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研究成果 1999 2019

  • 1211 引用
  • 15 h指数
  • 103 章 (査読済み)
  • 37 記事
  • 3 評論記事
  • 1 ポスター
フィルター
記事
2019

Biosynthetic Short Neuropeptides: A Rational Theory Based on Experimental Results for the Missing Pain-Relief Opioid Endomorphin Precursor Gene

Matsushima, A., Sese, J. & Koyanagi, K. O., 1 1 2019, : : ChemBioChem. 20, 16, p. 2054-2058 5 p.

研究成果: ジャーナルへの寄稿記事

Neuropeptides
Opioid Analgesics
Genes
Pain
Peptides

Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors

Masuya, T., Iwamoto, M., Liu, X. & Matsushima, A., 12 1 2019, : : Scientific reports. 9, 1, 9954.

研究成果: ジャーナルへの寄稿記事

公開
Cytoplasmic and Nuclear Receptors
Estrogens
Estrogen Receptors
Epoxy Resins
Endocrine Disruptors

Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors

Liu, X., Sakai, H., Nishigori, M., Suyama, K., Nawaji, T., Ikeda, S., Nishigouchi, M., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 8 15 2019, : : Toxicology and Applied Pharmacology. 377, 114610.

研究成果: ジャーナルへの寄稿記事

Cytoplasmic and Nuclear Receptors
Assays
Endocrine Disruptors
Peroxisome Proliferator-Activated Receptors
Competitive Binding
2016
4 引用 (Scopus)

Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X., Costa, T. & Shimohigashi, Y., 11 4 2016, : : Biopolymers. p. 460-469 10 p.

研究成果: ジャーナルへの寄稿記事

Sulfhydryl Compounds
Labeling
Peptides
Ligands
Binding sites
1 引用 (Scopus)

α-Helix-peptides comprising the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 11 4 2016, : : Biopolymers. p. 547-554 8 p.

研究成果: ジャーナルへの寄稿記事

Dimerization
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Peptides
Estrogens

核内受容体が示す有害化学物質ビスフェノール応答

Matsushima, A., 12 2016, : : Seikagaku. The Journal of Japanese Biochemical Society. 88, 6, p. 733-43 11 p.

研究成果: ジャーナルへの寄稿記事

2014
14 引用 (Scopus)

A characteristic back support structure in the bisphenol A-binding pocket in the human nuclear receptor ERRγ

Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 6 30 2014, : : PloS one. 9, 6, e101252.

研究成果: ジャーナルへの寄稿記事

bisphenol A
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
receptors
estrogens
3 引用 (Scopus)

N-methylthioacetylation of RYYRIK-NH2 with enhanced specific binding affinity and high antagonist activity for nociceptin ORL1 receptor

Li, J., Nishimura, H., Matsushima, A. & Shimohigashi, Y., 11 1 2014, : : Bioorganic and Medicinal Chemistry. 22, 21, p. 5721-5726 6 p.

研究成果: ジャーナルへの寄稿記事

Peptide Library
Atoms
Peptides
Peptide Receptors
Neuropeptides
2 引用 (Scopus)

Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor

Inamine, S., Nishimura, H., Li, J., Isozaki, K., Matsushima, A., Costa, T. & Shimohigashi, Y., 11 1 2014, : : Bioorganic and Medicinal Chemistry. 22, 21, p. 5902-5909 8 p.

研究成果: ジャーナルへの寄稿記事

Narcotic Antagonists
Tritium
Opioid Receptors
Binding Sites
Conformations
2013
15 引用 (Scopus)

An endocrine disruptor, bisphenol A, affects development in the protochordate Ciona intestinalis: Hatching rates and swimming behavior alter in a dose-dependent manner

Matsushima, A., Ryan, K., Shimohigashi, Y. & Meinertzhagen, I. A., 2 1 2013, : : Environmental Pollution. 173, p. 257-263 7 p.

研究成果: ジャーナルへの寄稿記事

Ciona intestinalis
Endocrine Disruptors
Mammals
Neurology
Polycarbonates
2012
10 引用 (Scopus)

Fine spatial assembly for construction of the phenol-binding pocket to capture bisphenol a in the human nuclear receptor estrogen-related receptor γ

Liu, X., Matsushima, A., Nakamura, M., Costa, T., Nose, T. & Shimohigashi, Y., 4 1 2012, : : Journal of biochemistry. 151, 4, p. 403-415 13 p.

研究成果: ジャーナルへの寄稿記事

Cytoplasmic and Nuclear Receptors
Phenol
Estrogen Receptors
Estrogens
Benzene
2011
2 引用 (Scopus)

Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor

Matsushima, A., Nishimura, H., Inamine, S., Uemura, S. & Shimohigashi, Y., 12 15 2011, : : Bioorganic and Medicinal Chemistry. 19, 24, p. 7597-7602 6 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Ethylmaleimide
Cysteine
Binding Sites
Sulfhydryl Compounds
54 引用 (Scopus)

Endocrine disrupter bisphenol a increases in situ estrogen production in the mouse urogenital sinus

Arase, S., Ishii, K., Igarashi, K., Aisaki, K., Yoshio, Y., Matsushima, A., Shimohigashi, Y., Arima, K., Kanno, J. & Sugimura, Y., 4 1 2011, : : Biology of Reproduction. 84, 4, p. 734-742 9 p.

研究成果: ジャーナルへの寄稿記事

Estrogens
Aromatase
Messenger RNA
Prostate
Up-Regulation
15 引用 (Scopus)

Pigment-dispersing factor affects nocturnal activity rhythms, photic entrainment, and the free-running period of the circadian clock in the cricket gryllus bimaculatus

Hassaneen, E., El-Din Sallam, A., Abo-Ghalia, A., Moriyama, Y., Karpova, S. G., Abdelsalam, S., Matsushima, A., Shimohigashi, Y. & Tomioka, K., 2 1 2011, : : Journal of Biological Rhythms. 26, 1, p. 3-13 11 p.

研究成果: ジャーナルへの寄稿記事

Gryllidae
Circadian Clocks
Photoperiod
Light
Double-Stranded RNA
2010
106 引用 (Scopus)

Bisphenol AF is a full agonist for the estrogen receptor ERα but a highly specific antagonist for ERβ

Matsushima, A., Liu, X., Okada, H., Shimohigashi, M. & Shimohigashi, Y., 9 1 2010, : : Environmental Health Perspectives. 118, 9, p. 1267-1272 6 p.

研究成果: ジャーナルへの寄稿記事

Estrogens
Reporter Genes
Estradiol
4,4'-hexafluorisopropylidene diphenol
Physiological Phenomena
16 引用 (Scopus)

Distinction of the binding modes for human nuclear receptor ERRγ between bisphenol A and 4-hydroxytamoxifen

Liu, X., Matsushima, A., Okada, H. & Shimohigashi, Y., 8 1 2010, : : Journal of biochemistry. 148, 2, p. 247-254 8 p.

研究成果: ジャーナルへの寄稿記事

Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estrogens
Phenol
Hydrogen Bonding
2009
5 引用 (Scopus)

Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)14, (Arg/Lys)15]nociceptin on ORL1 receptor binding and activation

Nishimura, H., Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 8 1 2009, : : Bioorganic and Medicinal Chemistry. 17, 15, p. 5683-5687 5 p.

研究成果: ジャーナルへの寄稿記事

Substitution reactions
Chemical activation
nociceptin
nociceptin receptor
Arg(14)-Lys(15)-nociceptin
60 引用 (Scopus)

Placenta expressing the greatest quantity of bisphenol A receptor ERRγ among the human reproductive tissues: Predominant expression of type-1 ERRγ isoform

Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 7 1 2009, : : Journal of biochemistry. 146, 1, p. 113-122 10 p.

研究成果: ジャーナルへの寄稿記事

Estrogen Receptors
Placenta
Protein Isoforms
Estrogens
Tissue
4 引用 (Scopus)

Spare interactions of highly potent [Arg14,Lys15]nociceptin for cooperative induction of ORL1 receptor activation

Isozaki, K., Li, J., Okada, K., Nishimura, H., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 12 1 2009, : : Bioorganic and Medicinal Chemistry. 17, 23, p. 7904-7908 5 p.

研究成果: ジャーナルへの寄稿記事

Chemical activation
Bioactivity
Acidic Amino Acids
nociceptin
nociceptin receptor
2008
14 引用 (Scopus)

Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist

Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 3 1 2008, : : Bioorganic and Medicinal Chemistry. 16, 5, p. 2635-2644 10 p.

研究成果: ジャーナルへの寄稿記事

Opioid Receptors
Peptide Library
Peptides
Carbon Monoxide
Analgesics
269 引用 (Scopus)

Direct evidence revealing structural elements essential for the high binding ability of bisphenol a to human estrogen-related receptor-γ

Okada, H., Tokunaga, T., Liu, X., Takayanagi, S., Matsushima, A. & Shimohigashi, Y., 1 1 2008, : : Environmental Health Perspectives. 116, 1, p. 32-38 7 p.

研究成果: ジャーナルへの寄稿記事

Estrogen Receptors
Endocrine Disruptors
Phenol
Luciferases
Reporter Genes
54 引用 (Scopus)

ERRγ tethers strongly bisphenol A and 4-α-cumylphenol in an induced-fit manner

Matsushima, A., Teramoto, T., Okada, H., Liu, X., Tokunaga, T., Kakuta, Y. & Shimohigashi, Y., 8 29 2008, : : Biochemical and Biophysical Research Communications. 373, 3, p. 408-413 6 p.

研究成果: ジャーナルへの寄稿記事

Estrogen Receptors
Estrogens
Phenol
Hydroxyl Radical
Crystal structure
1 引用 (Scopus)

Radar chart deviation analysis of prion protein amino acid composition defines characteristic structural abnormalities of the N-terminal octapeptide tandem repeat

Yokotani, S., Nose, T., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 9 1 2008, : : Protein and Peptide Letters. 15, 9, p. 949-955 7 p.

研究成果: ジャーナルへの寄稿記事

Radar
Tandem Repeat Sequences
Amino Acids
Aromatic Amino Acids
Prion Diseases
8 引用 (Scopus)

Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation

Okada, K., Isozaki, K., Li, J., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 10 15 2008, : : Bioorganic and Medicinal Chemistry. 16, 20, p. 9261-9267 7 p.

研究成果: ジャーナルへの寄稿記事

Chemical activation
Dipeptides
arginyllysine
Assays
Peptides
2007
4 引用 (Scopus)

Double-labelled in situ hybridization reveals the lack of co-localization of mRNAs for the circadian neuropeptide PDF and FMRFamide in brains of the flies Musca domestica and Drosophila melanogaster

Matsushima, A., Takano, K., Yoshida, T., Takeda, Y., Yokotani, S., Shimohigashi, Y. & Shimohigashi, M., 6 1 2007, : : Journal of biochemistry. 141, 6, p. 867-877 11 p.

研究成果: ジャーナルへの寄稿記事

FMRFamide
Houseflies
Neuropeptides
Drosophila melanogaster
Pigments
27 引用 (Scopus)
Endocrine Disruptors
Phenol
Estrogen Receptors
Hydroxyl Radical
Hydrogen
143 引用 (Scopus)

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ

Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S-I., Kimura, M. & Shimohigashi, Y., 10 1 2007, : : Journal of biochemistry. 142, 4, p. 517-524 8 p.

研究成果: ジャーナルへの寄稿記事

Endocrine Disruptors
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estrogens
Ligands
2006
235 引用 (Scopus)

Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor γ (ERRγ) with high constitutive activity

Takayanagi, S., Tokunaga, T., Liu, X., Okada, H., Matsushima, A. & Shimohigashi, Y., 12 1 2006, : : Toxicology Letters. 167, 2, p. 95-105 11 p.

研究成果: ジャーナルへの寄稿記事

Endocrine Disruptors
Estrogen Receptors
Estrogens
Cytoplasmic and Nuclear Receptors
Assays
17 引用 (Scopus)

Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: Immunocytochemical evidence from specific monoclonal antibodies

Honda, T., Matsushima, A., Sumida, K., Chuman, Y., Sakaguchi, K., Onoue, H., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., 11 20 2006, : : Journal of Comparative Neurology. 499, 3, p. 404-421 18 p.

研究成果: ジャーナルへの寄稿記事

Gryllidae
Neuropeptides
Protein Isoforms
Monoclonal Antibodies
Peptides
2004
19 引用 (Scopus)

cDNA cloning of the housefly pigment-dispersing factor (PDF) precursor protein and its peptides comparison among the insect circadian neuropeptides

Matsushima, A., Sato, S., Chuman, Y., Takeda, Y., Yokotani, S., Nose, T., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., 2 1 2004, : : Journal of Peptide Science. 10, 2, p. 82-91 10 p.

研究成果: ジャーナルへの寄稿記事

Houseflies
Protein Precursors
Cloning
Neuropeptides
Pigments
10 引用 (Scopus)

Structural analysis and identification of novel isoforms of the circadian clock gene period in the silk moth Bombyx mori

Takeda, Y., Chuman, Y., Shirasu, N., Sato, S., Matsushima, A., Kaneki, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 9 1 2004, : : Zoological science. 21, 9, p. 903-915 13 p.

研究成果: ジャーナルへの寄稿記事

Bombyx mori
silk
circadian rhythm
moths
alternative splicing
2003
7 引用 (Scopus)

Molecular cloning and circadian expression profile of insect neuropeptide PDF in black blowfly, Phormia regina

Matsushima, A., Yokotani, S., Lui, X., Sumida, K., Honda, T., Sato, S., Kaneki, A., Takeda, Y., Chuman, Y., Ozaki, M., Asai, D., Nose, T., Onoue, H., Ito, Y., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 11 1 2003, : : Letters in Peptide Science. 10, 5-6, p. 419-430 12 p.

研究成果: ジャーナルへの寄稿記事

Cloning
Molecular Cloning
Neuropeptides
Peptides
Protein Precursors
2002
24 引用 (Scopus)

A circadian neuropeptide, pigment-dispersing factor-PDF, in the last-summer cicada Meimuna opalifera: cDNA cloning and immunocytochemistry

Sato, S., Chuman, Y., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 8 1 2002, : : Zoological science. 19, 8, p. 821-828 8 p.

研究成果: ジャーナルへの寄稿記事

Cicadidae
neuropeptides
immunocytochemistry
molecular cloning
pigments
21 引用 (Scopus)

cDNA cloning and nuclear localization of the circadian neuropeptide designated as pigment-dispersing factor PDF in the cricket Gryllus bimaculatus

Chuman, Y., Matsushima, A., Sato, S., Tomioka, K., Tominaga, Y., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., 1 1 2002, : : Journal of Biochemistry. 131, 6, p. 895-903 9 p.

研究成果: ジャーナルへの寄稿記事

Gryllidae
Cloning
Neuropeptides
Pigments
Insects
2000
24 引用 (Scopus)

Edge-to-face CH/π interaction between ligand Phe-phenyl and receptor aromatic group in the thrombin receptor activation

Matsushima, A., Fujita, T., Nose, T. & Shimohigashi, Y., 1 1 2000, : : Journal of biochemistry. 128, 2, p. 225-232 8 p.

研究成果: ジャーナルへの寄稿記事

Thrombin Receptors
Phenylalanine
Chemical activation
Ligands
Hydrogen
5 引用 (Scopus)

Exploration of the role of phenylalanine in the thrombin receptor tethered-ligand peptide by substitution with a series of trifluorophenylalanines

Matsushima, A., Fujita, T., Okada, K., Shirasu, N., Nose, T. & Shimohigashi, Y., 11 1 2000, : : Bulletin of the Chemical Society of Japan. 73, 11, p. 2531-2538 8 p.

研究成果: ジャーナルへの寄稿記事

thrombin receptor peptide SFLLRNP
Thrombin Receptors
Phenylalanine
Hydrogen
Substitution reactions
16 引用 (Scopus)

Synthesis of a complete set of L-difluorophenylalanines, L-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor

Fujita, T., Nose, T., Matsushima, A., Okada, K., Asai, D., Yamauchi, Y., Shirasu, N., Honda, T., Shigehiro, D. & Shimohigashi, Y., 2 5 2000, : : Tetrahedron Letters. 41, 6, p. 923-927 5 p.

研究成果: ジャーナルへの寄稿記事

thrombin receptor peptide SFLLRNP
Thrombin Receptors
Peptide Receptors
Hydrogen
Ligands