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研究成果 1988 2019

フィルター
記事
2003

Polymorphisms of Two Anion Transporters (OATP-C and MRP2) Genes - Consequences for Pravastatin Pharmacokinetics

Ieiri, I., Otsubo, K., Kusuhara, H., Suzuki, H., Sugiyama, Y., Higuchi, S., Kimura, M., Irie, S., Urae, A. & Kawabata, K., 12 1 2003, : : Japanese Pharmacology and Therapeutics. 31, SUPPL. 1

研究成果: ジャーナルへの寄稿記事

Organic Anion Transporters
Pravastatin
Genetic Polymorphisms
Anions
Pharmacokinetics
79 引用 (Scopus)

Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy

Hirota, T., Ieiri, I., Takane, H., Sano, H., Kawamoto, K., Aono, H., Yamasaki, A., Takeuchi, H., Masada, M., Shimizu, E., Higuchi, S. & Otsubo, K., 5 1 2003, : : Drug Metabolism and Disposition. 31, 5, p. 677-680 4 p.

研究成果: ジャーナルへの寄稿記事

Genetic Association Studies
Morphine
Glucuronosyltransferase
Single Nucleotide Polymorphism
Neoplasms
Propanil
Carbaryl
High Pressure Liquid Chromatography
Urine
Serum
6 引用 (Scopus)

The antiplatelet aggregation effects of aspirin suppositories

Nakayasu, H., Maeda, M., Soda, T., Iijima, K., Ishimoto, M., Ieiri, I., Tabuchi, F., Otsubo, K. & Nakashima, K., 2003, : : Cerebrovascular Diseases. 16, 1, p. 31-35 5 p.

研究成果: ジャーナルへの寄稿記事

Suppositories
Aspirin
Platelet Aggregation
Stroke
Adenosine Diphosphate
2002

Comparison of the kinetic disposition of and serum gastrin change by lansoprazole versus rabeprazole during an 8-day dosing scheme in relation to CYP2C19 polymorphism

Ieiri, I., Kishimoto, Y., Okochi, H., Momiyama, K., Morita, T., Kitano, M., Morisawa, T., Fukushima, Y., Nakagawa, K., Hasegawa, J., Otsubo, K. & Ishizaki, T., 5 23 2002, : : Cancer Chemotherapy and Pharmacology, Supplement. 49, 7, p. 485-492 8 p.

研究成果: ジャーナルへの寄稿記事

Rabeprazole
Lansoprazole
Gastrins
Serum
Proton Pump Inhibitors

Contribution of angiotensin converting enzyme gene polymorphism to the action of angiotensin II receptor antagonist (CS-866)

Urae, A., Okada, M., Ieiri, I., Higuchi, S., Hisaoka, M., Tajima, M., Ogihara, T. & Nakano, S., 1 1 2002, : : Japanese Journal of Clinical Pharmacology and Therapeutics. 33, 2, p. 37-46 10 p.

研究成果: ジャーナルへの寄稿記事

Angiotensin Receptor Antagonists
Peptidyl-Dipeptidase A
Genotype
Genes
Angiotensin II
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP2C19
147 引用 (Scopus)

Neurotoxicity induced by tacrolimus after liver transplantation: Relation to genetic polymorphisms of the ABCB1 (MDR1) gene

Yamauchi, A., Ieiri, I., Kataoka, Y., Tanabe, M., Nishizaki, T., Oishi, R., Higuchi, S., Otsubo, K. & Sugimachi, K., 8 27 2002, : : Transplantation. 74, 4, p. 571-573 3 p.

研究成果: ジャーナルへの寄稿記事

Tacrolimus
Genetic Polymorphisms
Liver Transplantation
Genes
P-Glycoprotein
9 引用 (Scopus)

Polymorphism of MDR1 Gene in Healthy Japanese Subjects: A Novel SNP with an Amino Acid Substitution (Glu108Lys)

Honda, T., Dan, Y., Koyabu, N., Ohtani, H., Sawada, Y., Ieiri, I., Otsubo, K. & Higuchi, S., 1 1 2002, : : Drug metabolism and pharmacokinetics. 17, 5, p. 479-481 3 p.

研究成果: ジャーナルへの寄稿記事

MDR Genes
Amino Acid Substitution
Single Nucleotide Polymorphism
Healthy Volunteers
Homozygote
243 引用 (Scopus)

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein

Kurata, Y., Ieiri, I., Kimura, M., Morita, T., Irie, S., Urae, A., Ohdo, S., Ohtani, H., Sawada, Y., Higuchi, S. & Otsubo, K., 8 1 2002, : : Clinical Pharmacology and Therapeutics. 72, 2, p. 209-219 11 p.

研究成果: ジャーナルへの寄稿記事

Digoxin
P-Glycoprotein
Biological Availability
Genes
Clarithromycin
2001
56 引用 (Scopus)

Comparison of the kinetic disposition of and serum gastrin change by lansoprazole versus rabeprazole during an 8-day dosing scheme in relation to CYP2C19 polymorphism

Ieiri, I., Kishimoto, Y., Okochi, H., Momiyama, K., Morita, T., Kitano, M., Morisawa, T., Fukushima, Y., Nakagawa, K., Hasegawa, J., Otsubo, K. & Ishizaki, T., 2001, : : European Journal of Clinical Pharmacology. 57, 5-6, p. 485-492 8 p.

研究成果: ジャーナルへの寄稿記事

Rabeprazole
Lansoprazole
Gastrins
Serum
Proton Pump Inhibitors
496 引用 (Scopus)

Expression of P-glycoprotein in human placenta: Relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene

Tanabe, M., Ieiri, I., Nagata, N., Inoue, K., Ito, S., Kanamori, Y., Takahashi, M., Kurata, Y., Kigawa, J., Higuchi, S., Terakawa, N. & Otsubo, K., 6 1 2001, : : Journal of Pharmacology and Experimental Therapeutics. 297, 3, p. 1137-1143 7 p.

研究成果: ジャーナルへの寄稿記事

MDR Genes
P-Glycoprotein
Genetic Polymorphisms
Placenta
Single Nucleotide Polymorphism
84 引用 (Scopus)

Genetic polymorphisms and functional characterization of the 5′-flanking region of the human CYP2C9 gene: In vitro and in vivo studies

Shintani, M., Ieiri, I., Inoue, K., Mamiya, K., Ninomiya, H., Tashiro, N., Higuchi, S. & Otsubo, K., 9 3 2001, : : Clinical Pharmacology and Therapeutics. 70, 2, p. 175-182 8 p.

研究成果: ジャーナルへの寄稿記事

5' Flanking Region
Genetic Polymorphisms
Luciferases
Phenytoin
Mutation
28 引用 (Scopus)

Phenytoin intoxication induced by fluvoxamine

Mamiya, K., Kojima, K., Yukawa, E., Higuchi, S., Ieiri, I., Ninomiya, H. & Tashiro, N., 2 8 2001, : : Therapeutic drug monitoring. 23, 1, p. 75-77 3 p.

研究成果: ジャーナルへの寄稿記事

Fluvoxamine
Phenytoin
Serotonin Uptake Inhibitors
Ataxia
Alleles
28 引用 (Scopus)

P-hydroxylation of phenobarbital: Relationship to (s)-mephenytoin hydroxylation (CYP2C19) polymorphism

Hadama, A., Ieiri, I., Morita, T., Kimura, M., Urae, A., Irie, S., Kaneda, T., Mamiya, K., Tashiro, N., Higuchi, S. & Otsubo, K., 4 5 2001, : : Therapeutic Drug Monitoring. 23, 2, p. 115-118 4 p.

研究成果: ジャーナルへの寄稿記事

Mephenytoin
Hydroxylation
Phenobarbital
Cytochrome P-450 CYP2C19
Serum
223 引用 (Scopus)

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

Ito, S., Ieiri, I., Tanabe, M., Suzuki, A., Higuchi, S. & Otsubo, K., 3 26 2001, : : Pharmacogenetics. 11, 2, p. 175-184 10 p.

研究成果: ジャーナルへの寄稿記事

Anion Transport Proteins
MDR Genes
Multidrug Resistance-Associated Proteins
DNA Primers
ATP-Binding Cassette Transporters
2000
57 引用 (Scopus)

CYP2C19 polymorphism effect on phenobarbitone. Pharmacokineties in Japanese patients with epilepsy: Analysis by population pharmacokinetics

Mamiya, K., Hadama, A., Yukawa, E., Ieiri, I., Otsubo, K., Ninomiya, H., Tashiro, N. & Higuchi, S., 1 1 2000, : : European Journal of Clinical Pharmacology. 55, 11-12, p. 821-825 5 p.

研究成果: ジャーナルへの寄稿記事

Phenobarbital
Epilepsy
Pharmacokinetics
Population
Genotype
106 引用 (Scopus)

Genetic polymorphism of the CYP2C subfamily and excessive serum phenytoin concentration with central nervous system intoxication

Ninomiya, H., Mamiya, K., Matsuo, S. I., Ieiri, I., Higuchi, S. & Tashiro, N., 4 1 2000, : : Therapeutic drug monitoring. 22, 2, p. 230-232 3 p.

研究成果: ジャーナルへの寄稿記事

Phenytoin
Genetic Polymorphisms
Central Nervous System
Serum
Poisons
50 引用 (Scopus)

Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9*3 allele

Shimamoto, J., Ieiri, I., Urae, A., Kimura, M., Irie, S., Kubota, T., Chiba, K., Ishizaki, T., Otsubo, K. & Higuchi, S., 1 1 2000, : : European Journal of Clinical Pharmacology. 56, 1, p. 65-68 4 p.

研究成果: ジャーナルへの寄稿記事

Diclofenac
Healthy Volunteers
Pharmacokinetics
Alleles
Cytochrome P-450 CYP2C9
130 引用 (Scopus)

Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: Genetic analysis of the CYP2C9 locus

Imai, J., Ieiri, I., Mamiya, K., Miyahara, S., Furuumi, H., Nanba, E., Yamane, M., Fukumaki, Y., Ninomiya, H., Tashiro, N., Otsubo, K. & Higuchi, S., 3 22 2000, : : Pharmacogenetics. 10, 1, p. 85-89 5 p.

研究成果: ジャーナルへの寄稿記事

Steroid 16-alpha-Hydroxylase
Steroid Hydroxylases
Aryl Hydrocarbon Hydroxylases
Phenytoin
Amino Acid Substitution
1999
36 引用 (Scopus)

Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping: Possible effect of age, liver disease and length of therapy

Kimura, M., Ieiri, I., Wada, Y., Mamiya, K., Urae, A., Iimori, E., Sakai, T., Otsubo, K. & Higuchi, S., 1 28 1999, : : British journal of clinical pharmacology. 47, 1, p. 115-119 5 p.

研究成果: ジャーナルへの寄稿記事

Omeprazole
Hydroxylation
Liver Diseases
Mephenytoin
Exons
1998
11 引用 (Scopus)

Association of polymorphisms in the cytochrome P450 (CYP) 2C19 and 2C18 genes in Japanese epileptic patients

Mamiya, K., Ieiri, I., Miyahara, S., Imai, J., Furuumi, H., Fukumaki, Y., Ninomiya, H., Tashiro, N., Yamada, H. & Higuchi, S., 3 16 1998, : : Pharmacogenetics. 8, 1, p. 87-90 4 p.

研究成果: ジャーナルへの寄稿記事

173 引用 (Scopus)

Genetic polymorphism of cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese population

Kimura, M., Ieiri, I., Mamiya, K., Urae, A. & Higuchi, S., 6 1 1998, : : Therapeutic Drug Monitoring. 20, 3, p. 243-247 5 p.

研究成果: ジャーナルへの寄稿記事

Genetic Polymorphisms
Cytochromes
Gene Frequency
Population
Cytochrome P-450 CYP2C9

Pharmacogenetics of CYP2C subfamily in a Japanese population

Ieiri, I. & Higuchi, S., 7 1 1998, : : Journal of Toxicological Sciences. 23, SUPPL. 2, p. 129-131 3 p.

研究成果: ジャーナルへの寄稿記事

Steroid 16-alpha-Hydroxylase
Steroid Hydroxylases
Gingival Hyperplasia
Aryl Hydrocarbon Hydroxylases
Hydroxylation
154 引用 (Scopus)

The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: Studies in stereoselective hydroxylation and population pharmacokinetics

Mamiya, K., Ieiri, I., Shimamoto, J., Yukawa, E., Imai, J., Ninomiya, H., Yamada, H., Otsubo, K., Higuchi, S. & Tashiro, N., 12 1 1998, : : Epilepsia. 39, 12, p. 1317-1323 7 p.

研究成果: ジャーナルへの寄稿記事

Phenytoin
Genetic Polymorphisms
Hydroxylation
Epilepsy
Pharmacokinetics
1997
28 引用 (Scopus)

Stereoselective 4'-hydroxylation of phenytoin: Relationship to (S)-mephenytoin polymorphism in Japanese

Ieiri, I., Mamiya, K., Urae, A., Wada, Y., Kimura, M., Irie, S., Amamoto, T., Kubota, T., Yoshioka, S., Nakamura, K., Nakano, S., Tashiro, N. & Higuchi, S., 1 1 1997, : : British journal of clinical pharmacology. 43, 4, p. 441-445 5 p.

研究成果: ジャーナルへの寄稿記事

Mephenytoin
Phenytoin
Hydroxylation
Omeprazole
Genotype
1996
5 引用 (Scopus)

Evaluation of the therapeutic range of whole blood cyclosporin concentration in the treatment of psoriasis

Ieiri, I., Nakayama, J., Murakami, H., Hori, Y. & Higuchi, S., 3 20 1996, : : International Journal of Clinical Pharmacology and Therapeutics. 34, 3, p. 106-111 6 p.

研究成果: ジャーナルへの寄稿記事

Psoriasis
Cyclosporine
Therapeutics
Hypertension
Fluorescence Polarization Immunoassay
19 引用 (Scopus)

Instability of standard calibrators may be involved in overestimating vancomycin concentrations determined by fluorescence polarization immunoassay

Morishige, H., Shuto, H., Ieiri, I., Otsubo, K. & Oishi, R., 2 6 1996, : : Therapeutic drug monitoring. 18, 1, p. 80-85 6 p.

研究成果: ジャーナルへの寄稿記事

Fluorescence Polarization Immunoassay
Vancomycin
Cytidine Diphosphate
Serum
High Pressure Liquid Chromatography
126 引用 (Scopus)

Pharmacokinetics of omeprazole (a substrate of CYP2C19) and comparison with two mutant alleles, CYP2C19(m1) in exon 5 and CYP2C19(m2) in exon 4, in Japanese subjects

Ieiri, I., Kubota, T., Urae, A., Kimura, M., Wada, Y., Mamiya, K., Yoshioka, S., Irie, S., Amamoto, T., Nakamura, K., Nakano, S. & Higuchi, S., 6 1 1996, : : Clinical Pharmacology and Therapeutics. 59, 6, p. 647-653 7 p.

研究成果: ジャーナルへの寄稿記事

Omeprazole
Exons
Pharmacokinetics
Alleles
Genotype
4 引用 (Scopus)

Pharmacokinetic study of zonisamide in patients undergoing brain surgery

Ieiri, I., Morioka, T., Kim, S., Nishio, S., Fukui, M. & Higuchi, S., 1 1 1996, : : Journal of Pharmacy and Pharmacology. 48, 12, p. 1270-1275 6 p.

研究成果: ジャーナルへの寄稿記事

zonisamide
Pharmacokinetics
Erythrocytes
Brain
Area Under Curve
1995
19 引用 (Scopus)

Drug interactions of zonisamide with phenytoin and sodium valproate: serum concentrations and protein binding

Tasaki, K., Minami, T., Ieiri, I., Ohtsubo, K., Hirakawa, Y., Ueda, K. & Higuchi, S., 1 1 1995, : : Brain and Development. 17, 3, p. 182-185 4 p.

研究成果: ジャーナルへの寄稿記事

zonisamide
Valproic Acid
Phenytoin
Drug Interactions
Protein Binding
17 引用 (Scopus)

Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study

Ieiri, I., Goto, W., Higuchi, S., Hirata, K., Toshitani, A., Imayama, S., Ohyama, Y., Yamada, H. & Ohtsubo, K., 11 1 1995, : : European Journal of Clinical Pharmacology. 49, 1-2, p. 51-56 6 p.

研究成果: ジャーナルへの寄稿記事

Gingival Hyperplasia
Phenytoin
Fibroblasts
Poisons
In Vitro Techniques
4 引用 (Scopus)

Pharmacokinetic study of valproic acid sustained-release preparation in patients undergoing brain surgery

Ieiri, I., Morioka, T., Ichimiya, T., Nishio, S., Fukui, M., Ohtsubo, K. & Higuchi, S., 1 1 1995, : : Therapeutic drug monitoring. 17, 1, p. 6-11 6 p.

研究成果: ジャーナルへの寄稿記事

Delayed-Action Preparations
Valproic Acid
Ambulatory Surgical Procedures
Pharmacokinetics
Brain

The effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic side effects: In vivo and in vitro studies

Ieiri, I., Goto, W., Hirata, K., Toshitani, A., Imayama, S., Ohyama, Y., Yamada, H., Ohtsubo, K. & Higuchi, S., 1 1 1995, : : Psychiatry and Clinical Neurosciences. 49, 3

研究成果: ジャーナルへの寄稿記事

Stereoisomerism
Phenytoin
Cell Division
Anticonvulsants
Chronic Disease
1994
25 引用 (Scopus)

Influence of Additional Therapy with Zonisamide (Excegran) on Protein Binding and Metabolism of Carbamazepine

Minami, T., Ieiri, I., Ohtsubo, K., Hirakawa, Y., Ueda, K., Higuchi, S. & Aoyama, T., 1 1 1994, : : Epilepsia. 35, 5, p. 1023-1025 3 p.

研究成果: ジャーナルへの寄稿記事

zonisamide
Carbamazepine
Protein Binding
Therapeutics
1992
14 引用 (Scopus)

Pharmacoepidemiological Study on Adverse Reactions of Antiepileptic Drugs

Ieiri, I., Higuchi, S., Toshinobu, A., Hirata, K., Kojima, K. & Ikeda, M., 1 1 1992, : : Chemical and Pharmaceutical Bulletin. 40, 5, p. 1280-1288 9 p.

研究成果: ジャーナルへの寄稿記事

Anticonvulsants
Phenytoin
Benzodiazepines
Carbamazepine
Drug Combinations
1991
1 引用 (Scopus)

Serum levels of carbamazepine and valproic acid in paediatric patients - influence of age and drug combination therapy on L/D ratios

Suzuki, A., Yukawa, E., Ohtsubo, K., Ieiri, I., Teshima, D., Higuchi, S. & Aoyama, T., 1 1 1991, : : Japanese Journal of Hospital Pharmacy. 17, 1, p. 26-33 8 p.

研究成果: ジャーナルへの寄稿記事

Carbamazepine
Valproic Acid
Combination Drug Therapy
Pediatrics
Serum
1 引用 (Scopus)

Studies on Pharmacoepidemiology of Antiepileptic Adverse Reactions (2)

Hirata, K., Ieiri, I., Kajiwara, M., Kuroda, T., Kojima, K., Ikeda, M., Higuchi, S., Yamada, H. & Aoyama, T., 1 1 1991, : : Psychiatry and Clinical Neurosciences. 45, 2, p. 464-467 4 p.

研究成果: ジャーナルへの寄稿記事

The effect of phenytoin withdrawal on valproic acid free fraction: a case report

Ieiri, I., Nakano, K., Higuchi, S., Yukawa, E., Ohtsubo, K., Hirata, K., Aoyama, T. & Yamada, H., 1 1 1991, : : Japanese Journal of Hospital Pharmacy. 17, 1, p. 52-58 7 p.

研究成果: ジャーナルへの寄稿記事

Valproic Acid
Phenytoin
1990
1 引用 (Scopus)

ANALYSIS OF THE FACTORS INFLUENCING ANTI‐EPILEPTIC DRUG CONCENTRATIONS‐CARBAMAZEPINE

Ichikou, N., Ieiri, I., Higuchi, S., Hirata, K., Yamada, H. & Aoyama, T., 1 1 1990, : : Journal of Clinical Pharmacy and Therapeutics. 15, 5, p. 337-349 13 p.

研究成果: ジャーナルへの寄稿記事

Carbamazepine
Anticonvulsants
Statistical Factor Analysis
Serum
Phenytoin
2 引用 (Scopus)

ANALYSIS OF THE FACTORS INFLUENCING ANTI‐EPILEPTIC DRUG CONCENTRATIONS‐VALPROIC ACID

Ieiri, I., Higuchi, S., Hirata, K., Yamada, H. & Aoyama, T., 1 1 1990, : : Journal of Clinical Pharmacy and Therapeutics. 15, 5, p. 351-363 13 p.

研究成果: ジャーナルへの寄稿記事

Valproic Acid
Anticonvulsants
Statistical Factor Analysis
Acids
Carbamazepine
2 引用 (Scopus)

Studies on pharmacoepidemiology of antiepileptic adverse reactions

Komatsubara, A., Ieiri, I., Higuchi, S., Hirata, K., Yamada, H. & Ao yama, T., 1 1 1990, : : Japanese Journal of Psychiatry and Neurology. 44, 2, p. 389-391 3 p.

研究成果: ジャーナルへの寄稿記事

Drug Dose Response Relationship
Pharmacoepidemiology
Neurologic Examination
Nervous System Diseases
Anticonvulsants

Therapeutic drug monitoring services at kyushu university hospital in Japan

Ieiri, I., Higuchi, S., Nakao, Y., Yukawa, E., Ohtsubo, K., Yoshikawa, M. & Aoyama, T., 1 1 1990, : : Annals of Pharmacotherapy. 24, 6, p. 629-632 4 p.

研究成果: ジャーナルへの寄稿記事

Drug Monitoring
Japan
Referral and Consultation
Pharmacokinetics
Digoxin
1988
1 引用 (Scopus)
Bayes Theorem
Linear Models
Least-Squares Analysis
Pharmaceutical Preparations
Serum
1 引用 (Scopus)

The effect of age and concurrent administration of antiepileptic drugs on phenobarbital serum concentration/dosage ratio in children

Yukawa, E., Higuchi, S., Ieiri, I., Teshima, D., Nakao, Y. & Aoyama, T., 1 1 1988, : : Japanese Journal of Hospital Pharmacy. 14, 3, p. 172-177 6 p.

研究成果: ジャーナルへの寄稿記事

Phenobarbital
Anticonvulsants
Serum