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研究成果 1988 2019

フィルター
記事
2019
2 引用 (Scopus)

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers

Mori, D., Kashihara, Y., Yoshikado, T., Kimura, M., Hirota, T., Matsuki, S., Maeda, K., Irie, S., Ieiri, I., Sugiyama, Y. & Kusuhara, H., 2 1 2019, : : Drug metabolism and pharmacokinetics. 34, 1, p. 78-86 9 p.

研究成果: ジャーナルへの寄稿記事

Sulfates
Healthy Volunteers
Genotype
fluvastatin
Pharmaceutical Preparations

Effects of magnesium oxide on pharmacokinetics of L-dopa/carbidopa and assessment of pharmacodynamic changes by a model-based simulation

Kashihara, Y., Terao, Y., Yoda, K., Hirota, T., Kubota, T., Kimura, M., Matsuki, S., Hirakawa, M., Irie, S. & Ieiri, I., 3 6 2019, : : European Journal of Clinical Pharmacology. 75, 3, p. 351-361 11 p.

研究成果: ジャーナルへの寄稿記事

Magnesium Oxide
Carbidopa
Levodopa
Pharmacokinetics
Meta-Analysis
1 引用 (Scopus)

Efficacy of DPP-4 inhibitors, GLP-1 analogues, and SGLT2 inhibitors as add-ons to metformin monotherapy in T2DM patients: a model-based meta-analysis

Inoue, H., Tamaki, Y., Kashihara, Y., Muraki, S., Kakara, M., Hirota, T. & Ieiri, I., 2 1 2019, : : British journal of clinical pharmacology. 85, 2, p. 393-402 10 p.

研究成果: ジャーナルへの寄稿記事

Glucagon-Like Peptide 1
Metformin
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Meta-Analysis
1 引用 (Scopus)

Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy

Fujita, S., Hirota, T., Sakiyama, R., Baba, M. & Ieiri, I., 2 1 2019, : : Journal of Neurochemistry. 148, 3, p. 373-385 13 p.

研究成果: ジャーナルへの寄稿記事

oxaliplatin
Peripheral Nervous System Diseases
Spinal Ganglia
Platinum
Pharmaceutical Preparations

Pharmacokinetics, Pharmacodynamics, and Safety of E6011, a Novel Humanized Antifractalkine (CX3CL1) Monoclonal Antibody: A Randomized, Double-Blind, Placebo-Controlled Single-Ascending-Dose Study

Tabuchi, H., Katsurabara, T., Mori, M., Aoyama, M., Obara, T., Yasuda, N., Kawano, T., Imai, T., Ieiri, I. & Kumagai, Y., 5 1 2019, : : Journal of Clinical Pharmacology. 59, 5, p. 688-701 14 p.

研究成果: ジャーナルへの寄稿記事

Pharmacokinetics
Monoclonal Antibodies
Placebos
Safety
Serum

The association of tobacco use with prescription of muscle relaxants, benzodiazepines, and opioid analgesics for non-cancer pain

Takaki, H., Ieiri, I., Shibuta, H., Onozuka, D. & Hagihara, A., 1 9 2019, : : American Journal on Addictions.

研究成果: ジャーナルへの寄稿記事

Tobacco Use
Benzodiazepines
Opioid Analgesics
Prescriptions
Pain
2018
1 引用 (Scopus)

Characterization of changes in HbA1c in patients with and without secondary failure after metformin treatments by a population pharmacodynamic analysis using mixture models

Tamaki, Y., Maema, K., Kakara, M., Fukae, M., Kinoshita, R., Kashihara, Y., Muraki, S., Hirota, T. & Ieiri, I., 12 1 2018, : : Drug metabolism and pharmacokinetics. 33, 6, p. 264-269 6 p.

研究成果: ジャーナルへの寄稿記事

Metformin
Population
Therapeutics
Electronic Health Records
Glycosylated Hemoglobin A
3 引用 (Scopus)
CpG Islands
Human Activities
Methylation
Skin
Messenger RNA
1 引用 (Scopus)

Nucleosome positioning and gene regulation of the SGLT2 gene in the renal proximal tubular epithelial cells

Takesue, H., Hirota, T., Tachimura, M., Tokashiki, A. & Ieiri, I., 9 1 2018, : : Molecular Pharmacology. 94, 3, p. 953-962 10 p.

研究成果: ジャーナルへの寄稿記事

Sodium-Glucose Transport Proteins
Nucleosomes
Epithelial Cells
Kidney
Genes

Population Pharmacodynamic Analysis of Uric Acid–Lowering Effects of Febuxostat Based on Electronic Medical Records in Two Hospitals

Muraki, S., Moriki, K., Shigematsu, S., Fukae, M., Kakara, M., Yamashita, D., Hirota, T., Takane, H., Shimada, M., Hirakawa, M. & Ieiri, I., 3 1 2018, : : Journal of Clinical Pharmacology. 58, 3, p. 304-313 10 p.

研究成果: ジャーナルへの寄稿記事

Electronic Health Records
Uric Acid
Population
Blood Urea Nitrogen
Urban Hospitals

Population Pharmacokinetics and Pharmacodynamics of Oral Propranolol in Pediatric Patients With Infantile Hemangioma

Takechi, T., Kumokawa, T., Kato, R., Higuchi, T., Kaneko, T. & Ieiri, I., 10 1 2018, : : Journal of Clinical Pharmacology. 58, 10, p. 1361-1370 10 p.

研究成果: ジャーナルへの寄稿記事

Hemangioma
Propranolol
Pharmacokinetics
Pediatrics
Population

Psychological assessment of acute schizophrenia patients who experienced seclusion either alone or in combination with restraint

Eguchi, R., Onozuka, D., Ikeda, K., Kuroda, K., Ieiri, I. & Hagihara, A., 5 1 2018, : : International Journal of Psychiatry in Medicine. 53, 3, p. 171-188 18 p.

研究成果: ジャーナルへの寄稿記事

Schizophrenia
Psychiatry
Psychology
Brief Psychiatric Rating Scale
Hostility
2 引用 (Scopus)
CpG Islands
DNA Methylation
Liver
Proteins
Messenger RNA
1 引用 (Scopus)
Intravenous Administration
Nanoparticles
Pharmacokinetics
Placebos
Research Personnel
1 引用 (Scopus)

The relationship between fine particulate matter (PM) and schizophrenia severity

Eguchi, R., Onozuka, D., Ikeda, K., Kuroda, K., Ieiri, I. & Hagihara, A., 4 23 2018, : : International Archives of Occupational and Environmental Health.

研究成果: ジャーナルへの寄稿記事

Particulate Matter
Schizophrenia
Brief Psychiatric Rating Scale
Patient Admission
Air Pollution
2017
6 引用 (Scopus)

Characterization of ADME gene variation in 21 populations by exome sequencing

Hovelson, D. H., Xue, Z., Zawistowski, M., Ehm, M. G., Harris, E. C., Stocker, S. L., Gross, A. S., Jang, I. J., Ieiri, I., Lee, J. E., Cardon, L. R., Chissoe, S. L., Abecasis, G. & Nelson, M. R., 1 1 2017, : : Pharmacogenetics and Genomics. 27, 3, p. 89-100 12 p.

研究成果: ジャーナルへの寄稿記事

Exome
Population
Genes
Gene Frequency
8 引用 (Scopus)

Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide

Miyake, T., Mizuno, T., Mochizuki, T., Kimura, M., Matsuki, S., Irie, S., Ieiri, I., Maeda, K. & Kusuhara, H., 9 1 2017, : : Journal of Pharmaceutical Sciences. 106, 9, p. 2542-2550 9 p.

研究成果: ジャーナルへの寄稿記事

Cations
Kidney
trimethyloxamine
Tetraethylammonium
Tissue Distribution
13 引用 (Scopus)

Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP

Kashihara, Y., Ieiri, I., Yoshikado, T., Maeda, K., Fukae, M., Kimura, M., Hirota, T., Matsuki, S., Irie, S., Izumi, N., Kusuhara, H. & Sugiyama, Y., 9 1 2017, : : Journal of Pharmaceutical Sciences. 106, 9, p. 2688-2694 7 p.

研究成果: ジャーナルへの寄稿記事

Citrus paradisi
Pharmacogenetics
Pharmacokinetics
Sulfasalazine
Pharmaceutical Preparations
2016
7 引用 (Scopus)

Circulating intestine-derived exosomal miR-328 in plasma, a possible biomarker for estimating BCRP function in the human intestines

Gotanda, K., Hirota, T., Saito, J., Fukae, M., Egashira, Y., Izumi, N., Deguchi, M., Kimura, M., Matsuki, S., Irie, S. & Ieiri, I., 8 30 2016, : : Scientific reports. 6, 32299.

研究成果: ジャーナルへの寄稿記事

Intestines
Biomarkers
Breast Neoplasms
Proteins
Area Under Curve
18 引用 (Scopus)

Clarification of the mechanism of clopidogrel-mediated drug-drug interaction in a clinical cassette small-dose study and its prediction based on in vitro information

Kim, S. J., Yoshikado, T., Ieiri, I., Maeda, K., Kimura, M., Irie, S., Kusuhara, H. & Sugiyama, Y., 10 1 2016, : : Drug Metabolism and Disposition. 44, 10, p. 1622-1632 11 p.

研究成果: ジャーナルへの寄稿記事

clopidogrel
repaglinide
pioglitazone
Drug Interactions
Pharmaceutical Preparations
Human Body
Pharmacokinetics
Pharmaceutical Preparations
Renal Elimination
1 引用 (Scopus)

Population pharmacodynamic analysis of hemoglobin A1c-lowering effects by adding treatment of DPP-4 inhibitors (sitagliptin) in type 2 diabetes mellitus patients based on electronic medical records

Kakara, M., Nomura, H., Ezaki, M., Fukae, M., Hirota, T., Matsubayashi, S., Hirakawa, M. & Ieiri, I., 9 1 2016, : : Journal of Diabetes and Its Complications. 30, 7, p. 1282-1286 5 p.

研究成果: ジャーナルへの寄稿記事

Electronic Health Records
pioglitazone
Type 2 Diabetes Mellitus
Hemoglobins
Population
7 引用 (Scopus)

Population pharmacokinetic–pharmacodynamic modeling and model-based prediction of docetaxel-induced neutropenia in Japanese patients with non-small cell lung cancer

Fukae, M., Shiraishi, Y., Hirota, T., Sasaki, Y., Yamahashi, M., Takayama, K., Nakanishi, Y. & Ieiri, I., 11 1 2016, : : Cancer chemotherapy and pharmacology. 78, 5, p. 1013-1023 11 p.

研究成果: ジャーナルへの寄稿記事

docetaxel
Neutropenia
Non-Small Cell Lung Carcinoma
Cells
Population
2015
4 引用 (Scopus)

Effects of multiple-dose rifampicin 450 mg on the pharmacokinetics of fexofenadine enantiomers in Japanese volunteers

Akamine, Y., Miura, M., Yasui-Furukori, N., Ieiri, I. & Uno, T., 1 1 2015, : : Journal of Clinical Pharmacy and Therapeutics. 40, 1, p. 98-103 6 p.

研究成果: ジャーナルへの寄稿記事

fexofenadine
Rifampin
Volunteers
Pharmacokinetics
P-Glycoprotein

Pharmacogenomics of anti-cancer drugs for individual treatment

Ieiri, I., 2 1 2015, : : Nippon rinsho. Japanese journal of clinical medicine. 73, p. 120-125 6 p.

研究成果: ジャーナルへの寄稿記事

Precision Medicine
Drug Monitoring
Pharmacogenetics
Human Genome
Antineoplastic Agents
11 引用 (Scopus)

The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion

Akamine, Y., Miura, M., Komori, H., Tamai, I., Ieiri, I., Yasui-Furukori, N. & Uno, T., 10 10 2015, : : Drug metabolism and pharmacokinetics. 30, 5, p. 352-357 6 p.

研究成果: ジャーナルへの寄稿記事

fexofenadine
Citrus paradisi
Pharmacokinetics
Eating
2014
29 引用 (Scopus)

Addition of bevacizumab enhances antitumor activity of erlotinib against non-small cell lung cancer xenografts depending on VEGF expression

Li, H., Takayama, K., Wang, S., Shiraishi, Y., Gotanda, K., Harada, T., Furuyama, K., Iwama, E., Ieiri, I., Okamoto, I. & Nakanishi, Y., 10 9 2014, : : Cancer chemotherapy and pharmacology. 74, 6, p. 1297-1305 9 p.

研究成果: ジャーナルへの寄稿記事

Heterografts
Non-Small Cell Lung Carcinoma
Vascular Endothelial Growth Factor A
Cells
Tumors
11 引用 (Scopus)

Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers

Akamine, Y., Miura, M., Komori, H., Saito, S., Kusuhara, H., Tamai, I., Ieiri, I., Uno, T. & Yasui-Furukori, N., 1 1 2014, : : European Journal of Clinical Pharmacology. 70, 9, p. 1087-1095 9 p.

研究成果: ジャーナルへの寄稿記事

fexofenadine
Malus
Pharmacokinetics
Eating
Anions
8 引用 (Scopus)

Identification and functional characterization of novel nonsynonymous variants in the human multidrug and toxin extrusion 2-K

Nishimura, K., Ide, R., Hirota, T., Kawazu, K., Kodama, S., Takesue, H. & Ieiri, I., 1 1 2014, : : Drug Metabolism and Disposition. 42, 9, p. 1432-1437 6 p.

研究成果: ジャーナルへの寄稿記事

Single Nucleotide Polymorphism
Cations
Cell Membrane
Antiporters
Tetraethylammonium
2 引用 (Scopus)

Influences of artificial heart-lung machine operation on the binding sites of albumin: Possibility of an effective administration plan

Totoribe, K., Takamura, N., Ogata, K., Tokunaga, J., Kawai, K., Nakamura, K., Ieiri, I. & Higuchi, S., 1 1 2014, : : International Journal of Artificial Organs. 37, 2, p. 99-108 10 p.

研究成果: ジャーナルへの寄稿記事

Heart-Lung Machine
Artificial heart
Artificial Heart
Binding sites
Serum Albumin
10 引用 (Scopus)

Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters: A DMET Plus microarray assessment

Yi, S., An, H., Lee, H., Lee, S., Ieiri, I., Lee, Y., Cho, J. Y., Hirota, T., Fukae, M., Yoshida, K., Nagatsuka, S., Kimura, M., Irie, S., Sugiyama, Y., Shin, D. W., Lim, K. S., Chung, J. Y., Yu, K. S. & Jang, I. J., 10 10 2014, : : Pharmacogenetics and Genomics. 24, 10, p. 477-485 9 p.

研究成果: ジャーナルへの寄稿記事

Ethnic Groups
Enzymes
Principal Component Analysis
Pharmaceutical Preparations
Population
2 引用 (Scopus)

Mechanism of the 24-hour rhythm of tumor necrosis factor-alpha formed by onset of rheumatoid arthritis

Yoshimatsu, H., Okazaki, F., Ieiri, I. & To, H., 1 1 2014, : : Chronobiology International. 31, 4, p. 564-571 8 p.

研究成果: ジャーナルへの寄稿記事

Lymphotoxin-alpha
Rheumatoid Arthritis
Tumor Necrosis Factor-alpha
Cytokines
Serum Amyloid A Protein
4 引用 (Scopus)

Modeling and simulation of bone mineral density response from a phase 2 study of ONO-5334, a new cathepsin K inhibitor, to support dose selection in osteoporosis

Hasegawa, C., Kastrissios, H., Monteleone, J., Ohno, T., Umemura, T., Ohyama, M., Nagase, S., Small, M., Deacon, S., Ogawa, M. & Ieiri, I., 1 1 2014, : : Journal of Clinical Pharmacology. 54, 8, p. 937-948 12 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin K
Bone Density
Tablets
Osteoporosis
Pharmacokinetics
5 引用 (Scopus)

Neonatal Dubin-Johnson syndrome: Novel compound heterozygous mutation in the ABCC2 gene

Okada, H., Kusaka, T., Fuke, N., Kunikata, J., Kondo, S., Iwase, T., Nan, W., Hirota, T., Ieiri, I. & Itoh, S., 1 1 2014, : : Pediatrics International. 56, 5, p. e62-e64

研究成果: ジャーナルへの寄稿記事

Chronic Idiopathic Jaundice
Bilirubin
Mutation
Missense Mutation
Genes
6 引用 (Scopus)

Population pharmacodynamic analysis of LDL-cholesterol lowering effects by statins and co-medications based on electronic medical records

Kakara, M., Nomura, H., Fukae, M., Gotanda, K., Hirota, T., Matsubayashi, S., Shimomura, H., Hirakawa, M. & Ieiri, I., 10 1 2014, : : British journal of clinical pharmacology. 78, 4, p. 824-835 12 p.

研究成果: ジャーナルへの寄稿記事

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Electronic Health Records
LDL Cholesterol
Population
Anticholesteremic Agents
5 引用 (Scopus)

Population pharmacokinetic and pharmacodynamic modeling of different formulations of ono-5334, cathepsin k inhibitor, in caucasian and japanese postmenopausal females

Hasegawa, C., Ohno, T., Umemura, T., Honda, N., Ohyama, M., Nagase, S., Small, M., Deacon, S., Ogawa, M. & Ieiri, I., 1 1 2014, : : Journal of Clinical Pharmacology. 54, 1, p. 23-34 12 p.

研究成果: ジャーナルへの寄稿記事

Cathepsins
Tablets
Pharmacokinetics
Bone Resorption
Population
1 引用 (Scopus)
Secretory Phospholipase A2
Hydroxymethylglutaryl-CoA Reductase Inhibitors
LDL Lipoproteins
Endothelial Cells
Tumor Necrosis Factor-alpha
2013
31 引用 (Scopus)

Apple juice greatly reduces systemic exposure to atenolol

Jeon, H., Jang, I. J., Lee, S., Ohashi, K., Kotegawa, T., Ieiri, I., Cho, J. Y., Yoon, S. H., Shin, S. G., Yu, K. S. & Lim, K. S., 1 2013, : : British Journal of Clinical Pharmacology. 75, 1, p. 172-179 8 p.

研究成果: ジャーナルへの寄稿記事

Atenolol
Malus
Pharmacokinetics
Water
Healthy Volunteers
17 引用 (Scopus)
5' Flanking Region
DNA methylation
DNA Methylation
placenta
Individuality
2 引用 (Scopus)

Direct and rapid genotyping of SLCO1B1 388A>G and 521T>C in human blood specimens using the SmartAmp-2 method

Yoshida, K., Takano, J., Ishizu, Y., Lezhava, A., Ieiri, I., Maeda, K., Hayashizaki, Y. & Sugiyama, Y., 4 1 2013, : : AAPS Journal. 15, 2, p. 618-622 5 p.

研究成果: ジャーナルへの寄稿記事

Genotype
Solute Carrier Organic Anion Transporter Family Member 1b1
Anions
Pharmacokinetics
Pharmaceutical Preparations
23 引用 (Scopus)

Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam (CYP3A4), fexofenadine (p-Glycoprotein), and pravastatin (OATP1B1) as probe drugs

Ieiri, I., Tsunemitsu, S., Maeda, K., Ando, Y., Izumi, N., Kimura, M., Yamane, N., Okuzono, T., Morishita, M., Kotani, N., Kanda, E., Deguchi, M., Matsuguma, K., Matsuki, S., Hirota, T., Irie, S., Kusuhara, H. & Sugiyama, Y., 6 1 2013, : : Journal of Clinical Pharmacology. 53, 6, p. 654-661 8 p.

研究成果: ジャーナルへの寄稿記事

fexofenadine
Saquinavir
Cytochrome P-450 CYP3A
Pravastatin
Ritonavir
35 引用 (Scopus)
Thymidylate Synthase
MicroRNAs
HeLa Cells
Fluorouracil
Messenger RNA
9 引用 (Scopus)

Role of methotrexate polyglutamation and reduced folate carrier 1 (RFC1) gene polymorphisms in clinical assessment indexes

Ando, Y., Shimada, H., Matsumoto, N., Hirota, T., Oribe, M., Otsuka, E., Ishii, K., Morimoto, T., Ohashi, K. & Ieiri, I., 1 1 2013, : : Drug metabolism and pharmacokinetics. 28, 5, p. 442-445 4 p.

研究成果: ジャーナルへの寄稿記事

Reduced Folate Carrier Protein
Methotrexate
Genes
Erythrocytes
2012
12 引用 (Scopus)

Association of multidrug resistance-associated protein 2 single nucleotide polymorphism rs12762549 with the basal plasma levels of phase II metabolites of isoflavonoids in healthy Japanese individuals

Kato, K., Kusuhara, H., Kumagai, Y., Ieiri, I., Mori, H., Ito, S., Nakai, Y., Maeda, K. & Sugiyama, Y., 5 1 2012, : : Pharmacogenetics and Genomics. 22, 5, p. 344-354 11 p.

研究成果: ジャーナルへの寄稿記事

Single Nucleotide Polymorphism
Genistein
Liquid Chromatography
Mass Spectrometry
Metabolomics
6 引用 (Scopus)

Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure

Endo, S., Fukahori, A., Tokuhiro, S., Shinagawa, A., Walker, J., Yoshihara, K., Ishizuka, H., Ieiri, I. & Sugiyama, Y., 8 1 2012, : : Journal of Human Genetics. 57, 8, p. 531-544 14 p.

研究成果: ジャーナルへの寄稿記事

Genetic Polymorphisms
Hispanic Americans
African Americans
Haplotypes
Pharmacokinetics
26 引用 (Scopus)

Comparison of pharmacokinetics, pharmacodynamics, safety, and tolerability of the amyloid β monoclonal antibody solanezumab in japanese and white patients with mild to moderate Alzheimer disease

Uenaka, K., Nakano, M., Willis, B. A., Friedrich, S., Ferguson-Sells, L., Dean, R. A., Ieiri, I. & Siemers, E. R., 1 1 2012, : : Clinical Neuropharmacology. 35, 1, p. 25-29 5 p.

研究成果: ジャーナルへの寄稿記事

solanezumab
Amyloid
Alzheimer Disease
Pharmacokinetics
Monoclonal Antibodies
39 引用 (Scopus)

Dihydropyrimidine dehydrogenase (DPD) expression is negatively regulated by certain microRNAs in human lung tissues

Hirota, T., Date, Y., Nishibatake, Y., Takane, H., Fukuoka, Y., Taniguchi, Y., Burioka, N., Shimizu, E., Nakamura, H., Otsubo, K. & Ieiri, I., 7 1 2012, : : Lung Cancer. 77, 1, p. 16-23 8 p.

研究成果: ジャーナルへの寄稿記事

Dihydrouracil Dehydrogenase (NADP)
MicroRNAs
Lung
Fluorouracil
Neoplasms
28 引用 (Scopus)

Food-drug interaction of tacrolimus with pomelo, ginger, and turmeric juice in rats

Egashira, K., Sasaki, H., Higuchi, S. & Ieiri, I., 1 1 2012, : : Drug Metabolism and Pharmacokinetics. 27, 2, p. 242-247 6 p.

研究成果: ジャーナルへの寄稿記事

Food-Drug Interactions
Ginger
Curcuma
Tacrolimus
Citrus paradisi
106 引用 (Scopus)
P-Glycoprotein
Genetic Polymorphisms
Breast Neoplasms
ATP-Binding Cassette Transporters
Pharmaceutical Preparations