Pureに変更を加えた場合、すぐここに表示されます。

研究成果 2005 2019

  • 515 引用
  • 13 h指数
  • 23 記事
  • 6 評論記事
  • 1
  • 1 コメント/討論
2019

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload

Nishimura, A., Shimoda, K., Tanaka, T., Toyama, T., Nishiyama, K., Shinkai, Y., Numaga-Tomita, T., Yamazaki, D., Kanda, Y., Akaike, T., Kumagai, Y. & Nishida, M., 1 1 2019, : : Science Signaling. 12, 587, eaaw1920.

研究成果: ジャーナルへの寄稿記事

Filamins
Hemodynamics
Cardiac Myocytes
Oxidation-Reduction
Rats
1 引用 (Scopus)

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

Nishiyama, K., Numaga-Tomita, T., Fujimoto, Y., Tanaka, T., Toyama, C., Nishimura, A., Yamashita, T., Naoya, M., Satoru, K., Azuma, Y. T., Ibuki, Y., Uchida, K., Ohdo, S. & Nishida, M., 9 1 2019, : : British Journal of Pharmacology. 176, 18, p. 3723-3738 16 p.

研究成果: ジャーナルへの寄稿記事

NADPH Oxidase
Doxorubicin
Tobacco Smoke Pollution
Proteins
Pharmaceutical Preparations
1 引用 (Scopus)

Mitochondrial dynamics in exercise physiology

Tanaka, T., Nishimura, A., Nishiyama, K., Goto, T., Numaga-Tomita, T. & Nishida, M., 1 1 2019, : : Pflugers Archiv European Journal of Physiology.

研究成果: ジャーナルへの寄稿評論記事

Mitochondrial Dynamics
Physiology
Organelle Biogenesis
Post Translational Protein Processing
Homeostasis

Monitoring RhoGDI extraction of lipid-modified Rho GTPases from membranes using click chemistry

Nishimura, A. & Linder, M. E., 1 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 297-306 10 p. (Methods in Molecular Biology; 巻数 2009).

研究成果: 著書/レポートタイプへの貢献

Click Chemistry
rho GTP-Binding Proteins
Lipids
Membranes
Terpenes

TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy

Sudi, S. B., Tanaka, T., Oda, S., Nishiyama, K., Nishimura, A., Sunggip, C., Mangmool, S., Numaga-Tomita, T. & Nishida, M., 12 1 2019, : : Scientific reports. 9, 1, 9785.

研究成果: ジャーナルへの寄稿記事

公開
Cardiac Myocytes
Malnutrition
Atrophy
Adenosine Triphosphate
Reactive Oxygen Species
1 引用 (Scopus)

TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN

Numaga-Tomita, T., Shimauchi, T., Oda, S., Tanaka, T., Nishiyama, K., Nishimura, A., Birnbaumer, L., Mori, Y. & Nishida, M., 9 1 2019, : : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 9, p. 9785-9796 12 p.

研究成果: ジャーナルへの寄稿記事

Cell membranes
Vascular Smooth Muscle
Membrane Potentials
Smooth Muscle Myocytes
Muscle
2 引用 (Scopus)

TRPC channels in exercise-mimetic therapy

Numaga-Tomita, T., Oda, S., Nishiyama, K., Tanaka, T., Nishimura, A. & Nishida, M., 3 7 2019, : : Pflugers Archiv European Journal of Physiology. 471, 3, p. 507-517 11 p.

研究成果: ジャーナルへの寄稿評論記事

Exercise Therapy
Muscle
Mechanical Stress
Proteins
Oxidative stress
2018
9 引用 (Scopus)

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence

Nishimura, A., Shimauchi, T., Tanaka, T., Shimoda, K., Toyama, T., Kitajima, N., Ishikawa, T., Shindo, N., Numaga-Tomita, T., Yasuda, S., Sato, Y., Kuwahara, K., Kumagai, Y., Akaike, T., Ide, T., Ojida, A., Mori, Y. & Nishida, M., 11 13 2018, : : Science Signaling. 11, 556, eaat5185.

研究成果: ジャーナルへの寄稿記事

Filamins
Dynamins
Actins
Mitochondrial Dynamics
Proteins

Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells

Parichatikanond, W., Nishimura, A., Nishida, M. & Mangmool, S., 11 1 2018, : : Journal of Pharmacological Sciences. 138, 3, p. 184-191 8 p.

研究成果: ジャーナルへの寄稿記事

Adrenergic Receptors
Insulin Resistance
Insulin
Glucose
Smooth Muscle Myocytes
5 引用 (Scopus)

TRPC5-eNOS axis negatively regulates ATP-induced cardiomyocyte hypertrophy

Sunggip, C., Shimoda, K., Oda, S., Tanaka, T., Nishiyama, K., Mangmool, S., Nishimura, A., Numaga-Tomita, T. & Nishida, M., 5 22 2018, : : Frontiers in Pharmacology. 9, MAY, 523.

研究成果: ジャーナルへの寄稿記事

Cardiac Myocytes
Hypertrophy
Adenosine Triphosphate
NFATC Transcription Factors
Cyclic GMP-Dependent Protein Kinases
2017
81 引用 (Scopus)

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Akaike, T., Ida, T., Wei, F. Y., Nishida, M., Kumagai, Y., Alam, M. M., Ihara, H., Sawa, T., Matsunaga, T., Kasamatsu, S., Nishimura, A., Morita, M., Tomizawa, K., Nishimura, A., Watanabe, S., Inaba, K., Shima, H., Tanuma, N., Jung, M., Fujii, S. および6人, Watanabe, Y., Ohmuraya, M., Nagy, P., Feelisch, M., Fukuto, J. M. & Motohashi, H., 12 1 2017, : : Nature communications. 8, 1, 1177.

研究成果: ジャーナルへの寄稿記事

cysteinyl-tRNA synthetase
cysteine
Energy Metabolism
Cysteine
Cysteine Synthase
1 引用 (Scopus)

Eco-pharma of approved drug focused on mitochondria fission

Shimauchi, T., Nishimura, A., Ishikawa, T. & Nishida, M., 1 1 2017, : : Folia Pharmacologica Japonica. 149, 6, p. 269-273 5 p.

研究成果: ジャーナルへの寄稿コメント/討論

Drug Repositioning
Mitochondrial Dynamics
Drug Approval
Cell Aging
Mitochondria
5 引用 (Scopus)

Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension

Sunggip, C., Nishimura, A., Shimoda, K., Numaga-Tomita, T., Makoto, T. & Nishida, M., 6 1 2017, : : Pharmacological Research. 120, p. 51-59 9 p.

研究成果: ジャーナルへの寄稿評論記事

Purinergic Receptors
Hypertension
Angiotensin Type 1 Receptor
clopidogrel
Purinergic P2Y12 Receptors
17 引用 (Scopus)

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases

Nishimura, A., Sunggip, C., Oda, S., Numaga-Tomita, T., Makoto, T. & Nishida, M., 12 1 2017, : : Pharmacology and Therapeutics. 180, p. 113-128 16 p.

研究成果: ジャーナルへの寄稿評論記事

Purinergic P2Y Receptors
G-Protein-Coupled Receptors
Cardiovascular System
Cardiovascular Diseases
Uracil Nucleotides

Purinergic signaling in cardiovascular system

Nishimura, A. & Nishida, M., 1 1 2017, : : Folia Pharmacologica Japonica. 149, 2, p. 84-90 7 p.

研究成果: ジャーナルへの寄稿記事

Uracil
Cardiovascular System
Adenosine
Signal Transduction
Hypertension
6 引用 (Scopus)

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells

Nishida, M., Nishimura, A., Matsunaga, T., Motohashi, H., Kasamatsu, S. & Akaike, T., 8 1 2017, : : Free Radical Biology and Medicine. 109, p. 132-140 9 p.

研究成果: ジャーナルへの寄稿評論記事

Metabolism
Oxidation-Reduction
Nitric Oxide
Cardiovascular Physiological Phenomena
Cell signaling
18 引用 (Scopus)

Stimulation of adenosine A2B receptor inhibits endothelin-1-induced cardiac Fibroblast proliferation and α-smooth muscle actin synthesis through the cAMP/Epac/PI3K/Akt-signaling pathway

Phosri, S., Arieyawong, A., Bunrukchai, K., Parichatikanond, W., Nishimura, A., Nishida, M. & Mangmool, S., 6 30 2017, : : Frontiers in Pharmacology. 8, JUN, 428.

研究成果: ジャーナルへの寄稿記事

Endothelin A Receptors
Phosphatidylinositol 3-Kinases
Adenosine
Endothelin-1
Smooth Muscle
8 引用 (Scopus)

TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy

Shimauchi, T., Numaga-Tomita, T., Ito, T., Nishimura, A., Matsukane, R., Oda, S., Hoka, S., Ide, T., Koitabashi, N., Uchida, K., Sumimoto, H., Mori, Y. & Nishida, M., 8 3 2017, : : JCI insight. 2, 15

研究成果: ジャーナルへの寄稿記事

公開
NADPH Oxidase
Doxorubicin
Atrophy
Cardiac Myocytes
Compliance
3 引用 (Scopus)

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

Oda, S., Numaga-Tomita, T., Kitajima, N., Toyama, T., Harada, E., Shimauchi, T., Nishimura, A., Ishikawa, T., Kumagai, Y., Birnbaumer, L. & Nishida, M., 12 1 2017, : : Scientific reports. 7, 1, 7511.

研究成果: ジャーナルへの寄稿記事

NADPH Oxidase
Hyperglycemia
Heart Failure
Proteins
Reactive Oxygen Species
2016
28 引用 (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Makoto, T., Robaye, B., Inoue, K. & Nishida, M., 1 19 2016, : : Science Signaling. 9, 411, aac9187.

研究成果: ジャーナルへの寄稿記事

Purinergic Receptors
Angiotensin Type 1 Receptor
Angiotensin II
Hypertension
Arrestin
18 引用 (Scopus)

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis

Numaga-Tomita, T., Kitajima, N., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., 12 19 2016, : : Scientific reports. 6, 39383.

研究成果: ジャーナルへの寄稿記事

Cardiac Myocytes
Fibrosis
Microtubules
Pressure
Fibroblasts
31 引用 (Scopus)

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling

Kitajima, N., Numaga-Tomita, T., Watanabe, M., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., 11 11 2016, : : Scientific reports. 6, 37001.

研究成果: ジャーナルへの寄稿記事

NADPH Oxidase
Reactive Oxygen Species
Physiological Adaptation
Proteasome Endopeptidase Complex
Cardiac Myocytes
2015
18 引用 (Scopus)

Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases

Gentry, L. R., Nishimura, A., Cox, A. D., Martin, T. D., Tsygankov, D., Nishida, M., Elston, T. C. & Der, C. J., 9 11 2015, : : Journal of Biological Chemistry. 290, 37, p. 22851-22861 11 p.

研究成果: ジャーナルへの寄稿記事

Endopeptidases
GTP Phosphohydrolases
Post Translational Protein Processing
Protein Isoforms
Cell Membrane
3 引用 (Scopus)

Light-dependent activation of G proteins by two isoforms of chicken melanopsins

Torii, M., Kojima, D., Nishimura, A., Itoh, H. & Fukada, Y., 1 1 2015, : : Photochemical and Photobiological Sciences. 14, 11, p. 1991-1997 7 p.

研究成果: ジャーナルへの寄稿記事

chickens
pineal gland
GTP-Binding Proteins
Opsins
Protein Isoforms
2013

[New research initiatives in the regulatory mechanisms of heterotrimeric G protein signaling].

Itoh, H., Nishimura, A. & Nagai, Y., 1 1 2013, : : Unknown Journal. 85, 7, p. 531-542 12 p.

研究成果: ジャーナルへの寄稿評論記事

Heterotrimeric GTP-Binding Proteins
Biological Models
G-Protein-Coupled Receptors
Tertiary Protein Structure
Signal Transduction
41 引用 (Scopus)

Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding

Nishimura, A. & Linder, M. E., 4 1 2013, : : Molecular and cellular biology. 33, 7, p. 1417-1429 13 p.

研究成果: ジャーナルへの寄稿記事

Lipoylation
Prenylation
Cysteine
Palmitates
GTP Phosphohydrolases
2011
15 引用 (Scopus)

Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells

Aittaleb, M., Nishimura, A., Linder, M. E. & Tesmer, J. J. G., 10 30 2011, : : Journal of Biological Chemistry. 286, 39, p. 34448-34456 9 p.

研究成果: ジャーナルへの寄稿記事

Rho Guanine Nucleotide Exchange Factors
Lipoylation
Cell membranes
Cell Membrane
Association reactions
2010
37 引用 (Scopus)

Ric-8B stabilizes the α subunit of stimulatory G protein by inhibiting its ubiquitination

Nagai, Y., Nishimura, A., Tago, K., Mizuno, N. & Itoh, H., 4 9 2010, : : Journal of Biological Chemistry. 285, 15, p. 11114-11120 7 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitination
Cholinesterase Inhibitors
GTP-Binding Proteins
Proteins
Ubiquitinated Proteins
100 引用 (Scopus)

Structural basis for the specific inhibition of heterotrimeric G q protein by a small molecule

Nishimura, A., Kitano, K., Takasaki, J., Taniguchi, M., Mizuno, N., Tago, K., Hakoshima, T. & Itoh, H., 8 3 2010, : : Proceedings of the National Academy of Sciences of the United States of America. 107, 31, p. 13666-13671 6 p.

研究成果: ジャーナルへの寄稿記事

Heterotrimeric GTP-Binding Proteins
GTP-Binding Proteins
G-Protein-Coupled Receptors
Gq-G11 GTP-Binding Protein alpha Subunits
Depsipeptides
2006
38 引用 (Scopus)

Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells

Nishimura, A., Okamoto, M., Sugawara, Y., Mizuno, N., Yamauchi, J. & Itoh, H., 5 1 2006, : : Genes to Cells. 11, 5, p. 487-498 12 p.

研究成果: ジャーナルへの寄稿記事

G-Protein-Coupled Receptors
Signal Transduction
Guanine Nucleotide Exchange Factors
Two-Hybrid System Techniques
Guanine Nucleotides
2005
28 引用 (Scopus)

G protein-coupled receptor signaling through Gq and JNK negatively regulates neural progenitor cell migration

Mizuno, N., Kokubu, H., Sato, M., Nishimura, A., Yamauchi, J., Kurose, H. & Itoh, H., 8 30 2005, : : Proceedings of the National Academy of Sciences of the United States of America. 102, 35, p. 12365-12370 6 p.

研究成果: ジャーナルへの寄稿記事

G-Protein-Coupled Receptors
Cell Movement
Phosphotransferases
Stem Cells
Endothelin-1