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研究成果

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Article
2019

Logical design of oral glucose ingestion pattern minimizing blood glucose in humans

Fujii, M., Murakami, Y., Karasawa, Y., Sumitomo, Y., Fujita, S., Koyama, M., Uda, S., Kubota, H., Inoue, H., Konishi, K., Oba, S., Ishii, S. & Kuroda, S., 12 1 2019, : : npj Systems Biology and Applications. 5, 1, 31.

研究成果: Contribution to journalArticle

公開

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. I. & Kuroda, S., 1 2019, : : Genes to Cells. 24, 1, p. 82-93 12 p.

研究成果: Contribution to journalArticle

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Ohigashi, I., Tanaka, Y., Kondo, K., Fujimori, S., Kondo, H., Palin, A. C., Hoffmann, V., Kozai, M., Matsushita, Y., Uda, S., Motosugi, R., Hamazaki, J., Kubota, H., Murata, S., Tanaka, K., Katagiri, T., Kosako, H. & Takahama, Y., 11 26 2019, : : Cell Reports. 29, 9, p. 2901-2916.e6

研究成果: Contribution to journalArticle

公開
5 引用 (Scopus)
2018

Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects

Ohashi, K., Fujii, M., Uda, S., Kubota, H., Komada, H., Sakaguchi, K., Ogawa, W. & Kuroda, S., 12 1 2018, : : npj Systems Biology and Applications. 4, 1, 14.

研究成果: Contribution to journalArticle

7 引用 (Scopus)

Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects

Ohashi, K., Fujii, M., Uda, S., Kubota, H., Komada, H., Sakaguchi, K., Ogawa, W. & Kuroda, S., 2018, : : npj Systems Biology and Applications. 4, 14.

研究成果: Contribution to journalArticle

公開

In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

Kubota, H., Uda, S., Matsuzaki, F., Yamauchi, Y. & Kuroda, S., 7 25 2018, : : Cell Systems. 7, 1, p. 118-128.e3

研究成果: Contribution to journalArticle

5 引用 (Scopus)

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K. I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 9 28 2018, : : iScience. 7, p. 212-229 18 p.

研究成果: Contribution to journalArticle

公開
8 引用 (Scopus)
2017

System identification of signaling dependent gene expression with different time-scale data

Tsuchiya, T., Fujii, M., Matsuda, N., Kunida, K., Uda, S., Kubota, H., Konishi, K. & Kuroda, S., 12 2017, : : PLoS Computational Biology. 13, 12, e1005913.

研究成果: Contribution to journalArticle

3 引用 (Scopus)
2016

Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system

Fukuda, S., Nishida-Fukuda, H., Nanba, D., Nakashiro, K. I., Nakayama, H., Kubota, H. & Higashiyama, S., 2 2 2016, : : Scientific reports. 6, 20209.

研究成果: Contribution to journalArticle

4 引用 (Scopus)

Selective control of up-regulated and down-regulated genes by temporal patterns and doses of insulin

Sano, T., Kawata, K., Ohno, S., Yugi, K., Kakuda, H., Kubota, H., Uda, S., Fujii, M., Kunida, K., Hoshino, D., Hatano, A., Ito, Y., Sato, M., Suzuki, Y. & Kuroda, S., 11 22 2016, : : Science Signaling. 9, 455, ra112.

研究成果: Contribution to journalArticle

7 引用 (Scopus)
2015

An optogenetic system for interrogating the temporal dynamics of Akt

Katsura, Y., Kubota, H., Kunida, K., Kanno, A., Kuroda, S. & Ozawa, T., 10 1 2015, : : Scientific reports. 5, 14589.

研究成果: Contribution to journalArticle

30 引用 (Scopus)

Glucose homeostatic law: Insulin clearance predicts the progression of glucose intolerance in humans

Ohashi, K., Komada, H., Uda, S., Kubota, H., Iwaki, T., Fukuzawa, H., Komori, Y., Fujii, M., Toyoshima, Y., Sakaguchi, K., Ogawa, W. & Kuroda, S., 12 1 2015, : : PloS one. 10, 12, A38.

研究成果: Contribution to journalArticle

12 引用 (Scopus)
2014

Reconstruction of insulin signal flow from phosphoproteome and metabolome data

Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K. I., Kashikura, K., Endo, K., Ikeda, K., Soga, T. & Kuroda, S., 8 21 2014, : : Cell Reports. 8, 4, p. 1171-1183 13 p.

研究成果: Contribution to journalArticle

42 引用 (Scopus)
2013

Robustness and compensation of information transmission of signaling pathways

Uda, S., Saito, T. H., Kudo, T., Kokaji, T., Tsuchiya, T., Kubota, H., Komori, Y., Ozaki, Y. I. & Kuroda, S., 1 1 2013, : : Science. 341, 6145, p. 558-561 4 p.

研究成果: Contribution to journalArticle

68 引用 (Scopus)

The Extraction of Simple Relationships in Growth Factor-Specific Multiple-Input and Multiple-Output Systems in Cell-Fate Decisions by Backward Elimination PLS Regression

Akimoto, Y., Yugi, K., Uda, S., Kudo, T., Komori, Y., Kubota, H. & Kuroda, S., 9 9 2013, : : PloS one. 8, 9, e72780.

研究成果: Contribution to journalArticle

3 引用 (Scopus)

The selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns

Noguchi, R., Kubota, H., Yugi, K., Toyoshima, Y., Komori, Y., Soga, T. & Kuroda, S., 2013, : : Molecular Systems Biology. 9, 1, 664.

研究成果: Contribution to journalArticle

29 引用 (Scopus)
2012

Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway

Kubota, H., Noguchi, R., Toyoshima, Y., Ozaki, Y. I., Uda, S., Watanabe, K., Ogawa, W. & Kuroda, S., 6 29 2012, : : Molecular Cell. 46, 6, p. 820-832 13 p.

研究成果: Contribution to journalArticle

67 引用 (Scopus)
2010

A quantitative image cytometry technique for time series or population analyses of signaling networks

Ozaki, Y. I., Uda, S., Saito, T. H., Chung, J., Kubota, H. & Kuroda, S., 2010, : : PloS one. 5, 4, e9955.

研究成果: Contribution to journalArticle

26 引用 (Scopus)

Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics

Fujita, K. A., Toyoshima, Y., Uda, S., Ozaki, Y. I., Kubota, H. & Kuroda, S., 7 27 2010, : : Science Signaling. 3, 132, p. ra56

研究成果: Contribution to journalArticle

45 引用 (Scopus)

Timing-dependent actions of NGF required for cell differentiation

Chung, J., Kubota, H., Ozaki, Y. I., Uda, S. & Kuroda, S., 2 2 2010, : : PloS one. 5, 2, e9011.

研究成果: Contribution to journalArticle

35 引用 (Scopus)
2005

The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation

Matsuo, R., Kubota, H., Obata, T., Kito, K., Ota, K., Kitazono, T., Ibayashi, S., Sasaki, T., Iida, M. & Ito, T., 4 25 2005, : : FEBS Letters. 579, 11, p. 2433-2438 6 p.

研究成果: Contribution to journalArticle

17 引用 (Scopus)
2004

Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast

Ichimura, T., Kubota, H., Goma, T., Mizushima, N., Ohsumi, Y., Iwago, M., Kakiuchi, K., Shekhar, H. U., Shinkawa, T., Taoka, M., Ito, T. & Isobe, T., 5 25 2004, : : Biochemistry. 43, 20, p. 6149-6158 10 p.

研究成果: Contribution to journalArticle

34 引用 (Scopus)
2003

Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2α kinase GCN2

Kubota, H., Obata, T., Ota, K., Sasaki, T. & Ito, T., 6 6 2003, : : Journal of Biological Chemistry. 278, 23, p. 20457-20460 4 p.

研究成果: Contribution to journalArticle

80 引用 (Scopus)
2001

Budding Yeast GCN1 Binds the GI Domain to Activate the eIF2α Kinase GCN2

Kubota, H., Ota, K., Sakaki, Y. & Ito, T., 5 18 2001, : : Journal of Biological Chemistry. 276, 20, p. 17591-17596 6 p.

研究成果: Contribution to journalArticle

38 引用 (Scopus)
2000
41 引用 (Scopus)