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研究成果 1983 2019

  • 3007 引用
  • 33 h指数
  • 132 記事
  • 3 評論記事
  • 1 コメント/討論
  • 1 レター
2019

2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation

Morishige, S., Takahashi-Yanaga, F., Ishikane, S., Arioka, M., Igawa, K., Kuroo, A., Tomooka, K., Shiose, A. & Sasaguri, T., 10 2019, : : Biochemical Pharmacology. 168, p. 82-90 9 p.

研究成果: ジャーナルへの寄稿記事

Glycogen Synthase Kinase 3
Phosphorylation
Cardiomegaly
Fibroblasts
Isoproterenol
2 引用 (Scopus)

Catalytic methane oxidation by a supramolecular conjugate based on a μ-nitrido-bridged iron porphyrinoid dimer

Yamada, Y., Morita, K., Mihara, N., Igawa, K., Tomooka, K. & Tanaka, K., 1 1 2019, : : New Journal of Chemistry. 43, 29, p. 11477-11482 6 p.

研究成果: ジャーナルへの寄稿記事

Rotaxanes
Porphyrins
Methane
Dimers
Iron
公開
STAT3 Transcription Factor
Cyclin D1
Cell Proliferation
Breast Neoplasms
STAT Transcription Factors

Preparation of enantioenriched chiral organic molecules by dynamic asymmetric induction from a outer chiral source

Igawa, K., Kawasaki, Y., Ano, Y., Kashiwagi, T., Ogawa, K., Hayashi, J. I., Morita, R., Yoshioka, Y., Uehara, K. & Tomooka, K., 1 1 2019, : : Chemistry Letters. 48, 7, p. 726-729 4 p.

研究成果: ジャーナルへの寄稿評論記事

公開
Molecules
Stereochemistry
6 引用 (Scopus)

Site-Selective Supramolecular Complexation Activates Catalytic Ethane Oxidation by a Nitrido-Bridged Iron Porphyrinoid Dimer

Mihara, N., Yamada, Y., Takaya, H., Kitagawa, Y., Igawa, K., Tomooka, K., Fujii, H. & Tanaka, K., 3 1 2019, : : Chemistry - A European Journal. 25, 13, p. 3369-3375 7 p.

研究成果: ジャーナルへの寄稿記事

Ethane
Complexation
Dimers
Iron
Oxidation

Synthesis and stereochemical analysis of dynamic planar chiral nine-membered diallylic amide: Significant substituent effect on stereochemical stability

Hayashi, J. I., Uehara, K., Ano, Y., Kawasaki, Y., Igawa, K. & Tomooka, K., 1 1 2019, : : Heterocycles. 99, 2, p. 856-864 9 p.

研究成果: ジャーナルへの寄稿記事

公開
Stereochemistry
Enantiomers
Chirality
X ray analysis
Amides

Synthesis of NMs-DACN: Small and hydrophilic click reaction device

Kawasaki, Y., Yamanaka, Y., Seto, Y., Igawa, K. & Tomooka, K., 1 1 2019, : : Chemistry Letters. 48, 5, p. 495-497 3 p.

研究成果: ジャーナルへの寄稿記事

Azides
Copper
Solubility
Water
2018
14 引用 (Scopus)

Asymmetric Synthesis of Axially Chiral Benzocarbazole Derivatives Based on Catalytic Enantioselective Hydroarylation of Alkynes

Arae, S., Beppu, S., Kawatsu, T., Igawa, K., Tomooka, K. & Irie, R., 8 17 2018, : : Organic Letters. 20, 16, p. 4796-4800 5 p.

研究成果: ジャーナルへの寄稿記事

Alkynes
indoles
alkynes
Derivatives
Reaction intermediates
2 引用 (Scopus)
Silica Gel
Alkenes
Isomerization
Isomers
Molecules
3 引用 (Scopus)

Internal-Edge-Substituted Coumarin-Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self-Assembly

Usui, K., Yamamoto, K., Ueno, Y., Igawa, K., Hagihara, R., Masuda, T., Ojida, A., Karasawa, S., Tomooka, K., Hirai, G. & Suemune, H., 10 1 2018, : : Chemistry - A European Journal. 24, 55, p. 14617-14621 5 p.

研究成果: ジャーナルへの寄稿記事

Self assembly
X ray crystallography
Quantum yield
Electronic structure
Physical properties
9 引用 (Scopus)

Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation

Meguro, T., Yoshida, S., Igawa, K., Tomooka, K. & Hosoya, T., 7 6 2018, : : Organic Letters. 20, 13, p. 4126-4130 5 p.

研究成果: ジャーナルへの寄稿記事

azides (organic)
Alkynes
Azides
alkynes
sulfur
1 引用 (Scopus)

Vinylidene ortho-quinone methides: Unique chiral reaction intermediates in catalytic asymmetric synthesis

Arae, S., Furusawa, M., Beppu, S., Igawa, K., Tomooka, K. & Irie, R., 1 1 2018, : : Chimia. 72, 12, p. 892-899 8 p.

研究成果: ジャーナルへの寄稿記事

Reaction intermediates
Benzopyrans
Benzofurans
Carbazoles
Indoles
2017
8 引用 (Scopus)

2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through GSK-3 activation

Fujita, A., Takahashi-Yanaga, F., Morimoto, S., Yoshihara, T., Arioka, M., Igawa, K., Tomooka, K., Hoka, S. & Sasaguri, T., 2 1 2017, : : Hypertension Research. 40, 2, p. 130-139 10 p.

研究成果: ジャーナルへの寄稿記事

Glycogen Synthase Kinase 3
Ventricular Remodeling
Pressure
Constriction
Heart Failure
9 引用 (Scopus)
Glycogen Synthase Kinase 3
Cell proliferation
Cell Movement
Tumors
Melanoma
14 引用 (Scopus)

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

Egashira, I., Takahashi-Yanaga, F., Nishida, R., Arioka, M., Igawa, K., Tomooka, K., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Kitazono, T. & Sasaguri, T., 1 1 2017, : : Cancer Science. 108, 1, p. 108-115 8 p.

研究成果: ジャーナルへの寄稿記事

Celecoxib
Intestinal Neoplasms
Catenins
Wnt Signaling Pathway
Growth
1 引用 (Scopus)

Chemistry of planar chiral medium-sized heterocycles

Tomooka, K., 1 1 2017, : : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 75, 5, p. 449-457 9 p.

研究成果: ジャーナルへの寄稿評論記事

Chirality
Cyclization
Alkenes
Ketones
Carbon
15 引用 (Scopus)

Construction of Condensed Polycyclic Aromatic Frameworks through Intramolecular Cycloaddition Reactions Involving Arynes Bearing an Internal Alkyne Moiety

Yoshida, S., Shimizu, K., Uchida, K., Hazama, Y., Igawa, K., Tomooka, K. & Hosoya, T., 11 2 2017, : : Chemistry - A European Journal. 23, 61, p. 15332-15335 4 p.

研究成果: ジャーナルへの寄稿記事

Bearings (structural)
Alkynes
Cycloaddition
Derivatives
Aromatic compounds
15 引用 (Scopus)

Oxygen Reduction to Water by a Cofacial Dimer of Iron(III)–Porphyrin and Iron(III)–Phthalocyanine Linked through a Highly Flexible Fourfold Rotaxane

Mihara, N., Yamada, Y., Takaya, H., Kitagawa, Y., Aoyama, S., Igawa, K., Tomooka, K. & Tanaka, K., 1 1 2017, : : Chemistry - A European Journal. 23, 31, p. 7508-7514 7 p.

研究成果: ジャーナルへの寄稿記事

Rotaxanes
Porphyrins
Dimers
Iron
Oxygen
10 引用 (Scopus)

Stereoselective Intramolecular Dearomatizative [4+2] Cycloaddition of Linked Ethynylnaphthol–Benzofuran Systems

Beppu, S., Arae, S., Furusawa, M., Arita, K., Fujimoto, H., Sumimoto, M., Imahori, T., Igawa, K., Tomooka, K. & Irie, R., 12 15 2017, : : European Journal of Organic Chemistry. 2017, 46, p. 6914-6918 5 p.

研究成果: ジャーナルへの寄稿記事

Cycloaddition
furans
cycloaddition
quinones
vinylidene
6 引用 (Scopus)

Synthesis and stereochemical properties of chiral hetero[7]helicenes structured by a benzodiheterole ring core

Arae, S., Mori, T., Kawatsu, T., Ueda, D., Shigeta, Y., Hamamoto, N., Fujimoto, H., Sumimoto, M., Imahori, T., Igawa, K., Tomooka, K., Punniyamurthy, T. & Irie, R., 1 1 2017, : : Chemistry Letters. 46, 8, p. 1214-1216 3 p.

研究成果: ジャーナルへの寄稿記事

Pyrroles
Chemical stability
Discrete Fourier transforms
Kinetics
Temperature
5 引用 (Scopus)

Synthesis of Stereoselectively Functionalized Silacyclopentanes

Igawa, K., Kuroo, A., Yoshihiro, D., Yamanaka, Y. & Tomooka, K., 11 13 2017, : : Synlett. 28, 18, p. 2445-2448 4 p.

研究成果: ジャーナルへの寄稿記事

Silicon
Carboxylic Acids
Amines
Substitution reactions
Carbon
6 引用 (Scopus)

Thieme Chemistry Journals Awardees: Where Are They Now? One-Pot Synthesis of Versatile Buckle Units for Click Chemistry: 4,8-Diazacyclononynes (DACNs)

Igawa, K., Aoyama, S., Kawasaki, Y., Kashiwagi, T., Seto, Y., Ni, R., Mitsuda, N. & Tomooka, K., 1 1 2017, : : Synlett. 28, 16, p. 2110-2114 5 p.

研究成果: ジャーナルへの寄稿記事

Copper
2-butyne-1,4-diol
2016
16 引用 (Scopus)

Enantioselective Synthesis of Silacyclopentanes

Igawa, K., Yoshihiro, D., Abe, Y. & Tomooka, K., 5 4 2016, : : Angewandte Chemie - International Edition. 55, 19, p. 5814-5818 5 p.

研究成果: ジャーナルへの寄稿記事

Serotonin Receptors
Discrete Fourier transforms
Oxides
Assays
Proteins
20 引用 (Scopus)

Rational Design and Synthesis of [5]Helicene-Derived Phosphine Ligands and Their Application in Pd-Catalyzed Asymmetric Reactions

Yamamoto, K., Shimizu, T., Igawa, K., Tomooka, K., Hirai, G., Suemune, H. & Usui, K., 11 8 2016, : : Scientific reports. 6, 36211.

研究成果: ジャーナルへの寄稿記事

phosphine
Ligands
Indoles
Acetates
Alcohols
5 引用 (Scopus)

Synthesis and Stereochemical Analysis of Planar-Chiral (E)-4-[7]Orthocyclophene

Igawa, K., Machida, K., Noguchi, K., Uehara, K. & Tomooka, K., 12 2 2016, : : Journal of Organic Chemistry. 81, 23, p. 11587-11593 7 p.

研究成果: ジャーナルへの寄稿記事

Chirality
Isomerization
Lewis Acids
Oxidation
Sulfones
19 引用 (Scopus)

Thiazolobenzyne: A versatile intermediate for multisubstituted benzothiazoles

Yoshida, S., Yano, T., Nishiyama, Y., Misawa, Y., Kondo, M., Matsushita, T., Igawa, K., Tomooka, K. & Hosoya, T., 1 1 2016, : : Chemical Communications. 52, 75, p. 11199-11202 4 p.

研究成果: ジャーナルへの寄稿記事

Benzothiazoles
Thiazoles
Iodine
Magnesium
benzyne
2015
9 引用 (Scopus)

Catalytic Enantioselective Synthesis of Planar-Chiral Cyclic Amides Based on a Pd-Catalyzed Asymmetric Allylic Substitution Reaction

Igawa, K., Ichikawa, N., Ano, Y., Katanoda, K., Ito, M., Akiyama, T. & Tomooka, K., 6 17 2015, : : Journal of the American Chemical Society. 137, 23, p. 7294-7297 4 p.

研究成果: ジャーナルへの寄稿記事

Cyclization
Amides
Substitution reactions
Ligands
10 引用 (Scopus)

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

Kubokura, N., Takahashi-Yanaga, F., Arioka, M., Yoshihara, T., Igawa, K., Tomooka, K., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Matsumoto, T., Kitazono, T. & Sasaguri, T., 1 1 2015, : : Journal of Pharmacological Sciences. 127, 4, p. 446-455 10 p.

研究成果: ジャーナルへの寄稿記事

Growth
Neoplasms
Intestinal Neoplasms
Catenins
Dictyostelium
65 引用 (Scopus)

Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation

Yoshida, S., Yano, T., Misawa, Y., Sugimura, Y., Igawa, K., Shimizu, S., Tomooka, K. & Hosoya, T., 11 11 2015, : : Journal of the American Chemical Society. 137, 44, p. 14071-14074 4 p.

研究成果: ジャーナルへの寄稿記事

sulfilimine
46 引用 (Scopus)

Heteroatom-embedded medium-sized cycloalkynes: Concise synthesis, structural analysis, and reactions

Ni, R., Mitsuda, N., Kashiwagi, T., Igawa, K. & Tomooka, K., 1 19 2015, : : Angewandte Chemie - International Edition. 54, 4, p. 1190-1194 5 p.

研究成果: ジャーナルへの寄稿記事

Cycloparaffins
Alkynes
Cycloaddition
Structural analysis
Peptides

Synthesis, stereochemical characteristics, and coordination behavior of 2,2'-binaphthyl-1,1'-biisoquinoline as a new axially chiral bidentate ligand

Kawatsu, T., Tokushima, H., Takedomi, Y., Imahori, T., Igawa, K., Tomooka, K. & Irie, R., 7 6 2015, : : Arkivoc. 2015, 4, p. 161-175 15 p.

研究成果: ジャーナルへの寄稿記事

Ligands
Stereoisomerism
Chloroform
Temperature
X ray diffraction analysis
1 引用 (Scopus)

Synthesis and structural analysis of nine-membered enyne nitrogen heterocycles

Igawa, K., Kawabata, T., Uehara, K. & Tomooka, K., 1 1 2015, : : Heterocycles. 90, 2, p. 901-906 6 p.

研究成果: ジャーナルへの寄稿記事

Alkynes
Chirality
X ray analysis
Alkenes
Structural analysis
2014
45 引用 (Scopus)

An efficient generation method and remarkable reactivities of 3-triflyloxybenzyne

Yoshida, S., Uchida, K., Igawa, K., Tomooka, K. & Hosoya, T., 12 11 2014, : : Chemical Communications. 50, 95, p. 15059-15062 4 p.

研究成果: ジャーナルへの寄稿記事

Nucleophiles
Iodine
Magnesium
iodobenzene
3 引用 (Scopus)

Asymmetric ozone oxidation of silylalkenes using a C2- symmetrical dialkoxysilyl group as a chiral auxiliary

Igawa, K., Kawasaki, Y., Nishino, K., Mitsuda, N. & Tomooka, K., 7 21 2014, : : Chemistry - A European Journal. 20, 30, p. 9255-9258 4 p.

研究成果: ジャーナルへの寄稿記事

Ozone
Oxidation
Alkynes
Carbonyl compounds
Alkenes
18 引用 (Scopus)

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Igawa, K., Tomooka, K., Watanabe, Y., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y. & Sasaguri, T., 6 1 2014, : : Biochemical Pharmacology. 89, 3, p. 340-348 9 p.

研究成果: ジャーナルへの寄稿記事

T Cell Transcription Factor 1
Glycogen Synthase Kinase 3
Phosphorylation
Cyclin D1
Tumors
2 引用 (Scopus)
Cyclization
Benzofurans
Benzopyrans
Heterocyclic Compounds
Benzene
9 引用 (Scopus)

Planar chiral dialkoxysilane: Introduction of inherent chirality and high reactivity in conventional achiral alkene

Tomooka, K., Miyasaka, S., Motomura, S. & Igawa, K., 6 16 2014, : : Chemistry - A European Journal. 20, 25, p. 7598-7602 5 p.

研究成果: ジャーナルへの寄稿記事

Epoxidation
Azides
Cycloaddition
Chirality
Alkenes
2013
22 引用 (Scopus)

Base-catalyzed Schmittel cycloisomerization of o-phenylenediyne-linked bis(arenol)s to indeno[1,2-c]chromenes

Furusawa, M., Arita, K., Imahori, T., Igawa, K., Tomooka, K. & Irie, R., 12 25 2013, : : Tetrahedron Letters. 54, 52, p. 7107-7110 4 p.

研究成果: ジャーナルへの寄稿記事

Benzopyrans
Cycloaddition
Cycloaddition Reaction
Transition metals
Metals
10 引用 (Scopus)

Oxidation of silanes to silanols on Pd nanoparticles: H2 desorption accelerated by surface oxygen atom

Kamachi, T., Shimizu, K. I., Yoshihiro, D., Igawa, K., Tomooka, K. & Yoshizawa, K., 11 7 2013, : : Journal of Physical Chemistry C. 117, 44, p. 22967-22973 7 p.

研究成果: ジャーナルへの寄稿記事

Silanes
silanes
oxygen atoms
Desorption
desorption
14 引用 (Scopus)

Palladium-catalyzed tandem cyclodehydrogenation of o-phenylenediyne-linked bis(arenol)s to produce benzodifuran-containing condensed heteroaromatic ring systems

Furusawa, M., Imahori, T., Igawa, K., Tomooka, K. & Irie, R., 10 16 2013, : : Chemistry Letters. 42, 10, p. 1134-1136 3 p.

研究成果: ジャーナルへの寄稿記事

Palladium
Water
Hysteresis loops
Freezing
Dielectric properties
4 引用 (Scopus)

Synthesis, structural analysis, and reaction of 3-Aza-5-[7]orthocyclophyne

Igawa, K., Kawabata, T., Ni, R. & Tomooka, K., 11 11 2013, : : Chemistry Letters. 42, 11, p. 1374-1376 3 p.

研究成果: ジャーナルへの寄稿記事

Chirality
Structural analysis
Halogenation
Temperature
2012
39 引用 (Scopus)

Catalytic enantioselective synthesis of alkenylhydrosilanes

Igawa, K., Yoshihiro, D., Ichikawa, N., Kokan, N. & Tomooka, K., 12 14 2012, : : Angewandte Chemie - International Edition. 51, 51, p. 12745-12748 4 p.

研究成果: ジャーナルへの寄稿記事

Silanes
Alkenylation
Alkynes
Hydrides
Catalysts
21 引用 (Scopus)

Nucleophilic substitution reaction at the nitrogen of arylsulfonamides with phosphide anion

Yoshida, S., Igawa, K. & Tomooka, K., 11 28 2012, : : Journal of the American Chemical Society. 134, 47, p. 19358-19361 4 p.

研究成果: ジャーナルへの寄稿記事

Amines
Anions
Substitution reactions
Nitrogen
Negative ions
14 引用 (Scopus)

Planar-chiral [7]orthocyclophanes

Tomooka, K., Iso, C., Uehara, K., Suzuki, M., Nishikawa-Shimono, R. & Igawa, K., 10 8 2012, : : Angewandte Chemie - International Edition. 51, 41, p. 10355-10358 4 p.

研究成果: ジャーナルへの寄稿記事

Chirality
Nitrogen
Molecules
Temperature
2011
12 引用 (Scopus)

Addition-type oxidation of silylalkene using ozone: An efficient approach for acyloin and its derivatives

Igawa, K., Kawasaki, Y. & Tomooka, K., 2 28 2011, : : Chemistry Letters. 40, 3, p. 233-235 3 p.

研究成果: ジャーナルへの寄稿記事

Ozone
Derivatives
Oxidation
Alkynes
Ketones
14 引用 (Scopus)
Celecoxib
Dilated Cardiomyopathy
Signal Transduction
Cyclooxygenase 2
2,5-dimethylcelecoxib
60 引用 (Scopus)

Directing group-controlled hydrosilylation: Regioselective functionalization of alkyne

Kawasaki, Y., Ishikawa, Y., Igawa, K. & Tomooka, K., 12 28 2011, : : Journal of the American Chemical Society. 133, 51, p. 20712-20715 4 p.

研究成果: ジャーナルへの寄稿記事

Hydrosilylation
Alkynes
Regioselectivity
Alkenes
Olefins
17 引用 (Scopus)

Dynamic chirality of (E)-5-cyclononen-1-one and its enolate

Tomooka, K., Ezawa, T., Inoue, H., Uehara, K. & Igawa, K., 2 16 2011, : : Journal of the American Chemical Society. 133, 6, p. 1754-1756 3 p.

研究成果: ジャーナルへの寄稿記事

Chirality
Hydrolysis
Nucleophiles
Enzymatic hydrolysis

Erratum: Stereoselective multimodal transformations of planar chiral 9-membered diallylic amides (Organic Letters)

Tomooka, K., Suzuki, M., Shimada, M., Ni, R. & Uehara, K., 11 4 2011, : : Organic Letters. 13, 21, 1 p.

研究成果: ジャーナルへの寄稿コメント/討論

13 引用 (Scopus)

Stereoselective multimodal transformations of planar chiral 9-membered diallylic amides

Tomooka, K., Suzuki, M., Shimada, M., Ni, R. & Uehara, K., 9 16 2011, : : Organic Letters. 13, 18, p. 4926-4929 4 p.

研究成果: ジャーナルへの寄稿記事

Amides
amides
Lewis Acids
Chirality
chirality