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研究成果 2004 2018

2018
3 引用 (Scopus)

The role of telomere binding molecules for normal and abnormal hematopoiesis

Hosokawa, K. & Arai, F., 6 1 2018, : : International journal of hematology. 107, 6, p. 646-655 10 p.

研究成果: ジャーナルへの寄稿評論記事

Telomere
Hematopoiesis
Hematopoietic Stem Cells
Hematopoietic System
DNA Damage
2017
8 引用 (Scopus)

The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

Hosokawa, K., MacArthur, B. D., Ikushima, Y. M., Toyama, H., Masuhiro, Y., Hanazawa, S., Suda, T. & Arai, F., 12 1 2017, : : Nature communications. 8, 1, 804.

研究成果: ジャーナルへの寄稿記事

Telomere-Binding Proteins
telomeres
stem cells
Telomere
Hematopoietic Stem Cells
2015
6 引用 (Scopus)

Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes

Sakamoto, H., Takeda, N., Arai, F., Hosokawa, K., Garcia, P., Suda, T., Frampton, J. & Ogawa, M., 2 1 2015, : : STEM CELLS. 33, 2, p. 479-490 12 p.

研究成果: ジャーナルへの寄稿記事

Proto-Oncogene Proteins c-myb
Hematopoietic Stem Cells
Oncogene Proteins
Hematopoiesis
Bromodeoxyuridine
2014
79 引用 (Scopus)

Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression

Horio, E., Kadomatsu, T., Miyata, K., Arai, Y., Hosokawa, K., Doi, Y., Ninomiya, T., Horiguchi, H., Endo, M., Tabata, M., Tazume, H., Tian, Z., Takahashi, O., Terada, K., Takeya, M., Hao, H., Hirose, N., Minami, T., Suda, T., Kiyohara, Y. および3人, Ogawa, H., Kaikita, K. & Oike, Y., 4 2014, : : Arteriosclerosis, thrombosis, and vascular biology. 34, 4, p. 790-800 11 p.

研究成果: ジャーナルへの寄稿記事

Angiopoietins
Blood Vessels
Atherosclerosis
Endothelial Cells
Inflammation
2013
9 引用 (Scopus)

Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells

Ikushima, Y. M., Arai, F., Nakamura, Y., Hosokawa, K., Kubota, Y., Hirashima, M., Toyama, H. & Suda, T., 1 4 2013, : : Biochemical and Biophysical Research Communications. 430, 1, p. 20-25 6 p.

研究成果: ジャーナルへの寄稿記事

Angiopoietin-1
Hematopoietic Stem Cells
Stem cells
Transgenic Mice
Hematopoiesis
17 引用 (Scopus)

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells

Yamashita, M., Nitta, E., Nagamatsu, G., Ikushima, Y. M., Hosokawa, K., Arai, F. & Suda, T., 11 8 2013, : : Biochemical and Biophysical Research Communications. 441, 1, p. 196-201 6 p.

研究成果: ジャーナルへの寄稿記事

Hematopoietic Stem Cells
Stem cells
Maintenance
DNA Damage
Apoptosis
24 引用 (Scopus)

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

Ikushima, Y. M., Arai, F., Hosokawa, K., Toyama, H., Takubo, K., Furuyashiki, T., Narumiya, S. & Suda, T., 1 1 2013, : : Blood. 121, 11, p. 1995-2007 13 p.

研究成果: ジャーナルへの寄稿記事

Hematopoietic Stem Cells
Stem cells
Mesenchymal Stromal Cells
Dinoprostone
Recovery
2012

Gene expression profiling and regulatory networks in single cells

Arai, F., Hosokawa, K., Matsumoto, Y., Toyama, H. & Suda, T., 2 1 2012, New Frontiers of Network Analysis in Systems Biology. Springer Netherlands, p. 1-13 13 p.

研究成果: 著書/レポートタイプへの貢献

Gene Expression Profiling
Gene Expression
Population
Complementary DNA
DNA Sequence Analysis
3 引用 (Scopus)

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs

Toyama, H., Arai, F., Hosokawa, K., Ikushima, Y. M. & Suda, T., 11 23 2012, : : Biochemical and Biophysical Research Communications. 428, 3, p. 354-359 6 p.

研究成果: ジャーナルへの寄稿記事

Cadherins
Hematopoietic Stem Cells
Stem cells
Liver
Bone
30 引用 (Scopus)

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Arai, F., Hosokawa, K., Toyama, H., Matsumoto, Y. & Suda, T., 1 1 2012, : : Annals of the New York Academy of Sciences. 1266, 1, p. 72-77 6 p.

研究成果: ジャーナルへの寄稿記事

Cadherins
Hematopoietic Stem Cells
Stem cells
Bone
Bone Marrow
2011
161 引用 (Scopus)

P57 Kip2 and p27 Kip1 cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70

Zou, P., Yoshihara, H., Hosokawa, K., Tai, I., Shinmyozu, K., Tsukahara, F., Maru, Y., Nakayama, K., Nakayama, K. & Suda, T., 9 2 2011, : : Cell stem cell. 9, 3, p. 247-261 15 p.

研究成果: ジャーナルへの寄稿記事

HSC70 Heat-Shock Proteins
Hematopoietic Stem Cells
Cell Cycle
Cyclin D1
Cyclin-Dependent Kinase Inhibitor p57
41 引用 (Scopus)

Telomerase reverse transcriptase protectsATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism

Nitta, E., Yamashita, M., Hosokawa, K., Xian, M. J., Takubo, K., Arai, F., Nakada, S. & Suda, T., 4 21 2011, : : Blood. 117, 16, p. 4169-4180 12 p.

研究成果: ジャーナルへの寄稿記事

Telomerase
Telomere
Hematopoietic Stem Cells
Stem cells
Reactive Oxygen Species
2010
70 引用 (Scopus)

Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Hembree, M., Yin, T., Nakamura, Y., Gomei, Y., Takubo, K., Shiama, H., Matsuoka, S., Li, L. & Suda, T., 3 5 2010, : : Cell stem cell. 6, 3, p. 194-198 5 p.

研究成果: ジャーナルへの寄稿レター

Stem Cell Niche
Gene Expression Regulation
Cadherins
Hematopoietic Stem Cells
Cell Adhesion
2 引用 (Scopus)

Erratum: Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells (Nature Medicine (2006)12 (446-451))

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y. & Suda, T., 1 1 2010, : : Nature medicine. 16, 1, 1 p.

研究成果: ジャーナルへの寄稿コメント/討論

p38 Mitogen-Activated Protein Kinases
Hematopoietic Stem Cells
Reactive Oxygen Species
Medicine
25 引用 (Scopus)

Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells

Gomei, Y., Nakamura, Y., Yoshihara, H., Hosokawa, K., Iwasaki, H., Suda, T. & Arai, F., 1 1 2010, : : Experimental Hematology. 38, 2

研究成果: ジャーナルへの寄稿記事

Angiopoietin-2
Angiopoietin-1
Hematopoietic Stem Cells
Bone Marrow
Ligands
134 引用 (Scopus)

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

Nakamura, Y., Arai, F., Iwasaki, H., Hosokawa, K., Kobayashi, I., Gomei, Y., Matsumoto, Y., Yoshihara, H. & Suda, T., 9 2 2010, : : Blood. 116, 9, p. 1422-1432 11 p.

研究成果: ジャーナルへの寄稿記事

Activated-Leukocyte Cell Adhesion Molecule
Hematopoietic Stem Cells
Stem cells
Cells
Population
83 引用 (Scopus)

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Nakamura, Y., Gomei, Y. & Suda, T., 7 29 2010, : : Blood. 116, 4, p. 554-563 10 p.

研究成果: ジャーナルへの寄稿記事

Cadherins
Hematopoietic Stem Cells
Stem cells
Small Interfering RNA
Bone
2009
47 引用 (Scopus)

Niche regulation of hematopoietic stem cells in the endosteum: The role of thrombopoietinmpl signaling in the maintenance of quiescent Hematopoietic Stem Cells

Arai, F., Yoshihara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H. & Suda, T., 1 1 2009, Hematopoietic Stem Cells VII. Blackwell Publishing Inc., p. 36-46 11 p. (Annals of the New York Academy of Sciences; 巻数 1176).

研究成果: 著書/レポートタイプへの貢献会議での発言

Hematopoietic Stem Cells
Stem cells
Maintenance
Bone
Stem Cell Niche
35 引用 (Scopus)

Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice

Shima, H., Takubo, K., Iwasaki, H., Yoshihara, H., Gomei, Y., Hosokawa, K., Arai, F., Takahashi, T. & Suda, T., 1 16 2009, : : Biochemical and Biophysical Research Communications. 378, 3, p. 467-472 6 p.

研究成果: ジャーナルへの寄稿記事

Hematopoietic Stem Cells
Stem cells
Fetal Blood
Blood
Cells
2008
118 引用 (Scopus)

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., Miyamoto, K., Yoshiwara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Hayashi, Y., Matsuzaki, Y., Nakayama, K., Ikeda, Y. および4人, Hata, A., Chiba, S., Nakayama, K. I. & Suda, T., 4 15 2008, : : Genes and Development. 22, 8, p. 986-991 6 p.

研究成果: ジャーナルへの寄稿記事

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Hematopoietic Stem Cells
SKP Cullin F-Box Protein Ligases
Cell Cycle
Leukemia
2007
558 引用 (Scopus)

Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool

Miyamoto, K., Araki, K. Y., Naka, K., Arai, F., Takubo, K., Yamazaki, S., Matsuoka, S., Miyamoto, T., Ito, K., Ohmura, M., Chen, C., Hosokawa, K., Nakauchi, H., Nakayama, K., Nakayama, K. I., Harada, M., Motoyama, N., Suda, T. & Hirao, A., 6 7 2007, : : Cell stem cell. 1, 1, p. 101-112 12 p.

研究成果: ジャーナルへの寄稿記事

Hematopoietic Stem Cells
Maintenance
Forkhead Transcription Factors
Critical Pathways
Hematopoiesis
90 引用 (Scopus)

Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction

Hosokawa, K., Arai, F., Yoshihara, H., Nakamura, Y., Gomei, Y., Iwasaki, H., Miyamoto, K., Shima, H., Ito, K. & Suda, T., 11 23 2007, : : Biochemical and Biophysical Research Communications. 363, 3, p. 578-583 6 p.

研究成果: ジャーナルへの寄稿記事

Stem Cell Niche
Oxidative stress
Hematopoietic Stem Cells
Stem cells
Cell Communication
86 引用 (Scopus)

Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes

Ito, K., Takubo, K., Arai, F., Satoh, H., Matsuoka, S., Ohmura, M., Naka, K., Azuma, M., Miyamoto, K., Hosokawa, K., Ikeda, Y., Mak, T. W., Suda, T. & Hirao, A., 1 1 2007, : : Journal of Immunology. 178, 1, p. 103-110 8 p.

研究成果: ジャーナルへの寄稿記事

Double-Stranded DNA Breaks
Reactive Oxygen Species
Lymphocytes
Acetylcysteine
Genetic Recombination
445 引用 (Scopus)

Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche

Yoshihara, H., Arai, F., Hosokawa, K., Hagiwara, T., Takubo, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Matsuoka, S., Miyamoto, K., Miyazaki, H., Takahashi, T. & Suda, T., 12 13 2007, : : Cell stem cell. 1, 6, p. 685-697 13 p.

研究成果: ジャーナルへの寄稿記事

Thrombopoietin
Hematopoietic Stem Cells
Cell Communication
Thrombopoietin Receptors
CDC2 Protein Kinase
2006
872 引用 (Scopus)

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y. & Suda, T., 4 1 2006, : : Nature medicine. 12, 4, p. 446-451 6 p.

研究成果: ジャーナルへの寄稿記事

p38 Mitogen-Activated Protein Kinases
Hematopoietic Stem Cells
Stem cells
Reactive Oxygen Species
Maintenance
2004
827 引用 (Scopus)

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., Ikeda, Y., Mak, T. W. & Suda, T., 10 21 2004, : : Nature. 431, 7011, p. 997-1002 6 p.

研究成果: ジャーナルへの寄稿記事

Ataxia Telangiectasia
Hematopoietic Stem Cells
Oxidative Stress
Reactive Oxygen Species
Bone Marrow