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研究成果 2011 2019

  • 748 引用
  • 11 h指数
  • 35 記事
  • 4 評論記事
  • 1 レター
2019

Genetic Profiling of Non-Small Cell Lung Cancer at Development of Resistance to First- or Second-Generation EGFR-TKIs by CAPP-Seq Analysis of Circulating Tumor DNA

Otsubo, K., Sakai, K., Takeshita, M., Harada, D., Azuma, K., Ota, K., Akamatsu, H., Goto, K., Horiike, A., Kurata, T., Nakagaki, N., Nosaki, K., Iwama, E., Nakanishi, Y., Nishio, K. & Okamoto, I., 1 1 2019, : : Oncologist.

研究成果: ジャーナルへの寄稿記事

High-Throughput Nucleotide Sequencing
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
DNA

Identification of genomic alterations acquired during treatment with EGFR-TKIs in non-small cell lung cancer

Kubo, N., Harada, T., Shiraishi, Y., Nosaki, K., Nakagaki, N., Takeshita, M., Ouchi, H., Iwama, E., Tanaka, K., Okamoto, I., Sasaki, H. & Nakanishi, Y., 2 1 2019, : : Anticancer research. 39, 2, p. 671-677 7 p.

研究成果: ジャーナルへの寄稿記事

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
Exome

Safety and efficacy of PD-1 inhibitors in non–small cell lung cancer patients positive for antinuclear antibodies

Yoneshima, Y., Tanaka, K., Shiraishi, Y., Hata, K., Watanabe, H., Harada, T., Otsubo, K., Iwama, E., Inoue, H., Masuda, S., Nakanishi, Y. & Okamoto, I., 4 1 2019, : : Lung Cancer. 130, p. 5-9 5 p.

研究成果: ジャーナルへの寄稿記事

Antinuclear Antibodies
Non-Small Cell Lung Carcinoma
Safety
Autoimmune Diseases
Disease-Free Survival
2018

Association of nephrotoxicity during platinum-etoposide doublet therapy with UGT1A1 polymorphisms in small cell lung cancer patients

Anai, S., Iwama, E., Yoneshima, Y., Otsubo, K., Tanaka, K., Nakanishi, Y. & Okamoto, I., 12 1 2018, : : Lung Cancer. 126, p. 156-161 6 p.

研究成果: ジャーナルへの寄稿記事

Small Cell Lung Carcinoma
Etoposide
Platinum
Alleles
irinotecan
1 引用 (Scopus)

Combined therapy with epidermal growth factor receptor tyrosine kinase inhibitors for non–small cell lung cancer

Iwama, E., Nakanishi, Y. & Okamoto, I., 3 4 2018, : : Expert Review of Anticancer Therapy. 18, 3, p. 267-276 10 p.

研究成果: ジャーナルへの寄稿評論記事

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Therapeutics

Detection of identical T cell clones in peritumoral pleural effusion and pneumonitis lesions in a cancer patient during immune-checkpoint blockade

Tanaka, K., Yanagihara, T., Ikematsu, Y., Inoue, H., ota, K., Kashiwagi, E., Suzuki, K., Hamada, N., takeuchi, A., Tatsugami, K., Eto, M., Ijichi, K., Oda, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., 7 17 2018, : : Oncotarget. 9, 55, p. 30587-30593 7 p.

研究成果: ジャーナルへの寄稿記事

Bronchoalveolar Lavage Fluid
Pleural Effusion
Pneumonia
Clone Cells
T-Cell Antigen Receptor

Exploration of resistance mechanisms for epidermal growth factor receptor-tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next-generation sequencing

Iwama, E., Sakai, K., Azuma, K., Harada, D., Nosaki, K., Hotta, K., Nishio, M., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., 12 1 2018, : : Cancer Science. 109, 12, p. 3921-3933 13 p.

研究成果: ジャーナルへの寄稿記事

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Polymerase Chain Reaction
Mutation
Neoplasms

Expression of brain-derived neurotrophic factor and its receptor TrkB is associated with poor prognosis and a malignant phenotype in small cell lung cancer

Kimura, S., Harada, T., Ijichi, K., Tanaka, K., Liu, R., Shibahara, D., Kawano, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., 6 1 2018, : : Lung Cancer. 120, p. 98-107 10 p.

研究成果: ジャーナルへの寄稿記事

trkB Receptor
Brain-Derived Neurotrophic Factor
Small Cell Lung Carcinoma
Phenotype
Non-Small Cell Lung Carcinoma
3 引用 (Scopus)

Intrinsic and Extrinsic Regulation of PD-L2 Expression in Oncogene-Driven Non–Small Cell Lung Cancer

Shibahara, D., Tanaka, K., Iwama, E., Kubo, N., ota, K., Azuma, K., Harada, T., Fujita, J., Nakanishi, Y. & Okamoto, I., 7 1 2018, : : Journal of Thoracic Oncology. 13, 7, p. 926-937 12 p.

研究成果: ジャーナルへの寄稿記事

Oncogenes
Non-Small Cell Lung Carcinoma
Cell Death
Ligands
STAT3 Transcription Factor
10 引用 (Scopus)

PD-L1 expression in lung adenocarcinoma harboring EGFR mutations or ALK rearrangements

Yoneshima, Y., Ijichi, K., Anai, S., ota, K., Otsubo, K., Iwama, E., Tanaka, K., Oda, Y., Nakanishi, Y. & Okamoto, I., 4 1 2018, : : Lung Cancer. 118, p. 36-40 5 p.

研究成果: ジャーナルへの寄稿記事

Mutation
Neoplasms
Adenocarcinoma of lung
Protein-Tyrosine Kinases
Oncogenes
1 引用 (Scopus)
Therapeutic Uses
Platinum
Non-Small Cell Lung Carcinoma
Perfusion
Tomography
2017
11 引用 (Scopus)

Alectinib for Patients with ALK Rearrangement–Positive Non–Small Cell Lung Cancer and a Poor Performance Status (Lung Oncology Group in Kyushu 1401)

Iwama, E., Goto, Y., Murakami, H., Harada, T., Tsumura, S., Sakashita, H., Mori, Y., Nakagaki, N., Fujita, Y., Seike, M., Bessho, A., Ono, M., Okazaki, A., Akamatsu, H., Morinaga, R., Ushijima, S., Shimose, T., Tokunaga, S., Hamada, A., Yamamoto, N. および3人Nakanishi, Y., Sugio, K. & Okamoto, I., 7 1 2017, : : Journal of Thoracic Oncology. 12, 7, p. 1161-1166 6 p.

研究成果: ジャーナルへの寄稿記事

Non-Small Cell Lung Carcinoma
Lung
Confidence Intervals
Patient Safety
CH5424802
3 引用 (Scopus)

CD44 variant–dependent regulation of redox balance in EGFR mutation–positive non–small cell lung cancer: A target for treatment

Kawano, Y., Iwama, E., Tsuchihashi, K., Shibahara, D., Harada, T., Tanaka, K., Nagano, O., Saya, H., Nakanishi, Y. & Okamoto, I., 11 1 2017, : : Lung Cancer. 113, p. 72-78 7 p.

研究成果: ジャーナルへの寄稿記事

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Oxidation-Reduction
Reactive Oxygen Species
Cisplatin
1 引用 (Scopus)

Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

Ogata, H., Okamoto, I., Yoshimoto, G., Obara, T., Ijichi, K., Iwama, E., Harada, T., Akashi, K. & Nakanishi, Y., 3 1 2017, : : Respiratory Investigation. 55, 2, p. 181-183 3 p.

研究成果: ジャーナルへの寄稿記事

Leukemia, Myelomonocytic, Chronic
erbB-1 Genes
Blast Crisis
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
15 引用 (Scopus)

Monitoring of somatic mutations in circulating cell-free DNA by digital PCR and next-generation sequencing during afatinib treatment in patients with lung adenocarcinoma positive for EGFR activating mutations

Iwama, E., Sakai, K., Azuma, K., Harada, T., Harada, D., Nosaki, K., Hotta, K., Ohyanagi, F., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., 1 1 2017, : : Annals of Oncology. 28, 1, p. 136-141 6 p.

研究成果: ジャーナルへの寄稿記事

Epidermal Growth Factor Receptor
Polymerase Chain Reaction
Mutation
DNA
Alleles
12 引用 (Scopus)

Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non–small cell lung cancer

Hidaka, N., Iwama, E., Kubo, N., Harada, T., Miyawaki, K., Tanaka, K., Okamoto, I., Baba, E., Akashi, K., Sasaki, H. & Nakanishi, Y., 6 1 2017, : : Lung Cancer. 108, p. 75-82 8 p.

研究成果: ジャーナルへの寄稿記事

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Alleles
Mutation
Protein-Tyrosine Kinases
7 引用 (Scopus)

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer

Otsubo, K., Nosaki, K., Imamura, C. K., Ogata, H., Fujita, A., Sakata, S., Hirai, F., Toyokawa, G., Iwama, E., Harada, T., Seto, T., Takenoyama, M., Ozeki, T., Mushiroda, T., Inada, M., Kishimoto, J., Tsuchihashi, K., Suina, K., Nagano, O., Saya, H. および2人Nakanishi, Y. & Okamoto, I., 9 1 2017, : : Cancer Science. 108, 9, p. 1843-1849 7 p.

研究成果: ジャーナルへの寄稿記事

Pemetrexed
Sulfasalazine
Non-Small Cell Lung Carcinoma
Cisplatin
Neoplastic Stem Cells

Severe Aplastic Anemia during Osimertinib Therapy in a Patient with EGFR Tyrosine Kinase Inhibitor–Resistant Non–Small Cell Lung Cancer

Ogata, H., Yamamoto, Y., Harada, T., Nakanishi, Y., Okamoto, I., Iwama, E., Iwama, E., Kato, K. & Oda, Y., 5 1 2017, : : Journal of Thoracic Oncology. 12, 5, p. e46-e47

研究成果: ジャーナルへの寄稿レター

Aplastic Anemia
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
osimertinib
2016
5 引用 (Scopus)

Characteristics of smoking patients with lung cancer with emphysematous bullae

Iwama, E., Okamoto, I., Yabuuchi, H., Takayama, K., Harada, T., Matsuo, Y., Tokunaga, S., Baba, E. & Nakanishi, Y., 1 1 2016, : : Journal of Thoracic Oncology. 11, 9, p. 1586-1590 5 p.

研究成果: ジャーナルへの寄稿記事

Blister
Lung Neoplasms
Smoking
Emphysema
Epidermal Growth Factor
14 引用 (Scopus)

Phase II trial of weekly nab-paclitaxel for previously treated advanced non–small cell lung cancer: Kumamoto thoracic oncology study group (KTOSG) trial 1301

Sakata, S., Saeki, S., Okamoto, I., Otsubo, K., Komiya, K., Morinaga, R., Yoneshima, Y., Koga, Y., Enokizu, A., Kishi, H., Hirosako, S., Yamaguchi, E., Aragane, N., Fujii, S., Harada, T., Iwama, E., Semba, H., Nakanishi, Y. & Kohrogi, H., 9 1 2016, : : Lung Cancer. 99, p. 41-45 5 p.

研究成果: ジャーナルへの寄稿記事

Non-Small Cell Lung Carcinoma
Thorax
docetaxel
Confidence Intervals
Febrile Neutropenia
2015

Clinical benefits associated with first line treatment using afatinib

Iwama, E. & Okamoto, I., 10 20 2015, : : Japanese Journal of Lung Cancer. 55, 6, p. 866-870 5 p.

研究成果: ジャーナルへの寄稿評論記事

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Therapeutics
Mutation
Paronychia
16 引用 (Scopus)

Highly sensitive and quantitative evaluation of the EGFR T790M mutation by nanofluidic digital PCR

Iwama, E., Takayama, K., Harada, T., Okamoto, I., Ookubo, F., Kishimoto, J., Baba, E., Oda, Y. & Nakanishi, Y., 1 1 2015, : : Oncotarget. 6, 24, p. 20466-20473 8 p.

研究成果: ジャーナルへの寄稿記事

Polymerase Chain Reaction
Mutation
Alleles
Therapeutics
Neoplasms
9 引用 (Scopus)

Hypermethylation of the CpG dinucleotide in epidermal growth factor receptor codon 790: Implications for a mutational hotspot leading to the T790M mutation in non-small-cell lung cancer

Fujii, A., Harada, T., Iwama, E., ota, K., Furuyama, K., Ijichi, K., Okamoto, T., Okamoto, I., Takayama, K. & Nakanishi, Y., 5 1 2015, : : Cancer Genetics. 208, 5, p. 271-278 8 p.

研究成果: ジャーナルへの寄稿記事

5-Methylcytosine
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Codon
Mutation

II. Development and future prospects of the third-generation EGFR-tyrosine kinase inhibitor

Sakata, S., Iwama, E. & Okamoto, I., 8 1 2015, : : Japanese Journal of Cancer and Chemotherapy. 42, 8, p. 935-939 5 p.

研究成果: ジャーナルへの寄稿記事

Protein-Tyrosine Kinases

II. Development and Future Prospects of the Third-Generation EGFR-Tyrosine Kinase Inhibitor

Sakata, S., Iwama, E. & Okamoto, I., 8 1 2015, : : Japanese Journal of Cancer and Chemotherapy. 42, 8, p. 935-939 5 p.

研究成果: ジャーナルへの寄稿記事

Drug Design
Protein Kinase Inhibitors
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
194 引用 (Scopus)

Induction of PD-L1 expression by the EML4-ALK oncoprotein and down stream signaling pathways in non-small cell lung cancer

ota, K., Azuma, K., Kawahara, A., Hattori, S., Iwama, E., Tanizaki, J., Harada, T., Matsumoto, K., Takayama, K., Takamori, S., Kage, M., Hoshino, T., Nakanishi, Y. & Okamoto, I., 9 1 2015, : : Clinical Cancer Research. 21, 17, p. 4014-4021 8 p.

研究成果: ジャーナルへの寄稿記事

Oncogene Proteins
Non-Small Cell Lung Carcinoma
Gene Fusion
Phosphatidylinositol 3-Kinases
Cell Line
4 引用 (Scopus)

Infected complex renal cysts during crizotinib therapy in a patient with non-small cell lung cancer positive for ALK rearrangement

Yoneshima, Y., Okamoto, I., Arimura-Omori, M., Kimura, S., Hidaka-Fujimoto, N., Iwama, E., Harada, T., Takayama, K. & Nakanishi, Y., 4 1 2015, : : Investigational New Drugs. 33, 2, p. 510-512 3 p.

研究成果: ジャーナルへの寄稿記事

Non-Small Cell Lung Carcinoma
Cysts
Kidney
Therapeutics
Low Back Pain
17 引用 (Scopus)

Nicotine induces resistance to erlotinib via cross-talk between α 1 nAChR and EGFR in the non-small cell lung cancer xenograft model

Li, H., Wang, S., Takayama, K., Harada, T., Okamoto, I., Iwama, E., Fujii, A., ota, K., Hidaka, N., Kawano, Y. & Nakanishi, Y., 4 1 2015, : : Lung Cancer. 88, 1, p. 1-8 8 p.

研究成果: ジャーナルへの寄稿記事

Nicotinic Receptors
Nicotine
Heterografts
Non-Small Cell Lung Carcinoma
MAP Kinase Signaling System
10 引用 (Scopus)

Risk factors for predicting severe neutropenia induced by pemetrexed plus carboplatin therapy in patients with advanced non-small cell lung cancer

Ikesue, H., Watanabe, H., Hirano, M., Chikamori, A., Suetsugu, K., Ryokai, Y., Egashira, N., Yamada, T., Ikeda, M., Iwama, E., Harada, T., Takayama, K., Nakanishi, Y. & Masuda, S., 8 1 2015, : : Biological and Pharmaceutical Bulletin. 38, 8, p. 1192-1198 7 p.

研究成果: ジャーナルへの寄稿記事

Pemetrexed
Carboplatin
Neutropenia
Non-Small Cell Lung Carcinoma
Hemoglobins
9 引用 (Scopus)

Severe acute interstitial lung disease in a patient with anaplastic lymphoma kinase rearrangement-positive non-small cell lung cancer treated with alectinib

Yamamoto, Y., Okamoto, I., Otsubo, K., Iwama, E., Hamada, N., Harada, T., Takayama, K. & Nakanishi, Y., 10 22 2015, : : Investigational New Drugs. 33, 5, p. 1148-1150 3 p.

研究成果: ジャーナルへの寄稿記事

Interstitial Lung Diseases
Non-Small Cell Lung Carcinoma
Tomography
Lymphocytosis
Bronchoalveolar Lavage Fluid
6 引用 (Scopus)

Successful treatment with alectinib after crizotinib-induced esophageal ulceration

Yoneshima, Y., Okamoto, I., Takano, T., Enokizu, A., Iwama, E., Harada, T., Takayama, K. & Nakanishi, Y., 6 1 2015, : : Lung Cancer. 88, 3, p. 349-351 3 p.

研究成果: ジャーナルへの寄稿記事

Therapeutics
Protein-Tyrosine Kinases
crizotinib
CH5424802
Wounds and Injuries
2014
1 引用 (Scopus)

[Personalized medicine in non-small-cell carcinoma].

Iwama, E., Takayama, K., Baba, E. & Nakanishi, Y., 1 1 2014, : : Fukuoka igaku zasshi = Hukuoka acta medica. 105, 3, p. 57-66 10 p.

研究成果: ジャーナルへの寄稿評論記事

Serine Endopeptidases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ret
Antineoplastic Combined Chemotherapy Protocols
Molecular Targeted Therapy

A case of smoking-related interstitial lung disease with a histopathologic pattern overlapping that of usual interstitial pneumonia and respiratory bronchiolitis

Sawada, Y., Kitasato, Y., Watanabe, K., Okamoto, M., Iwama, E., Yoshimi, M., Okabayashi, K., Tarata, S., Kawayama, T. & Hoshino, T., 1 1 2014, : : Japanese Journal of Chest Diseases. 73, 5, p. 580-586 7 p.

研究成果: ジャーナルへの寄稿記事

Idiopathic Pulmonary Fibrosis
Bronchiolitis
Interstitial Lung Diseases
Smoking
Lung
29 引用 (Scopus)

Addition of bevacizumab enhances antitumor activity of erlotinib against non-small cell lung cancer xenografts depending on VEGF expression

Li, H., Takayama, K., Wang, S., Shiraishi, Y., Gotanda, K., Harada, T., Furuyama, K., Iwama, E., Ieiri, I., Okamoto, I. & Nakanishi, Y., 10 9 2014, : : Cancer chemotherapy and pharmacology. 74, 6, p. 1297-1305 9 p.

研究成果: ジャーナルへの寄稿記事

Heterografts
Non-Small Cell Lung Carcinoma
Vascular Endothelial Growth Factor A
Cells
Tumors
290 引用 (Scopus)

Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer

Azuma, K., ota, K., Kawahara, A., Hattori, S., Iwama, E., Harada, T., Matsumoto, K., Takayama, K., Takamori, S., Kage, M., Hoshino, T., Nakanishi, Y. & Okamoto, I., 10 1 2014, : : Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 25, 10, p. 1935-1940 6 p.

研究成果: ジャーナルへの寄稿記事

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Ligands
Mutation
Cell Line
29 引用 (Scopus)

Development of anaplastic lymphoma kinase (ALK) inhibitors and molecular diagnosis in ALK rearrangement-positive lung cancer

Iwama, E., Okamoto, I., Harada, T., Takayama, K. & Nakanishi, Y., 3 5 2014, : : OncoTargets and Therapy. 7, p. 375-385 11 p.

研究成果: ジャーナルへの寄稿評論記事

Lung Neoplasms
Non-Small Cell Lung Carcinoma
anaplastic lymphoma kinase
United States Food and Drug Administration
Oncogenes
4 引用 (Scopus)

Pemetrexed combined with platinum-based chemotherapy for advanced malignant peritoneal mesothelioma: Retrospective analysis of six cases

Nakano, M., Kusaba, H., Makiyama, A., ariyama, H., Arita, S., Oda, H., Esaki, T., Takayoshi, K., Uchino, K., Tamura, S., Kumagai, H., Iwama, E., Shirakawa, T., Mitsugi, K., Takaishi, S., Akashi, K. & Baba, E., 1 1 2014, : : Anticancer Research. 34, 1, p. 215-220 6 p.

研究成果: ジャーナルへの寄稿記事

Pemetrexed
Platinum
Mesothelioma
Ascites
Drug Therapy
10 引用 (Scopus)

PICT1 expression is a poor prognostic factor in non-small cell lung cancer

Okamura, K., Takayama, K., Kawahara, K., Harada, T., Nishio, M., Otsubo, K., Ijichi, K., Kohno, M., Iwama, E., Fujii, A., ota, K., Koga, T., Okamoto, T., Suzuki, A. & Nakanishi, Y., 1 1 2014, : : Oncoscience. 1, 5, p. 375-382 8 p.

研究成果: ジャーナルへの寄稿記事

Non-Small Cell Lung Carcinoma
Neoplasms
Cytoplasm
Multivariate Analysis
Smoking
2013
25 引用 (Scopus)

Sensitivity and kinase activity of epidermal growth factor receptor (EGFR) exon 19 and others to EGFR-tyrosine kinase inhibitors

Furuyama, K., Harada, T., Iwama, E., Shiraishi, Y., Okamura, K., Ijichi, K., Fujii, A., ota, K., Wang, S., Li, H., Takayama, K., Giaccone, G. & Nakanishi, Y., 5 1 2013, : : Cancer Science. 104, 5, p. 584-589 6 p.

研究成果: ジャーナルへの寄稿記事

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Exons
Mutation
Phosphotransferases
2011
12 引用 (Scopus)

Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues

Iwama, E., Tsuchimoto, D., Iyama, T., Kunihiko, S., Nakagawara, A., Takayama, K., Nakanishi, Y. & Nakabeppu, Y., 6 1 2011, : : Journal of Molecular Neuroscience. 44, 2, p. 103-114 12 p.

研究成果: ジャーナルへの寄稿記事

Nerve Tissue
Guanosine Triphosphate
Nucleotides
Spinal Ganglia
Neoplasms