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研究成果 2003 2019

  • 1145 引用
  • 20 h指数
  • 31 記事
  • 2 レター
  • 2 評論記事
2019
10 引用 (Scopus)

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y. および6人, Yagita, K., Ikeda, M., Kinoshita, T., Kay, S. A., Itami, K. & Hirota, T., 1 23 2019, : : Science Advances. 5, 1, eaau9060.

研究成果: ジャーナルへの寄稿記事

公開
Circadian Rhythm
Circadian Clocks
Phosphotransferases
Growth
Neoplasms
2017
20 引用 (Scopus)

Inhibition of USP10 induces degradation of oncogenic FLT3

Weisberg, E. L., Schauer, N. J., Yang, J., Lamberto, I., Doherty, L., Bhatt, S., Nonami, A., Meng, C., Letai, A., Wright, R., Tiv, H., Gokhale, P. C., Ritorto, M. S., De Cesare, V., Trost, M., Christodoulou, A., Christie, A., Weinstock, D. M., Adamia, S., Stone, R. および8人, Chauhan, D., Anderson, K. C., Seo, H. S., Dhe-Paganon, S., Sattler, M., Gray, N. S., Griffin, J. D. & Buhrlage, S. J., 12 1 2017, : : Nature Chemical Biology. 13, 12, p. 1207-1215 9 p.

研究成果: ジャーナルへの寄稿記事

Acute Myeloid Leukemia
Phosphotransferases
Proteasome Endopeptidase Complex
Ubiquitin
Point Mutation
5 引用 (Scopus)

Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors

Tan, L., Rao, S., Mowafy, S., Du, G., Gray, N. S., Gurbani, D., Weisberg, E. L., Jones, D. S., Singer, W. D., Bernard, F. M., Jenney, A., Nonami, A., Griffin, J. D., Lauffenburger, D. A., Westover, K. D. & Sorger, P. K., 1 1 2017, : : Bioorganic and Medicinal Chemistry. 25, 4, p. 1320-1328 9 p.

研究成果: ジャーナルへの寄稿記事

Polypharmacology
Phosphotransferases
Neoplasms
Cells
Derivatives
2016
20 引用 (Scopus)

Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia

Wu, H., Hu, C., Wang, A., Weisberg, E. L., Chen, Y., Yun, C. H., Wang, W., Liu, Y., Liu, X., Tian, B., Wang, J., Zhao, Z., Liang, Y., Li, B., Wang, L., Wang, B., Chen, C., Buhrlage, S. J., Qi, Z., Zou, F. および14人, Nonami, A., Li, Y., Fernandes, S. M., Adamia, S., Stone, R. M., Galinsky, I. A., Wang, X., Yang, G., Griffin, J. D., Brown, J. R., Eck, M. J., Liu, J., Gray, N. S. & Liu, Q., 1 1 2016, : : Leukemia. 30, 1, p. 173-181 9 p.

研究成果: ジャーナルへの寄稿記事

Lymphoma
Leukemia
Phosphotransferases
B-Lymphocytes
Acute Myeloid Leukemia
13 引用 (Scopus)

Ibrutinib selectively targets FLT3-ITD in mutant FLT3-positive AML

Wu, H., Hu, C., Wang, A., Weisberg, E. L., Wang, W., Chen, C., Zhao, Z., Yu, K., Liu, J., Wu, J., Nonami, A., Wang, L., Wang, B., Stone, R. M., Liu, S., Griffin, J. D., Liu, J. & Liu, Q., 3 1 2016, : : Leukemia. 30, 3, p. 754-757 4 p.

研究成果: ジャーナルへの寄稿レター

Leukemic Gene Expression Regulation
Heterocyclic Bridged Bicyclo Compounds
fms-Like Tyrosine Kinase 3
Benzamides
Pyrazoles
2015
7 引用 (Scopus)

Identification of ILK as a novel therapeutic target for acute and chronic myeloid leukemia

de la Puente, P., Weisberg, E., Muz, B., Nonami, A., Luderer, M., Stone, R. M., Melo, J. V., Griffin, J. D. & Azab, A. K., 4 24 2015, : : Leukemia Research. 39, 11, p. 1299-1308 10 p.

研究成果: ジャーナルへの寄稿記事

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Acute Myeloid Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Therapeutics
7 引用 (Scopus)

Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach

Nonami, A., Sattler, M., Weisberg, E., Liu, Q., Zhang, J., Patricelli, M. P., Christie, A. L., Saur, A. M., Kohl, N. E., Kung, A. L., Yoon, H., Sim, T., Gray, N. S. & Griffin, J. D., 1 1 2015, : : Blood. 125, 20, p. 3133-3143 11 p.

研究成果: ジャーナルへの寄稿記事

公開
Leukemia
Phosphotransferases
MAP Kinase Kinase Kinases
Mutation
Molecules
29 引用 (Scopus)

Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies

Weisberg, E., Nonami, A., Chen, Z., Liu, F., Zhang, J., Sattler, M., Nelson, E., Cowens, K., Christie, A. L., Mitsiades, C., Wong, K. K., Liu, Q., Gray, N. & Griffin, J. D., 1 10 2015, : : Leukemia. 29, 1, p. 27-37 11 p.

研究成果: ジャーナルへの寄稿記事

Sarcoma
Leukemia
Neoplasms
Sirolimus
Lung Neoplasms
20 引用 (Scopus)

Inhibition of wild-type p53-expressing AML by the novel small molecule HDM2 inhibitor CGM097

Weisberg, E., Halilovic, E., Cooke, V. G., Nonami, A., Ren, T., Sanda, T., Simkin, I., Yuan, J., Antonakos, B., Barys, L., Ito, M., Stone, R., Galinsky, I., Cowens, K., Nelson, E., Sattler, M., Jeay, S., Wuerthner, J. U., McDonough, S. M., Wiesmann, M. および1人, Griffin, J. D., 10 1 2015, : : Molecular Cancer Therapeutics. 14, 10, p. 2249-2259 11 p.

研究成果: ジャーナルへの寄稿記事

公開
Apoptosis
Cell Line
Mitogen-Activated Protein Kinase Kinases
Cell Cycle Checkpoints
NVP-CGM097
16 引用 (Scopus)

Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells

Bhanot, H., Reddy, M. M., Nonami, A., Weisberg, E. L., Bonal, D., Kirschmeier, P. T., Salgia, S., Podar, K., Galinsky, I., Chowdary, T. K., Neuberg, D., Tonon, G., Stone, R. M., Asara, J., Griffin, J. D. & Sattler, M., 7 13 2015, : : Leukemia. 29, 7, p. 1555-1563 9 p.

研究成果: ジャーナルへの寄稿記事

Adenylate Kinase
Glycogen Synthase
Myeloid Leukemia
Myeloid Cells
Glycogen
2014
2 引用 (Scopus)

Combination therapy with nilotinib for drug-sensitive and drug-resistant BCR-ABL-positive leukemia and other malignancies

Weisberg, E., Nonami, A. & Griffin, J. D., 11 29 2014, : : Archives of Toxicology. 88, 12, p. 2233-2242 10 p.

研究成果: ジャーナルへの寄稿評論記事

Drug Resistance
Leukemia
Pharmaceutical Preparations
P-Glycoproteins
Philadelphia Chromosome
71 引用 (Scopus)

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

Placke, T., Faber, K., Nonami, A., Putwain, S. L., Salih, H. R., Heidel, F. H., Krämer, A., Root, D. E., Barbie, D. A., Krivtsov, A. V., Armstrong, S. A., Hahn, W. C., Huntly, B. J., Sykes, S. M., Milsom, M. D., Scholl, C. & Fröhling, S., 7 3 2014, : : Blood. 124, 1, p. 13-23 11 p.

研究成果: ジャーナルへの寄稿記事

Acute Myeloid Leukemia
Leukemia
Fusion reactions
Cells
Methyltransferases
8 引用 (Scopus)

Upregulation of IGF1R by mutant RAS in leukemia and potentiation of RAS signaling inhibitors by small-molecule inhibition of IGF1R

Weisberg, E., Nonami, A., Chen, Z., Nelson, E., Chen, Y., Liu, F., Cho, H. Y., Zhang, J., Sattler, M., Mitsiades, C., Wong, K. K., Liu, Q., Gray, N. S. & Griffin, J. D., 11 1 2014, : : Clinical Cancer Research. 20, 21, p. 5483-5495 13 p.

研究成果: ジャーナルへの寄稿記事

公開
Mitogen-Activated Protein Kinase Kinases
Leukemia
Up-Regulation
Apoptosis
Gene Knockdown Techniques
2013
32 引用 (Scopus)

Selective Akt Inhibitors Synergize with Tyrosine Kinase Inhibitors and Effectively Override Stroma-Associated Cytoprotection of Mutant FLT3-Positive AML Cells

Weisberg, E., Liu, Q., Zhang, X., Nelson, E., Sattler, M., Liu, F., Nicolais, M., Zhang, J., Mitsiades, C., Smith, R. W., Stone, R., Galinsky, I., Nonami, A., Griffin, J. D. & Gray, N., 2 21 2013, : : PloS one. 8, 2, e56473.

研究成果: ジャーナルへの寄稿記事

公開
myeloid leukemia
Cytoprotection
Myeloid Cells
Acute Myeloid Leukemia
Protein-Tyrosine Kinases
2011
63 引用 (Scopus)

Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome

Kumar, M. S., Narla, A., Nonami, A., Mullally, A., Dimitrova, N., Ball, B., McAuley, J. R., Poveromo, L., Kutok, J. L., Galili, N., Raza, A., Attar, E., Gilliland, D. G., Jacks, T. & Ebert, B. L., 10 27 2011, : : Blood. 118, 17, p. 4666-4673 8 p.

研究成果: ジャーナルへの寄稿記事

公開
MicroRNAs
Genes
Thrombocytosis
Proteins
Transcription Factors
2009
26 引用 (Scopus)

Encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation

Matsuo, Y., Kamezaki, K., Takeishi, S., Takenaka, K., Eto, T., Nonami, A., Miyamoto, T., Iwasaki, H., Harada, N., Nagafuji, K., Teshima, T. & Akashi, K., 10 5 2009, : : Internal Medicine. 48, 16, p. 1453-1456 4 p.

研究成果: ジャーナルへの寄稿記事

Encephalomyelitis
Homologous Transplantation
Graft vs Host Disease
Bone Marrow Transplantation
Multiple Sclerosis
2008

An unexpected cause of a febrile patient with huge splenomegaly

Nonami, A., Yamamoto, H., Nakamura, M., Nagafuji, K. & Teshima, T., 7 1 2008, : : Clinical Rheumatology. 27, 7, p. 941-943 3 p.

研究成果: ジャーナルへの寄稿記事

Splenomegaly
Fever
Retroperitoneal Fibrosis
Differential Diagnosis
Peritoneal Fibrosis
22 引用 (Scopus)

Successful treatment of parainfluenza virus 3 pneumonia with oral ribavirin and methylprednisolone in a bone marrow transplant recipient

Shima, T., Yoshimoto, G., Nonami, A., Yoshida, S., Kamezaki, K., Iwasaki, H., Takenaka, K., Miyamoto, T., Harada, N., Teshima, T., Akashi, K. & Nagafuji, K., 10 1 2008, : : International journal of hematology. 88, 3, p. 336-340 5 p.

研究成果: ジャーナルへの寄稿記事

Paramyxoviridae Infections
Ribavirin
Methylprednisolone
Pneumonia
Bone Marrow
2007
2 引用 (Scopus)

Marked improvement of cardiac function early after non-myeloablative BMT in a heavily transfused patient with severe aplastic anemia and heart failure [1]

Kunisaki, Y., Takase, K., Miyamoto, T., Fukata, M., Nonami, A., Kamezaki, K., Kaji, Y., Gondo, H., Harada, M. & Nagafuji, K., 9 1 2007, : : Bone Marrow Transplantation. 40, 6, p. 593-595 3 p.

研究成果: ジャーナルへの寄稿レター

Severity of Illness Index
Transplantation Conditioning
Aplastic Anemia
Bone Marrow Transplantation
Blood Transfusion
67 引用 (Scopus)

Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis

Nagafuji, K., Nonami, A., Kumano, T., Kikushige, Y., Yoshimoto, G., Takenaka, K., Shimoda, K., Ohga, S., Yasukawa, M., Horiuchi, H., Ishii, E. & Harada, M., 7 1 2007, : : Haematologica. 92, 7, p. 978-981 4 p.

研究成果: ジャーナルへの寄稿記事

Hemophagocytic Lymphohistiocytosis
Perforin
Mutation
Genes
Sequence Deletion
17 引用 (Scopus)

Rituximab does not compromise the mobilization and engraftment of autologous peripheral blood stem cells in diffuse-large B-cell lymphoma

Kamezaki, K., Kikushige, Y., Numata, A., Miyamoto, T., Takase, K., Henzan, H., Aoki, K., Kato, K., Nonami, A., Kamimura, T., Arima, F., Takenaka, K., Harada, N., Fukuda, T., Hayashi, S., Ohno, Y., Eto, T., Harada, M. & Nagafuji, K., 5 1 2007, : : Bone Marrow Transplantation. 39, 9, p. 523-527 5 p.

研究成果: ジャーナルへの寄稿記事

Lymphoma, Large B-Cell, Diffuse
Integrin alpha4beta1
Transplants
Peripheral Blood Stem Cell Transplantation
Rituximab
23 引用 (Scopus)

Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Behçet's disease by up-front cord blood transplantation

Nonami, A., Takenaka, K., Sumida, C., Aizawa, K., Kamezaki, K., Miyamoto, T., Harada, N., Nagafuji, K., Teshima, T. & Harada, M., 10 15 2007, : : Internal Medicine. 46, 20, p. 1753-1756 4 p.

研究成果: ジャーナルへの寄稿記事

Intestinal Diseases
Myelodysplastic Syndromes
Fetal Blood
Transplantation
Therapeutics
20 引用 (Scopus)

Successful treatment of primary cardiac lymphoma by rituximab-CHOP and high-dose chemotherapy with autologous peripheral blood stem cell transplantation

Nonami, A., Takenaka, K., Kamezaki, K., Miyamoto, T., Harada, N., Nagafuji, K., Teshima, T. & Harada, M., 4 1 2007, : : International Journal of Hematology. 85, 3, p. 264-266 3 p.

研究成果: ジャーナルへの寄稿記事

Peripheral Blood Stem Cell Transplantation
Lymphoma
Drug Therapy
Therapeutics
Lymphoma, Large B-Cell, Diffuse
7 引用 (Scopus)

Successful treatment of primary plasma cell leukaemia by allogeneic stem cell transplantation from haploidentical sibling

Nonami, A., Miyamoto, T., Kuroiwa, M., Kunisaki, Y., Kamezaki, K., Takenaka, K., Harada, N., Teshima, T., Harada, M. & Nagafuji, K., 12 1 2007, : : Japanese journal of clinical oncology. 37, 12, p. 969-972 4 p.

研究成果: ジャーナルへの寄稿記事

Plasma Cell Leukemia
Stem Cell Transplantation
Siblings
Hematopoietic Stem Cell Transplantation
HLA Antigens
35 引用 (Scopus)

Toxoplasmosis encephalitis following severe graft-vs.-host disease after allogeneic hematopoietic stem cell transplantation: 17 Yr experience in Fukuoka BMT group

Matsuo, Y., Takeishi, S., Miyamoto, T., Nonami, A., Kikushige, Y., Kunisaki, Y., Kamezaki, K., Tu, L., Hisaeda, H., Takenaka, K., Harada, N., Kamimura, T., Ohno, Y., Eto, T., Teshima, T., Gondo, H., Harada, M. & Nagafuji, K., 10 1 2007, : : European Journal of Haematology. 79, 4, p. 317-321 5 p.

研究成果: ジャーナルへの寄稿記事

Hematopoietic Stem Cell Transplantation
Toxoplasmosis
Encephalitis
Transplants
Polymerase Chain Reaction
2006
1 引用 (Scopus)

Primary hepatic lymphoma 1 year after resection of hepatocellular carcinoma

Nonami, A., Takenaka, K., Harada, N., Kono, K., Kamezaki, K., Numata, A., Karube, K., Miyamoto, T., Nagafuji, K., Ohshima, K. & Harada, M., 12 20 2006, : : Journal of Clinical Oncology. 24, 36, p. 5784-5786 3 p.

研究成果: ジャーナルへの寄稿記事

Antineoplastic Combined Chemotherapy Protocols
Second Primary Neoplasms
Liver Neoplasms
Non-Hodgkin's Lymphoma
Hepatocellular Carcinoma
2005
102 引用 (Scopus)

Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia

Taketomi, T., Yoshiga, D., Taniguchi, K., Kobayashi, T., Nonami, A., Kato, R., Sasaki, M., Sasaki, A., Ishibashi, H., Moriyama, M., Nakamura, K. I., Nishimura, J. & Yoshimura, A., 7 25 2005, : : Nature Neuroscience. 8, 7, p. 855-857 3 p.

研究成果: ジャーナルへの寄稿記事

Glial Cell Line-Derived Neurotrophic Factor
Esophageal Achalasia
Hyperplasia
Intestinal Pseudo-Obstruction
Neurons
86 引用 (Scopus)

Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness

Inoue, H., Kato, R., Fukuyama, S., Nonami, A., Taniguchi, K., Matsumoto, K., Nakano, T., Tsuda, M., Matsumura, M., Kubo, M., Ishikawa, F., Moon, B. G., Takatsu, K., Nakanishi, Y. & Yoshimura, A., 1 3 2005, : : Journal of Experimental Medicine. 201, 1, p. 73-82 10 p.

研究成果: ジャーナルへの寄稿記事

Extracellular Signal-Regulated MAP Kinases
Eosinophilia
Allergens
Interleukin-5
Transducers
31 引用 (Scopus)

The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1

Nonami, A., Taketomi, T., Kimura, A., Saeki, K., Takaki, H., Sanada, T., Taniguchi, K., Harada, M., Kato, R. & Yoshimura, A., 9 1 2005, : : Genes to Cells. 10, 9, p. 887-895 9 p.

研究成果: ジャーナルへの寄稿記事

公開
Caveolin 1
Caveolae
Lipids
Proteins
Caveolins
2004
15 引用 (Scopus)

Human herpes virus 8-negative primary effusion lymphoma (PEL) in a patient after repeated chylous ascites and chylothorax

Nonami, A., Yokoyama, T., Takeshita, M., Ohshima, K., Kubota, A. & Okamura, S., 3 1 2004, : : Internal Medicine. 43, 3, p. 236-242 7 p.

研究成果: ジャーナルへの寄稿記事

公開
Primary Effusion Lymphoma
Chylous Ascites
Chylothorax
Viruses
Lymphoma
6 引用 (Scopus)

Pulmonary metastasis from pancreatic cancer: A case showing biphasic radiological and histological patterns

Okafuji, T., Sakai, S., Yoshimitsu, K., Soeda, H., Furuya, A., Matsuura, S., Horiuchi, T., Nonami, A. & Honda, H., 10 2004, : : CMIGExtra: Cases. 28, 7, p. 68-71 4 p.

研究成果: ジャーナルへの寄稿記事

Pancreatic Neoplasms
Adenocarcinoma
Neoplasm Metastasis
Lung
Histology
67 引用 (Scopus)

Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells

Nonami, A., Kato, R., Taniguchi, K., Yoshiga, D., Taketomi, T., Fukuyama, S., Harada, M., Sasaki, A. & Yoshimura, A., 12 10 2004, : : Journal of Biological Chemistry. 279, 50, p. 52543-52551 9 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-3
Mitogen-Activated Protein Kinases
Chemical activation
Stem Cell Factor
Bone
2003
181 引用 (Scopus)

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1

Sasaki, A., Taketomi, T., Kato, R., Saeki, K., Nonami, A., Sasaki, M., Kuriyama, M., Saito, N., Shibuya, M. & Yoshimura, A., 5 1 2003, : : Nature Cell Biology. 5, 5, p. 427-432 6 p.

研究成果: ジャーナルへの寄稿記事

Extracellular Signal-Regulated MAP Kinases
Intercellular Signaling Peptides and Proteins
Blood Vessels
Fibroblast Growth Factors
Mitogen-Activated Protein Kinase Kinases
32 引用 (Scopus)

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

Sasaki, A., Taketomi, T., Kato, R., Saeki, K., Nonami, A., Sasaki, M., Kuriyama, M., Saito, N., Shibuya, M. & Yoshimura, A., 1 1 2003, : : Cell cycle (Georgetown, Tex.). 2, 4, p. 280-281 2 p.

研究成果: ジャーナルへの寄稿評論記事

Nerve Tissue Proteins
Proto-Oncogene Proteins c-raf
ras Proteins
Vascular Endothelial Growth Factor Receptor-2
Enzyme Activation
82 引用 (Scopus)

Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation

Kato, R., Nonami, A., Taketomi, T., Wakioka, T., Kuroiwa, A., Matsuda, Y. & Yoshimura, A., 3 21 2003, : : Biochemical and Biophysical Research Communications. 302, 4, p. 767-772 6 p.

研究成果: ジャーナルへの寄稿記事

Cloning
Molecular Cloning
Protein-Tyrosine Kinases
Phosphotransferases
Chemical activation