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研究成果 2012 2019

  • 97 引用
  • 5 h指数
  • 10 記事
フィルター
記事
2019

DMSO-Perturbing Assay for Identifying Promiscuous Enzyme Inhibitors

Tomohara, K., Adachi, I., Horino, Y., Kesamaru, H., Abe, H., Suyama, K. & Nose, T., 1 1 2019, : : ACS Medicinal Chemistry Letters. 10, 6, p. 923-928 6 p.

研究成果: ジャーナルへの寄稿記事

Enzyme Inhibitors
Dimethyl Sulfoxide
Assays
Enzymes
Conformations
2017
3 引用 (Scopus)

Controllable Stereoselective Synthesis of (Z)- and (E)-Homoallylic Alcohols Using a Palladium-Catalyzed Three-Component Reaction

Horino, Y., Sugata, M., Mutsuura, I., Tomohara, K. & Abe, H., 11 3 2017, : : Organic Letters. 19, 21, p. 5968-5971 4 p.

研究成果: ジャーナルへの寄稿記事

Palladium
palladium
alcohols
Alcohols
aldehydes
3 引用 (Scopus)

Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions

Tomohara, K., Ito, T., Onikata, S., Kato, A. & Adachi, I., 1 1 2017, : : Bioorganic and Medicinal Chemistry Letters. 27, 7, p. 1620-1623 4 p.

研究成果: ジャーナルへの寄稿記事

Hyaluronoglucosaminidase
Catechin
Dimethyl Sulfoxide
Biological Products
Assays
4 引用 (Scopus)

Multiple production of α,α-disubstituted amino acid derivatives through direct chemical derivatization of natural plant extracts: An apparently difficult but successful route

Tomohara, K., Ito, T., Furusawa, K., Hasegawa, N., Tsuge, K., Kato, A. & Adachi, I., 1 1 2017, : : Tetrahedron Letters. 58, 32, p. 3143-3147 5 p.

研究成果: ジャーナルへの寄稿記事

Paeonia
Hydantoins
Ginger
Carbamates
Plant Extracts
2016
5 引用 (Scopus)

Asymmetric synthesis of multisubstituted dihydrobenzofurans by intramolecular conjugate addition of short-lived C-O axially chiral enolates

Tomohara, K., Kasamatsu, K., Yoshimura, T., Furuta, T. & Kawabata, T., 1 1 2016, : : Chemical and Pharmaceutical Bulletin. 64, 7, p. 899-906 8 p.

研究成果: ジャーナルへの寄稿記事

Addition reactions
Carbon
10 引用 (Scopus)

Direct chemical derivatization of natural plant extract: Straightforward synthesis of natural plant-like hydantoin

Tomohara, K., Ito, T., Hasegawa, N., Kato, A. & Adachi, I., 2 24 2016, : : Tetrahedron Letters. 57, 8, p. 924-927 4 p.

研究成果: ジャーナルへの寄稿記事

Hydantoins
Curcuma
Plant Extracts
Chemical properties
Carbon
3 引用 (Scopus)

Interpreting the behavior of concentration-response curves of hyaluronidase inhibitors under DMSO-perturbed assay conditions

Tomohara, K., Ito, T., Onikata, S., Furusawa, K., Kato, A. & Adachi, I., 7 1 2016, : : Bioorganic and Medicinal Chemistry Letters. 26, 13, p. 3153-3157 5 p.

研究成果: ジャーナルへの寄稿記事

Hyaluronoglucosaminidase
Dimethyl Sulfoxide
Assays
Hyaluronic Acid
Enzymes
2013
16 引用 (Scopus)

Asymmetric induction via short-lived chiral enolates with a chiral C-O axis

Yoshimura, T., Tomohara, K. & Kawabata, T., 5 15 2013, : : Journal of the American Chemical Society. 135, 19, p. 7102-7105 4 p.

研究成果: ジャーナルへの寄稿記事

Cyclic Ethers
Ethers
Cyclization
Half-Life
Carbon
38 引用 (Scopus)

Asymmetric α-arylation of amino acid derivatives by clayden rearrangement of ester enolates via memory of chirality

Tomohara, K., Yoshimura, T., Hyakutake, R., Yang, P. & Kawabata, T., 9 11 2013, : : Journal of the American Chemical Society. 135, 36, p. 13294-13297 4 p.

研究成果: ジャーナルへの寄稿記事

Hydantoins
Chirality
Amino acids
Esters
Carbon
2012
15 引用 (Scopus)

Protonation-assisted conjugate addition of axially chiral enolates: Asymmetric synthesis of multisubstituted β-lactams from α-amino acids

Yoshimura, T., Takuwa, M., Tomohara, K., Uyama, M., Hayashi, K., Yang, P., Hyakutake, R., Sasamori, T., Tokitoh, N. & Kawabata, T., 11 26 2012, : : Chemistry - A European Journal. 18, 48, p. 15330-15336 7 p.

研究成果: ジャーナルへの寄稿記事

Lactams
Protonation
Amino acids
Amino Acids
Carbonates