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研究成果 1989 2019

フィルター
記事
2010
69 引用 (Scopus)

Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1 +/ mice

Wang, H., Bauzon, F., Ji, P., Xu, X., Sun, D., Locker, J., Sellers, R. S., Nakayama, K., Nakayama, K., Cobrinik, D. & Zhu, L., 1 1 2010, : : Nature genetics. 42, 1, p. 83-88 6 p.

研究成果: ジャーナルへの寄稿記事

Melanotrophs
Carcinogenesis
Survival
SKP Cullin F-Box Protein Ligases
Intermediate Pituitary Gland
275 引用 (Scopus)

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

Lin, H. K., Chen, Z., Wang, G., Nardella, C., Lee, S. W., Chan, C. H., Yang, W. L., Wang, J., Egia, A., Nakayama, K., Cordon-Cardo, C., Teruya-Feldstein, J. & Pandolfi, P. P., 3 18 2010, : : Nature. 464, 7287, p. 374-379 6 p.

研究成果: ジャーナルへの寄稿記事

Cell Aging
Carcinogenesis
Neoplasms
Tumor Suppressor Genes
Ubiquitin-Protein Ligases
42 引用 (Scopus)

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

Okumura, F., Matsunaga, Y., Katayama, Y., Nakayama, K. I. & Hatakeyama, S., 7 1 2010, : : Journal of Cell Science. 123, 13, p. 2238-2245 8 p.

研究成果: ジャーナルへの寄稿記事

Proteins
RING Finger Domains
Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
2009
13 引用 (Scopus)

CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P

Mitra, P., Ghule, P. N., Van Der Deen, M., Medina, R., Xie, R. L., Holmes, W. F., Ye, X., Nakayama, K., Harper, J. W., Stein, J. L., Stein, G. S. & Van Wijnen, A. J., 5 1 2009, : : Journal of cellular physiology. 219, 2, p. 438-448 11 p.

研究成果: ジャーナルへの寄稿記事

Histones
Cell Cycle
Genes
Chemical activation
Cells
89 引用 (Scopus)

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis

Nishiyama, M., Oshikawa, K., Tsukada, Y. I., Nakagawa, T., Iemura, S. I., Natsume, T., Fan, Y., Kikuchi, A., Skoultchi, A. I. & Nakayama, K. I., 1 19 2009, : : Nature Cell Biology. 11, 2, p. 172-182 11 p.

研究成果: ジャーナルへの寄稿記事

Histones
Embryonic Development
Apoptosis
Transcriptional Activation
DNA Helicases
13 引用 (Scopus)

Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models

Jamal, M., Ameno, K., Miki, T., Wang, W., Kumihashi, M., Isse, T., Kawamoto, T., Kitagawa, K., Nakayama, K., Ijiri, I. & Kinoshita, H., 10 12 2009, : : Brain Research. 1295, p. 37-43 7 p.

研究成果: ジャーナルへの寄稿記事

Frontal Lobe
Cholinergic Agents
Alcohols
Choline O-Acetyltransferase
Acetaldehyde
39 引用 (Scopus)

Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model

Susaki, E., Nakayama, K., Yamasaki, L. & Nakayama, K. I., 3 31 2009, : : Proceedings of the National Academy of Sciences of the United States of America. 106, 13, p. 5192-5197 6 p.

研究成果: ジャーナルへの寄稿記事

Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases
E2F1 Transcription Factor
Genes
Apoptosis
14 引用 (Scopus)

Ethanol metabolism in ALDH2 knockout mice - Blood acetate levels

Kiyoshi, A., Weihuan, W., Mostofa, J., Mitsuru, K., Toyoshi, I., Toshihiro, K., Kyoko, K., Keiichi, N., Iwao, I. & Hiroshi, K., 4 1 2009, : : Legal Medicine. 11, SUPPL. 1, p. S413-S415

研究成果: ジャーナルへの寄稿記事

Aldehyde Dehydrogenase
Knockout Mice
Acetaldehyde
Acetates
Ethanol
62 引用 (Scopus)

Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development

Saiga, T., Fukuda, T., Matsumoto, M., Tada, H., Okano, H. J., Okano, H. & Nakayama, K. I., 7 1 2009, : : Molecular and cellular biology. 29, 13, p. 3529-3543 15 p.

研究成果: ジャーナルへの寄稿記事

Ligases
Ubiquitin
F-Box Proteins
Neuromuscular Junction
Consensus Sequence
6 引用 (Scopus)

Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration

Kimura, T., Sakai, M., Tabu, K., Wang, L., Tsunematsu, R., Tsuda, M., Sawa, H., Nagashima, K., Nishihara, H., Hatakeyama, S., Nakayama, K., Ladanyi, M., Tanaka, S. & Nakayama, K. I., 6 1 2009, : : Laboratory Investigation. 89, 6, p. 645-656 12 p.

研究成果: ジャーナルへの寄稿記事

Synovial Sarcoma
Proto-Oncogenes
Embryonic Development
Cell Movement
Genetic Translocation
18 引用 (Scopus)

Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages

Tsukuba, T., Yanagawa, M., Okamoto, K., Okamoto, Y., Yasuda, Y., Nakayama, K. I., Kadowaki, T. & Yamamoto, K., 5 1 2009, : : Journal of biochemistry. 145, 5, p. 565-573 9 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin E
Macrophages
Cell adhesion
Cell Surface Receptors
Chemotaxis
24 引用 (Scopus)

Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels

Matsuda, M., Tsutsumi, K., Kanematsu, T., Fukami, K., Terada, Y., Takenawa, T., Nakayama, K. & Hirata, M., 12 1 2009, : : Biology of Reproduction. 81, 4, p. 681-689 9 p.

研究成果: ジャーナルへの寄稿記事

Type C Phospholipases
Gonadotropins
Knockout Mice
Luteinizing Hormone
Proteins
42 引用 (Scopus)

Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways

Matsumoto, M., Oyamada, K., Takahashi, H., Sato, T., Hatakeyama, S. & Nakayama, K., 7 1 2009, : : Proteomics. 9, 13, p. 3549-3563 15 p.

研究成果: ジャーナルへの寄稿記事

Phosphorylation
T-Cell Antigen Receptor
Proteomics
Tyrosine
B-Lymphocytes
17 引用 (Scopus)

Mechanoregulation of proliferation

Jiang, X., Austin, P. F., Niederhoff, R. A., Manson, S. R., Riehm, J. J., Cook, B. L., Pengue, G., Chitaley, K., Nakayama, K., Nakayama, K. I. & Weintraub, S. J., 9 1 2009, : : Molecular and cellular biology. 29, 18, p. 5104-5114 11 p.

研究成果: ジャーナルへの寄稿記事

Intercellular Signaling Peptides and Proteins
Smooth Muscle
Calcium
Critical Pathways
Protein Stability
45 引用 (Scopus)

Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36

Endo, A., Matsumoto, M., Inada, T., Yamamoto, A., Nakayama, K. I., Kitamura, N. & Komada, M., 3 1 2009, : : Journal of Cell Science. 122, 5, p. 678-686 9 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitination
Ribosomes
Enzymes
Basic Amino Acids
Nuclear Proteins
101 引用 (Scopus)

P53-altered FBXW7 expression determines poor prognosis in gastric cancer cases

Yokobori, T., Mimori, K., Iwatsuki, M., Ishii, H., Onoyama, I., Fukagawa, T., Kuwano, H., Nakayama, K. I. & Mori, M., 5 1 2009, : : Cancer Research. 69, 9, p. 3788-3794 7 p.

研究成果: ジャーナルへの寄稿記事

Stomach Neoplasms
Mutation
Tumor Suppressor Genes
Cell Cycle
Lymph Nodes
173 引用 (Scopus)

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

Lin, H. K., Wang, G., Chen, Z., Teruya-Feldstein, J., Liu, Y., Chan, C. H., Yang, W. L., Erdjument-Bromage, H., Nakayama, K., Nimer, S., Tempst, P. & Pandolfi, P. P., 3 9 2009, : : Nature Cell Biology. 11, 4, p. 420-432 13 p.

研究成果: ジャーナルへの寄稿記事

S-Phase Kinase-Associated Proteins
Proto-Oncogene Proteins c-akt
Ubiquitin-Protein Ligases
Ubiquitination
Phosphorylation
20 引用 (Scopus)

PKCδ mediates Nrf2-dependent protection of neuronal cells from NO-induced apoptosis

Zhang, J., Hung, A. C., Ng, P. Y., Nakayama, K., Hu, Y., Li, B., Porter, A. G. & Dhakshinamoorthy, S., 9 4 2009, : : Biochemical and Biophysical Research Communications. 386, 4, p. 750-756 7 p.

研究成果: ジャーナルへの寄稿記事

Protein Kinase C-delta
Cytoprotection
Nitric Oxide
Apoptosis
Heme Oxygenase-1
42 引用 (Scopus)

Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein

Saita, S., Shirane, M., Natume, T., Iemura, S. I. & Nakayama, K. I., 5 15 2009, : : Journal of Biological Chemistry. 284, 20, p. 13766-13777 12 p.

研究成果: ジャーナルへの寄稿記事

R-SNARE Proteins
Neurites
PC12 Cells
RNA Interference
Rats
52 引用 (Scopus)

Protein kinase C-δ and phosphatidylinositol 3-Kinase/Akt activate mammalian target of rapamycin to modulate NF-κB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells

Minhajuddin, M., Bijli, K. M., Fazal, F., Sassano, A., Nakayama, K. I., Hay, N., Platanias, L. C. & Rahman, A., 2 13 2009, : : Journal of Biological Chemistry. 284, 7, p. 4052-4061 10 p.

研究成果: ジャーナルへの寄稿記事

Phosphatidylinositol 3-Kinase
Endothelial cells
Sirolimus
Intercellular Adhesion Molecule-1
Protein Kinase C
30 引用 (Scopus)

S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo

Wu, Y. J., Sala-Newby, G. B., Shu, K. T., Yeh, H. I., Nakayama, K., Nakayama, K., Newby, A. C. & Bond, M., 11 1 2009, : : Journal of Vascular Surgery. 50, 5, p. 1135-1142 8 p.

研究成果: ジャーナルへの寄稿記事

S-Phase Kinase-Associated Proteins
Neointima
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Proliferation
5 引用 (Scopus)

The reduction of cell death and proliferation by p27 Kip1 minimizes DNA damage in an experimental model of genotoxicity

Ranchal, I., González, R., Bello, R. I., Ferrín, G., Hidalgo, A. B., Linares, C. I., Aguilar-Melero, P., González-Rubio, S., Barrera, P., Marchal, T., Nakayama, K. I., De La Mata, M. & Muntané, J., 11 15 2009, : : International Journal of Cancer. 125, 10, p. 2270-2280 11 p.

研究成果: ジャーナルへの寄稿記事

Aflatoxin B1
DNA Damage
Cell Death
Theoretical Models
Cell Proliferation
33 引用 (Scopus)

Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis

Oyamada, A., Ikebe, H., Itsumi, M., Saiwai, H., Okada, S., Shimoda, K., Iwakura, Y., Nakayama, K. I., Iwamoto, Y., Yoshikai, Y. & Yamada, H., 12 1 2009, : : Journal of Immunology. 183, 11, p. 7539-7546 8 p.

研究成果: ジャーナルへの寄稿記事

TYK2 Kinase
Autoimmune Experimental Encephalomyelitis
T-Lymphocytes
Myelin-Oligodendrocyte Glycoprotein
Knockout Mice
53 引用 (Scopus)

USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1

Lu, Y., Adegoke, O. A. J., Nepveu, A., Nakayama, K. I., Bedard, N., Cheng, D., Peng, J. & Wing, S. S., 1 1 2009, : : Molecular and cellular biology. 29, 2, p. 547-558 12 p.

研究成果: ジャーナルへの寄稿記事

Cyclin-Dependent Kinases
Ligases
Ubiquitin
S Phase
Cell Proliferation
2008
46 引用 (Scopus)

Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease

Agarwal, A., Bumm, T. G. P., Corbin, A. S., O'Hare, T., Loriaux, M., Van Dyke, J., Willis, S. G., Deininger, J., Nakayama, K. I., Druker, B. J. & Deininger, M. W., 9 1 2008, : : Blood. 112, 5, p. 1960-1970 11 p.

研究成果: ジャーナルへの寄稿記事

S-Phase Kinase-Associated Proteins
Bone Marrow
Cells
F-Box Proteins
Transformed Cell Line
57 引用 (Scopus)

A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors

Miranda-Carboni, G. A., Krum, S. A., Yee, K., Nava, M., Deng, Q. E., Pervin, S., Collado-Hidalgo, A., Galić, Z., Zack, J. A., Nakayama, K., Nakayama, K. I. & Lane, T. F., 11 15 2008, : : Genes and Development. 22, 22, p. 3121-3134 14 p.

研究成果: ジャーナルへの寄稿記事

Cullin Proteins
Breast Neoplasms
Wnt Proteins
Null Lymphocytes
Ubiquitin-Protein Ligases
9 引用 (Scopus)

Association of cathepsin E deficiency with the increased territorial aggressive response of mice

Shigematsu, N., Fukuda, T., Yamamoto, T., Nishioku, T., Yamaguchi, T., Himeno, M., Nakayama, K. I., Tsukuba, T., Kadowaki, T., Okamoto, K., Higuchi, S. & Yamamoto, K., 5 1 2008, : : Journal of Neurochemistry. 105, 4, p. 1394-1404 11 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin E
Substance P
Neurokinin-1 Receptors
Brain
Aspartic Acid Proteases
154 引用 (Scopus)

Blue light-induced autophosphorylation of phototropin is a primary step for signaling

Inoue, S. I., Kinoshita, T., Matsumoto, M., Nakayama, K. I., Doi, M. & Shimazaki, K. I., 4 8 2008, : : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5626-5631 6 p.

研究成果: ジャーナルへの寄稿記事

Phototropins
Phototropism
Chloroplasts
Light
Phosphotransferases
26 引用 (Scopus)

Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase

Tamamori-Adachi, M., Takagi, H., Hashimoto, K., Goto, K., Hidaka, T., Koshimizu, U., Yamada, K., Goto, I., Maejima, Y., Isobe, M., Nakayama, K. I., Inomata, N. & Kitajima, S., 11 1 2008, : : Cardiovascular research. 80, 2, p. 181-190 10 p.

研究成果: ジャーナルへの寄稿記事

S-Phase Kinase-Associated Proteins
Cyclin D1
Ligases
Ubiquitin
Cardiac Myocytes
33 引用 (Scopus)

Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis

Mukai, A., Mizuno, E., Kobayashi, K., Matsumoto, M., Nakayama, K. I., Kitamura, N. & Komada, M., 4 15 2008, : : Journal of Cell Science. 121, 8, p. 1325-1333 9 p.

研究成果: ジャーナルへの寄稿記事

Cytokinesis
Ubiquitination
Proteins
Aurora Kinase B
SNARE Proteins
18 引用 (Scopus)

Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice

Matsumoto, A., Kawamoto, T., Mutoh, F., Isse, T., Oyama, T., Kitagawa, K., Nakayama, K. I. & Ichiba, M., 10 1 2008, : : Pharmacogenetics and Genomics. 18, 10, p. 847-852 6 p.

研究成果: ジャーナルへの寄稿記事

Aldehyde Dehydrogenase
Knockout Mice
Ethanol
Alanine Transaminase
Liver
117 引用 (Scopus)

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., Miyamoto, K., Yoshiwara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Hayashi, Y., Matsuzaki, Y., Nakayama, K., Ikeda, Y. および4人, Hata, A., Chiba, S., Nakayama, K. I. & Suda, T., 4 15 2008, : : Genes and Development. 22, 8, p. 986-991 6 p.

研究成果: ジャーナルへの寄稿記事

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Hematopoietic Stem Cells
SKP Cullin F-Box Protein Ligases
Cell Cycle
Leukemia
41 引用 (Scopus)

Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for Nemo-like kinase (NLK)-induced degradation

Kanei-Ishii, C., Nomura, T., Takagi, T., Watanabe, N., Nakayama, K. I. & Ishii, S., 11 7 2008, : : Journal of Biological Chemistry. 283, 45, p. 30540-30548 9 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitin-Protein Ligases
Phosphotransferases
Degradation
Phosphorylation
myb Genes
39 引用 (Scopus)

Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants

Sakae, N., Yamasaki, N., Kitaichi, K., Fukuda, T., Yamada, M., Yoshikawa, H., Hiranita, T., Tatsumi, Y., Kira, J. I., Yamamoto, T., Miyakawa, T. & Nakayama, K. I., 10 13 2008, : : Human Molecular Genetics. 17, 20, p. 3191-3203 13 p.

研究成果: ジャーナルへの寄稿記事

Fasciculation
Schizophrenia
Methamphetamine
Proteins
Aminobutyrates
40 引用 (Scopus)

Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7

Ishikawa, Y., Onoyama, I., Nakayama, K. & Nakayama, K., 10 16 2008, : : Oncogene. 27, 47, p. 6164-6174 11 p.

研究成果: ジャーナルへの寄稿記事

Cell Cycle Checkpoints
Fibroblasts
Apoptosis
Phenotype
F-Box Proteins
31 引用 (Scopus)

Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse

Shirane, M., Ogawa, M., Motoyama, J. & Nakayama, K. I., 6 1 2008, : : Genes to Cells. 13, 6, p. 635-651 17 p.

研究成果: ジャーナルへの寄稿記事

Neural Tube
Neurites
Apoptosis
Embryonic Structures
Sacrococcygeal Region
23 引用 (Scopus)

SCFβTrCP1 activates and ubiquitylates TAp63γ

Gallegos, J. R., Litersky, J., Lee, H., Sun, Y., Nakayama, K., Nakayama, K. & Lu, H., 1 4 2008, : : Journal of Biological Chemistry. 283, 1, p. 66-75 10 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitin-Protein Ligases
Ubiquitination
Protein Isoforms
Up-Regulation
Stabilization
43 引用 (Scopus)

Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition

Song, M. S., Song, S. J., Kim, S. J., Nakayama, K., Nakayama, K. I. & Lim, D. S., 5 15 2008, : : Oncogene. 27, 22, p. 3176-3185 10 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitin
Cell Cycle
Phosphorylation
Cell Proliferation
Cyclin-Dependent Kinase 4
155 引用 (Scopus)

Targeting the p27 E3 ligase SCF Skp2 results in p27and Skp2-mediated cell-cycle arrest and activation of autophagy

Chen, Q., Xie, W., Kuhn, D. J., Voorhees, P. M., Lopez-Girona, A., Mendy, D., Corral, L. G., Krenitsky, V. P., Xu, W., Parseval, L. M. D., Webb, D. R., Mercurio, F., Nakayama, K. I., Nakayama, K. & Orlowski, R. Z., 5 1 2008, : : Blood. 111, 9, p. 4690-4699 10 p.

研究成果: ジャーナルへの寄稿記事

Proteasome Inhibitors
Ubiquitin-Protein Ligases
Autophagy
Ligases
Cell Cycle Checkpoints
34 引用 (Scopus)

The role of β-TrCP1 and β-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2

Ohsaki, K., Oishi, K., Kozono, Y., Nakayama, K., Nakayama, K. & Ishida, N., 11 1 2008, : : Journal of biochemistry. 144, 5, p. 609-618 10 p.

研究成果: ジャーナルへの寄稿記事

Circadian Rhythm
Proteolysis
Clocks
Circadian Clocks
Suprachiasmatic Nucleus
47 引用 (Scopus)

Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by γδ T cells

Nakamura, R., Shibata, K., Yamada, H., Shimoda, K., Nakayama, K. & Yoshikai, Y., 8 1 2008, : : Journal of Immunology. 181, 3, p. 2071-2075 5 p.

研究成果: ジャーナルへの寄稿記事

TYK2 Kinase
Interleukin-23
Interleukin-17
Escherichia coli
T-Lymphocytes
2007
6 引用 (Scopus)

Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration

Ueyama, C., Akashiba, H., Nakayama, K., Nakayama, K., Nishiyama, N. & Matsuki, N., 11 2007, : : NeuroReport. 18, 17, p. 1781-1785 5 p.

研究成果: ジャーナルへの寄稿記事

Kainic Acid
Seizures
Cell Death
Retinoblastoma Protein
Cyclin-Dependent Kinases
39 引用 (Scopus)

Anchoring of the 26S proteasome to the organellar membrane by FKBP38

Nakagawa, T., Shirane, M., Lemura, S. I., Natsume, T. & Nakayama, K., 6 1 2007, : : Genes to Cells. 12, 6, p. 709-719 11 p.

研究成果: ジャーナルへの寄稿記事

Tacrolimus Binding Proteins
Membranes
Immunophilins
Tandem Repeat Sequences
ATP dependent 26S protease
35 引用 (Scopus)

Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-δ knockout mice

Shukla, A., Lounsbury, K. M., Barrett, T. F., Gell, J., Rincon, M., Butnor, K. J., Taatjes, D. J., Davis, G. S., Vacek, P., Nakayama, K., Nakayama, K., Steele, C. & Mossman, B. T., 1 1 2007, : : American Journal of Pathology. 170, 1, p. 140-151 12 p.

研究成果: ジャーナルへの寄稿記事

Asbestos
Knockout Mice
Protein Kinase C
Cell Proliferation
Cytokines
18 引用 (Scopus)

Bcl-2 and Bcl-XL are indispensable for the late phase of mast cell development from mouse embryonic stem cells

Möller, C., Karlberg, M., Åbrink, M., Nakayama, K., Motoyama, N. & Nilsson, G., 3 1 2007, : : Experimental Hematology. 35, 3, p. 385-393 9 p.

研究成果: ジャーナルへの寄稿記事

Mast Cells
Embryonic Stem Cells
Interleukin-3
Stem Cell Factor
Cell Survival
45 引用 (Scopus)

Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages

Yanagawa, M., Tsukuba, T., Nishioku, T., Okamoto, Y., Okamoto, K., Takii, R., Terada, Y., Nakayama, K., Kadowaki, T. & Yamamoto, K., 1 19 2007, : : Journal of Biological Chemistry. 282, 3, p. 1851-1862 12 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin E
Sialoglycoproteins
Macrophages
Membranes
Lysosome-Associated Membrane Glycoproteins
64 引用 (Scopus)

Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface

Kawakubo, T., Okamoto, K., Iwata, J. I., Shin, M., Okamoto, Y., Yasukochi, A., Nakayama, K. I., Kadowaki, T., Tsukuba, T. & Yamamoto, K., 11 15 2007, : : Cancer Research. 67, 22, p. 10869-10878 10 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin E
Neoplasm Metastasis
Growth
Neoplasms
Apoptosis
129 引用 (Scopus)

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis

Onoyama, I., Tsunematsu, R., Matsumoto, A., Kimura, T., De Alborán, I. M., Nakayama, K. & Nakayama, K. I., 11 26 2007, : : Journal of Experimental Medicine. 204, 12, p. 2875-2888 14 p.

研究成果: ジャーナルへの寄稿記事

Cell Differentiation
Cell Cycle
T-Lymphocytes
SKP Cullin F-Box Protein Ligases
Thymus Hyperplasia
45 引用 (Scopus)

Cyclin D2 translocates p27 out of the nucleus and promotes its degradation at the G0-G1 transition

Susaki, E., Nakayama, K. & Nakayama, K. I., 7 1 2007, : : Molecular and cellular biology. 27, 13, p. 4626-4640 15 p.

研究成果: ジャーナルへの寄稿記事

Cyclin D2
Cell Nucleus Active Transport
Cytoplasm
Cyclin-Dependent Kinase Inhibitor p27
Cyclin D
67 引用 (Scopus)

Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic β cells

Zhong, L., Georgia, S., Tschen, S. I., Nakayama, K., Nakayama, K. & Bhushan, A., 10 1 2007, : : Journal of Clinical Investigation. 117, 10, p. 2869-2876 8 p.

研究成果: ジャーナルへの寄稿記事

Growth
Insulin Resistance
Endoreduplication
Polyploidy
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