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研究成果 1993 2019

フィルター
記事
11 引用 (Scopus)

17,20-Lyase inhibitors. Part 4: Design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors

Kaku, T., Matsunaga, N., Ojida, A., Tanaka, T., Hara, T., Yamaoka, M., Kusaka, M. & Tasaka, A., 3 1 2011, : : Bioorganic and Medicinal Chemistry. 19, 5, p. 1751-1770 20 p.

研究成果: ジャーナルへの寄稿記事

Steroid 17-alpha-Hydroxylase
Structure-Activity Relationship
Derivatives
Cytochrome P-450 CYP3A
Human Activities
3 引用 (Scopus)

A host-guest system based on collagen-like triple-helix hybridization

Delsuc, N., Uchinomiya, S., Ojida, A. & Hamachi, I., 1 1 2017, : : Chemical Communications. 53, 51, p. 6856-6859 4 p.

研究成果: ジャーナルへの寄稿記事

Collagen
Proteins
15 引用 (Scopus)

Artificial receptors designed for intracellular delivery of anionic phosphate derivatives

Kohira, T., Honda, K., Ojida, A. & Hamachi, I., 3 25 2008, : : ChemBioChem. 9, 5, p. 698-701 4 p.

研究成果: ジャーナルへの寄稿記事

Organometallic Compounds
Artificial Receptors
Molecular Conformation
Drug Delivery Systems
Fluorescence Microscopy
21 引用 (Scopus)

Aza-crown-ether-appended xanthene: Selective ratiometric fluorescent probe for silver(I) ion based on arene-metal ion interaction

Takashima, I., Kanegae, A., Sugimoto, M. & Ojida, A., 7 21 2014, : : Inorganic Chemistry. 53, 14, p. 7080-7082 3 p.

研究成果: ジャーナルへの寄稿記事

Xanthenes
Crown Ethers
Fluorescent Dyes
Silver
Metal ions
17 引用 (Scopus)

Binuclear Ni II -DpaTyr complex as a high affinity probe for an oligo-aspartate tag tethered to proteins

Ojida, A., Fujishima, S. H., Honda, K., Nonaka, H., Uchinomiya, S. & Hamachi, I., 4 1 2010, : : Chemistry - An Asian Journal. 5, 4, p. 877-886 10 p.

研究成果: ジャーナルへの寄稿記事

Aspartic Acid
Peptides
Coordination Complexes
Chromophore-Assisted Light Inactivation
Proteins
152 引用 (Scopus)

Bis(Dpa-Zn II ) appended xanthone: Excitation ratiometric chemosensor for phosphate anions

Ojida, A., Nonaka, H., Miyahara, Y., Tamaru, S. I., Sada, K. & Hamachi, I., 8 18 2006, : : Angewandte Chemie - International Edition. 45, 33, p. 5518-5521 4 p.

研究成果: ジャーナルへの寄稿記事

Anions
Phosphates
Zinc
Negative ions
Fluorophores
50 引用 (Scopus)

C17,20-lyase inhibitors. Part 2: Design, synthesis and structure-activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors

Matsunaga, N., Kaku, T., Ojida, A., Tanaka, T., Hara, T., Yamaoka, M., Kusaka, M. & Tasaka, A., 8 15 2004, : : Bioorganic and Medicinal Chemistry. 12, 16, p. 4313-4336 24 p.

研究成果: ジャーナルへの寄稿記事

Imidazoles
Lyases
Biosynthesis
Structure-Activity Relationship
Liver
8 引用 (Scopus)

Cell Surface-Anchored Fluorescent Probe Capable of Real-Time Imaging of Single Mast Cell Degranulation Based on Histamine-Induced Coordination Displacement

Oshikawa, Y., Furuta, K., Tanaka, S. & Ojida, A., 2 2 2016, : : Analytical chemistry. 88, 3, p. 1526-1529 4 p.

研究成果: ジャーナルへの寄稿記事

Fluorescent Dyes
Histamine
Imaging techniques
Fluorescence
Coloring Agents

Challenges for Futuristic Nanomedical Detection, Diagnosis and Treatment

Ojida, A. & Kato, M., 1 1 2012, : : Yakugaku Zasshi. 132, 2, 1 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Coordination ligand exchange of a xanthene probe-Ce(iii) complex for selective fluorescence sensing of inorganic pyrophosphate

Kittiloespaisan, E., Takashima, I., Kiatpathomchai, W., Wongkongkatep, J. & Ojida, A., 2 28 2014, : : Chemical Communications. 50, 17, p. 2126-2128 3 p.

研究成果: ジャーナルへの寄稿記事

Xanthenes
Amplification
Fluorescence
Ligands
DNA-Directed DNA Polymerase
101 引用 (Scopus)

Cross-linking strategy for molecular recognition and fluorescent sensing of a multi-phosphorylated peptide in aqueous solution

Ojida, A., Inoue, M. A., Mito-oka, Y. & Hamachi, I., 8 27 2003, : : Journal of the American Chemical Society. 125, 34, p. 10184-10185 2 p.

研究成果: ジャーナルへの寄稿記事

Molecular recognition
Peptides
Membrane Proteins
Artificial Receptors
Proteins
6 引用 (Scopus)

Design and synthesis of a novel pre-column derivatization reagent with a 6-methoxy-4-quinolone moiety for fluorescence and tandem mass spectrometric detection and its application to chiral amino acid analysis

Oyama, T., Negishi, E., Onigahara, H., Kusano, N., Miyoshi, Y., Mita, M., Nakazono, M., Ohtsuki, S., Ojida, A., Lindner, W. & Hamase, K., 12 10 2015, : : Journal of Pharmaceutical and Biomedical Analysis. 116, p. 71-79 9 p.

研究成果: ジャーナルへの寄稿記事

Fluorescence
Amino Acids
4-Quinolones
Electrospray ionization
Enantiomers
34 引用 (Scopus)
Peptides
Phosphorylation
Proteins
Fluorescence
Phosphates
7 引用 (Scopus)

Design of a binuclear Ni(II)-iminodiacetic acid (IDA) complex for selective recognition and covalent labeling of His-tag fused proteins

Takahira, I., Fuchida, H., Tabata, S., Shindo, N., Uchinomiya, S., Hamachi, I. & Ojida, A., 7 1 2014, : : Bioorganic and Medicinal Chemistry Letters. 24, 13, p. 2855-2858 4 p.

研究成果: ジャーナルへの寄稿記事

His-His-His-His-His-His
Labeling
Molecular Probes
Proteins
G-Protein-Coupled Receptors
64 引用 (Scopus)

Design of a hybrid biosensor for enhanced phosphopeptide recognition based on a phosphoprotein binding domain coupled with a fluorescent chemosensor

Anai, T., Nakata, E., Koshi, Y., Ojida, A. & Hamachi, I., 5 16 2007, : : Journal of the American Chemical Society. 129, 19, p. 6233-6239 7 p.

研究成果: ジャーナルへの寄稿記事

Phosphopeptides
Phosphoproteins
Biosensing Techniques
Biosensors
Fluorescence
20 引用 (Scopus)

Design of a multinuclear Zn(ii) complex as a new molecular probe for fluorescence imaging of His-tag fused proteins

Fujishima, S. H., Nonaka, H., Uchinomiya, S., Kawase, Y. A., Ojida, A. & Hamachi, I., 1 14 2012, : : Chemical Communications. 48, 4, p. 594-596 3 p.

研究成果: ジャーナルへの寄稿記事

Molecular Probes
G-Protein-Coupled Receptors
Fluorescent Dyes
Histidine
Fluorescence
3 引用 (Scopus)

Design of coordination interaction of Zn(II) complex with oligo-aspartate peptide to afford a high-affinity tag-probe pair

Fuchida, H., Tabata, S., Shindo, N., Takashima, I., Leng, Q., Hatsuyama, Y., Hamachi, I. & Ojida, A., 1 1 2015, : : Bulletin of the Chemical Society of Japan. 88, 6, p. 784-791 8 p.

研究成果: ジャーナルへの寄稿記事

Aspartic Acid
Peptides
Zinc
Maltose-Binding Proteins
Pyridines
87 引用 (Scopus)

Design of dual-emission chemosensors for ratiometric detection of ATP derivatives

Ojida, A., Miyahara, Y., Wongkongkatep, J., Tamaru, S. I., Sada, K. & Hamachi, I., 11 9 2006, : : Chemistry - An Asian Journal. 1, 4, p. 555-563 9 p.

研究成果: ジャーナルへの寄稿記事

Nucleosides
Adenosine Triphosphate
Derivatives
Fluorescence
Apyrase
23 引用 (Scopus)

Design of ratiometric fluorescent probes based on arene-metal-ion interactions and their application to CdII and hydrogen sulfide imaging in living cells

Takashima, I., Kinoshita, M., Kawagoe, R., Nakagawa, S., Sugimoto, M., Hamachi, I. & Ojida, A., 2 17 2014, : : Chemistry - A European Journal. 20, 8, p. 2184-2192 9 p.

研究成果: ジャーナルへの寄稿記事

Hydrogen Sulfide
Hydrogen sulfide
Fluorescent Dyes
Metal ions
Cells
19 引用 (Scopus)

Development of an AND logic-gate-type fluorescent probe for ratiometric imaging of autolysosome in cell autophagy

Takashima, I., Kawagoe, R., Hamachi, I. & Ojida, A., 1 26 2015, : : Chemistry - A European Journal. 21, 5, p. 2038-2044 7 p.

研究成果: ジャーナルへの寄稿記事

Logic gates
Fluorescent Dyes
Xanthenes
Fluorescence
Xanthones
147 引用 (Scopus)

Development of highly sensitive fluorescent probes for detection of intracellular copper(I) in living systems

Taki, M., Iyoshi, S., Ojida, A., Hamachi, I. & Yamamoto, Y., 5 5 2010, : : Journal of the American Chemical Society. 132, 17, p. 5938-5939 2 p.

研究成果: ジャーナルへの寄稿記事

Fluorescent Dyes
Copper
Fluorescein
Reaction products
Ether
1 引用 (Scopus)

Discovery of highly reactive peptide tag by ELISA-type screening for specific cysteine conjugation

Kurashige, N., Fuchida, H., Tabata, S., Uchinomiya, S. & Ojida, A., 4 18 2017, (受理済み/印刷中) : : Bioorganic and Medicinal Chemistry Letters.

研究成果: ジャーナルへの寄稿記事

Cysteine
Screening
Enzyme-Linked Immunosorbent Assay
Peptides
Labeling
101 引用 (Scopus)

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

Kaku, T., Hitaka, T., Ojida, A., Matsunaga, N., Adachi, M., Tanaka, T., Hara, T., Yamaoka, M., Kusaka, M., Okuda, T., Asahi, S., Furuya, S. & Tasaka, A., 11 1 2011, : : Bioorganic and Medicinal Chemistry. 19, 21, p. 6383-6399 17 p.

研究成果: ジャーナルへの寄稿記事

Steroid 17-alpha-Hydroxylase
Prostatic Neoplasms
Derivatives
Phase III Clinical Trials
Dehydroepiandrosterone
77 引用 (Scopus)

Effective disruption of phosphoprotein-protein surface interaction using Zn(II) dipicolylamine-based artificial receptors via two-point interaction

Ojida, A., Inoue, M. A., Mito-Oka, Y., Tsutsumi, H., Sada, K. & Hamachi, I., 2 15 2006, : : Journal of the American Chemical Society. 128, 6, p. 2052-2058 7 p.

研究成果: ジャーナルへの寄稿記事

Artificial Receptors
Phosphoproteins
Membrane Proteins
Proteins
Peptides
102 引用 (Scopus)

Efficient fluorescent ATP-sensing based on coordination chemistry under aqueous neutral conditions

Ojida, A., Park, S. K., Mito-Oka, Y. & Hamachi, I., 8 26 2002, : : Tetrahedron Letters. 43, 35, p. 6193-6195 3 p.

研究成果: ジャーナルへの寄稿記事

Adenosine Triphosphate
bis-dipicolylamine-Zinc(II)
anthracene
304 引用 (Scopus)

First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution

Ojida, A., Mito-Oka, Y., Inoue, M. A. & Hamachi, I., 6 5 2002, : : Journal of the American Chemical Society. 124, 22, p. 6256-6258 3 p.

研究成果: ジャーナルへの寄稿記事

Artificial Receptors
Peptides
Anthracene
Zinc
Fluorescence
13 引用 (Scopus)

FLAG-tag selective covalent protein labeling via a binding-induced acyl-transfer reaction

Nonaka, H., Fujishima, S. H., Uchinomiya, S., Ojida, A. & Hamachi, I., 12 1 2009, : : Bioorganic and Medicinal Chemistry Letters. 19, 23, p. 6696-6699 4 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Proteins
FLAG peptide
175 引用 (Scopus)

Fluorescence imaging of intracellular cadmium using a dual-excitation ratiometric chemosensor

Taki, M., Desaki, M., Ojida, A., Iyoshi, S., Hirayama, T., Hamachi, I. & Yamamoto, Y., 9 24 2008, : : Journal of the American Chemical Society. 130, 38, p. 12564-12565 2 p.

研究成果: ジャーナルへの寄稿記事

Optical Imaging
Cadmium
Fluorescence
Imaging techniques
Quantum yield
122 引用 (Scopus)

Fluorescent BODIPY-based Zn(II) complex as a molecular probe for selective detection of neurofibrillary tangles in the brains of alzheimer's disease patients

Ojida, A., Sakamoto, T., Inoue, M. A., Fujishima, S. H., Lippens, G. & Hamachi, I., 5 13 2009, : : Journal of the American Chemical Society. 131, 18, p. 6543-6548 6 p.

研究成果: ジャーナルへの寄稿記事

Molecular Probes
tau Proteins
Neurofibrillary Tangles
Brain Diseases
Brain
84 引用 (Scopus)
Lewis Acids
Regioselectivity
Molecular orbitals
Orbital calculations
Anions
43 引用 (Scopus)

Highly Enantioselective Reformatsky Reaction of Ketones: Chelation-Assisted Enantioface Discrimination

Ojida, A., Yamano, T., Taya, N. & Tasaka, A., 9 5 2002, : : Organic Letters. 4, 18, p. 3051-3054 4 p.

研究成果: ジャーナルへの寄稿記事

Cinchona Alkaloids
chelation
alkaloids
Enantioselectivity
Chelation
9 引用 (Scopus)

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence

Nishimura, A., Shimauchi, T., Tanaka, T., Shimoda, K., Toyama, T., Kitajima, N., Ishikawa, T., Shindo, N., Numaga-Tomita, T., Yasuda, S., Sato, Y., Kuwahara, K., Kumagai, Y., Akaike, T., Ide, T., Ojida, A., Mori, Y. & Nishida, M., 11 13 2018, : : Science Signaling. 11, 556, eaat5185.

研究成果: ジャーナルへの寄稿記事

Filamins
Dynamins
Actins
Mitochondrial Dynamics
Proteins
45 引用 (Scopus)

Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure

Tamamura, H., Ojida, A., Ogawa, T., Tsutsumi, H., Masuno, H., Nakashima, H., Yamamoto, N., Hamachi, I. & Fujii, N., 6 1 2006, : : Journal of Medicinal Chemistry. 49, 11, p. 3412-3415 4 p.

研究成果: ジャーナルへの寄稿記事

Chemokine Receptors
Molecular Weight
HIV
Drug Therapy
zinc(II) dipicolylamine
36 引用 (Scopus)

In-cell covalent labeling of reactive His-tag fused proteins

Uchinomiya, S., Nonaka, H., Wakayama, S., Ojida, A. & Hamachi, I., 6 4 2013, : : Chemical Communications. 49, 44, p. 5022-5024 3 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Proteins
Cells
4 引用 (Scopus)

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Naoya, M., Ikeda, E., Kakimoto, K., Watanabe, M., Shindo, N., Tsuruta, A., Ikeyama, H., Hamamura, K., Higashi, K., Yamashita, T., Kondo, H., Yoshida, Y., Matsuda, M., Ogino, T., Tokushige, K., Itcho, K., Furuichi, Y., Nakao, T., Yasuda, K., Doi, A. および7人, Amamoto, T., Aramaki, H., Makoto, T., Inoue, K., Ojida, A., Satoru, K. & Ohdo, S., 11 1 2016, : : EBioMedicine. 13, p. 262-273 12 p.

研究成果: ジャーナルへの寄稿記事

Chronic Renal Insufficiency
Switches
Inflammation
Kidney
Gene encoding
3 引用 (Scopus)

Internal-Edge-Substituted Coumarin-Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self-Assembly

Usui, K., Yamamoto, K., Ueno, Y., Igawa, K., Hagihara, R., Masuda, T., Ojida, A., Karasawa, S., Tomooka, K., Hirai, G. & Suemune, H., 10 1 2018, : : Chemistry - A European Journal. 24, 55, p. 14617-14621 5 p.

研究成果: ジャーナルへの寄稿記事

Self assembly
X ray crystallography
Quantum yield
Electronic structure
Physical properties
8 引用 (Scopus)

Intracellular delivery of chemical probes using a glutathione-responsive traceless tag

Aoyama, E., Fuchida, H., Oshikawa, Y., Uchinomiya, S. & Ojida, A., 1 1 2016, : : Chemical Communications. 52, 49, p. 7715-7718 4 p.

研究成果: ジャーナルへの寄稿記事

Glutathione
Molecules
60 引用 (Scopus)

Label-free, real-time glycosyltransferase assay based on a fluorescent artificial chemosensor

Wongkongkatep, J., Miyahara, Y., Ojida, A. & Hamachi, I., 1 16 2006, : : Angewandte Chemie - International Edition. 45, 4, p. 665-668 4 p.

研究成果: ジャーナルへの寄稿記事

Glycosyltransferases
Labels
Assays
Screening
Fluorescence
3 引用 (Scopus)

Label-free fluorescent detection of loop-mediated isothermal amplification of nucleic acid using pyrophosphate-selective xanthene-based Zn(II)-coordination chemosensor

Kittiloespaisan, E., Ojida, A., Hamachi, I., Seetang-Nun, Y., Kiatpathomchai, W. & Wongkongkatep, J., 2012, : : Chemistry Letters. 41, 12, p. 1666-1668 3 p.

研究成果: ジャーナルへの寄稿記事

Xanthenes
Nucleic Acids
Amplification
Labels
Viruses
79 引用 (Scopus)

Ligand-directed acyl imidazole chemistry for labeling of membrane-bound proteins on live cells

Fujishima, S. H., Yasui, R., Miki, T., Ojida, A. & Hamachi, I., 3 7 2012, : : Journal of the American Chemical Society. 134, 9, p. 3961-3964 4 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Membrane Proteins
Ligands
Proteins
Membranes
191 引用 (Scopus)

Molecular recognition, fluorescence sensing, and biological assay of phosphate anion derivatives using artificial Zn(II)-Dpa complexes

Sakamoto, T., Ojida, A. & Hamachi, I., 1 5 2009, : : Chemical Communications. 2, p. 141-152 12 p.

研究成果: ジャーナルへの寄稿記事

Molecular recognition
Anions
Assays
Phosphates
Negative ions
292 引用 (Scopus)
Artificial Receptors
Molecular recognition
Titration
Peptides
Zinc
165 引用 (Scopus)

Molecular recognition in a supramolecular hydrogel to afford a semi-wet sensor chip

Yoshimura, I., Miyahara, Y., Kasagi, N., Yamane, H., Ojida, A. & Hamachi, I., 10 6 2004, : : Journal of the American Chemical Society. 126, 39, p. 12204-12205 2 p.

研究成果: ジャーナルへの寄稿記事

Molecular recognition
Hydrogel
Hydrogels
Sensors
Immobilization
80 引用 (Scopus)

Non-enzymatic covalent protein labeling using a reactive tag

Nonaka, H., Tsukiji, S., Ojida, A. & Hamachi, I., 12 26 2007, : : Journal of the American Chemical Society. 129, 51, p. 15777-15779 3 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Proteins
Molecular Probes
Molecular recognition
Peptides
139 引用 (Scopus)

Oligo-Asp Tag/Zn(II) complex probe as a new pair for labeling and fluorescence imaging of proteins

Ojida, A., Honda, K., Shinmi, D., Kiyonaka, S., Mori, Y. & Hamachi, I., 8 16 2006, : : Journal of the American Chemical Society. 128, 32, p. 10452-10459 8 p.

研究成果: ジャーナルへの寄稿記事

Optical Imaging
Labeling
Fluorescence
Proteins
Imaging techniques
1 引用 (Scopus)

Optimized reaction pair of the Cyshis tag and Ni(II)-Nta probe for highly selective chemical labeling of membrane proteins

Zenmyo, N., Tokumaru, H., Uchinomiya, S., Fuchida, H., Tabata, S., Hamachi, I., Shigemoto, R. & Ojida, A., 1 1 2019, : : Bulletin of the Chemical Society of Japan. 92, 5, p. 995-1000 6 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Membrane Proteins
Proteins
Cells
Molecular Probes
88 引用 (Scopus)

Organelle-localizable fluorescent chemosensors for site-specific multicolor imaging of nucleoside polyphosphate dynamics in living cells

Kurishita, Y., Kohira, T., Ojida, A. & Hamachi, I., 11 14 2012, : : Journal of the American Chemical Society. 134, 45, p. 18779-18789 11 p.

研究成果: ジャーナルへの寄稿記事

Polyphosphates
Nucleosides
Organelles
Cells
Imaging techniques

Organic chemistry for creation and regulation of protein functions

Ojida, A., Miyahara, Y. & Hamachi, I., 1 1 2006, : : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 64, 2, p. 141-150 10 p.

研究成果: ジャーナルへの寄稿記事

Proteins
Labeling
Molecules
Covalent bonds
Proteome
11 引用 (Scopus)

PET-dependent fluorescence sensing of enzyme reactions using the large and tunable pKa shift of aliphatic amines

Oshikawa, Y. & Ojida, A., 12 18 2013, : : Chemical Communications. 49, 97, p. 11373-11375 3 p.

研究成果: ジャーナルへの寄稿記事

Amines
Enzymes
Fluorescence
Fluorescent Dyes
32 引用 (Scopus)

Phosphoprotein-selective recognition and staining in SDS-PAGE by bis-Zn(II)-dipycolylamine-appended anthracene

Ojida, A., Kohira, T. & Hamachi, I., 8 5 2004, : : Chemistry Letters. 33, 8, p. 1024-1025 2 p.

研究成果: ジャーナルへの寄稿記事

Phosphoproteins
Electrophoresis
Fluorescent Dyes
Gels
Fluorescence