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研究成果 1999 2019

  • 831 引用
  • 17 h指数
  • 54 記事
  • 3 評論記事
  • 1 コメント/討論
2019
4 引用 (Scopus)

Development of Turn-On Probes for Acids Triggered by Aromaticity Enhancement Using Tricyclic Amidine Derivatives

Matsumoto, S., Fuchi, Y., Usui, K., Hirai, G. & Karasawa, S., 6 7 2019, : : Journal of Organic Chemistry. 84, 11, p. 6612-6622 11 p.

研究成果: ジャーナルへの寄稿記事

Amidines
Fluorescence
Protonation
Quantum yield
Derivatives

Effects of Substituents on the Properties of Metal-Free MRI Contrast Agents

Shiraishi, R., Kaneko, T., Usui, K., Naganuma, T., Iizuka, N., Morishita, K., Kobayashi, S., Fuchi, Y., Matsuoka, Y., Hirai, G., Yamada, K. I. & Karasawa, S., 12 10 2019, : : ACS Omega. 4, 24, p. 20715-20723 9 p.

研究成果: ジャーナルへの寄稿記事

公開
Magnetic resonance
Contrast Media
Gadolinium
Metals
Imaging techniques

Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C 2 , by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis

Jiang, Y., Lu, S., Hirai, G., Kato, T., Onaka, H. & Kakeya, H., 4 11 2019, : : Tetrahedron Letters. 60, 15, p. 1072-1074 3 p.

研究成果: ジャーナルへの寄稿記事

Mycolic Acids
Metabolites
Bacteria

Nuciferols A and B: Novel sesquineolignans from Cocos nucifera

Elsbaey, M., Jie, B., Tanaka, C., Kato, H., Tsukamoto, S., Usui, K., Hirai, G. & Miyamoto, T., 8 15 2019, : : Tetrahedron Letters. 60, 33, 150948.

研究成果: ジャーナルへの寄稿記事

Cocos
Scavenging
Neuroprotective Agents
Cell death
Skeleton

Synthesis of All Stereoisomers of Monomeric Spectomycin A1/A2 and Evaluation of Their Protein SUMOylation-Inhibitory Activity

Nomura, Y., Thuaud, F., Sekine, D., Ito, A., Maeda, S., Koshino, H., Hashizume, D., Muranaka, A., Cruchter, T., Uchiyama, M., Ichikawa, S., Matsuda, A., Yoshida, M., Hirai, G. & Sodeoka, M., 6 21 2019, : : Chemistry - A European Journal. 25, 35, p. 8387-8392 6 p.

研究成果: ジャーナルへの寄稿記事

Stereoisomerism
Isomers
Stereochemistry
Proteins
Optical rotation
1 引用 (Scopus)

Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists

Mikame, Y., Yoshida, K., Hashizume, D., Hirai, G., Nagasawa, K., Osada, H. & Sodeoka, M., 3 7 2019, : : Chemistry - A European Journal. 25, 14, p. 3496-3500 5 p.

研究成果: ジャーナルへの寄稿記事

Abscisic Acid
Stereochemistry
Stereoisomerism
Agrochemicals
Lead compounds
3 引用 (Scopus)

Synthesis of CH 2 -Linked α(1,6)-Disaccharide Analogues by α-Selective Radical Coupling C-Glycosylation

Kiya, N., Hidaka, Y., Usui, K. & Hirai, G., 3 15 2019, : : Organic Letters. 21, 6, p. 1588-1592 5 p.

研究成果: ジャーナルへの寄稿記事

Glycosylation
Glycoconjugates
Disaccharides
carbohydrates
linkages
2018
3 引用 (Scopus)

Internal-Edge-Substituted Coumarin-Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self-Assembly

Usui, K., Yamamoto, K., Ueno, Y., Igawa, K., Hagihara, R., Masuda, T., Ojida, A., Karasawa, S., Tomooka, K., Hirai, G. & Suemune, H., 10 1 2018, : : Chemistry - A European Journal. 24, 55, p. 14617-14621 5 p.

研究成果: ジャーナルへの寄稿記事

Self assembly
X ray crystallography
Quantum yield
Electronic structure
Physical properties

Synthesis of dendritic bisphosphonates as bone targeting ligands

Shimoda, K., Mitsuoka, T., Ueda, K., Suemune, H., Hirai, G. & Aso, M., 12 19 2018, : : Tetrahedron Letters. 59, 51, p. 4528-4531 4 p.

研究成果: ジャーナルへの寄稿記事

Diphosphonates
Bone
Ligands
Bone and Bones
Durapatite
6 引用 (Scopus)

Thienyl-Substituted α-Ketoamide: A Less Hydrophobic Reactive Group for Photo-Affinity Labeling

Ota, E., Usui, K., Oonuma, K., Koshino, H., Nishiyama, S., Hirai, G. & Sodeoka, M., 4 20 2018, : : ACS Chemical Biology. 13, 4, p. 876-880 5 p.

研究成果: ジャーナルへの寄稿記事

Mannose
Labeling
Photolysis
Concanavalin A
Hydrophobic and Hydrophilic Interactions
2017
1 引用 (Scopus)

7-Hydroxy-3-methyleneisoindolin-1-one as a New ESIPT-Fluorescent Probe to Monitor Aqueous Environments

Kimuro, Y., Usui, K., Karasawa, S., Hirai, G. & Aso, M., 2017, : : Chemical and Pharmaceutical Bulletin. 65, 8, p. 796-800 5 p.

研究成果: ジャーナルへの寄稿記事

Proton transfer
Fluorescent Dyes
Excited states
Protons
Density functional theory
2 引用 (Scopus)

Synthesis of polyunsaturated fatty acid-containing glucuronosyl-diacylglycerol through direct glycosylation

Wang, Q., Kuramoto, Y., Okazaki, Y., Ota, E., Morita, M., Hirai, G., Saito, K. & Sodeoka, M., 1 1 2017, : : Tetrahedron Letters. 58, 30, p. 2915-2918 4 p.

研究成果: ジャーナルへの寄稿記事

Glycosylation
Glycerides
Glycolipids
Glucuronides
Unsaturated Fatty Acids
5 引用 (Scopus)

Synthesis of the Right‐Side Structure of Type B Physalins

Morita, M., Kojima, S., Ohkubo, M., Koshino, H., Hashizume, D., Hirai, G., Maruoka, K. & Sodeoka, M., 2017, : : Israel Journal of Chemistry. 57, 3-4, p. 309-318 10 p.

研究成果: ジャーナルへの寄稿記事

Methylation
Kinetics
physalin B
3 引用 (Scopus)

Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes

Morishita, K., Okamoto, Y., Murayama, S., Usui, K., Ohashi, E., Hirai, G., Aoki, I. & Karasawa, S., 8 8 2017, : : Langmuir. 33, 31, p. 7810-7817 8 p.

研究成果: ジャーナルへの寄稿記事

Dehydration
dehydration
Hydration
hydration
Protons
2016
26 引用 (Scopus)

A new carbamidemethyl-linked lanthanoid chelating tag for PCS NMR spectroscopy of proteins in living HeLa cells

Hikone, Y., Hirai, G., Mishima, M., Inomata, K., Ikeya, T., Arai, S., Shirakawa, M., Sodeoka, M. & Ito, Y., 10 1 2016, : : Journal of Biomolecular NMR. 66, 2, p. 99-110 12 p.

研究成果: ジャーナルへの寄稿記事

Biomolecular Nuclear Magnetic Resonance
Lanthanoid Series Elements
Chelation
HeLa Cells
Nuclear magnetic resonance spectroscopy
9 引用 (Scopus)

Comparative characterization of the leaf tissue of physalis alkekengi and physalis peruviana using RNA-seq and metabolite profiling

Fukushima, A., Nakamura, M., Suzuki, H., Yamazaki, M., Knoch, E., Mori, T., Umemoto, N., Morita, M., Hirai, G., Sodeoka, M. & Saito, K., 12 20 2016, : : Frontiers in Plant Science. 7, DECEMBER2016, 1883.

研究成果: ジャーナルへの寄稿記事

Physalis alkekengi
Physalis peruviana
Physalis
unigenes
RNA
2 引用 (Scopus)

Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast

Sun, X., Hirai, G., Ueki, M., Hirota, H., Wang, Q., Hongo, Y., Nakamura, T., Hitora, Y., Takahashi, H., Sodeoka, M., Osada, H., Hamamoto, M., Yoshida, M. & Yashiroda, Y., 2 19 2016, : : Scientific reports. 6, 20856.

研究成果: ジャーナルへの寄稿記事

Catabolite Repression
Schizosaccharomyces
Nitrogen
Fatty Acids
Amino Acids
4 引用 (Scopus)

Photochemical and Additive-Free Coupling Reaction of α-Cumyl α-Keto Esters via Intermolecular C-H Bond Activation

Ota, E., Mikame, Y., Hirai, G., Nishiyama, S. & Sodeoka, M., 1 4 2016, : : Synlett. 27, 7, p. 1128-1132 5 p.

研究成果: ジャーナルへの寄稿記事

Esters
Chemical activation
Derivatives
Amides
Hydroxy Acids
19 引用 (Scopus)

Rational Design and Synthesis of [5]Helicene-Derived Phosphine Ligands and Their Application in Pd-Catalyzed Asymmetric Reactions

Yamamoto, K., Shimizu, T., Igawa, K., Tomooka, K., Hirai, G., Suemune, H. & Usui, K., 11 8 2016, : : Scientific reports. 6, 36211.

研究成果: ジャーナルへの寄稿記事

phosphine
Ligands
Indoles
Acetates
Alcohols
2 引用 (Scopus)

Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation

Ohyoshi, T., Tamura, Y., Hayakawa, I., Hirai, G., Miyazawa, Y., Funakubo, S., Sodeoka, M. & Kigoshi, H., 1 1 2016, : : Organic and Biomolecular Chemistry. 14, 48, p. 11426-11437 12 p.

研究成果: ジャーナルへの寄稿記事

Protein Kinase C
analogs
Derivatives
proteins
evaluation
2015

C-Sialosides: Synthesis and biological activities

Hirai, G., Ota, E., Sakai, M., Nishiyama, S. & Sodeoka, M., 1 1 2015, : : Trends in Glycoscience and Glycotechnology. 27, 154, p. 47-60 14 p.

研究成果: ジャーナルへの寄稿評論記事

Neuraminidase
N-Acetylneuraminic Acid
Bioactivity
Ireland
Derivatives
6 引用 (Scopus)
Biological Products
Phosphoric Monoester Hydrolases
norcantharidin
Phosphoprotein Phosphatases
Derivatives
4 引用 (Scopus)
Bioactivity
Biological Products
Molecules
Experiments
5 引用 (Scopus)

Photo-induced formation of cyclopropanols from α-ketoamides via γ-C-H bond activation

Ota, E., Mikame, Y., Hirai, G., Koshino, H., Nishiyama, S. & Sodeoka, M., 10 28 2015, : : Tetrahedron Letters. 56, 44, p. 5991-5994 4 p.

研究成果: ジャーナルへの寄稿記事

Amides
Chemical activation
Bearings (structural)
Isotopes
Hydrogen
4 引用 (Scopus)

Reactions of carbonyl compounds with phosphorus ylide generated from tribromofluoromethane and tris(dimethylamino)phosphine

Hirai, G., Nishizawa, E., Kakumoto, D., Morita, M., Okada, M., Hashizume, D., Nagashima, S. & Sodeoka, M., 1 1 2015, : : Chemistry Letters. 44, 10, p. 1389-1391 3 p.

研究成果: ジャーナルへの寄稿記事

phosphine
Carbonyl compounds
Ketones
Phosphorus
Epoxy Compounds
8 引用 (Scopus)

Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

Lu, S., Nishimura, S., Hirai, G., Ito, M., Kawahara, T., Izumikawa, M., Sodeoka, M., Shin-Ya, K., Tsuchida, T. & Kakeya, H., 5 11 2015, : : Chemical Communications. 51, 38, p. 8074-8077 4 p.

研究成果: ジャーナルへの寄稿記事

Spectroscopic analysis
Chirality
Macrolides
Cytotoxicity
Tumors
2014
5 引用 (Scopus)

RE12 derivatives displaying Vaccinia H1-related phosphatase (VHR) inhibition in the presence of detergent and their anti-proliferative activity against HeLa cells

Thuaud, F., Kojima, S., Hirai, G., Oonuma, K., Tsuchiya, A., Uchida, T., Tsuchimoto, T. & Sodeoka, M., 5 1 2014, : : Bioorganic and Medicinal Chemistry. 22, 9, p. 2771-2782 12 p.

研究成果: ジャーナルへの寄稿記事

Vaccinia
HeLa Cells
Phosphoric Monoester Hydrolases
Detergents
Derivatives
2013
6 引用 (Scopus)

CDC25A-inhibitory RE derivatives bind to pocket adjacent to the catalytic site

Tsuchiya, A., Asanuma, M., Hirai, G., Oonuma, K., Muddassar, M., Nishizawa, E., Koyama, Y., Otani, Y., Zhang, K. Y. J. & Sodeoka, M., 5 1 2013, : : Molecular BioSystems. 9, 5, p. 1026-1034 9 p.

研究成果: ジャーナルへの寄稿記事

Catalytic Domain
Dual-Specificity Phosphatases
Peptides
Avidin
Phosphoprotein Phosphatases
11 引用 (Scopus)

Contribution of cage-shaped structure of physalins to their mode of action in inhibition of NF-κB activation

Ozawa, M., Morita, M., Hirai, G., Tamura, S., Kawai, M., Tsuchiya, A., Oonuma, K., Maruoka, K. & Sodeoka, M., 8 8 2013, : : ACS Medicinal Chemistry Letters. 4, 8, p. 730-735 6 p.

研究成果: ジャーナルへの寄稿記事

Withanolides
Chemical activation
Steroids
Degradation
Phosphorylation
18 引用 (Scopus)

Development of bis-unsaturated ester aldehydes as amino-glue probes: Sequential double azaelectrocyclization as a promising strategy for bioconjugation

Tanaka, K., Nakamoto, Y., Siwu, E. R. O., Pradipta, A. R., Morimoto, K., Fujiwara, T., Yoshida, S., Hosoya, T., Tamura, Y., Hirai, G., Sodeoka, M. & Fukase, K., 11 14 2013, : : Organic and Biomolecular Chemistry. 11, 42, p. 7326-7333 8 p.

研究成果: ジャーナルへの寄稿記事

glues
Glues
aldehydes
Aldehydes
Adhesives
18 引用 (Scopus)

Unexpected diels-Alder/carbonyl-ene cascade toward the biomimetic synthesis of chloropupukeananin

Suzuki, T., Miyajima, Y., Suzuki, K., Iwakiri, K., Koshimizu, M., Hirai, G., Sodeoka, M. & Kobayashi, S., 4 5 2013, : : Organic Letters. 15, 7, p. 1748-1751 4 p.

研究成果: ジャーナルへの寄稿記事

Biomimetics
biomimetics
cascades
Pressure
Enantiomers
2012
20 引用 (Scopus)

Dual-specificity phosphatase CDC25A/B inhibitor identified from a focused library with nonelectrophilic core structure

Tsuchiya, A., Hirai, G., Koyama, Y., Oonuma, K., Otani, Y., Osada, H. & Sodeoka, M., 4 12 2012, : : ACS Medicinal Chemistry Letters. 3, 4, p. 294-298 5 p.

研究成果: ジャーナルへの寄稿記事

Dual-Specificity Phosphatases
G2 Phase
Phosphoprotein Phosphatases
Cell Cycle Checkpoints
Cell Division
9 引用 (Scopus)

Kinetically controlled one-pot formation of DEFGH-rings of type B physalins through domino-type transformations

Morita, M., Hirai, G., Ohkubo, M., Koshino, H., Hashizume, D., Maruoka, K. & Sodeoka, M., 7 6 2012, : : Organic Letters. 14, 13, p. 3434-3437 4 p.

研究成果: ジャーナルへの寄稿記事

rings
Michael reaction
physalin B
2011
6 引用 (Scopus)

Design and synthesis of protein kinase Cα activators based on 'out of pocket' interactions

Hirai, G., Ohkubo, M., Tamura, Y. & Sodeoka, M., 6 15 2011, : : Bioorganic and Medicinal Chemistry Letters. 21, 12, p. 3587-3590 4 p.

研究成果: ジャーナルへの寄稿記事

Inositol
Protein Kinase C
Bearings (structural)
Phorbol Esters
Binding Sites
17 引用 (Scopus)

Development of a Vaccinia H1-Related (VHR) Phosphatase Inhibitor with a Nonacidic Phosphate-Mimicking Core Structure

Hirai, G., Tsuchiya, A., Koyama, Y., Otani, Y., Oonuma, K., Dodo, K., Simizu, S., Osada, H. & Sodeoka, M., 4 4 2011, : : ChemMedChem. 6, 4, p. 617-622 6 p.

研究成果: ジャーナルへの寄稿記事

Dual-Specificity Phosphatases
Cultured Tumor Cells
Molecular Mimicry
Vaccinia
NIH 3T3 Cells
9 引用 (Scopus)

Studies on the selectivity between glycosylation and intermolecular aglycone transfer of thioglucoside in synthesis of lactose derivatives

Kato, M., Hirai, G. & Sodeoka, M., 2011, : : Chemistry Letters. 40, 8, p. 877-879 3 p.

研究成果: ジャーナルへの寄稿記事

Thioglucosides
Glycosylation
Lactose
Derivatives
Ether
2009
10 引用 (Scopus)

A strategy for constructing C-sialosides based on Ireland-Claisen rearrangement and its application for synthesis of CF2-linked ganglioside GM4 analog

Sodeoka, M., Hirai, G., Watanabe, T. & Miyagi, T., 3 9 2009, : : Pure and Applied Chemistry. 81, 2, p. 205-215 11 p.

研究成果: ジャーナルへの寄稿記事

Lymphocytes
Gangliosides
Bioactivity
Neuraminidase
GM4 ganglioside
5 引用 (Scopus)

Asymmetric synthesis of isobenzofuranone derivatives and their unique character as protein kinase Cα (PKCα) activators

Hirai, G., Ogoshi, Y., Ohkubo, M., Tamura, Y., Watanabe, T., Shimizu, T. & Sodeoka, M., 7 1 2009, : : Tetrahedron Letters. 50, 26, p. 3609-3612 4 p.

研究成果: ジャーナルへの寄稿記事

Protein Kinase C
Ligands
Derivatives
Carboxylation
K562 Cells
172 引用 (Scopus)

Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate

Fukuda, I., Ito, A., Hirai, G., Nishimura, S., Kawasaki, H., Saitoh, H., Kimura, K. I., Sodeoka, M. & Yoshida, M., 2 27 2009, : : Chemistry and Biology. 16, 2, p. 133-140 8 p.

研究成果: ジャーナルへの寄稿記事

Small Ubiquitin-Related Modifier Proteins
Sumoylation
Neurodegenerative diseases
Proteins
Assays
18 引用 (Scopus)

Synthesis of the DFGH ring system of type B physalins: Highly oxygenated, cage-shaped molecules

Ohkubo, M., Hirai, G. & Sodeoka, M., 5 11 2009, : : Angewandte Chemie - International Edition. 48, 21, p. 3862-3866 5 p.

研究成果: ジャーナルへの寄稿記事

Molecules
physalin B
2008
10 引用 (Scopus)

Enantioselective synthesis of the fully functionalized ABC ring of zoanthenol

Sugano, N., Koizumi, Y., Hirai, G., Oguri, H., Kobayashi, S., Yamashita, S. & Hirama, M., 9 1 2008, : : Chemistry - An Asian Journal. 3, 8-9, p. 1549-1557 9 p.

研究成果: ジャーナルへの寄稿記事

Carbon
Kinetics
zoanthenol
99 引用 (Scopus)

Limited inhibitory effects of oseltamivir and zanamivir on human sialidases

Hata, K., Koseki, K., Yamaguchi, K., Moriya, S., Suzuki, Y., Yingsakmongkon, S., Hirai, G., Sodeoka, M., Von Itzstein, M. & Miyagi, T., 10 1 2008, : : Antimicrobial Agents and Chemotherapy. 52, 10, p. 3484-3491 8 p.

研究成果: ジャーナルへの寄稿記事

Zanamivir
Oseltamivir
Neuraminidase
Enzymes
Pharmaceutical Preparations
27 引用 (Scopus)

Synthesis of CH2-linked α(2,3)sialylgalactose analogue: On the stereoselectivity of the key Ireland-Claisen rearrangement

Watanabe, T., Hirai, G., Kato, M., Hashizume, D., Miyagi, T. & Sodeoka, M., 12 1 2008, : : Organic Letters. 10, 19, p. 4167-4170 4 p.

研究成果: ジャーナルへの寄稿記事

Stereoselectivity
Ireland
Galactose
Hydroxyl Radical
Thermal effects
2007
7 引用 (Scopus)

Importance of interaction between C1 domain and lipids in protein kinase Cα activation: Hydrophobic side chain direction in isobenzofuranone ligands controls enzyme activation level

Hirai, G., Shimizu, A., Watanabe, T., Ogoshi, Y., Ohkubo, M. & Sodeoka, M., 7 9 2007, : : ChemMedChem. 2, 7, p. 1006-1009 4 p.

研究成果: ジャーナルへの寄稿記事

Enzyme Activation
Membrane Lipids
Protein Kinase C
Conformations
Chemical activation
48 引用 (Scopus)

Stereocontrolled and convergent entry to CF2-sialosides: Synthesis of CF2-linked ganglioside GM4

Hirai, G., Watanabe, T., Yamaguchi, K., Miyagi, T. & Sodeoka, M., 12 19 2007, : : Journal of the American Chemical Society. 129, 50, p. 15420-15421 2 p.

研究成果: ジャーナルへの寄稿記事

Gangliosides
Bioactivity
Neuraminidase
Ireland
GM4 ganglioside
2006
1 引用 (Scopus)

Chemical modification of bio-molecules to change their functionalities

Hirai, G., 1 1 2006, : : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 64, 12, p. 1306-1307 2 p.

研究成果: ジャーナルへの寄稿評論記事

Chemical modification
Gene transfer
Molecules
Proteins
Solubility
1 引用 (Scopus)
Protein Kinase C
Chemical activation
Ligands
Derivatives
Signal transduction
2004
30 引用 (Scopus)

Design, synthesis, and structure-activity relationship of new isobenzofuranone ligands of protein kinase C

Baba, Y., Ogoshi, Y., Hirai, G., Yanagisawa, T., Nagamatsu, K., Mayumi, S., Hashimoto, Y. & Sodeoka, M., 6 7 2004, : : Bioorganic and Medicinal Chemistry Letters. 14, 11, p. 2963-2967 5 p.

研究成果: ジャーナルへの寄稿記事

Structure-Activity Relationship
Protein Kinase C
Ligands
Derivatives
Signal transduction