トランスオミクス医学研究センター

研究成果 1994 2020

1 引用 (Scopus)

Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing

Matsuda, A., Asada, Y., Suita, N., Iwamoto, S., Hirakata, T., Yokoi, N., Ohkawa, Y., Okada, Y., Yokomizo, T. & Ebihara, N., 4 2019, : : Journal of Allergy and Clinical Immunology. 143, 4, p. 1610-1614.e6

研究成果: ジャーナルへの寄稿記事

Keratoconjunctivitis
RNA Sequence Analysis
Gene Expression Profiling

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 2018, : : iScience. 7, p. 212-229

研究成果: ジャーナルへの寄稿記事

Gene Regulatory Networks
Metabolic Networks and Pathways
Insulin
Immediate-Early Genes
Metabolomics
7 引用 (Scopus)

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K. I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 9 28 2018, : : iScience. 7, p. 212-229 18 p.

研究成果: ジャーナルへの寄稿記事

公開
Gene Regulatory Networks
Metabolic Networks and Pathways
insulin
Insulin
Immediate-Early Genes
78 引用 (Scopus)

Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers

Yugi, K., Kubota, H., Hatano, A. & Kuroda, S., 4 1 2016, : : Trends in biotechnology. 34, 4, p. 276-290 15 p.

研究成果: ジャーナルへの寄稿評論記事

Data integration
Metabolism
Life Style
Technology
Phenotype
1 引用 (Scopus)

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Ohigashi, I., Tanaka, Y., Kondo, K., Fujimori, S., Kondo, H., Palin, A. C., Hoffmann, V., Kozai, M., Matsushita, Y., Uda, S., Motosugi, R., Hamazaki, J., Kubota, H., Murata, S., Tanaka, K., Katagiri, T., Kosako, H. & Takahama, Y., 11 26 2019, : : Cell Reports. 29, 9, p. 2901-2916.e6

研究成果: ジャーナルへの寄稿記事

公開
Epithelial Cells
Cytology
Cyclin D1
Proteasome Endopeptidase Complex
Proteomics
2 引用 (Scopus)

Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans

Hada, K., Hirota, K., Inanobe, A., Kako, K., Miyata, M., Araoi, S., Matsumoto, M., Ohta, R., Arisawa, M., Daitoku, H., Hanada, T. & Fukamizu, A., 1 1 2019, : : Journal of Biological Chemistry. 294, 9, p. 3091-3099 9 p.

研究成果: ジャーナルへの寄稿記事

Acetylation
Citric Acid Cycle
Mitochondrial Proteins
Caenorhabditis elegans
Embryonic Development
18 引用 (Scopus)

TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells

Okumura, F., Okumura, A. J., Matsumoto, M., Nakayama, K. I. & Hatakeyama, S., 10 1 2011, : : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 10, p. 1784-1792 9 p.

研究成果: ジャーナルへの寄稿記事

Embryonic Stem Cells
Fingers
Down-Regulation
Proteins
22 引用 (Scopus)

Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels

Inoue, D., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K. & Kitamura, T., 3 1 2016, : : Experimental Hematology. 44, 3, p. 172-176.e1

研究成果: ジャーナルへの寄稿記事

Mutation
Neoplasms
Proteins
Myelodysplastic Syndromes
Hematologic Neoplasms
168 引用 (Scopus)

Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

Hatakeyama, S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, K., Higashi, H., Nakano, H., Okumura, K., Onoé, K., Good, R. A. & Nakayama, K. I., 3 30 1999, : : Proceedings of the National Academy of Sciences of the United States of America. 96, 7, p. 3859-3863 5 p.

研究成果: ジャーナルへの寄稿記事

F-Box Proteins
Ubiquitination
Ligases
Ubiquitin
SKP Cullin F-Box Protein Ligases
88 引用 (Scopus)

U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy

Hatakeyama, S., Matsumoto, M., Kamura, T., Murayama, M., Chui, D. H., Planel, E., Takahashi, R., Nakayama, K. I. & Takashima, A., 10 1 2004, : : Journal of Neurochemistry. 91, 2, p. 299-307 9 p.

研究成果: ジャーナルへの寄稿記事

HSC70 Heat-Shock Proteins
Tauopathies
Ubiquitination
Neurofibrillary Tangles
Proteins

Unique structure (construction and configuration) and evolution of the array of small serum protein genes of Protobothrops flavoviridis snake

Hattori, S., Oda-Ueda, N., Ohno, M., Chijiwa, T., Inamaru, K., Takeuchi, A., Maeda, M., Yamaguchi, K. & Shibata, H., 7 5 2019, : : Bioscience reports. 39, 7, BSR20190560.

研究成果: ジャーナルへの寄稿記事

公開
Snakes
Blood Proteins
Genes
DNA Transposable Elements
Nucleotides
22 引用 (Scopus)

Use of on-line supercritical fluid extraction-supercritical fluid chromatography/tandem mass spectrometry to analyze disease biomarkers in dried serum spots compared with serum analysis using liquid chromatography/tandem mass spectrometry

Suzuki, M., Nishiumi, S., Kobayashi, T., Sakai, A., Iwata, Y., Uchikata, T., Izumi, Y., Azuma, T., Bamba, T. & Yoshida, M., 5 30 2017, : : Rapid Communications in Mass Spectrometry. 31, 10, p. 886-894 9 p.

研究成果: ジャーナルへの寄稿記事

Supercritical fluids
Liquid chromatography
Biomarkers
Mass spectrometry
Metabolites
12 引用 (Scopus)

UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation

Matsunuma, R., Niida, H., Ohhata, T., Kitagawa, K., Sakai, S., Uchida, C., Shiotani, B., Matsumoto, M., Nakayama, K. I., Ogura, H., Shiiya, N. & Kitagawa, M., 1 1 2016, : : Molecular and cellular biology. 36, 3, p. 394-406 13 p.

研究成果: ジャーナルへの寄稿記事

Histone Acetyltransferases
Phosphorylation
Cell Proliferation
Replication Origin
DNA Damage
313 引用 (Scopus)

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Kamura, T., Maenaka, K., Kotoshiba, S., Matsumoto, M., Kohda, D., Conaway, R. C., Conaway, J. W. & Nakayama, K. I., 12 15 2004, : : Genes and Development. 18, 24, p. 3055-3065 11 p.

研究成果: ジャーナルへの寄稿記事

Suppressor of Cytokine Signaling Proteins
Ligases
Ubiquitin
Cullin Proteins
RNA Interference
13 引用 (Scopus)

Widely-targeted quantitative lipidomics method by supercritical fluid chromatography triple quadrupole mass spectrometry

Takeda, H., Izumi, Y., Takahashi, M., Paxton, T., Tamura, S., Koike, T., Yu, Y., Kato, N., Nagase, K., Shiomi, M. & Bamba, T., 1 1 2018, : : Journal of Lipid Research. 59, 7, p. 1283-1293 11 p.

研究成果: ジャーナルへの寄稿記事

Supercritical Fluid Chromatography
Mass spectrometry
Mass Spectrometry
Lipids
Biomarkers
2 引用 (Scopus)
Glycerides
Ointments
Nonesterified Fatty Acids
Mass spectrometry
Fatty Acids
17 引用 (Scopus)

Wnt signaling regulates left-right axis formation in the node of mouse embryos

Kitajima, K., Oki, S., Ohkawa, Y., Sumi, T. & Meno, C., 8 15 2013, : : Developmental Biology. 380, 2, p. 222-232 11 p.

研究成果: ジャーナルへの寄稿記事

Embryonic Structures
Crowns
Catenins
Mesoderm
Binding Sites
24 引用 (Scopus)

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway

Adachi, S., Homoto, M., Tanaka, R., Hioki, Y., Murakami, H., Suga, H., Matsumoto, M., Nakayama, K. I., Hatta, T., Iemura, S. I. & Natsume, T., 1 1 2014, : : Nucleic acids research. 42, 15, p. 10037-10049 13 p.

研究成果: ジャーナルへの寄稿記事

LDL Receptors
RNA Stability
Phosphotransferases
Messenger RNA
Antisense Oligonucleotides
29 引用 (Scopus)

β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation

Villacorte, M., Suzuki, K., Hirasawa, A., Ohkawa, Y., Suyama, M., Maruyama, T., Aoki, D., Ogino, Y., Miyagawa, S., Terabayashi, T., Tomooka, Y., Nakagata, N. & Yamada, G., 7 18 2013, : : Oncogene. 32, 29, p. 3477-3482 6 p.

研究成果: ジャーナルへの寄稿記事

Endometrial Hyperplasia
Catenins
Epithelium
Adenocarcinoma
Organogenesis