• 1241 引用
  • 21 h指数
20032019

年単位の研究成果

Pureに変更を加えた場合、すぐここに表示されます。

研究成果

  • 1241 引用
  • 21 h指数
  • 31 Article
  • 2 Letter
  • 2 Review article
2019

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y. および6人, Yagita, K., Ikeda, M., Kinoshita, T., Kay, S. A., Itami, K. & Hirota, T., 1 23 2019, : : Science Advances. 5, 1, eaau9060.

研究成果: Contribution to journalArticle

公開
23 引用 (Scopus)
2017

Inhibition of USP10 induces degradation of oncogenic FLT3

Weisberg, E. L., Schauer, N. J., Yang, J., Lamberto, I., Doherty, L., Bhatt, S., Nonami, A., Meng, C., Letai, A., Wright, R., Tiv, H., Gokhale, P. C., Ritorto, M. S., De Cesare, V., Trost, M., Christodoulou, A., Christie, A., Weinstock, D. M., Adamia, S., Stone, R. および8人, Chauhan, D., Anderson, K. C., Seo, H. S., Dhe-Paganon, S., Sattler, M., Gray, N. S., Griffin, J. D. & Buhrlage, S. J., 12 1 2017, : : Nature Chemical Biology. 13, 12, p. 1207-1215 9 p.

研究成果: Contribution to journalArticle

34 引用 (Scopus)

Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors

Tan, L., Rao, S., Mowafy, S., Du, G., Gray, N. S., Gurbani, D., Weisberg, E. L., Jones, D. S., Singer, W. D., Bernard, F. M., Jenney, A., Nonami, A., Griffin, J. D., Lauffenburger, D. A., Westover, K. D. & Sorger, P. K., 2017, : : Bioorganic and Medicinal Chemistry. 25, 4, p. 1320-1328 9 p.

研究成果: Contribution to journalArticle

9 引用 (Scopus)
2016

Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia

Wu, H., Hu, C., Wang, A., Weisberg, E. L., Chen, Y., Yun, C. H., Wang, W., Liu, Y., Liu, X., Tian, B., Wang, J., Zhao, Z., Liang, Y., Li, B., Wang, L., Wang, B., Chen, C., Buhrlage, S. J., Qi, Z., Zou, F. および14人, Nonami, A., Li, Y., Fernandes, S. M., Adamia, S., Stone, R. M., Galinsky, I. A., Wang, X., Yang, G., Griffin, J. D., Brown, J. R., Eck, M. J., Liu, J., Gray, N. S. & Liu, Q., 1 1 2016, : : Leukemia. 30, 1, p. 173-181 9 p.

研究成果: Contribution to journalArticle

23 引用 (Scopus)

Ibrutinib selectively targets FLT3-ITD in mutant FLT3-positive AML

Wu, H., Hu, C., Wang, A., Weisberg, E. L., Wang, W., Chen, C., Zhao, Z., Yu, K., Liu, J., Wu, J., Nonami, A., Wang, L., Wang, B., Stone, R. M., Liu, S., Griffin, J. D., Liu, J. & Liu, Q., 3 1 2016, : : Leukemia. 30, 3, p. 754-757 4 p.

研究成果: Contribution to journalLetter

17 引用 (Scopus)
2015

Identification of ILK as a novel therapeutic target for acute and chronic myeloid leukemia

de la Puente, P., Weisberg, E., Muz, B., Nonami, A., Luderer, M., Stone, R. M., Melo, J. V., Griffin, J. D. & Azab, A. K., 4 24 2015, : : Leukemia Research. 39, 11, p. 1299-1308 10 p.

研究成果: Contribution to journalArticle

11 引用 (Scopus)

Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach

Nonami, A., Sattler, M., Weisberg, E., Liu, Q., Zhang, J., Patricelli, M. P., Christie, A. L., Saur, A. M., Kohl, N. E., Kung, A. L., Yoon, H., Sim, T., Gray, N. S. & Griffin, J. D., 2015, : : Blood. 125, 20, p. 3133-3143 11 p.

研究成果: Contribution to journalArticle

公開
12 引用 (Scopus)

Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies

Weisberg, E., Nonami, A., Chen, Z., Liu, F., Zhang, J., Sattler, M., Nelson, E., Cowens, K., Christie, A. L., Mitsiades, C., Wong, K. K., Liu, Q., Gray, N. & Griffin, J. D., 1 10 2015, : : Leukemia. 29, 1, p. 27-37 11 p.

研究成果: Contribution to journalArticle

31 引用 (Scopus)

Inhibition of wild-type p53-expressing AML by the novel small molecule HDM2 inhibitor CGM097

Weisberg, E., Halilovic, E., Cooke, V. G., Nonami, A., Ren, T., Sanda, T., Simkin, I., Yuan, J., Antonakos, B., Barys, L., Ito, M., Stone, R., Galinsky, I., Cowens, K., Nelson, E., Sattler, M., Jeay, S., Wuerthner, J. U., McDonough, S. M., Wiesmann, M. および1人, Griffin, J. D., 10 1 2015, : : Molecular cancer therapeutics. 14, 10, p. 2249-2259 11 p.

研究成果: Contribution to journalArticle

公開
24 引用 (Scopus)

Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells

Bhanot, H., Reddy, M. M., Nonami, A., Weisberg, E. L., Bonal, D., Kirschmeier, P. T., Salgia, S., Podar, K., Galinsky, I., Chowdary, T. K., Neuberg, D., Tonon, G., Stone, R. M., Asara, J., Griffin, J. D. & Sattler, M., 7 13 2015, : : Leukemia. 29, 7, p. 1555-1563 9 p.

研究成果: Contribution to journalArticle

19 引用 (Scopus)
2014

Combination therapy with nilotinib for drug-sensitive and drug-resistant BCR-ABL-positive leukemia and other malignancies

Weisberg, E., Nonami, A. & Griffin, J. D., 11 29 2014, : : Archives of Toxicology. 88, 12, p. 2233-2242 10 p.

研究成果: Contribution to journalReview article

3 引用 (Scopus)

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

Placke, T., Faber, K., Nonami, A., Putwain, S. L., Salih, H. R., Heidel, F. H., Krämer, A., Root, D. E., Barbie, D. A., Krivtsov, A. V., Armstrong, S. A., Hahn, W. C., Huntly, B. J., Sykes, S. M., Milsom, M. D., Scholl, C. & Fröhling, S., 7 3 2014, : : Blood. 124, 1, p. 13-23 11 p.

研究成果: Contribution to journalArticle

85 引用 (Scopus)

Upregulation of IGF1R by mutant RAS in leukemia and potentiation of RAS signaling inhibitors by small-molecule inhibition of IGF1R

Weisberg, E., Nonami, A., Chen, Z., Nelson, E., Chen, Y., Liu, F., Cho, H. Y., Zhang, J., Sattler, M., Mitsiades, C., Wong, K. K., Liu, Q., Gray, N. S. & Griffin, J. D., 11 1 2014, : : Clinical Cancer Research. 20, 21, p. 5483-5495 13 p.

研究成果: Contribution to journalArticle

公開
8 引用 (Scopus)
2013

Selective Akt Inhibitors Synergize with Tyrosine Kinase Inhibitors and Effectively Override Stroma-Associated Cytoprotection of Mutant FLT3-Positive AML Cells

Weisberg, E., Liu, Q., Zhang, X., Nelson, E., Sattler, M., Liu, F., Nicolais, M., Zhang, J., Mitsiades, C., Smith, R. W., Stone, R., Galinsky, I., Nonami, A., Griffin, J. D. & Gray, N., 2 21 2013, : : PloS one. 8, 2, e56473.

研究成果: Contribution to journalArticle

公開
34 引用 (Scopus)
2011

Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome

Kumar, M. S., Narla, A., Nonami, A., Mullally, A., Dimitrova, N., Ball, B., McAuley, J. R., Poveromo, L., Kutok, J. L., Galili, N., Raza, A., Attar, E., Gilliland, D. G., Jacks, T. & Ebert, B. L., 10 27 2011, : : Blood. 118, 17, p. 4666-4673 8 p.

研究成果: Contribution to journalArticle

公開
65 引用 (Scopus)
2009

Encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation

Matsuo, Y., Kamezaki, K., Takeishi, S., Takenaka, K., Eto, T., Nonami, A., Miyamoto, T., Iwasaki, H., Harada, N., Nagafuji, K., Teshima, T. & Akashi, K., 2009, : : Internal Medicine. 48, 16, p. 1453-1456 4 p.

研究成果: Contribution to journalArticle

27 引用 (Scopus)
2008

An unexpected cause of a febrile patient with huge splenomegaly

Nonami, A., Yamamoto, H., Nakamura, M., Nagafuji, K. & Teshima, T., 7 2008, : : Clinical Rheumatology. 27, 7, p. 941-943 3 p.

研究成果: Contribution to journalArticle

Successful treatment of parainfluenza virus 3 pneumonia with oral ribavirin and methylprednisolone in a bone marrow transplant recipient

Shima, T., Yoshimoto, G., Nonami, A., Yoshida, S., Kamezaki, K., Iwasaki, H., Takenaka, K., Miyamoto, T., Harada, N., Teshima, T., Akashi, K. & Nagafuji, K., 10 2008, : : International journal of hematology. 88, 3, p. 336-340 5 p.

研究成果: Contribution to journalArticle

23 引用 (Scopus)
2007
2 引用 (Scopus)

Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis

Nagafuji, K., Nonami, A., Kumano, T., Kikushige, Y., Yoshimoto, G., Takenaka, K., Shimoda, K., Ohga, S., Yasukawa, M., Horiuchi, H., Ishii, E. & Harada, M., 7 2007, : : Haematologica. 92, 7, p. 978-981 4 p.

研究成果: Contribution to journalArticle

71 引用 (Scopus)

Rituximab does not compromise the mobilization and engraftment of autologous peripheral blood stem cells in diffuse-large B-cell lymphoma

Kamezaki, K., Kikushige, Y., Numata, A., Miyamoto, T., Takase, K., Henzan, H., Aoki, K., Kato, K., Nonami, A., Kamimura, T., Arima, F., Takenaka, K., Harada, N., Fukuda, T., Hayashi, S., Ohno, Y., Eto, T., Harada, M. & Nagafuji, K., 5 2007, : : Bone Marrow Transplantation. 39, 9, p. 523-527 5 p.

研究成果: Contribution to journalArticle

17 引用 (Scopus)

Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Behçet's disease by up-front cord blood transplantation

Nonami, A., Takenaka, K., Sumida, C., Aizawa, K., Kamezaki, K., Miyamoto, T., Harada, N., Nagafuji, K., Teshima, T. & Harada, M., 10 15 2007, : : Internal Medicine. 46, 20, p. 1753-1756 4 p.

研究成果: Contribution to journalArticle

25 引用 (Scopus)

Successful treatment of primary cardiac lymphoma by rituximab-CHOP and high-dose chemotherapy with autologous peripheral blood stem cell transplantation

Nonami, A., Takenaka, K., Kamezaki, K., Miyamoto, T., Harada, N., Nagafuji, K., Teshima, T. & Harada, M., 4 2007, : : International journal of hematology. 85, 3, p. 264-266 3 p.

研究成果: Contribution to journalArticle

22 引用 (Scopus)

Successful treatment of primary plasma cell leukaemia by allogeneic stem cell transplantation from haploidentical sibling

Nonami, A., Miyamoto, T., Kuroiwa, M., Kunisaki, Y., Kamezaki, K., Takenaka, K., Harada, N., Teshima, T., Harada, M. & Nagafuji, K., 12 2007, : : Japanese journal of clinical oncology. 37, 12, p. 969-972 4 p.

研究成果: Contribution to journalArticle

7 引用 (Scopus)

Toxoplasmosis encephalitis following severe graft-vs.-host disease after allogeneic hematopoietic stem cell transplantation: 17 Yr experience in Fukuoka BMT group

Matsuo, Y., Takeishi, S., Miyamoto, T., Nonami, A., Kikushige, Y., Kunisaki, Y., Kamezaki, K., Tu, L., Hisaeda, H., Takenaka, K., Harada, N., Kamimura, T., Ohno, Y., Eto, T., Teshima, T., Gondo, H., Harada, M. & Nagafuji, K., 10 1 2007, : : European Journal of Haematology. 79, 4, p. 317-321 5 p.

研究成果: Contribution to journalArticle

35 引用 (Scopus)
2006

Primary hepatic lymphoma 1 year after resection of hepatocellular carcinoma

Nonami, A., Takenaka, K., Harada, N., Kono, K., Kamezaki, K., Numata, A., Karube, K., Miyamoto, T., Nagafuji, K., Ohshima, K. & Harada, M., 12 20 2006, : : Journal of Clinical Oncology. 24, 36, p. 5784-5786 3 p.

研究成果: Contribution to journalArticle

1 引用 (Scopus)
2005

Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia

Taketomi, T., Yoshiga, D., Taniguchi, K., Kobayashi, T., Nonami, A., Kato, R., Sasaki, M., Sasaki, A., Ishibashi, H., Moriyama, M., Nakamura, K. I., Nishimura, J. & Yoshimura, A., 7 25 2005, : : Nature Neuroscience. 8, 7, p. 855-857 3 p.

研究成果: Contribution to journalArticle

105 引用 (Scopus)

Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness

Inoue, H., Kato, R., Fukuyama, S., Nonami, A., Taniguchi, K., Matsumoto, K., Nakano, T., Tsuda, M., Matsumura, M., Kubo, M., Ishikawa, F., Moon, B. G., Takatsu, K., Nakanishi, Y. & Yoshimura, A., 1 3 2005, : : Journal of Experimental Medicine. 201, 1, p. 73-82 10 p.

研究成果: Contribution to journalArticle

86 引用 (Scopus)

The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1

Nonami, A., Taketomi, T., Kimura, A., Saeki, K., Takaki, H., Sanada, T., Taniguchi, K., Harada, M., Kato, R. & Yoshimura, A., 9 2005, : : Genes to Cells. 10, 9, p. 887-895 9 p.

研究成果: Contribution to journalArticle

公開
34 引用 (Scopus)
2004

Human herpes virus 8-negative primary effusion lymphoma (PEL) in a patient after repeated chylous ascites and chylothorax

Nonami, A., Yokoyama, T., Takeshita, M., Ohshima, K., Kubota, A. & Okamura, S., 3 2004, : : Internal Medicine. 43, 3, p. 236-242 7 p.

研究成果: Contribution to journalArticle

公開
16 引用 (Scopus)

Pulmonary metastasis from pancreatic cancer: A case showing biphasic radiological and histological patterns

Okafuji, T., Sakai, S., Yoshimitsu, K., Soeda, H., Furuya, A., Matsuura, S., Horiuchi, T., Nonami, A. & Honda, H., 10 2004, : : CMIGExtra: Cases. 28, 7, p. 68-71 4 p.

研究成果: Contribution to journalArticle

6 引用 (Scopus)

Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells

Nonami, A., Kato, R., Taniguchi, K., Yoshiga, D., Taketomi, T., Fukuyama, S., Harada, M., Sasaki, A. & Yoshimura, A., 12 10 2004, : : Journal of Biological Chemistry. 279, 50, p. 52543-52551 9 p.

研究成果: Contribution to journalArticle

68 引用 (Scopus)
2003

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1

Sasaki, A., Taketomi, T., Kato, R., Saeki, K., Nonami, A., Sasaki, M., Kuriyama, M., Saito, N., Shibuya, M. & Yoshimura, A., 5 1 2003, : : Nature Cell Biology. 5, 5, p. 427-432 6 p.

研究成果: Contribution to journalArticle

185 引用 (Scopus)

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

Sasaki, A., Taketomi, T., Kato, R., Saeki, K., Nonami, A., Sasaki, M., Kuriyama, M., Saito, N., Shibuya, M. & Yoshimura, A., 1 1 2003, : : Cell cycle (Georgetown, Tex.). 2, 4, p. 280-281 2 p.

研究成果: Contribution to journalReview article

26 引用 (Scopus)

Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation

Kato, R., Nonami, A., Taketomi, T., Wakioka, T., Kuroiwa, A., Matsuda, Y. & Yoshimura, A., 3 21 2003, : : Biochemical and Biophysical Research Communications. 302, 4, p. 767-772 6 p.

研究成果: Contribution to journalArticle

87 引用 (Scopus)