Pureに変更を加えた場合、すぐここに表示されます。

研究成果 1992 2019

2019
Islands of Calleja
Neurogenesis
Dentate Gyrus
Phenotype
Lateral Ventricles
2018
1 引用 (Scopus)

A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain

Fujii, T., Yamasaki, R., Iinuma, K., Tsuchimoto, D., Hayashi, Y., Saitoh, B. Y., Matsushita, T., Kido, M. A., Aishima, S., Nakanishi, H., Nakabeppu, Y. & Kira, J. I., 8 2018, : : Annals of Neurology. 84, 2, p. 208-224 17 p.

研究成果: ジャーナルへの寄稿記事

Neuralgia
Autoantibodies
Spinal Ganglia
Neurons
Unmyelinated Nerve Fibers
2017

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

Asada, S., Ohta, E., Akimoto, Y., Abolhassani, N., Tsuchimoto, D. & Nakabeppu, Y., 12 1 2017, : : Scientific Reports. 7, 1, 6528.

研究成果: ジャーナルへの寄稿記事

公開
Adenosine Kinase
p38 Mitogen-Activated Protein Kinases
Adenosine Triphosphate
Cell Death
Nucleoside-Triphosphatase
2016
21 引用 (Scopus)

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity

Massaad, M. J., Zhou, J., Tsuchimoto, D., Chou, J., Jabara, H., Janssen, E., Glauzy, S., Olson, B. G., Morbach, H., Ohsumi, T. K., Schmitz, K., Kyriacos, M., Kane, J., torisu, K., Nakabeppu, Y., Notarangelo, L. D., Chouery, E., Megarbane, A., Kang, P. B., Al-Idrissi, E. および8人, Aldhekri, H., Meffre, E., Mizui, M., Tsokos, G. C., Manis, J. P., Al-Herz, W., Wallace, S. S. & Geha, R. S., 11 1 2016, : : Journal of Clinical Investigation. 126, 11, p. 4219-4236 18 p.

研究成果: ジャーナルへの寄稿記事

Deoxyribonuclease (Pyrimidine Dimer)
Autoimmunity
DNA Repair
B-Lymphocytes
Enzymes
4 引用 (Scopus)

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells

Yoneshima, Y., Abolhassani, N., Iyama, T., Kunihiko, S., Shiomi, N., Mori, M., Shiomi, T., Noda, T., Tsuchimoto, D. & Nakabeppu, Y., 9 13 2016, : : Scientific reports. 6, 32849.

研究成果: ジャーナルへの寄稿記事

DNA
Growth
Deamination
deoxyinosine
triphosphoric acid
2 引用 (Scopus)

PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice

torisu, K., Zhang, X., Nonaka, M., Kaji, T., Tsuchimoto, D., Kajitani, K., Kunihiko, S., torisu, T., Chida, K., Sueishi, K., Kubo, M., Hata, J., Kitazono, T., Kiyohara, Y. & Nakabeppu, Y., 10 1 2016, : : Genes to Cells. 21, 10, p. 1030-1048 19 p.

研究成果: ジャーナルへの寄稿記事

Apolipoproteins E
Lipid Metabolism
Atherosclerosis
High Fat Diet
Dyslipidemias
2015
Genome
DNA
Research
Genes
2 引用 (Scopus)
DNA Glycosylases
Carcinogenesis
Cell Death
Neoplasms
4-iodo-2,5-dimethoxyphenylisopropylamine
2014
5 引用 (Scopus)

Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells

Guikema, J. E. J., Linehan, E. K., Esa, N., Tsuchimoto, D., Nakabeppu, Y., Woodland, R. T. & Schrader, C. E., 7 15 2014, : : Journal of Immunology. 193, 2, p. 931-939 9 p.

研究成果: ジャーナルへの寄稿記事

DNA-(Apurinic or Apyrimidinic Site) Lyase
Germinal Center
DNA Damage
B-Lymphocytes
DNA Repair
26 引用 (Scopus)

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

Stavnezer, J., Linehan, E. K., Thompson, M. R., Habboub, G., Ucher, A. J., Kadungure, T., Tsuchimoto, D., Nakabeppu, Y. & Schrader, C. E., 6 24 2014, : : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. 9217-9222 6 p.

研究成果: ジャーナルへの寄稿記事

Germinal Center
B-Lymphocytes
Uracil-DNA Glycosidase
Base Pairing
DNA-(Apurinic or Apyrimidinic Site) Lyase
19 引用 (Scopus)

Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia

Nomaru, H., Kunihiko, S., Katogi, A., Ohnishi, Y. N., Kajitani, K., Tsuchimoto, D., Nestler, E. J. & Nakabeppu, Y., 1 1 2014, : : GLIA. 62, 8, p. 1284-1298 15 p.

研究成果: ジャーナルへの寄稿記事

Anaphylatoxin C5a Receptor
Complement C5a
Complement Receptors
Microglia
Kainic Acid
22 引用 (Scopus)

MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death

Oka, S., Leon, J., Tsuchimoto, D., Kunihiko, S. & Nakabeppu, Y., 1 1 2014, : : Oncogenesis. 3, 10, e121.

研究成果: ジャーナルへの寄稿記事

DNA Glycosylases
Poly(ADP-ribose) Polymerases
Cell Death
Carcinogenesis
DNA Mismatch Repair
2012
65 引用 (Scopus)

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

Sheng, Z., Oka, S., Tsuchimoto, D., Abolhassani, N., Nomaru, H., Kunihiko, S., Yamada, H. & Nakabeppu, Y., 12 3 2012, : : Journal of Clinical Investigation. 122, 12, p. 4344-4361 18 p.

研究成果: ジャーナルへの寄稿記事

Microglia
DNA Repair
Carcinogenesis
Oxidative Stress
Apoptosis Inducing Factor
2011
15 引用 (Scopus)

Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge

Guikema, J. E. J., Gerstein, R. M., Linehan, E. K., Cloherty, E. K., Evan-Browning, E., Tsuchimoto, D., Nakabeppu, Y. & Schrader, C. E., 2 15 2011, : : Journal of Immunology. 186, 4, p. 1943-1950 8 p.

研究成果: ジャーナルへの寄稿記事

DNA-(Apurinic or Apyrimidinic Site) Lyase
B-Lymphoid Precursor Cells
Endonucleases
B-Lymphocytes
DNA Repair
12 引用 (Scopus)

Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues

Iwama, E., Tsuchimoto, D., Iyama, T., Kunihiko, S., Nakagawara, A., Takayama, K., Nakanishi, Y. & Nakabeppu, Y., 6 1 2011, : : Journal of Molecular Neuroscience. 44, 2, p. 103-114 12 p.

研究成果: ジャーナルへの寄稿記事

Nerve Tissue
Guanosine Triphosphate
Nucleotides
Spinal Ganglia
Neoplasms
2010
8 引用 (Scopus)

A comprehensive screening system for damaged nucleotide-binding proteins

Tsuchimoto, D., Iyama, T., Nonaka, M., Abolhassani, N., Ohta, E., Kunihiko, S. & Nakabeppu, Y., 11 28 2010, : : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 703, 1, p. 37-42 6 p.

研究成果: ジャーナルへの寄稿評論記事

Inosine Triphosphate
Carrier Proteins
Nucleotides
Inosine Monophosphate
Adenosine Triphosphate
26 引用 (Scopus)

ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells

Kunihiko, S., Abolhassani, N., Behmanesh, M., Iyama, T., Tsuchimoto, D. & Nakabeppu, Y., 11 28 2010, : : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 703, 1, p. 43-50 8 p.

研究成果: ジャーナルへの寄稿評論記事

Inosine Triphosphate
Purine Nucleosides
Enzymes
Proteins
Embryonic Structures
38 引用 (Scopus)
Inosine Diphosphate
Inosine Triphosphate
Chromosomal Instability
Mammals
Nucleotides
27 引用 (Scopus)

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

Iyama, T., Abolhassani, N., Tsuchimoto, D., Nonaka, M. & Nakabeppu, Y., 4 10 2010, : : Nucleic acids research. 38, 14, p. 4834-4843 10 p., gkq249.

研究成果: ジャーナルへの寄稿記事

Inosine Triphosphate
Nucleotides
Diphosphates
DNA
Growth
49 引用 (Scopus)
Nucleoside-Triphosphatase
Purine Nucleosides
Cell Aging
Mutagenesis
Cell Death
2009
25 引用 (Scopus)

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes

Sabouri, Z., Okazaki, I. M., Shinkura, R., Begum, N., Nagaoka, H., Tsuchimoto, D., Nakabeppu, Y. & Honjo, T., 10 2 2009, : : International Immunology. 21, 8, p. 947-955 9 p.

研究成果: ジャーナルへの寄稿記事

Immunoglobulin Genes
Genetic Recombination
DNA Cleavage
DNA-(Apurinic or Apyrimidinic Site) Lyase
Exonucleases
30 引用 (Scopus)

Galectin-1 promotes basal and kainate-induced proliferation of neural progenitors in the dentate gyrus of adult mouse hippocampus

Kajitani, K., Nomaru, H., Ifuku, M., Yutsudo, N., Dan, Y., Miura, T., Tsuchimoto, D., Kunihiko, S., Kadoya, T., Horie, H., Poirier, F., Noda, M. & Nakabeppu, Y., 1 1 2009, : : Cell Death and Differentiation. 16, 3, p. 417-427 11 p.

研究成果: ジャーナルへの寄稿記事

Galectin 1
Kainic Acid
Dentate Gyrus
Hippocampus
Bromodeoxyuridine
46 引用 (Scopus)

ITPase-deficient mice show growth retardation and die before weaning

Behmanesh, M., Sakumi, K., Abolhassani, N., Toyokuni, S., Oka, S., Ohnishi, Y. N., Tsuchimoto, D. & Nakabeppu, Y., 6 9 2009, : : Cell Death and Differentiation. 16, 10, p. 1315-1322 8 p.

研究成果: ジャーナルへの寄稿記事

Inosine Triphosphate
Weaning
Pyrophosphatases
Purine Nucleosides
Sarcomeres
17 引用 (Scopus)

Mouse RS21-C6 is a mammalian 2′-deoxycytidine 5′-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine

Nonaka, M., Tsuchimoto, D., Kunihiko, S. & Nakabeppu, Y., 3 1 2009, : : FEBS Journal. 276, 6, p. 1654-1666 13 p.

研究成果: ジャーナルへの寄稿記事

Nucleotides
Inosine Triphosphate
Nucleosides
Adenosine Triphosphate
Mutagenesis
2008
5 引用 (Scopus)

Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus

Dan, Y., Ohta, Y., Tsuchimoto, D., Mizuki, O., Ide, Y., Sami, M., Kanda, T., Kunihiko, S. & Nakabeppu, Y., 9 1 2008, : : DNA Repair. 7, 9, p. 1437-1454 18 p.

研究成果: ジャーナルへの寄稿記事

Thymus
DNA Breaks
Thymocytes
Transcriptome
Gene expression
38 引用 (Scopus)

Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death

Ichikawa, J., Tsuchimoto, D., Oka, S., Mizuki, O., Furuichi, M., Kunihiko, S. & Nakabeppu, Y., 3 1 2008, : : DNA Repair. 7, 3, p. 418-430 13 p.

研究成果: ジャーナルへの寄稿記事

Nitroprusside
Cell death
Null Lymphocytes
Cell Death
Oxidation
141 引用 (Scopus)
Cell death
Mitochondrial DNA
Cell Death
DNA
DNA Glycosylases
2007
108 引用 (Scopus)

APE1- And APE2-dependent DNA breaks in immunoglobulin class switch recombination

Guikema, J. E. J., Linehan, E. K., Tsuchimoto, D., Nakabeppu, Y., Strauss, P. R., Stavnezer, J. & Schrader, C. E., 11 26 2007, : : Journal of Experimental Medicine. 204, 12, p. 3017-3026 10 p.

研究成果: ジャーナルへの寄稿記事

DNA Breaks
Immunoglobulin Isotypes
Genetic Recombination
Uracil-DNA Glycosidase
DNA-(Apurinic or Apyrimidinic Site) Lyase

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination (Journal of Experimental Medicine (November 26, 2007) 204: 12 (3017-3026))

Guikema, J. E. J., Linehan, E. K., Tsuchimoto, D., Nakabeppu, Y., Strauss, P. R., Stavnezer, J. & Schrader, C. E., 12 24 2007, : : Journal of Experimental Medicine. 204, 13, 1 p.

研究成果: ジャーナルへの寄稿コメント/討論

DNA Breaks
Immunoglobulin Isotypes
Genetic Recombination
Biomedical Research
160 引用 (Scopus)

Oxidative damage in nucleic acids and Parkinson's disease

Nakabeppu, Y., Tsuchimoto, D., yamaguchi, H. & Kunihiko, S., 4 1 2007, : : Journal of Neuroscience Research. 85, 5, p. 919-934 16 p.

研究成果: ジャーナルへの寄稿評論記事

Mitochondrial DNA
Nucleic Acids
DNA Glycosylases
Parkinson Disease
Dopaminergic Neurons

Prevention of the Mutagenecity and Cytotoxicity of Oxidized Purine Nucleotides

Nakabeppu, Y., Behmanesh, M., Ymaguchi, H., Tsuchimoto, D. & Kunihiko, S., 2007, Oxidative Damage to Nucleic Acids. Evans, MD. & Cooke, MS. (版). Landes Bioscience, Springer Science+Business Media, p. 40-53

研究成果: 著書/レポートタイプへの貢献

2006
52 引用 (Scopus)
Human Genome
Genetic Recombination
Single Nucleotide Polymorphism
Genome
Metaphase
61 引用 (Scopus)
Nucleoside-Triphosphatase
Purine Nucleosides
Purine Nucleotides
Cytotoxicity
Brain
179 引用 (Scopus)

Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.

Nakabeppu, Y., Kunihiko, S., Sakamoto, K., Tsuchimoto, D., Tsuzuki, T. & Nakatsu, Y., 1 1 2006, : : Biological chemistry. 387, 4, p. 373-379 7 p.

研究成果: ジャーナルへの寄稿Conference article

DNA Glycosylases
Mutagenesis
Nucleic Acids
Carcinogenesis
Genes
2005
34 引用 (Scopus)
DNA Glycosylases
Guanine
Adenine
DNA
Proteins
16 引用 (Scopus)

Characterization of the structure and expression of mouse Itpa gene and its related sequences in the mouse genome

Behmanesh, M., Kunihiko, S., Tsuchimoto, D., torisu, K., Ohnishi-Honda, Y., Rancourt, D. E. & Nakabeppu, Y., 1 1 2005, : : DNA Research. 12, 1, p. 39-51 13 p.

研究成果: ジャーナルへの寄稿記事

Pseudogenes
Genome
Genes
Chromosomes
Messenger RNA
50 引用 (Scopus)

Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein

torisu, K., Tsuchimoto, D., Ohnishi, Y. & Nakabeppu, Y., 12 1 2005, : : Journal of biochemistry. 138, 6, p. 763-772 10 p.

研究成果: ジャーナルへの寄稿記事

Deoxyribonuclease (Pyrimidine Dimer)
Tissue
Messenger RNA
Exons
Thymus
2004
7 引用 (Scopus)

A mechanism of transcriptional regulation of the CSF-1 gene by interferon-gamma

Tsuchimoto, D., Tojo, A. & Asano, S., 12 15 2004, : : Immunological Investigations. 33, 4, p. 397-405 9 p.

研究成果: ジャーナルへの寄稿記事

Macrophage Colony-Stimulating Factor
Interferon-gamma
Genes
5' Flanking Region
Transcription Initiation Site
55 引用 (Scopus)

Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: From mitochondria to nuclei

Nakabeppu, Y., Tsuchimoto, D., Ichinoe, A., Mizuki, O., Ide, Y., Hirano, S., Yoshimura, D., Tominaga, Y., Furuichi, M. & Kunihiko, S., 1 1 2004, : : Annals of the New York Academy of Sciences. 1011, p. 101-111 11 p.

研究成果: ジャーナルへの寄稿Conference article

Mitochondria
DNA Glycosylases
Nucleic Acids
Reactive Oxygen Species
Neurodegenerative diseases
29 引用 (Scopus)

Galectin-1β, a natural monomeric form of galectin-1 lacking its six amino-terminal residues promotes axonal regeneration but not cell death

Miura, T., Takahashi, M., Horie, H., Kurushima, H., Tsuchimoto, D., Kunihiko, S. & Nakabeppu, Y., 10 1 2004, : : Cell Death and Differentiation. 11, 10, p. 1076-1083 8 p.

研究成果: ジャーナルへの寄稿記事

Galectin 1
Regeneration
Cell Death
Jurkat Cells
Spinal Ganglia
31 引用 (Scopus)

Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice

Ide, Y., Tsuchimoto, D., Tominaga, Y., Nakashima, M., Watanabe, T., Kunihiko, S., Mizuki, O. & Nakabeppu, Y., 12 15 2004, : : Blood. 104, 13, p. 4097-4103 7 p.

研究成果: ジャーナルへの寄稿記事

Cells
Lymphocytes
Endonucleases
Ovalbumin
Proliferating Cell Nuclear Antigen
30 引用 (Scopus)

Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts

Ichinoe, A., Behmanesh, M., Tominaga, Y., ushijima, Y., Hirano, S., Sakai, Y., Tsuchimoto, D., Kunihiko, S., Wake, N. & Nakabeppu, Y., 3 10 2004, : : Nucleic acids research. 32, 2, p. 477-487 11 p.

研究成果: ジャーナルへの寄稿記事

Messenger RNA
Embryonic Stem Cells
Thymocytes
DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Glycosylases
29 引用 (Scopus)

MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domain

Tominaga, Y., ushijima, Y., Tsuchimoto, D., Mishima, M., Shirakawa, M., Hirano, S., Kunihiko, S. & Nakabeppu, Y., 8 17 2004, : : Nucleic acids research. 32, 10, p. 3198-3211 14 p.

研究成果: ジャーナルへの寄稿記事

Adenine
Uracil-DNA Glycosidase
DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA
Thymocytes
75 引用 (Scopus)
Mutagenesis
Cell death
Nucleic Acids
DNA Glycosylases
Cell Death
2003
22 引用 (Scopus)

Characterization of the genomic structure and expression of the mouse Apex2 gene

Ide, Y., Tsuchimoto, D., Tominaga, Y., Iwamoto, Y. & Nakabeppu, Y., 1 1 2003, : : Genomics. 81, 1, p. 47-57 11 p.

研究成果: ジャーナルへの寄稿記事

BALB 3T3 Cells
Genes
Messenger RNA
Intergenic DNA
Immunoelectron Microscopy
76 引用 (Scopus)

Mutator phenotype of MUTYH-null mouse embryonic stem cells

Hirano, S., Tominaga, Y., Ichinoe, A., ushijima, Y., Tsuchimoto, D., Honda-Ohnishi, Y., Ohtsubo, T., Kunihiko, S. & Nakabeppu, Y., 10 3 2003, : : Journal of Biological Chemistry. 278, 40, p. 38121-38124 4 p.

研究成果: ジャーナルへの寄稿記事

DNA Glycosylases
Adenine
Stem cells
Mutation Rate
Mutant Proteins
24 引用 (Scopus)

ΔFosB, but not FosB, induces delayed apoptosis independent of cell proliferation in the Rat1a embryo cell line

Tahara, K., Tsuchimoto, D., Tominaga, Y., Asoh, S., Ohta, S., Kitagawa, M., Horie, H., Kadoya, T. & Nakabeppu, Y., 5 1 2003, : : Cell Death and Differentiation. 10, 5, p. 496-507 12 p.

研究成果: ジャーナルへの寄稿記事

Cell Death
Embryonic Structures
Cell Proliferation
Apoptosis
Cell Line
2001
113 引用 (Scopus)
Proliferating Cell Nuclear Antigen
HeLa Cells
Mitochondria
Proteins
DNA-(Apurinic or Apyrimidinic Site) Lyase
1998
43 引用 (Scopus)

Molecular analysis of suppression of interleukin-8 production by rebamipide in Helicobacter pylori-stimulated gastric cancer cell lines

Aihara, M., Azuma, A., Takizawa, H., Tsuchimoto, D., Funakoshi, Y., Shindo, Y., Ohmoto, Y., Imagawa, K., Kikuchi, M., Mukaida, N. & Matsushima, K., 10 3 1998, : : Digestive Diseases and Sciences. 43, 9 SUPPL.

研究成果: ジャーナルへの寄稿記事

Interleukin-8
Helicobacter pylori
Stomach Neoplasms
Cell Line
Helicobacter Infections