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研究成果 1999 2019

  • 1211 引用
  • 15 h指数
  • 103 章 (査読済み)
  • 37 記事
  • 3 評論記事
  • 1 ポスター
2019

Biosynthetic Short Neuropeptides: A Rational Theory Based on Experimental Results for the Missing Pain-Relief Opioid Endomorphin Precursor Gene

Matsushima, A., Sese, J. & Koyanagi, K. O., 1 1 2019, : : ChemBioChem. 20, 16, p. 2054-2058 5 p.

研究成果: ジャーナルへの寄稿記事

Neuropeptides
Opioid Analgesics
Genes
Pain
Peptides

Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors

Masuya, T., Iwamoto, M., Liu, X. & Matsushima, A., 12 1 2019, : : Scientific reports. 9, 1, 9954.

研究成果: ジャーナルへの寄稿記事

公開
Cytoplasmic and Nuclear Receptors
Estrogens
Estrogen Receptors
Epoxy Resins
Endocrine Disruptors

Evaluation of the binding ability of an orphan nuclear receptor nurr1 to synthetic peptides.

Masuya, T., Tada, Y., Liu, X. & Matsushima, A., 2019, Peptide Science 2018. p. 133

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors

Liu, X., Sakai, H., Nishigori, M., Suyama, K., Nawaji, T., Ikeda, S., Nishigouchi, M., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 8 15 2019, : : Toxicology and Applied Pharmacology. 377, 114610.

研究成果: ジャーナルへの寄稿記事

Cytoplasmic and Nuclear Receptors
Assays
Endocrine Disruptors
Peroxisome Proliferator-Activated Receptors
Competitive Binding
2018
2 引用 (Scopus)
wildlife
Endocrine Disruptors
disrupting
bisphenols
DDT
DDT
wildlife
Endocrine Disruptors
disrupting
bisphenols

Homodimer function of human nuclear receptor ERR evidenced using -helix peptides in the dimer interface

Liu, X., Nakagawa, H., Sugiyama, M., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2018, Peptide Science 2017. p. 190 191 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Mutual co-work between nuclear receptor ERalpha and ERRgamma requires their homodimerization

Liu, X., Shimohigashi, M., Sugiyama, M., Matsushima, A. & Shimohigashi, Y., 2018, Peptide Science 2017,. p. 198 199 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Phe 2715.39 of Thronbin Receptor PAR-1 is a specific target of Phe-2-phenl group of its tethered ligand

Sugiyama, M., Fujita, T., Liu, X., Matsuyama, Y., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2018, Peptide Science 2017. p. 94 95 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2017

Docking simulation to elucidate the labeled cysteine residue of the nociception receptor ORL1 using a Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X. & Shimohigashi, Y., 2017, Peptide Science 2016. p. 87-88

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2016

Comparative analysis of the ligand binding domain secondary structures of human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 337-338

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Comprehensive structural analysis of the nociceptin ORL1 receptor by means of virtual and experimental Ala-scanning combinated methods

Matsushima, A., Nishimura, H., Liu, X., Takesue, Y., Matsuyama, Y. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 149-150

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Do the estrogen receptors function as a homodimer? experimental validation of homodimerization by inhibitory peptides

Sakito, S., Fujiyama, A., Motomatsu, Y., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 335-336

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Do the estrogen receptors function as a homodimer? experimental validation of homodimerization by inhibitory peptides

Sakito, S., Liu, X., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 335-336

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Expression analysis of neuropeptide PDF mRNA in the hypoactive and hyperactive fruit flies Drosophila melanogaster

Asuka, T., Matsuo, A., Shotaro, U., Matsuyama, Y., masayuki, N., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 317-318

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Functional role of the Phe-Phe stacking microswitch in the ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 147-148

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

ORL1 Nociceptin receptor response of opioid peptides derived from proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsuyama, Y., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 181-182

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

SCN Circadian rhythm signal transduction neuropeptides evoke hypoactive phenotype differently in male and female mice

Sugiyama, M., Motomatsu, Y., Matsuyama, Y., Kajiyama, S., Kameda, T., Uchimura, E., Saito, T., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 53-54

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

4 引用 (Scopus)

Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X., Costa, T. & Shimohigashi, Y., 11 4 2016, : : Biopolymers. p. 460-469 10 p.

研究成果: ジャーナルへの寄稿記事

Sulfhydryl Compounds
Labeling
Peptides
Ligands
Binding sites

Structure-function studies between the hormone-disrupting chemical bisphenols and the nuclear receptors

Matsushima, A., 1 1 2016, : : Seikagaku. 88, 6, p. 733-743 11 p.

研究成果: ジャーナルへの寄稿評論記事

Benzhydryl Compounds
Phenols
Structure-Activity Relationship
Cytoplasmic and Nuclear Receptors
Hormones
1 引用 (Scopus)

α-Helix-peptides comprising the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 11 4 2016, : : Biopolymers. p. 547-554 8 p.

研究成果: ジャーナルへの寄稿記事

Dimerization
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Peptides
Estrogens

核内受容体が示す有害化学物質ビスフェノール応答

Matsushima, A., 12 2016, : : Seikagaku. The Journal of Japanese Biochemical Society. 88, 6, p. 733-43 11 p.

研究成果: ジャーナルへの寄稿記事

2015

Alternative polyadenylation analyses of neuropeptide genes in bisphenol A-exposed hypoactive mouse brain

Sugiyama, M., Kajiyama, S., Saito, T., Uchimura, E., Motomatsu, Y., Matsuo, A., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 345-346

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

An in silico genomic search of endomorphin-like opioid peptides

Matsushima, A., Koyanagi, K. O., Nishimura, H., Inamine, S., Motomatsu, Y. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 281-282

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

A novel method identify and quantify the coactivator proteins that couple with human nuclear receptor: the use of interacting interface a-helix peptide for quantitative inhibition

Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Bisphenol A-induced substantial peak decay of Drosophila circadian neuropeptide hugin mRNA expression

Shotaro, U., Matsuo, A., Matsuyama, Y., Nakamura, M., Koga, K., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 41-42

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

GPCR functional role of Phe-269 and Phe-221 in the molecular switching of ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Receptor selectivity and specificity of a series of opioid peptides latent in the proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Kuramitsu, Y., Inamine, S., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 201-202

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structural and molecular evolutionary analysis of the ligand-binding domain of forty-eight human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 347-348

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structure-activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, M., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 319-320

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

The molecular switching of ORL1 nociceptin receptor in activation/inactivation

Nishimura, H., Li, J., Isozaki, K., yuuki, T., Matsushima, A., Liu, X., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 201-202

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2014
14 引用 (Scopus)

A characteristic back support structure in the bisphenol A-binding pocket in the human nuclear receptor ERRγ

Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 6 30 2014, : : PloS one. 9, 6, e101252.

研究成果: ジャーナルへの寄稿記事

bisphenol A
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
receptors
estrogens

Bisphenol A-induced Epigenetic Mutations in Circadian Pacemaker Neuropeptide mRNAs of Hyperactive Drosophila Fruit Flies

Matsuo, A., Umeno, S., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 457-458

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Constitutive α-Helix-peptides Required for Functional Dimerization of Estrogen-related Receptor γ (ERRγ).

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 429-430

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Expression and Mutation Analyses of Brain Neuropeptide Genes of Rndocrine-disrupting Bisphenol A-exposed Hypoactive Mouse

Sugiyama, M., Matsuo, A., Saito, T., Uchimura, E., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 453-454

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Functionally Essential Amino Acid Residues in ORL1 Nociceptin Receptor for Ligand-stimulated Receptor Activation

Nishimura, H., Li, J., abe, Y., Isozaki, K., Matsushima, A., Inamine, S., Costa, T. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 333-334

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Influence Analysis of the Circadian Evening Pacemaker Neuropeptide hugγ Gene in the Bisphenol A-exposed Fruit Fly Drosophila Brain

Umeno, S., Matsuo, A., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 455-456

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Multiple and Simultaneous Cys→Ala Mutations of ORL1 Nociceptin Receptor to Identify the Affinity Binding site of Cys(Npys)-Elongated RYYRIK Peptide Antagonist

Matsushima, A., Nishimura, H., Inamine, S. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 413-414

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

3 引用 (Scopus)

N-methylthioacetylation of RYYRIK-NH2 with enhanced specific binding affinity and high antagonist activity for nociceptin ORL1 receptor

Li, J., Nishimura, H., Matsushima, A. & Shimohigashi, Y., 11 1 2014, : : Bioorganic and Medicinal Chemistry. 22, 21, p. 5721-5726 6 p.

研究成果: ジャーナルへの寄稿記事

Peptide Library
Atoms
Peptides
Peptide Receptors
Neuropeptides

Specific Role of Phe Residues in Opioid Peptide Met-enkephalin- Arg-Phe in Binding to All Three Opioid Receptors

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Inamine, S., Kuramitsu, Y., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 317-318

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Structure-Activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 3 2014, Peptide Science 2013. p. 319-320 2 p.

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Three-dimensional Docking Modeling to Human Nuclear Receptors for Exploration of Bisphenol-A Targeting Receptors

Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 459-460

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2 引用 (Scopus)

Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor

Inamine, S., Nishimura, H., Li, J., Isozaki, K., Matsushima, A., Costa, T. & Shimohigashi, Y., 11 1 2014, : : Bioorganic and Medicinal Chemistry. 22, 21, p. 5902-5909 8 p.

研究成果: ジャーナルへの寄稿記事

Narcotic Antagonists
Tritium
Opioid Receptors
Binding Sites
Conformations
2013
15 引用 (Scopus)

An endocrine disruptor, bisphenol A, affects development in the protochordate Ciona intestinalis: Hatching rates and swimming behavior alter in a dose-dependent manner

Matsushima, A., Ryan, K., Shimohigashi, Y. & Meinertzhagen, I. A., 2 1 2013, : : Environmental Pollution. 173, p. 257-263 7 p.

研究成果: ジャーナルへの寄稿記事

Ciona intestinalis
Endocrine Disruptors
Mammals
Neurology
Polycarbonates

Bisphenol-binding pocket of constitutively active nuclear receptor CAR: Docking modeling for close-packing

Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 401-402

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Exploration of pharmacological chaperone for rescue of misfolded and/or unfolded ORL1 nociceptin receptor proteins

Nishimura, H., Inamine, S., Li, J., Matsushima, A. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 115-118

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Halogenated Phe-containing endomorphin-2 analogs with mixed agonist and antagonist activities

Nishio, K., Nishimura, H., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 25-26

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

High-precision binding assay procedure of tachykinin receptor NK-1 for highly potent Substance P analogs

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 213-214

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

Identification of affinity binding site of Cys(Npys)-elongated RYYRIK peptide antagonist by means of Cys→Ala mutated ORL1 nociceptin receptors

Matsushima, A., Nishimura, H., Inamine, S. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 207-208

研究成果: 著書/レポートタイプへの貢献章 (査読済み)