney.

Nakamura, N., Masuda, S., Takahashi, K., Saito, H., Okuda, M. & Inui, K. I., 2 2004, : : Drug metabolism and pharmacokinetics. 19, 1, p. 41-47 7 p.

研究成果: Contribution to journalArticle

22 引用 (Scopus)

Expression Levels of Renal Organic Anion Transporters (OATs) and Their Correlation with Anionic Drug Excretion in Patients with Renal Diseases

Sakurai, Y., Motohashi, H., Ueo, H., Masuda, S., Saito, H., Okuda, M., Mori, N., Matsuura, M., Doi, T., Fukatsu, A., Ogawa, O. & Inui, K. I., 1 1 2004, : : Pharmaceutical Research. 21, 1, p. 61-67 7 p.

研究成果: Contribution to journalArticle

75 引用 (Scopus)

Functional analysis of SNPs variants of BCRP/ABCG2

Kondo, C., Suzuki, H., Itoda, M., Ozawa, S., Sawada, J. I., Kobayashi, D., Ieiri, I., Mine, K., Ohtsubo, K. & Sugiyama, Y., 10 2004, : : Pharmaceutical Research. 21, 10, p. 1895-1903 9 p.

研究成果: Contribution to journalArticle

214 引用 (Scopus)

Gene expression variance based on random sequencing in rat remnant kidney

Horiba, N., Masuda, S., Takeuchi, A., Saito, H., Okuda, M. & Inui, K. I., 7 2004, : : Kidney International. 66, 1, p. 29-45 17 p.

研究成果: Contribution to journalArticle

12 引用 (Scopus)

Influence of common variants in the pharmacokinetic genes (OATP-C, UGT1A1, and MRP2) on serum bilirubin levels in healthy subjects

Ieiri, I., Suzuki, H., Kimura, M., Takane, H., Nishizato, Y., Irie, S., Urae, A., Kawabata, K., Higuchi, S., Otsubo, K. & Sugiyama, Y., 2004, : : Hepatology Research. 30, 2, p. 91-95 5 p.

研究成果: Contribution to journalArticle

50 引用 (Scopus)

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

Mikkaichi, T., Suzuki, T., Onogawa, T., Tanemoto, M., Mizutamari, H., Okada, M., Chaki, T., Masuda, S., Tokui, T., Eto, N., Abe, M., Satoh, F., Unno, M., Hishinuma, T., Inui, K. I., Ito, S., Goto, J. & Abe, T., 3 9 2004, : : Proceedings of the National Academy of Sciences of the United States of America. 101, 10, p. 3569-3574 6 p.

研究成果: Contribution to journalArticle

233 引用 (Scopus)

Tacrolimus therapy according to mucosal MDR1 levels in small-bowel transplant recipients

Masuda, S., Uemoto, S., Goto, M., Fujimoto, Y., Tanaka, K. & Inui, K. I., 4 2004, : : Clinical Pharmacology and Therapeutics. 75, 4, p. 352-361 10 p.

研究成果: Contribution to journalArticle

33 引用 (Scopus)
2005

Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice

Egashira, N., Iwasaki, K., Takashima, A., Watanabe, T., Kawabe, H., Matsuda, T., Mishima, K., Chidori, S., Nishimura, R. & Fujiwara, M., 10 12 2005, : : Brain Research. 1059, 1, p. 7-12 6 p.

研究成果: Contribution to journalArticle

35 引用 (Scopus)

Association between tubular toxicity of cisplatin and expression of organic cation transporter rOCT2 (Slc22a2) in the rat

Yonezawa, A., Masuda, S., Nishihara, K., Yano, I., Katsura, T. & Inui, K. I., 12 5 2005, : : Biochemical Pharmacology. 70, 12, p. 1823-1831 9 p.

研究成果: Contribution to journalArticle

123 引用 (Scopus)

Distinct inhibitory effects of tacrolimus and cyclosporin A on calcineurin phosphatase activity

Fukudo, M., Yano, I., Masuda, S., Okuda, M. & Inui, K. I., 2 1 2005, : : Journal of Pharmacology and Experimental Therapeutics. 312, 2, p. 816-825 10 p.

研究成果: Contribution to journalArticle

34 引用 (Scopus)

Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats

Hatip-Al-Khatib, I., Iwasaki, K., Yoshimitsu, Y., Arai, T., Egashira, N., Mishima, K., Ikeda, T. & Fujiwara, M., 2005, : : British Journal of Pharmacology. 145, 8, p. 1035-1044 10 p.

研究成果: Contribution to journalArticle

14 引用 (Scopus)