附属トランスオミクス医学研究センター

研究成果

記事

Inter-laboratory comparison of metabolite measurements for metabolomics data integration

Izumi, Y., Matsuda, F., Hirayama, A., Ikeda, K., Kita, Y., Horie, K., Saigusa, D., Saito, K., Sawada, Y., Nakanishi, H., Okahashi, N., Takahashi, M., Nakao, M., Hata, K., Hoshi, Y., Morihara, M., Tanabe, K., Bamba, T. & Oda, Y., 11 2019, : : Metabolites. 9, 11, 257.

研究成果: ジャーナルへの寄稿記事

公開

Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation

Matsumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nutt, S. L., Sakaguchi, S., Takeda, K., Kurosaki, T. & Baba, Y., 12 18 2014, : : Immunity. 41, 6, p. 1040-1051 12 p.

研究成果: ジャーナルへの寄稿記事

207 引用 (Scopus)

Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity

Nagata, M., Izumi, Y., Ishikawa, E., Kiyotake, R., Doi, R., Iwai, S., Omahdi, Z., Yamaji, T., Miyamoto, T., Bamba, T. & Yamasaki, S., 4 18 2017, : : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. E3285-E3294

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

Intronic variant in IQGAP3 associated with hereditary neuropathy with proximal lower dominancy, urinary disturbance, and paroxysmal dry cough

Miura, S., Kosaka, K., Shimojo, T., Matsuura, E., Noda, K., Fujioka, R., Mori, S. I., Umehara, F., Iwaki, T., Yamamoto, K., Saitsu, H. & Shibata, H., 1 1 2020, (受理済み/印刷中) : : Journal of Human Genetics.

研究成果: ジャーナルへの寄稿記事

In vitro steroid profiling system for the evaluation of endocrine disruptors

Nakano, Y., Yamashita, T., Okuno, M., Fukusaki, E. & Bamba, T., 9 1 2016, : : Journal of Bioscience and Bioengineering. 122, 3, p. 370-377 8 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

Kubota, H., Uda, S., Matsuzaki, F., Yamauchi, Y. & Kuroda, S., 7 25 2018, : : Cell Systems. 7, 1, p. 118-128.e3

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Isolation and characterization of Fetal Leydig progenitor cells of male mice

Inoue, M., Shima, Y., Miyabayashi, K., Tokunaga, K., Sato, T., Baba, T., Ohkawa, Y., Akiyama, H., Suyama, M. & Morohashi, K. I., 3 2016, : : Endocrinology. 157, 3, p. 1222-1233 12 p.

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)

JPOSTrepo: An international standard data repository for proteomes

Okuda, S., Watanabe, Y., Moriya, Y., Kawano, S., Yamamoto, T., Matsumoto, M., Takami, T., Kobayashi, D., Araki, N., Yoshizawa, A. C., Tabata, T., Sugiyama, N., Goto, S. & Ishihama, Y., 1 1 2017, : : Nucleic acids research. 45, D1, p. D1107-D1111

研究成果: ジャーナルへの寄稿記事

84 引用 (Scopus)

Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma

Terada, M., Horisawa, K., Miura, S., Takashima, Y., Ohkawa, Y., Sekiya, S., Matsuda-Ito, K. & Suzuki, A., 10 4 2016, : : Scientific reports. 6, 34691.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Laguerre filter analysis with partial least square regression reveals a priming effect of ERK and CREB on c-FOS induction

Kudo, T., Uda, S., Tsuchiya, T., Wada, T., Karasawa, Y., Fujii, M., Saito, T. H. & Kuroda, S., 8 2016, : : PloS one. 11, 8, e0160548.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Large-scale analysis of the human ubiquitin-related proteome

Matsumoto, M., Hatakeyama, S., Oyamada, K., Oda, Y., Nishimura, T. & Nakayama, K. I., 11 1 2005, : : Proteomics. 5, 16, p. 4145-4151 7 p.

研究成果: ジャーナルへの寄稿記事

147 引用 (Scopus)

Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways

Matsumoto, M., Oyamada, K., Takahashi, H., Sato, T., Hatakeyama, S. & Nakayama, K., 7 1 2009, : : Proteomics. 9, 13, p. 3549-3563 15 p.

研究成果: ジャーナルへの寄稿記事

43 引用 (Scopus)

LATS2 positively regulates polycomb repressive complex 2

Torigata, K., Daisuke, O., Mukai, S., Hatanaka, A., Ohka, F., Motooka, D., Nakamura, S., Ohkawa, Y., Yabuta, N., Kondo, Y. & Nojima, H., 7 1 2016, : : PloS one. 11, 7, e0158562.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Lipidomic analysis of cells and extracellular vesicles from high-and low-metastatic triple-negative breast cancer

Nishida-Aoki, N., Izumi, Y., Takeda, H., Takahashi, M., Ochiya, T. & Bamba, T., 2 2020, : : Metabolites. 10, 2, 67.

研究成果: ジャーナルへの寄稿記事

公開

Lipidomic analysis of plasma lipoprotein fractions in myocardial infarction-prone rabbits

Takeda, H., Koike, T., Izumi, Y., Yamada, T., Yoshida, M., Shiomi, M., Fukusaki, E. & Bamba, T., 10 1 2015, : : Journal of Bioscience and Bioengineering. 120, 4, p. 476-482 7 p.

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

Lipid Profiling of Serum and Lipoprotein Fractions in Response to Pitavastatin Using an Animal Model of Familial Hypercholesterolemia

Takeda, H., Izumi, Y., Tamura, S., Koike, T., Koike, Y., Shiomi, M. & Bamba, T., 3 6 2020, : : Journal of Proteome Research. 19, 3, p. 1100-1108 9 p.

研究成果: ジャーナルへの寄稿記事

Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation

Minami, S., Yamamoto, T., Takabatake, Y., Takahashi, A., Namba, T., Matsuda, J., Kimura, T., Kaimori, J. Y., Matsui, I., Hamano, T., Takeda, H., Takahashi, M., Izumi, Y., Bamba, T., Matsusaka, T., Niimura, F. & Isaka, Y., 10 3 2017, : : Autophagy. 13, 10, p. 1629-1647 19 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

Lipoprotein profiling methodology based on determination of apolipoprotein concentration

Takeda, H., Izumi, Y., Tomita, A., Koike, T., Shiomi, M., Fukusaki, E., Matsuda, F. & Bamba, T., 1 2017, : : Bioanalysis. 9, 1, p. 9-19 11 p.

研究成果: ジャーナルへの寄稿記事

Locomotor Training Increases Synaptic Structure With High NGL-2 Expression After Spinal Cord Hemisection

Kobayakawa, K., DePetro, K. A., Zhong, H., Pham, B., Hara, M., Harada, A., Nogami, J., Ohkawa, Y. & Edgerton, V. R., 1 1 2019, : : Neurorehabilitation and Neural Repair.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Logical design of oral glucose ingestion pattern minimizing blood glucose in humans

Fujii, M., Murakami, Y., Karasawa, Y., Sumitomo, Y., Fujita, S., Koyama, M., Uda, S., Kubota, H., Inoue, H., Konishi, K., Oba, S., Ishii, S. & Kuroda, S., 12 1 2019, : : npj Systems Biology and Applications. 5, 1, 31.

研究成果: ジャーナルへの寄稿記事

公開
56 引用 (Scopus)

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Tsuda, M., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., 5 15 2019, : : Science Advances. 5, 5, eaav5086.

研究成果: ジャーナルへの寄稿記事

公開
4 引用 (Scopus)

Mammalian E4 is required for cardiac development and maintenance of the nervous system

Kaneko-Oshikawa, C., Nakagawa, T., Yamada, M., Yoshikawa, H., Matsumoto, M., Yada, M., Hatakeyama, S., Nakayama, K. & Nakayama, K. I., 12 1 2005, : : Molecular and cellular biology. 25, 24, p. 10953-10964 12 p.

研究成果: ジャーナルへの寄稿記事

44 引用 (Scopus)

MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex

Takahashi, H., Takigawa, I., Watanabe, M., Anwar, D., Shibata, M., Tomomori-Sato, C., Sato, S., Ranjan, A., Seidel, C. W., Tsukiyama, T., Mizushima, W., Hayashi, M., Ohkawa, Y., Conaway, J. W., Conaway, R. C. & Hatakeyama, S., 1 9 2015, : : Nature communications. 6, 5941.

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells

Matsuda, J., Takahashi, A., Takabatake, Y., Sakai, S., Minami, S., Yamamoto, T., Fujimura, R., Namba-Hamano, T., Yonishi, H., Nakamura, J., Kimura, T., Kaimori, J. Y., Matsui, I., Takahashi, M., Nakao, M., Izumi, Y., Bamba, T., Matsusaka, T., Niimura, F., Yanagita, M. および2人, Yoshimori, T. & Isaka, Y., 1 1 2020, (受理済み/印刷中) : : Autophagy.

研究成果: ジャーナルへの寄稿記事

Metabolic engineering of oleaginous fungus Mortierella alpina for high production of oleic and linoleic acids

Sakamoto, T., Sakuradani, E., Okuda, T., Kikukawa, H., Ando, A., Kishino, S., Izumi, Y., Bamba, T., Shima, J. & Ogawa, J., 12 1 2017, : : Bioresource Technology. 245, p. 1610-1615 6 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Metabolic flux redirection from a central metabolic pathway toward a synthetic pathway using a metabolic toggle switch

Soma, Y., Tsuruno, K., Wada, M., Yokota, A. & Hanai, T., 5 2014, : : Metabolic Engineering. 23, p. 175-184 10 p.

研究成果: ジャーナルへの寄稿記事

95 引用 (Scopus)

Metabolome analysis reveals the effect of carbon catabolite control on the poly(γ-glutamic acid) biosynthesis of Bacillus licheniformis ATCC 9945

Mitsunaga, H., Meissner, L., Palmen, T., Bamba, T., Büchs, J. & Fukusaki, E., 4 1 2016, : : Journal of Bioscience and Bioengineering. 121, 4, p. 413-419 7 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Metabolomics approach to reduce the Crabtree effect in continuous culture of Saccharomyces cerevisiae

Imura, M., Iwakiri, R., Bamba, T. & Fukusaki, E., 8 2018, : : Journal of Bioscience and Bioengineering. 126, 2, p. 183-188 6 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells

Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T. & Nakayama, T., 5 22 2015, : : Journal of Biological Chemistry. 290, 21, p. 13095-13103 9 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Microbe participation in aroma production during soy sauce fermentation

Harada, R., Yuzuki, M., Ito, K., Shiga, K., Bamba, T. & Fukusaki, E., 6 2018, : : Journal of Bioscience and Bioengineering. 125, 6, p. 688-694 7 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Minimizing the Cross Validation Error to Mix Kernel Matrices of Heterogeneous Biological Data

Tsuda, K., Uda, S., Kin, T. & Asai, K., 2004, : : Neural Processing Letters. 19, p. 63-72

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation

Kozuka, T., Omori, Y., Watanabe, S., Tarusawa, E., Yamamoto, H., Chaya, T., Furuhashi, M., Morita, M., Sato, T., Hirose, S., Ohkawa, Y., Yoshimura, Y., Hikida, T. & Furukawa, T., 12 1 2019, : : Scientific reports. 9, 1, 3445.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

MNase, as a probe to study the sequence-dependent site exposures in the +1 nucleosomes of yeast

Luo, D., Kato, D., Nogami, J., Ohkawa, Y., Kurumizaka, H. & Kono, H., 1 1 2018, : : Nucleic acids research. 46, 14, p. 7124-7137 14 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

Molecular analysis of α-thalassemia in Nepal: Correlation with malaria endemicity

Sakai, Y., Kobayashi, S., Shibata, H., Furuumi, H., Endo, T., Fucharoen, S., Hamano, S., Acharya, G. P., Kawasaki, T. & Fukumaki, Y., 1 1 2000, : : Journal of Human Genetics. 45, 3, p. 127-132 6 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)
50 引用 (Scopus)

Molecular clearance of ataxin-3 is regulated by a mammalian E4

Matsumoto, M., Yada, M., Hatakeyama, S., Ishimoto, H., Tanimura, T., Tsuji, S., Kakizuka, A., Kitagawa, M. & Nakayama, K. I., 2 11 2004, : : EMBO Journal. 23, 3, p. 659-669 11 p.

研究成果: ジャーナルへの寄稿記事

113 引用 (Scopus)

Molecular dissection of the interactions among IκBα, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IκBα

Hattori, K., Hatakeyama, S., Shirane, M., Matsumoto, M. & Nakayama, K. I., 10 15 1999, : : Journal of Biological Chemistry. 274, 42, p. 29641-29647 7 p.

研究成果: ジャーナルへの寄稿記事

34 引用 (Scopus)

Molecular evolution of the 5′-flanking regions of the duplicated Amy genes in Drosophila melanogaster species subgroup

Okuyama, E., Shibata, H., Tachida, H. & Yamazaki, T., 4 1996, : : Molecular Biology and Evolution. 13, 4, p. 574-583 10 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)
64 引用 (Scopus)

Monoclonal antibody specific for Dhx9/NDHII/RHA

Kotani, M., Harada, A., Odawara, J., Azuma, M., Okada, S., Nishiyama, Y., Nakamura, M., Tachibana, T. & Ohkawa, Y., 6 1 2010, : : Hybridoma. 29, 3, p. 259-261 3 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones

Katoh-Fukui, Y., Baba, T., Sato, T., Otake, H., Nagakui-Noguchi, Y., Shindo, M., Suyama, M., Ohkawa, Y., Tsumura, H., Morohashi, K. I. & Fukami, M., 3 2019, : : Bone. 120, p. 219-231 13 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

MTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K. I., Clohessy, J. G. & Pandolfi, P. P., 1 12 2017, : : Nature. 541, 7636, p. 228-232 5 p.

研究成果: ジャーナルへの寄稿記事

172 引用 (Scopus)

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K., Clohessy, J. & Pandolfi, P. P., 2017, : : Nature. 541, 7636, p. 228 5 p., 541.

研究成果: ジャーナルへの寄稿記事

Mucosal dysbiosis in patients with gastrointestinal follicular lymphoma

Zeze, K., Hirano, A., Torisu, T., Esaki, M., Shibata, H., Moriyama, T., Umeno, J., Fujioka, S., Okamoto, Y., Fuyuno, Y., Matsuno, Y. & Kitazono, T., 4 1 2020, : : Hematological Oncology. 38, 2, p. 181-188 8 p.

研究成果: ジャーナルへの寄稿記事

Myeloperoxidase exacerbates secondary injury by generating highly reactive oxygen species and mediating neutrophil recruitment in experimental spinal cord injury

Kubota, K., Saiwai, H., Kumamaru, H., Maeda, T., Ohkawa, Y., Aratani, Y., Nagano, T., Iwamoto, Y. & Okada, S., 7 15 2012, : : Spine. 37, 16, p. 1363-1369 7 p.

研究成果: ジャーナルへの寄稿記事

33 引用 (Scopus)

MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex

De La Serna, I. L., Ohkawa, Y., Berkes, C. A., Bergstrom, D. A., Dacwag, C. S., Tapscott, S. J. & Imbalzano, A. N., 5 1 2005, : : Molecular and cellular biology. 25, 10, p. 3997-4009 13 p.

研究成果: ジャーナルへの寄稿記事

194 引用 (Scopus)

Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function

Mallappa, C., Nasipak, B. T., Etheridge, L., Androphy, E. J., Jones, S. N., Sagerström, C. G., Ohkawa, Y. & Imbalzano, A. N., 7 1 2010, : : Molecular and cellular biology. 30, 13, p. 3176-3186 11 p.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43

Ohzono, C., Etoh, S., Matsumoto, M., Nakayama, K. I., Hirota, Y., Tanaka, Y. & Fujita, H., 6 17 2010, : : Biological and Pharmaceutical Bulletin. 33, 6, p. 951-957 7 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

New horizons in biological research developed by nextgeneration proteomics: Say good-bye to western blotting

Nakatsumi, H., Matsumoto, M. & Nakayama, K., 12 1 2012, : : Seikagaku. 84, 1, p. 53-57 5 p.

研究成果: ジャーナルへの寄稿記事