トランスオミクス医学研究センター

研究成果 1994 2020

2010
6 引用 (Scopus)

A rat monoclonal antibody against the chromatin remodeling factor CHD5

Yoshimura, S., Yoshimi, T., Ohkawa, Y., Azuma, M. & Tachibana, T., 2 1 2010, : : Hybridoma. 29, 1, p. 63-66 4 p.

研究成果: ジャーナルへの寄稿記事

Chromatin Assembly and Disassembly
DNA-Binding Proteins
Monoclonal Antibodies
Immunoblotting
Antibodies
14 引用 (Scopus)

Comparative analysis of human Src-family kinase substrate specificity in vitro

Takeda, H., Kawamura, Y., Miura, A., Mori, M., Wakamatsu, A., Yamamoto, J. I., Isogai, T., Matsumoto, M., Nakayama, K., Natsume, T., Nomura, N. & Goshima, N., 11 5 2010, : : Journal of Proteome Research. 9, 11, p. 5982-5993 12 p.

研究成果: ジャーナルへの寄稿記事

src-Family Kinases
Substrate Specificity
Phosphorylation
Substrates
Signal transduction
45 引用 (Scopus)

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity

Tada, H., Okano, H. J., Takagi, H., Shibata, S., Yao, I., Matsumoto, M., Saiga, T., Nakayama, K. I., Kashima, H., Takahashi, T., Setou, M. & Okano, H., 2 5 2010, : : Journal of Biological Chemistry. 285, 6, p. 3840-3849 10 p.

研究成果: ジャーナルへの寄稿記事

Ligases
Ubiquitin
Synapses
Neurons
Degradation
4 引用 (Scopus)

Generation of a rat monoclonal antibody specific for Chd2

Harada, A., Yoshimura, S., Odawara, J., Azuma, M., Okada, S., Nakamura, M., Tachibana, T. & Ohkawa, Y., 4 1 2010, : : Hybridoma. 29, 2, p. 173-177 5 p.

研究成果: ジャーナルへの寄稿記事

Monoclonal Antibodies
Gene Expression
Euchromatin
Chromatin Assembly and Disassembly
Antibodies
6 引用 (Scopus)

Generation of a rat monoclonal antibody specific for heat shock cognate protein 70

Shiota, M., Saiwai, H., Mun, S., Harada, A., Okada, S., Odawara, J., Tanaka, M., Iwao, H. & Ohkawa, Y., 10 1 2010, : : Hybridoma. 29, 5, p. 453-456 4 p.

研究成果: ジャーナルへの寄稿記事

HSC70 Heat-Shock Proteins
Monoclonal Antibodies
Cytoplasm
Molecular Chaperones
Antibodies
5 引用 (Scopus)

High-throughput and highly sensitive analysis method for polyisoprene in plants by pyrolysis-gas chromatography/mass spectrometry

Takeno, S., Bamba, T., Nakazawa, Y., Fukusaki, E., Okazawa, A. & Kobayashi, A., 2 5 2010, : : Bioscience, Biotechnology and Biochemistry. 74, 1, p. 13-17 5 p.

研究成果: ジャーナルへの寄稿記事

Polyisoprenes
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
coenzyme Q10
18 引用 (Scopus)

Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress

Hayakawa, H., Fujikane, A., Ito, R., Matsumoto, M., Nakayama, K. & Sekiguchi, M., 12 10 2010, : : Biochemical and Biophysical Research Communications. 403, 2, p. 220-224 5 p.

研究成果: ジャーナルへの寄稿記事

Oxidative stress
Heterogeneous-Nuclear Ribonucleoproteins
Oxidative Stress
RNA
Hydrogen Peroxide

Monoclonal antibodies 2F12H4 and 3C3F1 against mouse Pax7

Ohkawa, Y., 2 1 2010, : : Hybridoma. 29, 1, 1 p.

研究成果: ジャーナルへの寄稿小調査

Monoclonal Antibodies

Monoclonal antibodies 6D2 and 8H3 against mouse Chd2

Ohkawa, Y., 6 1 2010, : : Hybridoma. 29, 3, 1 p.

研究成果: ジャーナルへの寄稿小調査

Monoclonal Antibodies

Monoclonal antibody 1E2G4 against mouse Myf5

Ohkawa, Y., 2 1 2010, : : Hybridoma. 29, 1, 1 p.

研究成果: ジャーナルへの寄稿小調査

Monoclonal Antibodies

Monoclonal antibody 1H7A10 against mouse Brm

Ohkawa, Y., 2 1 2010, : : Hybridoma. 29, 1, 1 p.

研究成果: ジャーナルへの寄稿小調査

Monoclonal Antibodies

Monoclonal antibody 8E3 against mouse Dhx9/NDHII/RHA

Ohkawa, Y., 6 1 2010, : : Hybridoma. 29, 3, 1 p.

研究成果: ジャーナルへの寄稿小調査

Monoclonal Antibodies
3 引用 (Scopus)

Monoclonal antibody specific for Dhx9/NDHII/RHA

Kotani, M., Harada, A., Odawara, J., Azuma, M., Okada, S., Nishiyama, Y., Nakamura, M., Tachibana, T. & Ohkawa, Y., 6 1 2010, : : Hybridoma. 29, 3, p. 259-261 3 p.

研究成果: ジャーナルへの寄稿記事

Monoclonal Antibodies
RNA Helicases
Antibodies
Proteins
Adenosine Triphosphate
20 引用 (Scopus)

Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function

Mallappa, C., Nasipak, B. T., Etheridge, L., Androphy, E. J., Jones, S. N., Sagerström, C. G., Ohkawa, Y. & Imbalzano, A. N., 7 1 2010, : : Molecular and cellular biology. 30, 13, p. 3176-3186 11 p.

研究成果: ジャーナルへの寄稿記事

Chromatin Assembly and Disassembly
MicroRNAs
Adenosine Triphosphate
Enzymes
Chromatin
11 引用 (Scopus)
Connexin 43
Lysosomes
Half-Life
Ubiquitination
Gap Junctions
6 引用 (Scopus)

Ossification of the posterior longitudinal ligament of the lumbar spine: A case series

Okada, S., Maeda, T., Saiwai, H., Ohkawa, Y., Shiba, K. & Iwamoto, Y., 11 1 2010, : : Neurosurgery. 67, 5, p. 1311-1318 8 p.

研究成果: ジャーナルへの寄稿記事

Ossification of Posterior Longitudinal Ligament
Pathologic Constriction
Ossification of the posterior longitudinal ligament of the spine
Osteogenesis
Spine
26 引用 (Scopus)

Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H3

Hatano, A., Matsumoto, M., Higashinakagawa, T. & Nakayama, K. I., 6 18 2010, : : Biochemical and Biophysical Research Communications. 397, 1, p. 93-99 7 p.

研究成果: ジャーナルへの寄稿記事

Phosphorylation
Histones
Chromatin
Histone Code
Lysine
5 引用 (Scopus)

Production of a rat monoclonal antibody specific for Myf5

Harada, A., Okada, S., Odawara, J., Kumamaru, H., Saiwai, H., Aoki, M., Nakamura, M., Nishiyama, Y. & Ohkawa, Y., 2 1 2010, : : Hybridoma. 29, 1, p. 59-62 4 p.

研究成果: ジャーナルへの寄稿記事

Myogenic Regulatory Factors
Myoblasts
Monoclonal Antibodies
Helix-Loop-Helix Motifs
Myogenin
5 引用 (Scopus)

Rat monoclonal antibody specific for MyoD

Harada, A., Ohkawa, Y., Ao, S., Odawara, J., Okada, S., Azuma, M., Nishiyama, Y., Nakamura, M. & Tachibana, T., 6 1 2010, : : Hybridoma. 29, 3, p. 255-258 4 p.

研究成果: ジャーナルへの寄稿記事

Skeletal Muscle
Monoclonal Antibodies
Helix-Loop-Helix Motifs
Myogenic Regulatory Factors
Myoblasts
1 引用 (Scopus)

Rat monoclonal antibody specific for the chromatin remodeling factor, CHD1

Yoshimura, S., Harada, A., Odawara, J., Azuma, M., Okada, S., Nakamura, M., Ohkawa, Y. & Tachibana, T., 6 1 2010, : : Hybridoma. 29, 3, p. 237-240 4 p.

研究成果: ジャーナルへの寄稿記事

Chromatin Assembly and Disassembly
Monoclonal Antibodies
Mammals
Chromatin
Adenosine Triphosphate
96 引用 (Scopus)

The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury

Saiwai, H., Ohkawa, Y., Yamada, H., Kumamaru, H., Harada, A., Okano, H., Yokomizo, T., Iwamoto, Y. & Okada, S., 5 2010, : : American Journal of Pathology. 176, 5, p. 2352-2366 15 p.

研究成果: ジャーナルへの寄稿記事

Leukotriene B4
Neutrophil Infiltration
Spinal Cord Injuries
Leukotriene B4 Receptors
Leukocytes
2009
6 引用 (Scopus)

An approach to peak detection in GC-MS chromatograms and application of KNApSAcK database in prediction of candidate metabolites

Oishi, T., Tanaka, K. I., Hashimoto, T., Shinbo, Y., Jumtee, K., Bamba, T., Fukusaki, E., Suzuki, H., Shibata, D., Takahashi, H., Asahi, H., Kurokawa, K., Nakamura, Y., Hirai, A., Nakamura, K., Altaf-Ul-Amin, M. & Kanaya, S., 2009, : : Plant Biotechnology. 26, 1, p. 167-174 8 p.

研究成果: ジャーナルへの寄稿記事

Metabolomics
Databases
metabolites
metabolomics
prediction
8 引用 (Scopus)

Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia

Arai, S., Shibata, H., Sakai, M., Ninomiya, H., Lwata, N., Ozaki, N. & Fukumaki, Y., 2 1 2009, : : Psychiatric Genetics. 19, 1, p. 6-13 8 p.

研究成果: ジャーナルへの寄稿記事

Glutamate Decarboxylase
Schizophrenia
Genes
Single Nucleotide Polymorphism
Haplotypes
22 引用 (Scopus)

Does ossification of the posterior longitudinal ligament affect the neurological outcome after traumatic cervical cord injury?

Okada, S., Maeda, T., Ohkawa, Y., Harimaya, K., Saiwai, H., Kumamaru, H., Matsumoto, Y., Doi, T., Ueta, T., Shiba, K. & Iwamoto, Y., 5 15 2009, : : Spine. 34, 11, p. 1148-1152 5 p.

研究成果: ジャーナルへの寄稿記事

Ossification of Posterior Longitudinal Ligament
Nervous System
Wounds and Injuries
Spinal Cord Injuries
Spinal Injuries
63 引用 (Scopus)

Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development

Saiga, T., Fukuda, T., Matsumoto, M., Tada, H., Okano, H. J., Okano, H. & Nakayama, K. I., 7 1 2009, : : Molecular and cellular biology. 29, 13, p. 3529-3543 15 p.

研究成果: ジャーナルへの寄稿記事

Ligases
Ubiquitin
F-Box Proteins
Neuromuscular Junction
Consensus Sequence
6 引用 (Scopus)

Generation of a rat monoclonal antibody specific for Brm

Okada, S., Harada, A., Saiwai, H., Nakamura, M. & Ohkawa, Y., 12 1 2009, : : Hybridoma. 28, 6, p. 455-458 4 p.

研究成果: ジャーナルへの寄稿記事

Monoclonal Antibodies
Myoblasts
DNA Repair
Adenosine Triphosphatases
Skeletal Muscle
8 引用 (Scopus)

Generation of a rat monoclonal antibody specific for Pax7

Harada, A., Okada, S., Saiwai, H., Aoki, M., Nakamura, M. & Ohkawa, Y., 12 1 2009, : : Hybridoma. 28, 6, p. 451-453 3 p.

研究成果: ジャーナルへの寄稿記事

Monoclonal Antibodies
Antibodies
Muscle Cells
Euchromatin
Ewing's Sarcoma
42 引用 (Scopus)

Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways

Matsumoto, M., Oyamada, K., Takahashi, H., Sato, T., Hatakeyama, S. & Nakayama, K., 7 1 2009, : : Proteomics. 9, 13, p. 3549-3563 15 p.

研究成果: ジャーナルへの寄稿記事

Phosphorylation
T-Cell Antigen Receptor
Proteomics
Tyrosine
B-Lymphocytes
45 引用 (Scopus)

Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36

Endo, A., Matsumoto, M., Inada, T., Yamamoto, A., Nakayama, K. I., Kitamura, N. & Komada, M., 3 1 2009, : : Journal of Cell Science. 122, 5, p. 678-686 9 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitination
Ribosomes
Enzymes
Basic Amino Acids
Nuclear Proteins
15 引用 (Scopus)

Production of a rat monoclonal antibody against Brg1

Ohkawa, Y., Harada, A., Nakamura, M., Yoshimura, S. & Tachibana, T., 12 1 2009, : : Hybridoma. 28, 6, p. 463-466 4 p.

研究成果: ジャーナルへの寄稿記事

Chromatin Assembly and Disassembly
Monoclonal Antibodies
Genes
Antibodies
Euchromatin

Specific features of transient Ras and sustained Rap1 activation

Ozaki, Y., Uda, S. & Kuroda, S., 2009, Systems Biology: the Challenge of Complexity Springer . p. 121-127

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

11 引用 (Scopus)

The identification and functional implications of human-specific "fixed" amino acid substitutions in the glutamate receptor family

Goto, H., Watanabe, K., Araragi, N., Kageyama, R., Tanaka, K., Kuroki, Y., Toyoda, A., Hattori, M., Sakaki, Y., Fujiyama, A., Fukumaki, Y. & Shibata, H., 10 12 2009, : : BMC Evolutionary Biology. 9, 1, 224.

研究成果: ジャーナルへの寄稿記事

amino acid substitution
substitution
amino acid
gene
Pan troglodytes
2008
18 引用 (Scopus)

Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia

Deng, X., Sagata, N., Takeuchi, N., Tanaka, M., Ninomiya, H., Iwata, N., Ozaki, N., Shibata, H. & Fukumaki, Y., 7 18 2008, : : BMC Psychiatry. 8, 58.

研究成果: ジャーナルへの寄稿記事

Neutral Amino Acid Transport Systems
Glycine Plasma Membrane Transport Proteins
Schizophrenia
Genes
Sample Size
154 引用 (Scopus)

Blue light-induced autophosphorylation of phototropin is a primary step for signaling

Inoue, S. I., Kinoshita, T., Matsumoto, M., Nakayama, K. I., Doi, M. & Shimazaki, K. I., 4 8 2008, : : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5626-5631 6 p.

研究成果: ジャーナルへの寄稿記事

Phototropins
Phototropism
Chloroplasts
Light
Phosphotransferases
35 引用 (Scopus)

Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis

Mukai, A., Mizuno, E., Kobayashi, K., Matsumoto, M., Nakayama, K. I., Kitamura, N. & Komada, M., 4 15 2008, : : Journal of Cell Science. 121, 8, p. 1325-1333 9 p.

研究成果: ジャーナルへの寄稿記事

Cytokinesis
Ubiquitination
Proteins
Aurora Kinase B
SNARE Proteins
98 引用 (Scopus)

Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16

Iwaki, A., Kawano, Y., Miura, S., Shibata, H., Matsuse, D., Li, W., Furuya, H., Ohyagi, Y., Taniwaki, T., Kira, J. & Fukumaki, Y., 1 1 2008, : : Journal of medical genetics. 45, 1, p. 32-35 4 p.

研究成果: ジャーナルへの寄稿記事

Spinocerebellar Ataxias
Haploinsufficiency
Intergenic DNA
Gene Dosage
Real-Time Polymerase Chain Reaction
71 引用 (Scopus)
Phanerochaete
Benzoic Acid
Metabolomics
Metabolome
Proteome
2007
33 引用 (Scopus)

Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia

Deng, X., Shibata, H., Takeuchi, N., Rachi, S., Sakai, M., Ninomiya, H., Iwata, N., Ozaki, N. & Fukumaki, Y., 4 5 2007, : : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 144, 3, p. 271-278 8 p.

研究成果: ジャーナルへの寄稿記事

Amino Acid Transport System X-AG
Schizophrenia
Genes
Haplotypes
Glutamate Receptors
109 引用 (Scopus)

The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling

Dacwag, C. S., Ohkawa, Y., Pal, S., Sif, S. & Imbalzano, A. N., 1 1 2007, : : Molecular and cellular biology. 27, 1, p. 384-394 11 p.

研究成果: ジャーナルへの寄稿記事

Protein-Arginine N-Methyltransferases
Chromatin Assembly and Disassembly
Muscle Development
Histones
Adenosine Triphosphate
2006
77 引用 (Scopus)

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

Niki, S., Oshikawa, K., Mouri, Y., Hirota, F., Matsushima, A., Yano, M., Han, H., Bando, Y., Izumi, K., Matsumoto, M., Nakayama, K. I., Kuroda, N. & Matsumoto, M., 5 1 2006, : : Journal of Clinical Investigation. 116, 5, p. 1292-1301 10 p.

研究成果: ジャーナルへの寄稿記事

Organ Specificity
Inbred NOD Mouse
Acinar Cells
Islets of Langerhans
Thymus Gland
41 引用 (Scopus)

Analysis of CDMA systems that are characterized by eigenvalue spectrum

Takeda, K., Uda, S. & Kabashima, Y., 2006, : : Europhysics Letters. 76, p. 1193-1199

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia

Shibata, H., Aramaki, T., Sakai, M., Ninomiya, H., Tashiro, N., Iwata, N., Ozaki, N. & Fukumaki, Y., 1 30 2006, : : Psychiatry research. 141, 1, p. 39-51 13 p.

研究成果: ジャーナルへの寄稿記事

Kainic Acid Receptors
Single Nucleotide Polymorphism
Schizophrenia
Genes
Haplotypes

Involvement of ubiquitin-proteasome system in polyglutamine disease

Matsumoto, M., 8 1 2006, : : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.. 51, 10 Suppl, p. 1428-1432 5 p.

研究成果: ジャーナルへの寄稿評論記事

Nerve Tissue Proteins
Ubiquitin-Conjugating Enzymes
Repressor Proteins
Intranuclear Inclusion Bodies
Ubiquitin-Protein Ligases
7 引用 (Scopus)

Technical problems and practical operations in plant metabolomics

Bamba, T. & Fukusaki, E., 8 31 2006, : : Journal of Pesticide Science. 31, 3, p. 300-304 5 p.

研究成果: ジャーナルへの寄稿評論記事

Metabolomics
metabolomics
Informatics
data analysis
Research Design
24 引用 (Scopus)

The contactin 4 gene locus at 3p26 is a candidate gene of SCA16

Miura, S., Shibata, H., Furuya, H., Ohyagi, Y., Osoegawa, M., Miyoshi, Y., Matsunaga, H., Shibata, A., Matsumoto, N., Iwaki, A., Taniwaki, T., Kikuchi, H., Kira, J. & Fukumaki, Y., 10 1 2006, : : Neurology. 67, 7, p. 1236-1241 6 p.

研究成果: ジャーナルへの寄稿記事

Contactins
Spinocerebellar Ataxias
Genes
Mutation
3' Untranslated Regions
2005
18 引用 (Scopus)
Flavonoids
Methylation
Liquid chromatography
Liquid Chromatography
Isotopes
38 引用 (Scopus)

Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia

Lee, H. J., Song, J. Y., Kim, J. W., Jin, S. Y., Hong, M. S., Park, J. K., Chung, J. H., Shibata, H. & Fukumaki, Y., 8 31 2005, : : Behavioral and Brain Functions. 1, 15.

研究成果: ジャーナルへの寄稿記事

Synapsins
Synaptic Vesicles
Schizophrenia
Genes
Haplotypes
4 引用 (Scopus)

Effect of EPS1 gene deletion in Saccharomyces cerevisiae on the secretion of foreign proteins which have disulfide bridges

He, J., Sakamoto, T., Song, Y., Saito, A., Harada, A., Azakami, H. & Kato, A., 4 25 2005, : : FEBS Letters. 579, 11, p. 2277-2283 7 p.

研究成果: ジャーナルへの寄稿記事

Gene Deletion
Cystatins
Muramidase
Disulfides
Yeast
71 引用 (Scopus)

Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p

Arinami, T., Ohtsuki, T., Ishiguro, H., Ujike, H., Tanaka, Y., Morita, Y., Mineta, M., Takeichi, M., Yamada, S., Imamura, A., Ohara, K., Shibuya, H., Ohara, K., Suzuki, Y., Muratake, T., Kaneko, N., Someya, T., Inada, T., Yoshikawa, T., Toyota, T. および32人, Yamada, K., Kojima, T., Takahashi, S., Osamu, O., Shinkai, T., Nakamura, M., Fukuzako, H., Hashiguchi, T., Niwa, S. I., Ueno, T., Tachikawa, H., Hori, T., Asada, T., Nanko, S., Kunugi, H., Hashimoto, R., Ozaki, N., Iwata, N., Harano, M., Arai, H., Ohnuma, T., Kusumi, I., Koyama, T., Yoneda, H., Fukumaki, Y., Shibata, H., Kaneko, S., Higuchi, H., Yasui-Furukori, N., Numachi, Y., Itokawa, M. & Okazaki, Y., 12 2005, : : American journal of human genetics. 77, 6, p. 937-944 8 p.

研究成果: ジャーナルへの寄稿記事

Single Nucleotide Polymorphism
Schizophrenia
Chromosomes
Siblings
Chromosome Mapping