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研究成果 1996 2019

フィルター
記事
2019
1 引用 (Scopus)

2-Oxo-histidine-containing dipeptides are functional oxidation products

Ihara, H., Kakihana, Y., Yamakage, A., Kai, K., Shibata, T., Nishida, M., Yamada, K-I. & Uchida, K., 1 1 2019, : : Journal of Biological Chemistry. 294, 4, p. 1279-1289 11 p.

研究成果: ジャーナルへの寄稿記事

Carnosine
Dipeptides
Histidine
Oxidation
Antioxidants
2 引用 (Scopus)

In Vivo Imaging of the Intra-and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging

Yasukawa, K., Shigemi, R., Kanbe, T., Mutsumoto, Y., Oda, F., Ichikawa, K., Yamada, K-I., Tun, X. & Utsumi, H., 1 1 2019, : : Antioxidants and Redox Signaling. 30, 9, p. 1147-1161 15 p.

研究成果: ジャーナルへの寄稿記事

Stomach Ulcer
Indomethacin
Oxidation-Reduction
Rats
Stomach

Kinetics and localisation of haemin-induced lipoprotein oxidation

Morales, N. P., Chunephisal, P., Janprasit, J., Ishida, Y., Luechapudiporn, R. & Yamada, K. I., 10 3 2019, : : Free Radical Research. 53, 9-10, p. 968-978 11 p.

研究成果: ジャーナルへの寄稿記事

Hemin
Lipoproteins
Oxidation
Kinetics
Paramagnetic resonance
1 引用 (Scopus)

Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model

Emoto, M. C., Sato-Akaba, H., Matsuoka, Y., Yamada, K-I. & Fujii, H. G., 1 18 2019, : : Neuroscience Letters. 690, p. 6-10 5 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Glutathione
Brain
Brain Mapping
Pentylenetetrazole

Radiation-induced redox alteration in the mouse brain

Nakamura, M., Yamasaki, T., Ueno, M., Shibata, S., Ozawa, Y., Kamada, T., Nakanishi, I., Yamada, K-I., Aoki, I. & Matsumoto, K. I., 11 1 2019, : : Free Radical Biology and Medicine. 143, p. 412-421 10 p.

研究成果: ジャーナルへの寄稿記事

Oxidation-Reduction
Brain
Carbon
Ion beams
Irradiation
2018
1 引用 (Scopus)

Antioxidant nitroxides protect hepatic cells from oxidative stress-induced cell death

Shinto, S., Matsuoka, Y., Yamato, M. & Yamada, K-I., 3 1 2018, : : Journal of Clinical Biochemistry and Nutrition. 62, 2, p. 132-138 7 p.

研究成果: ジャーナルへの寄稿記事

Oxidative stress
Cell death
Hepatocytes
Oxidative Stress
Cell Death
5 引用 (Scopus)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Connexins
varespladib methyl
Astrocytes
Parkinson Disease

Detection and inhibition of redox reaction and lipid derived radicals

Yamada, K-I., 1 1 2018, : : Drug Delivery System. 33, 3, p. 197-203 7 p.

研究成果: ジャーナルへの寄稿記事

Oxidation-Reduction
Lipids
Free Radicals
Animal Models
Carcinogenesis

Fluorescence tumor-imaging using a thermo-responsive molecule with an emissive aminoquinoline derivative

Araki, T., Fuchi, Y., Murayama, S., Shiraishi, R., Oyama, T., Aso, M., Aoki, I., Kobayashi, S., Yamada, K. I. & Karasawa, S., 10 2 2018, : : Nanomaterials. 8, 10, 782.

研究成果: ジャーナルへの寄稿記事

Aminoquinolines
Tumors
Fluorescence
Derivatives
Imaging techniques
3 引用 (Scopus)

Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells

Yamamoto, K., Yasui, H., Bo, T., Yamamori, T., Hiraoka, W., Yamasaki, T., Yamada, K-I. & Inanami, O., 8 1 2018, : : Applied Magnetic Resonance. 49, 8, p. 837-851 15 p.

研究成果: ジャーナルへの寄稿記事

oxygen consumption
electron paramagnetic resonance
respiration
tumors
mitochondria

Imaging Doxorubicin Free Radical in Mice with Overhauser Enhanced MRI and its Tumor Suppression Effect in Mice

Kato, N., Sato, S., Yamada, K-I. & Ichikawa, K., 8 1 2018, : : Applied Magnetic Resonance. 49, 8, p. 869-879 11 p.

研究成果: ジャーナルへの寄稿記事

free radicals
mice
tumors
retarding
magnetic resonance
1 引用 (Scopus)

Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury

Homma, T., Shirato, T., Akihara, R., Kobayashi, S., Lee, J., Yamada, K-I., Miyata, S., Takahashi, M. & Fujii, J., 9 15 2018, : : Toxicology Letters. 294, p. 37-43 7 p.

研究成果: ジャーナルへの寄稿記事

Thioacetamide
Liver
Wounds and Injuries
Metabolites
Cytochrome P-450 CYP2E1
Protein Phosphatase 2
Dextran Sulfate
Toll-Like Receptor 4
Protein Tyrosine Phosphatases
Colitis
1 引用 (Scopus)

The first multicenter, randomized, controlled trial of home telemonitoring for Japanese patients with heart failure: home telemonitoring study for patients with heart failure (HOMES-HF)

On Behalf Of The Homes-Hf Study Investigators, 8 1 2018, : : Heart and Vessels. 33, 8, p. 866-876 11 p.

研究成果: ジャーナルへの寄稿記事

Randomized Controlled Trials
Heart Failure
Home Care Services
Physiologic Monitoring
Registries
2017
3 引用 (Scopus)

Detection and inhibition of lipid-derived radicals in low-density lipoprotein

Ishida, Y., Okamoto, Y., Matsuoka, Y., Tada, A., Janprasit, J., Yamato, M., Morales, N. P. & Yamada, K-I., 12 1 2017, : : Free Radical Biology and Medicine. 113, p. 487-493 7 p.

研究成果: ジャーナルへの寄稿記事

LDL Lipoproteins
Lipids
Iron
Deferoxamine
Oxidative stress
1 引用 (Scopus)

Feasibility of magnetic resonance redox imaging at low magnetic field: Comparison at 1 T and 7 T

Nakamura, M., Shibata, S., Yamasaki, T., Ueno, M., Nakanishi, I., Matsumoto, K. I., Kamada, T., Yamada, K-I. & Aoki, I., 1 1 2017, : : American Journal of Translational Research. 9, 10, p. 4481-4491 11 p., AJTR0054131.

研究成果: ジャーナルへの寄稿記事

Magnetic resonance
Magnetic Fields
Oxidation-Reduction
Magnetic Resonance Imaging
Magnetic fields

Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a)

Homma, T., Akihara, R., Okano, S., Shichiri, M., Yoshida, Y., Yamada, K-I., Miyata, S., Nakajima, O. & Fujii, J., 2 15 2017, : : Behavioural Brain Research. 319, p. 219-224 6 p.

研究成果: ジャーナルへの寄稿記事

Ascorbic Acid
Aggression
Aldehyde Reductase
carbonyl reductase (NADPH)
Social Behavior

Lipid radicals cause light-induced retinal degeneration

Enoki, M., Shinto, S., Matsuoka, Y., Otsuka, A., Kaidzu, S., Tanito, M., Shibata, T., Uchida, K., Ohira, A., Yamato, M. & Yamada, K-I., 9 20 2017, : : Chemical Communications.

研究成果: ジャーナルへの寄稿記事

Lipids
Animals
Imaging techniques
Molecules
4 引用 (Scopus)

Lipid radicals cause light-induced retinal degeneration

Enoki, M., Shinto, S., Matsuoka, Y., Otsuka, A., Kaidzu, S., Tanito, M., Shibata, T., Uchida, K., Ohira, A., Yamato, M. & Yamada, K-I., 1 1 2017, : : Chemical Communications. 53, 79, p. 10922-10925 4 p.

研究成果: ジャーナルへの寄稿記事

Lipids
Animals
Imaging techniques
Molecules
6 引用 (Scopus)

Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells

Yasui, H., Yamamoto, K., Suzuki, M., Sakai, Y., Bo, T., Nagane, M., Nishimura, E., Yamamori, T., Inanami, O., Yamada, K-I. & Yamasaki, T., 4 1 2017, : : Cancer Letters. 390, p. 160-167 8 p.

研究成果: ジャーナルへの寄稿記事

Energy Metabolism
Radiation
Neoplasms
Adenosine Triphosphate
Cations
8 引用 (Scopus)
Electron Spin Resonance Spectroscopy
Oxidation-Reduction
Glutathione
Paramagnetic resonance
Brain
2016
6 引用 (Scopus)

Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress

Akihara, R., Homma, T., Lee, J., Yamada, K-I., Miyata, S. & Fujii, J., 9 16 2016, : : Biochemical and Biophysical Research Communications. 478, 2, p. 765-771 7 p.

研究成果: ジャーナルへの寄稿記事

Aldehyde Reductase
Endoplasmic Reticulum Stress
Oxidative stress
Carbon Tetrachloride
Ablation
20 引用 (Scopus)

A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats

Kimura, S., Inoguchi, T., Yamasaki, T., Yamato, M., Ide, M., Sonoda, N., Yamada, K-I. & Takayanagi, R., 3 1 2016, : : Metabolism: Clinical and Experimental. 65, 3, p. 138-145 8 p.

研究成果: ジャーナルへの寄稿記事

Dipeptidyl-Peptidase IV Inhibitors
Electron Spin Resonance Spectroscopy
Hydroxyl Radical
Dipeptidyl Peptidase 4
Experimental Diabetes Mellitus
5 引用 (Scopus)

A profluorescent nitroxide probe for ascorbic acid detection and its application to quantitative analysis of diabetic rat plasma

Matsuoka, Y., Ohkubo, K., Yamasaki, T., Yamato, M., Ohtabu, H., Shirouzu, T., Fukuzumi, S. & Yamada, K. I., 1 1 2016, : : RSC Advances. 6, 65, p. 60907-60915 9 p.

研究成果: ジャーナルへの寄稿記事

Ascorbic acid
Ascorbic Acid
Rats
Plasmas
Chemical analysis
14 引用 (Scopus)

Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy

Kurahashi, T., Lee, J., Nabeshima, A., Homma, T., Kang, E. S., Saito, Y., Yamada, S., Nakayama, T., Yamada, K-I., Miyata, S. & Fujii, J., 8 15 2016, : : Archives of Biochemistry and Biophysics. 604, p. 36-46 11 p.

研究成果: ジャーナルへの寄稿記事

Autophagy
Acetaminophen
Ascorbic Acid
Glutathione
Recovery
3 引用 (Scopus)

Brain contrasting ability of blood-brain-barrier–permeable nitroxyl contrast agents for magnetic resonance redox imaging

Matsumoto, K. I., Yamasaki, T., Nakamura, M., Ishikawa, J., Ueno, M., Nakanishi, I., Sekita, A., Ozawa, Y., Kamada, T., Aoki, I. & Yamada, K-I., 9 1 2016, : : Magnetic Resonance in Medicine. 76, 3, p. 935-945 11 p.

研究成果: ジャーナルへの寄稿記事

Contrast Media
Oxidation-Reduction
Magnetic Resonance Imaging
Brain
Pharmacokinetics
14 引用 (Scopus)

Fluorescence probes to detect lipid-derived radicals

Yamada, K-I., Mito, F., Matsuoka, Y., Ide, S., Shikimachi, K., Fujiki, A., Kusakabe, D., Ishida, Y., Enoki, M., Tada, A., Ariyoshi, M., Yamasaki, T. & Yamato, M., 8 1 2016, : : Nature Chemical Biology. 12, 8, p. 608-613 6 p.

研究成果: ジャーナルへの寄稿記事

Fluorescence
Lipids
Diethylnitrosamine
Apoptosis
Inflammation
8 引用 (Scopus)

Photodecomposition of tetrabromobisphenol A in aqueous humic acid suspension by irradiation with light of various wavelengths

Han, S. K., Yamasaki, T. & Yamada, K. I., 3 1 2016, : : Chemosphere. 147, p. 124-130 7 p.

研究成果: ジャーナルへの寄稿記事

Humic Substances
humic acid
Suspensions
irradiation
Irradiation
6 引用 (Scopus)

TEMPOL increases NAD+ and improves redox imbalance in obese mice

Yamato, M., Kawano, K., Yamanaka, Y., Saiga, M. & Yamada, K-I., 8 1 2016, : : Redox Biology. 8, p. 316-322 7 p.

研究成果: ジャーナルへの寄稿記事

Obese Mice
NAD
Oxidation
Nutrition
Diet
2015
9 引用 (Scopus)
Methamphetamine
Electron Spin Resonance Spectroscopy
Gadolinium
Magnetic resonance
Blood-Brain Barrier
7 引用 (Scopus)

Brain redox imaging in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy by using in vivo electron paramagnetic resonance and a nitroxide imaging probe

Emoto, M. C., Yamato, M., Sato-Akaba, H., Yamada, K-I. & Fujii, H. G., 11 3 2015, : : Neuroscience Letters. 608, p. 40-44 5 p.

研究成果: ジャーナルへの寄稿記事

Pentylenetetrazole
Electron Spin Resonance Spectroscopy
Neuroimaging
Oxidation-Reduction
Epilepsy

Diffusion studies of redox-sensitive nitroxyl spin probes through bilayer lipid membranes using 300 MHz electron spin resonance spectrometer

Benial, A. M. F., Dhas, M. K., Ichikawa, K., Yamada, K., Hyodo, F., Jawahar, A. & Utsumi, H., 1 1 2015, : : Biofizika. 60, 1, p. 88-94 7 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Lipid Bilayers
Membrane Lipids
Oxidation-Reduction
Liposomes
49 引用 (Scopus)

Overexpression of TFAM or twinkle increases mtDNA copy number and facilitates cardioprotection associated with limited mitochondrial oxidative stress

Ikeda, M., Ide, T., Fujino, T., Arai, S., Saku, K., Kakino, T., Tyynismaa, H., Yamasaki, T., Yamada, K. I., Kang, D., Suomalainen, A. & Sunagawa, K., 3 30 2015, : : PloS one. 10, 3, e0119687.

研究成果: ジャーナルへの寄稿記事

Mitochondria
Oxidative stress
Mitochondrial DNA
reactive oxygen species
Reactive Oxygen Species
2014
7 引用 (Scopus)

Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice

Ito, J., Otsuki, N., Zhang, X., Konno, T., Kurahashi, T., Takahashi, M., Yamato, M., Matsuoka, Y., Yamada, K-I., Miyata, S. & Fujii, J., 1 24 2014, : : Life Sciences. 95, 1, p. 1-8 8 p.

研究成果: ジャーナルへの寄稿記事

Pentobarbital
Knockout Mice
Ascorbic Acid
Anesthetics
Detoxification

Change in overhauser effect-enhanced MRI signal in response to uPA highly expressing in tumor

Niidome, T., Chijiiwa, N., Yamasaki, T., Yamada, K-I., Mori, T., Naganuma, T., Utsumi, H., Ichikawa, K. & Katayama, Y., 1 1 2014, : : Chemistry Letters. 43, 7, p. 999-1001 3 p.

研究成果: ジャーナルへの寄稿記事

Magnetic resonance imaging
Tumors
Peptide Hydrolases
Peptides
Lysine
22 引用 (Scopus)

Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides

Kajer, T. B., Fairfull-Smith, K. E., Yamasaki, T., Yamada, K. I., Fu, S., Bottle, S. E., Hawkins, C. L. & Davies, M. J., 5 2014, : : Free Radical Biology and Medicine. 70, p. 96-105 10 p.

研究成果: ジャーナルへの寄稿記事

Oxidants
Peroxidase
Neutrophils
Inhibitory Concentration 50
Plasma (human)
16 引用 (Scopus)
Dextran Sulfate
Toll-Like Receptor 4
Colitis
Nitric Oxide
Chemical activation
11 引用 (Scopus)

Kidney fibrosis is independent of the amount of ascorbic acid in mice with unilateral ureteral obstruction

Nishida, H., Kurahashi, T., Saito, Y., Otsuki, N., Kwon, M., Ohtake, H., Yamakawa, M., Yamada, K-I., Miyata, S., Tomita, Y. & Fujii, J., 1 1 2014, : : Free Radical Research. 48, 9, p. 1115-1124 10 p.

研究成果: ジャーナルへの寄稿記事

Ureteral Obstruction
Ascorbic Acid
Fibrosis
Kidney
Collagen
12 引用 (Scopus)

Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals

Kurahashi, T., Kwon, M., Homma, T., Saito, Y., Lee, J., Takahashi, M., Yamada, K-I., Miyata, S. & Fujii, J., 9 12 2014, : : Biochemical and Biophysical Research Communications. 452, 1, p. 136-141 6 p.

研究成果: ジャーナルへの寄稿記事

Acrolein
Aldehyde Reductase
Detoxification
Mammals
Fibroblasts
7 引用 (Scopus)

Tempol intake improves inflammatory status in aged mice

Yamato, M., Ishimatsu, A., Yamanaka, Y., Mine, T. & Yamada, K-I., 1 1 2014, : : Journal of Clinical Biochemistry and Nutrition. 55, 1, p. 11-14 4 p.

研究成果: ジャーナルへの寄稿記事

Oxidative stress
Antioxidants
Plasmas
Aging of materials
Body Temperature
2013
22 引用 (Scopus)

A disruption mechanism of the molecular clock in a MPTP mouse model of parkinson's disease

Hayashi, A., Matsunaga, N., Okazaki, H., Kakimoto, K., Kimura, Y., Azuma, H., Ikeda, E., Shiba, T., Yamato, M., Yamada, K. I., Koyanagi, S. & Ohdo, S., 6 1 2013, : : NeuroMolecular Medicine. 15, 2, p. 238-251 14 p.

研究成果: ジャーナルへの寄稿記事

AMP-Activated Protein Kinases
Parkinson Disease
Circadian Clocks
Dopaminergic Neurons
Adenosine Triphosphate
18 引用 (Scopus)

Novel ascorbic acid-resistive nitroxide in a lipid emulsion: An efficient brain imaging contrast agent for MRI of small rodents

Emoto, M. C., Yamada, K-I., Yamato, M. & Fujii, H. G., 6 24 2013, : : Neuroscience Letters. 546, p. 11-15 5 p.

研究成果: ジャーナルへの寄稿記事

Emulsions
Neuroimaging
Contrast Media
Ascorbic Acid
Rodentia
7 引用 (Scopus)

Permeability Studies of Redox-Sensitive Nitroxyl Spin Probes Through Lipid Membranes Using an L-Band ESR Spectrometer

Milton Franklin Benial, A., Kumara Dhas, M., Ichikawa, K., Yamada, K. I., Hyodo, F., Jawahar, A. & Utsumi, H., 1 1 2013, : : Applied Magnetic Resonance. 44, 4, p. 439-447 9 p.

研究成果: ジャーナルへの寄稿記事

ultrahigh frequencies
lipids
electron paramagnetic resonance
permeability
spectrometers
5 引用 (Scopus)

Redox potential of nitroxides is an index to evaluate superoxide dismutase mimic activity

Yamasaki, T., Matsuoka, Y., Mito, F., Yamato, M. & Yamada, K-I., 1 1 2013, : : Asian Journal of Organic Chemistry. 2, 5, p. 388-391 4 p.

研究成果: ジャーナルへの寄稿記事

Superoxides
Superoxide Dismutase
Oxidation-Reduction
2012
9 引用 (Scopus)

High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice

Yamato, M., Shiba, T., Ide, T., Seri, N., Kudo, W., Ando, M., Yamada, K-I., Kinugawa, S. & Tsutsui, H., 1 1 2012, : : Molecular and cellular biochemistry. 359, 1-2, p. 161-167 7 p.

研究成果: ジャーナルへの寄稿記事

Tumor Necrosis Factor Receptors
High Fat Diet
Nutrition
Bile Acids and Salts
Knockout Mice
45 引用 (Scopus)

Rapid and convenient detection of ascorbic acid using a fluorescent nitroxide switch

Matsuoka, Y., Yamato, M., Yamasaki, T., Mito, F. & Yamada, K-I., 12 1 2012, : : Free Radical Biology and Medicine. 53, 11, p. 2112-2118 7 p.

研究成果: ジャーナルへの寄稿記事

Ascorbic Acid
Switches
Fluorophores
Reducing Agents
Fluorescence

Synthesis and Utilization of α-Substituted Nitroxides

Yamasaki, T., Mito, F., Matsuoka, Y., Yamato, M. & Yamada, K-I., 9 12 2012, : : InTech. p. 247 262 p., 8.

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

The detrimental eff ect of nitric oxide on tissue is associated with infl ammatory events in the vascular endothelium and neutrophils in mice with dextran sodium sulfate-induced colitis

Yasukawa, K., Tokuda, H., Tun, X., Utsumi, H. & Yamada, K-I., 12 1 2012, : : Free Radical Research. 46, 12, p. 1427-1436 10 p.

研究成果: ジャーナルへの寄稿記事

Dextran Sulfate
Vascular Endothelium
Colitis
Nitric Oxide
Neutrophils
22 引用 (Scopus)

Whole-body kinetic image of a redox probe in mice using Overhauser-enhanced MRI

Kosem, N., Naganuma, T., Ichikawa, K., Phumala Morales, N., Yasukawa, K., Hyodo, F., Yamada, K. I. & Utsumi, H., 7 15 2012, : : Free Radical Biology and Medicine. 53, 2, p. 328-336 9 p.

研究成果: ジャーナルへの寄稿記事

Body Image
Magnetic resonance imaging
Oxidation-Reduction
Kinetics
Pharmacokinetics
2011
18 引用 (Scopus)

A novel ascorbic acid-resistant nitroxide in fat emulsion is an efficient brain imaging probe for in vivo EPR imaging of mouse

Emoto, M., Mito, F., Yamasaki, T., Yamada, K. I., Sato-Akaba, H., Hirata, H. & Fujii, H., 11 1 2011, : : Free Radical Research. 45, 11-12, p. 1325-1332 8 p.

研究成果: ジャーナルへの寄稿記事

Emulsions
Neuroimaging
Ascorbic Acid
Paramagnetic resonance
Brain