トランスオミクス医学研究センター

研究成果 1994 2020

2019
3 引用 (Scopus)

Development of a practical online supercritical fluid extraction–supercritical fluid chromatography/mass spectrometry system with an integrated split-flow method

Sakai, M., Hayakawa, Y., Funada, Y., Ando, T., Fukusaki, E. & Bamba, T., 5 10 2019, : : Journal of Chromatography A. 1592, p. 161-172 12 p.

研究成果: ジャーナルへの寄稿記事

Supercritical Fluid Chromatography
Supercritical fluids
Chromatography
Mass spectrometry
Mass Spectrometry

Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes

Konno, D., Kishida, C., Maehara, K., Ohkawa, Y., Kiyonari, H., Okada, S. & Matsuzaki, F., 8 2019, : : Development (Cambridge). 146, 15, dev174243.

研究成果: ジャーナルへの寄稿記事

公開
Telencephalon
Homeobox Genes
Gene Dosage
Olfactory Bulb
Neurogenesis

Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases

Honda, H., Matsumoto, M., Shijo, M., Hamasaki, H., Sadashima, S., Suzuki, S. O., Aishima, S., Kai, K., Nakayama, K. I., Sasagasako, N. & Iwaki, T., 10 1 2019, : : Journal of neuropathology and experimental neurology. 78, 10, p. 922-929 8 p.

研究成果: ジャーナルへの寄稿記事

Prion Diseases
Human Growth Hormone
Pituitary Gland
Molecular Weight
Dura Mater

Gas chromatography-mass spectrometry metabolomics-based prediction of potato tuber sprouting during long-term storage

Fukuda, T., Takamatsu, K., Bamba, T. & Fukusaki, E., 8 1 2019, : : Journal of Bioscience and Bioengineering. 128, 2, p. 249-254 6 p.

研究成果: ジャーナルへの寄稿記事

Metabolomics
Biomarkers
Solanum tuberosum
Gas chromatography
Gas Chromatography-Mass Spectrometry
2 引用 (Scopus)

Identification of metabolites associated with onset of CAD in diabetic patients using ce-ms analysis: A pilot study

Omori, K., Katakami, N., Yamamoto, Y., Ninomiya, H., Takahara, M., Matsuoka, T. A., Bamba, T., Fukusaki, E. & Shimomura, I., 1 1 2019, : : Journal of atherosclerosis and thrombosis. 26, 3, p. 233-245 13 p.

研究成果: ジャーナルへの寄稿記事

公開
Metabolites
Coronary Artery Disease
Medical problems
Arteries
Galactosamine

Identification of novel serum markers for the progression of coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia

Shiomi, M., Takeda, H., Irino, Y., Kimura, N., Yamada, S., Kuniyoshi, N., Kikumori, A., Koike, Y., Koike, T., Yoshida, M., Izumi, Y., Shinohara, M., Bamba, T. & Ishida, T., 5 1 2019, : : Atherosclerosis. 284, p. 18-23 6 p.

研究成果: ジャーナルへの寄稿記事

Hyperlipoproteinemia Type II
Coronary Artery Disease
Animal Models
Biomarkers
Rabbits

Improved quantitation of lipid classes using supercritical fluid chromatography with a charged aerosol detector

Takeda, H., Takahashi, M., Hara, T., Izumi, Y. & Bamba, T., 1 1 2019, : : Journal of Lipid Research. 60, 8, p. 1465-1474 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Supercritical Fluid Chromatography
Aerosols
Detectors
Lipids
Molecules

Inter-laboratory comparison of metabolite measurements for metabolomics data integration

Izumi, Y., Matsuda, F., Hirayama, A., Ikeda, K., Kita, Y., Horie, K., Saigusa, D., Saito, K., Sawada, Y., Nakanishi, H., Okahashi, N., Takahashi, M., Nakao, M., Hata, K., Hoshi, Y., Morihara, M., Tanabe, K., Bamba, T. & Oda, Y., 11 2019, : : Metabolites. 9, 11, 257.

研究成果: ジャーナルへの寄稿記事

公開
Metabolomics
Data integration
Metabolites
Solvent extraction
Assays

Locomotor Training Increases Synaptic Structure With High NGL-2 Expression After Spinal Cord Hemisection

Kobayakawa, K., DePetro, K. A., Zhong, H., Pham, B., Hara, M., Harada, A., Nogami, J., Ohkawa, Y. & Edgerton, V. R., 1 1 2019, : : Neurorehabilitation and Neural Repair.

研究成果: ジャーナルへの寄稿記事

Spinal Cord
Synapses
RNA
Synaptophysin
Gene Ontology

Logical design of oral glucose ingestion pattern minimizing blood glucose in humans

Fujii, M., Murakami, Y., Karasawa, Y., Sumitomo, Y., Fujita, S., Koyama, M., Uda, S., Kubota, H., Inoue, H., Konishi, K., Oba, S., Ishii, S. & Kuroda, S., 12 1 2019, : : npj Systems Biology and Applications. 5, 1, 31.

研究成果: ジャーナルへの寄稿記事

公開
Glucose
Blood
Blood Glucose
Eating
Insulin
1 引用 (Scopus)

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Tsuda, M., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., 5 15 2019, : : Science Advances. 5, 5, eaav5086.

研究成果: ジャーナルへの寄稿記事

公開
spinal cord injuries
macrophages
healing
interferon
lesions
1 引用 (Scopus)

miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation

Kozuka, T., Omori, Y., Watanabe, S., Tarusawa, E., Yamamoto, H., Chaya, T., Furuhashi, M., Morita, M., Sato, T., Hirose, S., Ohkawa, Y., Yoshimura, Y., Hikida, T. & Furukawa, T., 12 1 2019, : : Scientific reports. 9, 1, 3445.

研究成果: ジャーナルへの寄稿記事

Prefrontal Cortex
MicroRNAs
Central Nervous System
Methamphetamine
Pyramidal Cells

Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones

Katoh-Fukui, Y., Baba, T., Sato, T., Otake, H., Nagakui-Noguchi, Y., Shindo, M., Suyama, M., Ohkawa, Y., Tsumura, H., Morohashi, K. I. & Fukami, M., 3 2019, : : Bone. 120, p. 219-231 13 p.

研究成果: ジャーナルへの寄稿記事

Mesenchymal Stromal Cells
Bone and Bones
Cell Lineage
Genes
Polycomb-Group Proteins
2 引用 (Scopus)

Pathological changes of distal motor neurons after complete spinal cord injury

Yokota, K., Kubota, K., Kobayakawa, K., Saito, T., Hara, M., Kijima, K., Maeda, T., Katoh, H., Ohkawa, Y., Nakashima, Y. & Okada, S., 1 9 2019, : : Molecular Brain. 12, 1, 4.

研究成果: ジャーナルへの寄稿記事

Motor Neurons
Spinal Cord Injuries
Spinal Cord
Microdissection
Thoracic Injuries

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. I. & Kuroda, S., 1 2019, : : Genes to Cells. 24, 1, p. 82-93 12 p.

研究成果: ジャーナルへの寄稿記事

Insulin
Phosphorylation
Proteins
Protein Kinases
Hepatocellular Carcinoma
1 引用 (Scopus)

Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1

Sorida, M., Hirauchi, T., Ishizaki, H., Kaito, W., Shimada, A., Mori, C., Chikashige, Y., Hiraoka, Y., Suzuki, Y., Ohkawa, Y., Kato, H., Takahata, S. & Murakami, Y., 6 2019, : : PLoS genetics. 15, 6, e1008129.

研究成果: ジャーナルへの寄稿記事

公開
Heterochromatin
methylation
heterochromatin
Epigenomics
epigenetics
2 引用 (Scopus)

Spinocerebellar ataxia 27 with a novel nonsense variant (Lys177X) in FGF14

Miura, S., Kosaka, K., Fujioka, R., Uchiyama, Y., Shimojo, T., Morikawa, T., Irie, A., Taniwaki, T. & Shibata, H., 3 1 2019, : : European Journal of Medical Genetics. 62, 3, p. 172-176 5 p.

研究成果: ジャーナルへの寄稿記事

Dysarthria
Ataxia
Gait
Progressive Myoclonic Epilepsy
Genes

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle

Fukuda, S., Kaneshige, A., Kaji, T., Noguchi, Y. T., Takemoto, Y., Zhang, L., Tsujikawa, K., Kokubo, H., Uezumi, A., Maehara, K., Harada, A., Ohkawa, Y. & Fukada, S. I., 9 2019, : : eLife. 8, e48284.

研究成果: ジャーナルへの寄稿記事

公開
Stem cells
Muscle Cells
Muscle
Stem Cells
Muscles
1 引用 (Scopus)

Synthetic microbial consortium with specific roles designated by genetic circuits for cooperative chemical production

Honjo, H., Iwasaki, K., Soma, Y., Tsuruno, K., Hamada, H. & Hanai, T., 9 1 2019, : : Metabolic Engineering. 55, p. 268-275 8 p.

研究成果: ジャーナルへの寄稿記事

Microbial Consortia
Enzymes
Networks (circuits)
Microorganisms
Metabolic Networks and Pathways

The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis

Abdalla, M. O. A., Yamamoto, T., Maehara, K., Nogami, J., Ohkawa, Y., Miura, H., Poonperm, R., Hiratani, I., Nakayama, H., Nakao, M. & Saitoh, N., 12 1 2019, : : Nature communications. 10, 1, 3778.

研究成果: ジャーナルへの寄稿記事

公開
estrogens
Untranslated RNA
deprivation
apoptosis
loci
6 引用 (Scopus)

The jpost environment: An integrated proteomics data repository and database

Moriya, Y., Kawano, S., Okuda, S., Watanabe, Y., Matsumoto, M., Takami, T., Kobayashi, D., Yamanouchi, Y., Araki, N., Yoshizawa, A. C., Tabata, T., Iwasaki, M., Sugiyama, N., Tanaka, S., Goto, S. & Ishihama, Y., 1 8 2019, : : Nucleic acids research. 47, D1, p. D1218-D1224

研究成果: ジャーナルへの寄稿記事

Proteomics
Databases
Mass Spectrometry
Peptides
Proteome

The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment

Takii, R., Fujimoto, M., Matsumoto, M., Srivastava, P., Katiyar, A., Nakayama, K. I. & Nakai, A., 12 16 2019, : : EMBO Journal. 38, 24, e102566.

研究成果: ジャーナルへの寄稿記事

Heat-Shock Response
RNA Polymerase II
Proteins
Shock
Phosphorylation
1 引用 (Scopus)

Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing

Matsuda, A., Asada, Y., Suita, N., Iwamoto, S., Hirakata, T., Yokoi, N., Ohkawa, Y., Okada, Y., Yokomizo, T. & Ebihara, N., 4 2019, : : Journal of Allergy and Clinical Immunology. 143, 4, p. 1610-1614.e6

研究成果: ジャーナルへの寄稿記事

Keratoconjunctivitis
RNA Sequence Analysis
Gene Expression Profiling
1 引用 (Scopus)

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Ohigashi, I., Tanaka, Y., Kondo, K., Fujimori, S., Kondo, H., Palin, A. C., Hoffmann, V., Kozai, M., Matsushita, Y., Uda, S., Motosugi, R., Hamazaki, J., Kubota, H., Murata, S., Tanaka, K., Katagiri, T., Kosako, H. & Takahama, Y., 11 26 2019, : : Cell Reports. 29, 9, p. 2901-2916.e6

研究成果: ジャーナルへの寄稿記事

公開
Epithelial Cells
Cytology
Cyclin D1
Proteasome Endopeptidase Complex
Proteomics
2 引用 (Scopus)

Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans

Hada, K., Hirota, K., Inanobe, A., Kako, K., Miyata, M., Araoi, S., Matsumoto, M., Ohta, R., Arisawa, M., Daitoku, H., Hanada, T. & Fukamizu, A., 1 1 2019, : : Journal of Biological Chemistry. 294, 9, p. 3091-3099 9 p.

研究成果: ジャーナルへの寄稿記事

Acetylation
Citric Acid Cycle
Mitochondrial Proteins
Caenorhabditis elegans
Embryonic Development

Unique structure (construction and configuration) and evolution of the array of small serum protein genes of Protobothrops flavoviridis snake

Hattori, S., Oda-Ueda, N., Ohno, M., Chijiwa, T., Inamaru, K., Takeuchi, A., Maeda, M., Yamaguchi, K. & Shibata, H., 7 5 2019, : : Bioscience reports. 39, 7, BSR20190560.

研究成果: ジャーナルへの寄稿記事

公開
Snakes
Blood Proteins
Genes
DNA Transposable Elements
Nucleotides
2020
Pyruvate Dehydrogenase Complex
Synechococcus
Acetyl Coenzyme A
Fluxes
Pyruvic Acid

Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells

Matsuda, J., Takahashi, A., Takabatake, Y., Sakai, S., Minami, S., Yamamoto, T., Fujimura, R., Namba-Hamano, T., Yonishi, H., Nakamura, J., Kimura, T., Kaimori, J. Y., Matsui, I., Takahashi, M., Nakao, M., Izumi, Y., Bamba, T., Matsusaka, T., Niimura, F., Yanagita, M. および2人, Yoshimori, T. & Isaka, Y., 1 1 2020, (受理済み/印刷中) : : Autophagy.

研究成果: ジャーナルへの寄稿記事

Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis

Matsuhisa, K., Saito, A., Cai, L., Kaneko, M., Okamoto, T., Sakaue, F., Asada, R., Urano, F., Yanagida, K., Okochi, M., Kudo, Y., Matsumoto, M., Nakayama, K. I. & Imaizumi, K., 1 1 2020, : : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 1, p. 865-880 16 p.

研究成果: ジャーナルへの寄稿記事

公開
Proteolysis
Peptide Fragments
Endoplasmic Reticulum Stress
Peptide Hydrolases
Basic-Leucine Zipper Transcription Factors

The role of galanin in the differentiation of mucosal mast cells in mice

Yamaguchi, T., Ikeda, Y., Tashiro, K., Ohkawa, Y. & Kawabata, K., 1 1 2020, : : European Journal of Immunology. 50, 1, p. 110-118 9 p.

研究成果: ジャーナルへの寄稿記事

Galanin
Mast Cells
Connective Tissue Cells
Receptor, Galanin, Type 3
Dextran Sulfate