Pureに変更を加えた場合、すぐここに表示されます。

研究成果 2005 2019

2019
2 引用 (Scopus)

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Tozaki-Saitoh, H., Tsuda, M., Inoue, K. & Ueda, T., 3 15 2019, : : Purinergic Signalling. 15, 1, p. 27-35 9 p.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Monoclonal Antibodies
Antibodies
Purinergic P2X Receptors
Head
1 引用 (Scopus)

Microglia-neuron interactions in the models of neuropathic pain

Saitoh, H. & Makoto, T., 11 1 2019, : : Biochemical Pharmacology. 169, 113614.

研究成果: ジャーナルへの寄稿評論記事

Microglia
Neuralgia
Neurons
Chronic Pain
Chemical activation
1 引用 (Scopus)
oxaliplatin
Hyperalgesia
Pharmacology
Small Molecule Libraries
Peripheral Nervous System Diseases
3 引用 (Scopus)

Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development

Tozaki-Saitoh, H., Masuda, J., Kawada, R., Kojima, C., Yoneda, S., Masuda, T., Inoue, K. & Tsuda, M., 4 2019, : : GLIA. 67, 4, p. 729-740 12 p.

研究成果: ジャーナルへの寄稿記事

MafB Transcription Factor
Peripheral Nerve Injuries
Microglia
Neuralgia
Hypersensitivity
2018
3 引用 (Scopus)

Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin

Yoshihara, K., Matsuda, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., 5 1 2018, : : Journal of Pharmacological Sciences. 137, 1, p. 101-104 4 p.

研究成果: ジャーナルへの寄稿記事

Astrocytes
Skin
Automatic Data Processing
Photons
Formaldehyde

Green Pharma: A new strategy for drug discovery in academia by targeting glial cells and ATP receptors

Yamashita, T., Makoto, T., Saitoh, H. & Inoue, K., 1 1 2018, : : Yakugaku Zasshi. 138, 8, p. 1027-1031 5 p.

研究成果: ジャーナルへの寄稿評論記事

Purinergic P2 Receptors
Drug Discovery
Neuroglia
Hyperalgesia
Neuralgia
8 引用 (Scopus)

Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

Tashima, R., Koga, K., Sekine, M., Kanehisa, K., Kohro, Y., Tominaga, K., Matsushita, K., Tozaki-Saitoh, H., Fukazawa, Y., Inoue, K., Yawo, H., Furue, H. & Tsuda, M., 1 1 2018, : : eNeuro. 5, 1, e0450-17.2018.

研究成果: ジャーナルへの寄稿記事

Optogenetics
Peripheral Nerve Injuries
Neuralgia
Myelinated Nerve Fibers
Wounds and Injuries
6 引用 (Scopus)

Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents

Kohno, K., Kitano, J., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., 1 1 2018, : : Biological and Pharmaceutical Bulletin. 41, 7, p. 1096-1102 7 p.

研究成果: ジャーナルへの寄稿記事

Peripheral Nerve Injuries
Rodentia
Microglia
Neuralgia
S Phase
19 引用 (Scopus)

Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

Chen, T., Taniguchi, W., Chen, Q. Y., Tozaki-Saitoh, H., Song, Q., Liu, R. H., Koga, K., Matsuda, T., Kaito-Sugimura, Y., Wang, J., Li, Z. H., Lu, Y. C., Inoue, K., Tsuda, M., Li, Y. Q., Nakatsuka, T. & Zhuo, M., 12 1 2018, : : Nature communications. 9, 1, 1886.

研究成果: ジャーナルへの寄稿記事

cortexes
Gyrus Cinguli
pain
Modulation
Synaptic Transmission
2017
3 引用 (Scopus)

Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours

Koga, K., Kanehisa, K., Kohro, Y., Shiratori-Hayashi, M., Tozaki-Saitoh, H., Inoue, K., Furue, H. & Tsuda, M., 12 1 2017, : : Scientific reports. 7, 1, 4739.

研究成果: ジャーナルへの寄稿記事

Interneurons
Morphine
N-Methyl-D-Aspartate Receptors
Designer Drugs
Substantia Gelatinosa
4 引用 (Scopus)
NFATC Transcription Factors
Cell signaling
CC Chemokines
Microglia
Adenosine Diphosphate
1 引用 (Scopus)

Specific activation of inhibitory interneurons in the spinal dorsal horn suppresses repetitive scratching in mouse models of chronic itch

Kanehisa, K., Shiratori-Hayashi, M., Koga, K., Tozaki-Saitoh, H., Kohro, Y., Takamori, K. & Tsuda, M., 11 2017, : : Journal of Dermatological Science. 88, 2, p. 251-254 4 p.

研究成果: ジャーナルへの寄稿レター

Cyclopropanes
Muscarinic M3 Receptors
Genetic engineering
Clozapine
Animals
2016
33 引用 (Scopus)

A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

Matsumura, Y., Yamashita, T., Sasaki, A., Nakata, E., Kohno, K., Masuda, T., Tozaki-Saitoh, H., Imai, T., Kuraishi, Y., Tsuda, M. & Inoue, K., 8 31 2016, : : Scientific reports. 6, 32461.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Chronic Pain
Acute Pain
Pain
Down-Regulation
18 引用 (Scopus)

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

Tashima, R., Mikuriya, S., Tomiyama, D., Shiratori-Hayashi, M., Yamashita, T., Kohro, Y., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., 3 23 2016, : : Scientific reports. 6, 23701.

研究成果: ジャーナルへの寄稿記事

Peripheral Nerve Injuries
Microglia
Bone Marrow Cells
Population
Spinal Cord
49 引用 (Scopus)

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Masuda, T., Ozono, Y., Mikuriya, S., Kohro, Y., Tozaki-Saitoh, H., Iwatsuki, K., Uneyama, H., Ichikawa, R., Salter, M. W., Tsuda, M. & Inoue, K., 8 12 2016, : : Nature communications. 7, 12529.

研究成果: ジャーナルへの寄稿記事

Posterior Horn Cells
transporter
pain
adenosine triphosphate
nucleotides
19 引用 (Scopus)

Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury

Yamashita, T., Yamamoto, S., Zhang, J., Kometani, M., Tomiyama, D., Kohno, K., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., 10 2016, : : PloS one. 11, 10, e0165189.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Peripheral Nerve Injuries
peripheral nerves
Neuralgia
pain
30 引用 (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Tozaki-Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Tsuda, M., Robaye, B., Inoue, K. & Nishida, M., 1 19 2016, : : Science Signaling. 9, 411, aac9187.

研究成果: ジャーナルへの寄稿記事

Purinergic Receptors
Angiotensin Type 1 Receptor
Angiotensin II
Hypertension
Arrestin
2015
28 引用 (Scopus)

A new minimally-invasive method for microinjection into the mouse spinal dorsal horn

Kohro, Y., Sakaguchi, E., Tashima, R., Tozaki-Saitoh, H., Okano, H., Inoue, K. & Tsuda, M., 9 21 2015, : : Scientific reports. 5, 14306.

研究成果: ジャーナルへの寄稿記事

Microinjections
Laminectomy
Inflammation
Gene Expression
Peripheral Nerve Injuries
61 引用 (Scopus)

STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

Shiratori, M., Koga, K., Saitoh, H., Koro, Y., Toyonaga, H., Yamaguchi, C., Hasegawa, A., Nakahara, T., Hachisuka, J., Akira, S., Okano, H., Furue, M., Inoue, K. & Makoto, T., 8 8 2015, : : Nature medicine. 21, 8, p. 927-931 5 p.

研究成果: ジャーナルへの寄稿記事

STAT3 Transcription Factor
Lipocalins
Atopic Dermatitis
Dermatitis
Gastrin-Releasing Peptide
22 引用 (Scopus)

Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia

Masuda, T., Iwamoto, S., Mikuriya, S., Tozaki-Saitoh, H., Tamura, T., Tsuda, M. & Inoue, K., 9 4 2015, : : Journal of Pharmacological Sciences. 128, 4, p. 216-220 5 p.

研究成果: ジャーナルへの寄稿記事

Microglia
Interleukin-1
Transcription Factors
Gene Expression
Up-Regulation
2014
21 引用 (Scopus)

Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans

Kobayakawa, K., Kumamaru, H., Saiwai, H., Kubota, K., Ohkawa, Y., Kishimoto, J., Yokota, K., Ideta, R., Shiba, K., Tozaki-Saitoh, H., Inoue, K., Iwamoto, Y. & Okada, S., 10 1 2014, : : Science Translational Medicine. 6, 256, 256ra137.

研究成果: ジャーナルへの寄稿記事

Spinal Cord Injuries
Hyperglycemia
Obese Mice
Nervous System Trauma
Blood Glucose
37 引用 (Scopus)

Chemokine (C-C motif) receptor 5 Is an important pathological regulator in the development and maintenance of neuropathic pain

Matsushita, K., Tozaki-Saitoh, H., Kojima, C., Masuda, T., Tsuda, M., Inoue, K. & Hoka, S., 6 2014, : : Anesthesiology. 120, 6, p. 1491-1503 13 p.

研究成果: ジャーナルへの寄稿記事

CCR Receptors
Neuralgia
Hyperalgesia
Chemokine CCL3
Maintenance
10 引用 (Scopus)

Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents

Akagi, T., Matsumura, Y., Yasui, M., Minami, E., Inoue, H., Masuda, T., Tozaki-Saitoh, H., Tamura, T., Mizumura, K., Tsuda, M., Kiyama, H. & Inoue, K., 2014, : : Journal of Pharmacological Sciences. 126, 2, p. 172-176 5 p.

研究成果: ジャーナルへの寄稿記事

Hyperalgesia
Microglia
Rodentia
interferon regulatory factor-8
Knockout Mice
28 引用 (Scopus)

Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia

Ochi-ishi, R., Nagata, K., Inoue, T., Tozaki-Saitoh, H., Tsuda, M. & Inoue, K., 8 15 2014, : : Molecular Pain. 10, 1, 53.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X7 Receptors
CC Chemokines
Hyperalgesia
Paclitaxel
Chemokines
13 引用 (Scopus)

IRF8 is a transcriptional determinant for microglial motility

Masuda, T., Nishimoto, N., Tomiyama, D., Matsuda, T., Tozaki-Saitoh, H., Tamura, T., Kohsaka, S., Tsuda, M. & Inoue, K., 1 1 2014, : : Purinergic Signalling. 10, 3, p. 515-521 7 p.

研究成果: ジャーナルへの寄稿記事

Microglia
Chemotaxis
Adenosine Triphosphate
Complement C5a
interferon regulatory factor-8

Spinal cord is the primary site of action of the cannabinoid CB2 receptor agonist JWH133 that suppresses neuropathic pain: Possible involvement of microglia

Shimoyama, H., Makoto, T., Masuda, T., Yoshinaga, R., Tsukamoto, K., Saitoh, H. & Inoue, K., 1 1 2014, : : Open Pain Journal. 7, 1

研究成果: ジャーナルへの寄稿記事

Cannabinoid Receptor Agonists
Microglia
Neuralgia
Cannabinoid Receptor CB2
Spinal Cord
78 引用 (Scopus)

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

Masuda, T., Iwamoto, S., Yoshinaga, R., Tozaki-Saitoh, H., Nishiyama, A., Mak, T. W., Tamura, T., Tsuda, M. & Inoue, K., 5 13 2014, : : Nature communications. 5, 3771.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Interferon Regulatory Factors
interferon
pain
Microglia
2013
1 引用 (Scopus)

Intrathecal infusion of microglia cells

Masuda, T., Tsuda, M., Tozaki-Saitoh, H. & Inoue, K., 7 18 2013, Microglia: Methods and Protocols. p. 291-294 4 p. (Methods in Molecular Biology; 巻数 1041).

研究成果: 著書/レポートタイプへの貢献

Microglia
Peripheral Nerve Injuries
Subarachnoid Space
Neuralgia
Cultured Cells
4 引用 (Scopus)

Lentiviral transduction of cultured microglia

Masuda, T., Makoto, T., Saitoh, H. & Inoue, K., 2013, Microglia: Methods and Protocols. 巻 1041. p. 63-67 5 p. (Methods in Molecular Biology; 巻数 1041).

研究成果: 著書/レポートタイプへの貢献

Gene Transfer Techniques
Microglia
Neuroglia
Nervous System
Cultured Cells
77 引用 (Scopus)

Microglial regulation of neuropathic pain

Tsuda, M., Masuda, T., Tozaki-Saitoh, H. & Inoue, K., 2 26 2013, : : Journal of Pharmacological Sciences. 121, 2, p. 89-94 6 p.

研究成果: ジャーナルへの寄稿評論記事

Neuralgia
Microglia
Wounds and Injuries
Posterior Horn Cells
Gene Expression
62 引用 (Scopus)

P2X4 receptors and neuropathic pain

Tsuda, M., Masuda, T., Tozaki-Saitoh, H. & Inoue, K., 10 28 2013, : : Frontiers in Cellular Neuroscience. OCT, 191.

研究成果: ジャーナルへの寄稿評論記事

Purinergic P2X4 Receptors
Microglia
Neuralgia
Chemokine CCL21
CCR Receptors
50 引用 (Scopus)

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S

Hayashi, Y., Koyanagi, S., Kusunose, N., Okada, R., Wu, Z., Tozaki-Saitoh, H., Ukai, K., Kohsaka, S., Inoue, K., Ohdo, S. & Nakanishi, H., 10 14 2013, : : Scientific reports. 3, 2744.

研究成果: ジャーナルへの寄稿記事

cathepsin S
Microglia
Cats
Neurons
Spine
2012
53 引用 (Scopus)

CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia

Toyomitsu, E., Tsuda, M., Yamashita, T., Tozaki-Saitoh, H., Tanaka, Y. & Inoue, K., 6 1 2012, : : Purinergic Signalling. 8, 2, p. 301-310 10 p.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Microglia
Lysosomes
Exocytosis
Green Fluorescent Proteins
11 引用 (Scopus)

Involvement of protein kinase D in uridine diphosphate-induced microglial macropinocytosis and phagocytosis

Uesugi, A., Kataoka, A., Saitoh, H., Koga, Y., Makoto, T., Robaye, B., Boeynaems, J. M. & Inoue, K., 7 1 2012, : : GLIA. 60, 7, p. 1094-1105 12 p.

研究成果: ジャーナルへの寄稿記事

Uridine Diphosphate
Phagocytosis
Microglia
Microspheres
Vacuoles
131 引用 (Scopus)

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

Masuda, T., Makoto, T., Yoshinaga, R., Saitoh, H., Ozato, K., Tamura, T. & Inoue, K., 3 19 2012, : : Cell Reports. 1, 4, p. 334-340 7 p.

研究成果: ジャーナルへの寄稿記事

Microglia
Transcription Factors
Phenotype
Peripheral Nerve Injuries
Gene expression
4 引用 (Scopus)

P2X4R and P2X7R in neuropathic pain

Makoto, T., Hidetoshi, T. S. & Kazuhide, I., 7 1 2012, : : Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1, 4, p. 513-521 9 p.

研究成果: ジャーナルへの寄稿記事

Neuralgia
Purinergic Receptors
Microglia
Purinergic P2 Receptors
Posterior Horn Cells
9 引用 (Scopus)

P2Y receptors in microglia and neuroinflammation

Saitoh, H., Makoto, T. & Inoue, K., 7 1 2012, : : Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1, 4, p. 493-501 9 p.

研究成果: ジャーナルへの寄稿評論記事

Microglia
Central Nervous System
Purinergic Receptors
Cytophagocytosis
Uridine Diphosphate
40 引用 (Scopus)

Purinergic system, microglia and neuropathic pain

Makoto, T., Saitoh, H. & Inoue, K., 2 1 2012, : : Current Opinion in Pharmacology. 12, 1, p. 74-79 6 p.

研究成果: ジャーナルへの寄稿評論記事

Microglia
Neuralgia
Purinergic Receptors
Peripheral Nerve Injuries
Neuroglia
9 引用 (Scopus)

Role of the glia in neuropathic pain caused by peripheral nerve injury

Inoue, K., Makoto, T. & Saitoh, H., 11 2012, : : Brain and Nerve. 64, 11, p. 1233-1239 7 p.

研究成果: ジャーナルへの寄稿評論記事

Peripheral Nerve Injuries
Neuralgia
Neuroglia
Microglia
Astrocytes
2011
56 引用 (Scopus)
Purinergic P2Y1 Receptors
Middle Cerebral Artery Infarction
Brain Ischemia
Chemokines
Chemokine CXCL10
4 引用 (Scopus)

Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways

Kataoka, A., Koga, Y., Uesugi, A., Tozaki-Saitoh, H., Tsuda, M. & Inoue, K., 12 1 2011, : : Purinergic Signalling. 7, 4, p. 403-411 9 p.

研究成果: ジャーナルへの寄稿記事

Uridine Diphosphate
Actins
Microglia
Phosphorylation
Microfilament Proteins
148 引用 (Scopus)

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

Tsuda, M., Kohro, Y., Yano, T., Tsujikawa, T., Kitano, J., Tozaki-Saitoh, H., Koyanagi, S., Ohdo, S., Ji, R. R., Salter, M. W. & Inoue, K., 4 1 2011, : : Brain. 134, 4, p. 1127-1139 13 p.

研究成果: ジャーナルへの寄稿記事

Neuralgia
STAT3 Transcription Factor
Astrocytes
Maintenance
Janus Kinases
99 引用 (Scopus)

Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development

Biber, K., Tsuda, M., Tozaki-Saitoh, H., Tsukamoto, K., Toyomitsu, E., Masuda, T., Boddeke, H. & Inoue, K., 5 4 2011, : : EMBO Journal. 30, 9, p. 1864-1873 10 p.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Hyperalgesia
Microglia
Neuralgia
Up-Regulation
16 引用 (Scopus)

Platelet-activating factor and pain

Tsuda, M., Tozaki-Saitoh, H. & Inoue, K., 8 1 2011, : : Biological and Pharmaceutical Bulletin. 34, 8, p. 1159-1162 4 p.

研究成果: ジャーナルへの寄稿評論記事

Platelet Activating Factor
Pain
Neuralgia
Spinal Ganglia
Wounds and Injuries
31 引用 (Scopus)

Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases

Kuboyama, K., Tsuda, M., Tsutsui, M., Toyohara, Y., Tozaki-Saitoh, H., Shimokawa, H., Yanagihara, N. & Inoue, K., 7 14 2011, : : Molecular Pain. 7, 50.

研究成果: ジャーナルへの寄稿記事

Neuralgia
Nitric Oxide Synthase
Hyperalgesia
Wounds and Injuries
Pain
18 引用 (Scopus)

Role of Purinergic Receptors in CNS Function and Neuroprotection

Saitoh, H., Makoto, T. & Inoue, K., 1 1 2011, Advances in Pharmacology. Academic Press Inc., p. 495-528 34 p. (Advances in Pharmacology; 巻数 61).

研究成果: 著書/レポートタイプへの貢献

Purinergic Receptors
Microglia
Central Nervous System
Neuroglia
Oligodendroglia
2010
49 引用 (Scopus)

Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn

Maeda, M., Tsuda, M., Tozaki-Saitoh, H., Inoue, K. & Kiyama, H., 11 15 2010, : : GLIA. 58, 15, p. 1838-1846 9 p.

研究成果: ジャーナルへの寄稿記事

Microglia
Axons
Wounds and Injuries
Neuralgia
Purinergic P2 Receptors
81 引用 (Scopus)

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

Shiratori, M., Tozaki-Saitoh, H., Yoshitake, M., Tsuda, M. & Inoue, K., 8 2010, : : Journal of Neurochemistry. 114, 3, p. 810-819 10 p.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X7 Receptors
NFATC Transcription Factors
Microglia
Adenosine Triphosphate
Chemical activation
91 引用 (Scopus)

Pain and purinergic signaling

Makoto, T., Saitoh, H. & Inoue, K., 5 1 2010, : : Brain Research Reviews. 63, 1-2, p. 222-232 11 p.

研究成果: ジャーナルへの寄稿評論記事

Purinergic P2 Receptors
Microglia
Peripheral Nerve Injuries
Nucleotides
Second Messenger Systems
1 引用 (Scopus)

Purinergic regulation of microglia

Tozaki-Saitoh, H., Tsuda, M. & Inoue, K., 10 12 2010, : : Folia Pharmacologica Japonica. 136, 2, p. 93-97 5 p.

研究成果: ジャーナルへの寄稿評論記事

Purinergic P2Y12 Receptors
Purinergic P2X4 Receptors
Purinergic P2X7 Receptors
Purinergic P2 Receptors
Microglia