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研究成果 2009 2019

  • 765 引用
  • 17 h指数
  • 26 記事
フィルター
記事
2019
3 引用 (Scopus)

Regenerating Corticospinal Axons Innervate Phenotypically Appropriate Neurons within Neural Stem Cell Grafts

Kumamaru, H., Lu, P., Rosenzweig, E. S., Kadoya, K. & Tuszynski, M. H., 2 26 2019, : : Cell Reports. 26, 9, p. 2329-2339.e4

研究成果: ジャーナルへの寄稿記事

公開
Neural Stem Cells
Stem cells
Grafts
Neurons
Axons
2018

Activation of Intrinsic Growth State Enhances Host Axonal Regeneration into Neural Progenitor Cell Grafts

Kumamaru, H., Lu, P., Rosenzweig, E. S. & Tuszynski, M. H., 10 9 2018, : : Stem Cell Reports. 11, 4, p. 861-868 8 p.

研究成果: ジャーナルへの寄稿記事

Grafts
Regeneration
Stem Cells
Chemical activation
Transplants
3 引用 (Scopus)

Adult rat myelin enhances axonal outgrowth from neural stem cells

Poplawski, G. H. D., Lie, R., Hunt, M., Kumamaru, H., Kawaguchi, R., Lu, P., Schäfer, M. K. E., Woodruff, G., Robinson, J., Canete, P., Dulin, J. N., Geoffroy, C. G., Menzel, L., Zheng, B., Coppola, G. & Tuszynski, M. H., 5 23 2018, : : Science Translational Medicine. 10, 442, eaal2563.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Myelin Sheath
Stem Cells
Axons
Spinal Cord Injuries
8 引用 (Scopus)

Generation and post-injury integration of human spinal cord neural stem cells

Kumamaru, H., Kadoya, K., Adler, A. F., Takashima, Y., Graham, L., Coppola, G. & Tuszynski, M. H., 9 1 2018, : : Nature Methods. 15, 9, p. 723-731 9 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Stem cells
Spinal Cord
Wounds and Injuries
Pluripotent Stem Cells
15 引用 (Scopus)

Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts

Dulin, J. N., Adler, A. F., Kumamaru, H., Poplawski, G. H. D., Lee-Kubli, C., Strobl, H., Gibbs, D., Kadoya, K., Fawcett, J. W., Lu, P. & Tuszynski, M. H., 12 1 2018, : : Nature communications. 9, 1, 84.

研究成果: ジャーナルへの寄稿記事

axons
Grafts
Axons
Transplants
spinal cord
54 引用 (Scopus)

Restorative effects of human neural stem cell grafts on the primate spinal cord

Rosenzweig, E. S., Brock, J. H., Lu, P., Kumamaru, H., Salegio, E. A., Kadoya, K., Weber, J. L., Liang, J. J., Moseanko, R., Hawbecker, S., Huie, J. R., Havton, L. A., Nout-Lomas, Y. S., Ferguson, A. R., Beattie, M. S., Bresnahan, J. C. & Tuszynski, M. H., 5 1 2018, : : Nature medicine. 24, 4, p. 484-490 7 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Stem cells
Grafts
Primates
Spinal Cord
2017
17 引用 (Scopus)

Comprehensive Monosynaptic Rabies Virus Mapping of Host Connectivity with Neural Progenitor Grafts after Spinal Cord Injury

Adler, A. F., Lee-Kubli, C., Kumamaru, H., Kadoya, K. & Tuszynski, M. H., 6 6 2017, : : Stem Cell Reports. 8, 6, p. 1525-1533 9 p.

研究成果: ジャーナルへの寄稿記事

Rabies virus
Spinal Cord Injuries
Viruses
Grafts
Transplants
76 引用 (Scopus)

Interaction of reactive astrocytes with type i collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury

Hara, M., Kobayakawa, K., Ohkawa, Y., Kumamaru, H., Yokota, K., Saito, T., Kijima, K., Yoshizaki, S., Harimaya, K., Nakashima, Y. & Okada, S., 7 1 2017, : : Nature medicine. 23, 7, p. 818-828 11 p.

研究成果: ジャーナルへの寄稿記事

Cadherins
Spinal Cord Injuries
Integrins
Astrocytes
Cicatrix

Macrophage Infiltration Is a Causative Factor for Ligamentum Flavum Hypertrophy through the Activation of Collagen Production in Fibroblasts

Saito, T., Hara, M., Kumamaru, H., Kobayakawa, K., Yokota, K., Kijima, K., Yoshizaki, S., Harimaya, K., Matsumoto, Y., Kawaguchi, K., Hayashida, M., Inagaki, Y., Shiba, K., Nakashima, Y. & Okada, S., 12 1 2017, : : American Journal of Pathology. 187, 12, p. 2831-2840 10 p.

研究成果: ジャーナルへの寄稿記事

Ligamentum Flavum
Hypertrophy
Collagen
Fibroblasts
Macrophages
28 引用 (Scopus)

Prolonged human neural stem cell maturation supports recovery in injured rodent CNS

Lu, P., Ceto, S., Wang, Y., Graham, L., Wu, D., Kumamaru, H., Staufenberg, E. & Tuszynski, M. H., 9 1 2017, : : Journal of Clinical Investigation. 127, 9, p. 3287-3299 13 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Rodentia
Transplants
Spinal Cord Injuries
Astrocytes
20 引用 (Scopus)

Regulation of RhoA by STAT3 coordinates glial scar formation

Renault-Mihara, F., Mukaino, M., Shinozaki, M., Kumamaru, H., Kawase, S., Baudoux, M., Ishibashi, T., Kawabata, S., Nishiyama, Y., Sugai, K., Yasutake, K., Okada, S., Nakamura, M. & Okano, H., 1 1 2017, : : Journal of Cell Biology. 216, 8, p. 2533-2550 18 p.

研究成果: ジャーナルへの寄稿記事

STAT3 Transcription Factor
Neuroglia
Cicatrix
Astrocytes
Nestin
2016
91 引用 (Scopus)

Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration

Kadoya, K., Lu, P., Nguyen, K., Lee-Kubli, C., Kumamaru, H., Yao, L., Knackert, J., Poplawski, G., Dulin, J. N., Strobl, H., Takashima, Y., Biane, J., Conner, J., Zhang, S. C. & Tuszynski, M. H., 5 1 2016, : : Nature medicine. 22, 5, p. 479-487 9 p.

研究成果: ジャーナルへの寄稿記事

Grafts
Regeneration
Spinal Cord
Spinal Cord Injuries
Transplants
2014
21 引用 (Scopus)

Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans

Kobayakawa, K., Kumamaru, H., Saiwai, H., Kubota, K., Ohkawa, Y., Kishimoto, J., Yokota, K., Ideta, R., Shiba, K., Tozaki-Saitoh, H., Inoue, K., Iwamoto, Y. & Okada, S., 10 1 2014, : : Science Translational Medicine. 6, 256, 256ra137.

研究成果: ジャーナルへの寄稿記事

Spinal Cord Injuries
Hyperglycemia
Obese Mice
Nervous System Trauma
Blood Glucose
2013
53 引用 (Scopus)

Ly6C+Ly6G- Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury

Saiwai, H., Kumamaru, H., Ohkawa, Y., Kubota, K., Kobayakawa, K., Yamada, H., Yokomizo, T., Iwamoto, Y. & Okada, S., 4 1 2013, : : Journal of Neurochemistry. 125, 1, p. 74-88 15 p.

研究成果: ジャーナルへの寄稿記事

Spinal Cord Injuries
Repair
Tissue
Inflammation
Neurology
34 引用 (Scopus)

Therapeutic activities of engrafted neural stem/precursor cells are not dormant in the chronically injured spinal cord

Kumamaru, H., Saiwai, H., Kubota, K., Kobayakawa, K., Yokota, K., Ohkawa, Y., Shiba, K., Iwamoto, Y. & Okada, S., 8 1 2013, : : STEM CELLS. 31, 8, p. 1535-1547 13 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Spinal Cord
Spinal Cord Injuries
Transplantation
Oligodendroglia
2012
26 引用 (Scopus)

Age-related differences in cellular and molecular profiles of inflammatory responses after spinal cord injury

Kumamaru, H., Saiwai, H., Ohkawa, Y., Yamada, H., Iwamoto, Y. & Okada, S., 4 1 2012, : : Journal of Cellular Physiology. 227, 4, p. 1335-1346 12 p.

研究成果: ジャーナルへの寄稿記事

Spinal Cord Injuries
Cytokines
Spinal Cord
Chemokines
Infiltration
65 引用 (Scopus)

Chd2 interacts with H3.3 to determine myogenic cell fate

Harada, A., Okada, S., Konno, D., Odawara, J., Yoshimi, T., Yoshimura, S., Kumamaru, H., Saiwai, H., Tsubota, T., Kurumizaka, H., Akashi, K., Tachibana, T., Imbalzano, A. N. & Ohkawa, Y., 7 4 2012, : : EMBO Journal. 31, 13, p. 2994-3007 14 p.

研究成果: ジャーナルへの寄稿記事

DNA Helicases
Genes
Cell Differentiation
Chromatin Assembly and Disassembly
Essential Genes
41 引用 (Scopus)

Direct isolation and RNA-seq reveal environment-dependent properties of engrafted neural stem/progenitor cells

Kumamaru, H., Ohkawa, Y., Saiwai, H., Yamada, H., Kubota, K., Kobayakawa, K., Akashi, K., Okano, H., Iwamoto, Y. & Okada, S., 11 26 2012, : : Nature communications. 3, 1140.

研究成果: ジャーナルへの寄稿記事

spinal cord injuries
transplantation
sequencing
Neural Stem Cells
stem cells
2 引用 (Scopus)

Extradural nodular fasciitis arising in the spinal canal

Kubota, K., Okada, S., Maeda, T., Matsumoto, Y., Sakamoto, A., Harimaya, K., Saiwai, H., Kumamaru, H., Oda, Y. & Iwamoto, Y., 1 15 2012, : : Spine. 37, 2

研究成果: ジャーナルへの寄稿記事

Fasciitis
Spinal Canal
Primitive Neuroectodermal Tumors
Ewing's Sarcoma
Neoplasms
25 引用 (Scopus)

Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures

Kumamaru, H., Saiwai, H., Kobayakawa, K., Kubota, K., van Rooijen, N., Inoue, K., Iwamoto, Y. & Okada, S., 5 31 2012, : : Journal of neuroinflammation. 9, 116.

研究成果: ジャーナルへの寄稿記事

Clodronic Acid
Microglia
Astrocytes
Interleukin-6
Janus Kinases
29 引用 (Scopus)

Myeloperoxidase exacerbates secondary injury by generating highly reactive oxygen species and mediating neutrophil recruitment in experimental spinal cord injury

Kubota, K., Saiwai, H., Kumamaru, H., Maeda, T., Ohkawa, Y., Aratani, Y., Nagano, T., Iwamoto, Y. & Okada, S., 7 15 2012, : : Spine. 37, 16, p. 1363-1369 7 p.

研究成果: ジャーナルへの寄稿記事

Neutrophil Infiltration
Spinal Cord Injuries
Peroxidase
Reactive Oxygen Species
Wounds and Injuries
12 引用 (Scopus)

Neurological recovery is impaired by concurrent but not by asymptomatic pre-existing spinal cord compression after traumatic spinal cord injury

Kubota, K., Saiwai, H., Kumamaru, H., Kobayakawa, K., Maeda, T., Matsumoto, Y., Harimaya, K., Iwamoto, Y. & Okada, S., 8 1 2012, : : Spine. 37, 17, p. 1448-1455 8 p.

研究成果: ジャーナルへの寄稿記事

Spinal Stenosis
Spinal Cord Compression
Spinal Canal
Spinal Cord Injuries
Spinal Cord
2011
22 引用 (Scopus)

Flow cytometric sorting of neuronal and glial nuclei from central nervous system tissue

Okada, S., Saiwai, H., Kumamaru, H., Kubota, K., Harada, A., Yamaguchi, M., Iwamoto, Y. & Ohkawa, Y., 2 1 2011, : : Journal of cellular physiology. 226, 2, p. 552-558 7 p.

研究成果: ジャーナルへの寄稿記事

Nerve Tissue
Neurology
Sorting
Neuroglia
Nucleoproteins
2010
5 引用 (Scopus)

Production of a rat monoclonal antibody specific for Myf5

Harada, A., Okada, S., Odawara, J., Kumamaru, H., Saiwai, H., Aoki, M., Nakamura, M., Nishiyama, Y. & Ohkawa, Y., 2 1 2010, : : Hybridoma. 29, 1, p. 59-62 4 p.

研究成果: ジャーナルへの寄稿記事

Myogenic Regulatory Factors
Myoblasts
Monoclonal Antibodies
Helix-Loop-Helix Motifs
Myogenin
93 引用 (Scopus)

The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury

Saiwai, H., Ohkawa, Y., Yamada, H., Kumamaru, H., Harada, A., Okano, H., Yokomizo, T., Iwamoto, Y. & Okada, S., 1 1 2010, : : American Journal of Pathology. 176, 5, p. 2352-2366 15 p.

研究成果: ジャーナルへの寄稿記事

Leukotriene B4
Neutrophil Infiltration
Spinal Cord Injuries
Leukotriene B4 Receptors
Leukocytes
2009
22 引用 (Scopus)

Does ossification of the posterior longitudinal ligament affect the neurological outcome after traumatic cervical cord injury?

Okada, S., Maeda, T., Ohkawa, Y., Harimaya, K., Saiwai, H., Kumamaru, H., Matsumoto, Y., Doi, T., Ueta, T., Shiba, K. & Iwamoto, Y., 5 15 2009, : : Spine. 34, 11, p. 1148-1152 5 p.

研究成果: ジャーナルへの寄稿記事

Ossification of Posterior Longitudinal Ligament
Nervous System
Wounds and Injuries
Spinal Cord Injuries
Spinal Injuries