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研究成果 2014 2019

  • 211 引用
  • 7 h指数
  • 22 記事
  • 2 レター
2019
Retinal Cone Photoreceptor Cells
Ophthalmoscopy
Retinitis Pigmentosa
Lasers
Visual Field Tests
2 引用 (Scopus)

Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population

Hirata, J., Hosomichi, K., Sakaue, S., Kanai, M., Nakaoka, H., Ishigaki, K., Suzuki, K., Akiyama, M., Kishikawa, T., Ogawa, K., Masuda, T., Yamamoto, K., Hirata, M., Matsuda, K., Momozawa, Y., Inoue, I., Kubo, M., Kamatani, Y. & Okada, Y., 3 1 2019, : : Nature genetics. 51, 3, p. 470-480 11 p.

研究成果: ジャーナルへの寄稿記事

HLA Antigens
Phenotype
Population
Genes
Genome-Wide Association Study

GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture

Matoba, N., Akiyama, M., Ishigaki, K., Kanai, M., Takahashi, A., Momozawa, Y., Ikegawa, S., Ikeda, M., Iwata, N., Hirata, M., Matsuda, K., Kubo, M., Okada, Y. & Kamatani, Y., 5 1 2019, : : Nature Human Behaviour. 3, 5, p. 471-477 7 p.

研究成果: ジャーナルへの寄稿レター

Genetic Loci
Genome-Wide Association Study
Smoking
Linkage Disequilibrium
Tobacco Products
1 引用 (Scopus)

Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population

Suzuki, K., Akiyama, M., Ishigaki, K., Kanai, M., Hosoe, J., Shojima, N., Hozawa, A., Kadota, A., Kuriki, K., Naito, M., Tanno, K., Ishigaki, Y., Hirata, M., Matsuda, K., Iwata, N., Ikeda, M., Sawada, N., Yamaji, T., Iwasaki, M., Ikegawa, S. および12人Maeda, S., Murakami, Y., Wakai, K., Tsugane, S., Sasaki, M., Yamamoto, M., Okada, Y., Kubo, M., Kamatani, Y., Horikoshi, M., Yamauchi, T. & Kadowaki, T., 3 1 2019, : : Nature genetics. 51, 3, p. 379-386 8 p.

研究成果: ジャーナルへの寄稿レター

Genome-Wide Association Study
Gene Frequency
Type 2 Diabetes Mellitus
Population
Acinar Cells

Phenotypic Features of Oguchi Disease and Retinitis Pigmentosa in Patients with S-Antigen Mutations: A Long-Term Follow-up Study

Nishiguchi, K. M., Ikeda, Y., Fujita, K., Kunikata, H., Akiho, M., Hashimoto, K., Hosono, K., Kurata, K., Koyanagi, Y., Akiyama, M., Suzuki, T., Kawasaki, R., Wada, Y., Hotta, Y., Sonoda, K., Murakami, A., Nakazawa, M., Nakazawa, T. & Abe, T., 1 1 2019, : : Ophthalmology.

研究成果: ジャーナルへの寄稿記事

Retinitis Pigmentosa
Antigens
Mutation
Retinal Degeneration
Electroretinography
2018
23 引用 (Scopus)

A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder

Advanced Collaborative Study of Mood Disorder (COSMO) team, 3 1 2018, : : Molecular Psychiatry. 23, 3, p. 639-647 9 p.

研究成果: ジャーナルへの寄稿記事

Genome-Wide Association Study
Bipolar Disorder
Population
Psychiatry
Regulator Genes
1 引用 (Scopus)

Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn's disease in Asians

Han, B., Akiyama, M., Kim, K. K., Oh, H., Choi, H., Lee, C. H., Jung, S., Lee, H. S., Kim, E. E., Cook, S., Haritunians, T., Yamazaki, K., Park, S. H., Ye, B. D., McGovern, D. P. B., Esaki, M., Kawaguchi, T., Khor, S. S., Taylor, K. D., Rotter, J. I. および12人Suzuki, Y., Matsui, T., Motoya, S., Bang, S. Y., Kim, T. H., Momozawa, Y., Kamatani, Y., Tokunaga, K., Kubo, M., Okada, Y., Yang, S. K. & Song, K., 11 1 2018, : : Human Molecular Genetics. 27, 22, p. 3901-3910 10 p.

研究成果: ジャーナルへの寄稿記事

HLA Antigens
Crohn Disease
Amino Acids
Ulcerative Colitis
Inflammatory Bowel Diseases
4 引用 (Scopus)

Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese

Okada, Y., Momozawa, Y., Sakaue, S., Kanai, M., Ishigaki, K., Akiyama, M., Kishikawa, T., Arai, Y., Sasaki, T., Kosaki, K., Suematsu, M., Matsuda, K., Yamamoto, K., Kubo, M., Hirose, N. & Kamatani, Y., 12 1 2018, : : Nature communications. 9, 1, 1631.

研究成果: ジャーナルへの寄稿記事

公開
sequencing
genome
Genes
Genetic Selection
signatures
3 引用 (Scopus)

Elucidating the genetic architecture of reproductive ageing in the Japanese population

Horikoshi, M., Day, F. R., Akiyama, M., Hirata, M., Kamatani, Y., Matsuda, K., Ishigaki, K., Kanai, M., Wright, H., Toro, C. A., Ojeda, S. R., Lomniczi, A., Kubo, M., Ong, K. K. & Perry, J. R. B., 12 1 2018, : : Nature communications. 9, 1, 1977.

研究成果: ジャーナルへの寄稿記事

公開
Menopause
Receptor-Like Protein Tyrosine Phosphatases
Genes
Aging of materials
time measurement
38 引用 (Scopus)

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

Kanai, M., Akiyama, M., Takahashi, A., Matoba, N., Momozawa, Y., Ikeda, M., Iwata, N., Ikegawa, S., Hirata, M., Matsuda, K., Kubo, M., Okada, Y. & Kamatani, Y., 3 1 2018, : : Nature genetics. 50, 3, p. 390-400 11 p.

研究成果: ジャーナルへの寄稿記事

Population
Genome-Wide Association Study
Genetic Pleiotropy
Phenotype
2 引用 (Scopus)

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Lifelines Cohort Study, 12 1 2018, : : Nature communications. 9, 1, 4455.

研究成果: ジャーナルへの寄稿記事

公開
hormones
genome
Thyroid Hormones
Genes
Thyroid Diseases
6 引用 (Scopus)

Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma

Japan Glaucoma Society Omics Group (JGS-OG) & NEIGHBORHOOD Consortium, 4 15 2018, : : Human Molecular Genetics. 27, 8, p. 1486-1496 11 p.

研究成果: ジャーナルへの寄稿記事

Genome-Wide Association Study
Primary Open Angle Glaucoma
Blindness
Epidermal Growth Factor Receptor
Glaucoma
2 引用 (Scopus)

Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study

Hishida, A., Nakatochi, M., Akiyama, M., Kamatani, Y., Nishiyama, T., Ito, H., Oze, I., Nishida, Y., Hara, M., Takashima, N., Turin, T. C., Watanabe, M., Suzuki, S., Ibusuki, R., Shimoshikiryo, I., Nakamura, Y., Mikami, H., Ikezaki, H., Furusyo, N., Kuriki, K. および12人Endoh, K., Koyama, T., Matsui, D., Uemura, H., Arisawa, K., Sasakabe, T., Okada, R., Kawai, S., Naito, M., Momozawa, Y., Kubo, M. & Wakai, K., 6 1 2018, : : American Journal of Nephrology. 47, 5, p. 304-316 13 p.

研究成果: ジャーナルへの寄稿記事

Chromosomes, Human, Pair 18
Genome-Wide Association Study
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 2
Japan

Genome-wide association study suggests four variants influencing outcomes with ranibizumab therapy in exudative age-related macular degeneration

Akiyama, M., Takahashi, A., Momozawa, Y., Arakawa, S., Miya, F., Tsunoda, T., Ashikawa, K., Oshima, Y., Yasuda, M., Yoshida, S., Enaida, H., Tan, X., Yanagi, Y., Yasukawa, T., Ogura, Y., Nagai, Y., Takahashi, K., Fujisawa, K., Inoue, M., Arakawa, A. および6人Tanaka, K., Yuzawa, M., Kadonosono, K., Sonoda, K., Ishibashi, T. & Kubo, M., 10 1 2018, : : Journal of Human Genetics. 63, 10, p. 1083-1091 9 p.

研究成果: ジャーナルへの寄稿記事

Genome-Wide Association Study
Macular Degeneration
Visual Acuity
Therapeutics
Vascular Endothelial Growth Factor A
3 引用 (Scopus)

Integration of genetics and miRNA–target gene network identified disease biology implicated in tissue specificity

Sakaue, S., Hirata, J., Maeda, Y., Kawakami, E., Nii, T., Kishikawa, T., Ishigaki, K., Terao, C., Suzuki, K., Akiyama, M., Suita, N., Masuda, T., Ogawa, K., Yamamoto, K., Saeki, Y., Matsushita, M., Yoshimura, M., Matsuoka, H., Ikari, K., Taniguchi, A. および15人Yamanaka, H., Kawaji, H., Lassmann, T., Itoh, M., Yoshitomi, H., Ito, H., Ohmura, K., Forrest, A. R. R., Hayashizaki, Y., Carninci, P., Kumanogoh, A., Kamatani, Y., de Hoon, M., Yamamoto, K. & Okada, Y., 1 1 2018, : : Nucleic acids research. 46, 22, p. 11898-11909 12 p.

研究成果: ジャーナルへの寄稿記事

公開
Organ Specificity
Gene Regulatory Networks
MicroRNAs
Biomarkers
Genome-Wide Association Study
1 引用 (Scopus)

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

The International Genomics of Blood Pressure (iGEN-BP) Consortium, 12 1 2018, : : Nature communications. 9, 1, 5052.

研究成果: ジャーナルへの寄稿記事

公開
blood pressure
Blood pressure
descent
loci
Blood Pressure
6 引用 (Scopus)

Optical coherence tomography angiography of the macular microvasculature changes in retinitis pigmentosa

Koyanagi, Y., murakami, Y., Funatsu, J., Akiyama, M., Nakatake, S., Fujiwara, K., Tachibana, T., nakao, S., Hisatomi, T., Yoshida, S., Ishibashi, T., Sonoda, K. & Ikeda, Y., 2 1 2018, : : Acta Ophthalmologica. 96, 1, p. e59-e67

研究成果: ジャーナルへの寄稿記事

Retinitis Pigmentosa
Optical Coherence Tomography
Microvessels
Angiography
Visual Acuity
2017
53 引用 (Scopus)

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

Akiyama, M., Okada, Y., Kanai, M., Takahashi, A., Momozawa, Y., Ikeda, M., Iwata, N., Ikegawa, S., Hirata, M., Matsuda, K., Iwasaki, M., Yamaji, T., Sawada, N., Hachiya, T., Tanno, K., Shimizu, A., Hozawa, A., Minegishi, N., Tsugane, S., Yamamoto, M. および2人Kubo, M. & Kamatani, Y., 10 1 2017, : : Nature genetics. 49, 10, p. 1458-1467 10 p.

研究成果: ジャーナルへの寄稿記事

Genome-Wide Association Study
Body Mass Index
Obesity
Population
Lymphocyte Count
3 引用 (Scopus)

Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

Sakamoto, Y., Yamamoto, T., Sugano, N., Takahashi, D., Watanabe, T., Atsumi, T., Nakamura, J., Hasegawa, Y., Akashi, K., Narita, I., Miyamoto, T., Takeuchi, T., Ikari, K., Amano, K., Fujie, A., Kubo, T., Tada, Y., Kaneuji, A., Nakamura, H., Miyamura, T. および70人Kabata, T., Yamaji, K., Okawa, T., Sudo, A., Ohzono, K., Tanaka, Y., Yasunaga, Y., Matsuda, S., Imai, Y., Nakashima, Y., motomura, G., Ikemura, S., Yamaguchi, R., Karasuyama, K., Sonoda, K., Nishii, T., Sakai, T., Takao, M., Irie, T., Asano, T., Iwasaki, N., Atsumi, T., Tamaoki, S., Nakanishi, R., Tanabe, S., Kishida, S., Hagiwara, S., Seki, T., Tsukamoto, H., Niiro, H., Arinobu, Y., Akahoshi, M., Mitoma, H., Ayano, M., Kuroda, T., Toyama, Y., Funayama, A., Hanaoka, H., Yamaoka, K., Kawaguchi, Y., Yamanaka, H., Hosozawa, T., Momohara, S., Chino, K., Fujioka, M., Ueshima, K., Ishida, M., Saito, M., Hayashi, S., Ikegami, A., Ichiseki, T., Mizokawa, S., Ohta, Y., Kajino, Y., Sekiya, F., Higuchi, F., Hasegawa, M., Miyamoto, N., Miyazaki, S., Yamaguchi, T., Ando, W., Saito, K., Nakano, K., Kuroda, Y., Yamasaki, T., Akiyama, M., Kubo, M., Kamatani, Y., Iwamoto, Y. & Ikegawa, S., 12 1 2017, : : Scientific reports. 7, 1, 15035.

研究成果: ジャーナルへの寄稿記事

Osteonecrosis
Genome-Wide Association Study
Thigh
Hip Joint
Drinking
3 引用 (Scopus)

Genome-wide association study of neovascular age-related macular degeneration in the Thai population

Ruamviboonsuk, P., Tadarati, M., Singhanetr, P., Wattanapokayakit, S., Kunhapan, P., Wanitchanon, T., Wichukchinda, N., Mushiroda, T., Akiyama, M., Momozawa, Y., Kubo, M. & Mahasirimongkol, S., 11 1 2017, : : Journal of Human Genetics. 62, 11, p. 957-962 6 p.

研究成果: ジャーナルへの寄稿記事

Genome-Wide Association Study
Macular Degeneration
Complement Factor H
Population
Genes
2016
22 引用 (Scopus)

Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis

Okada, Y., Suzuki, A., Ikari, K., Terao, C., Kochi, Y., Ohmura, K., Higasa, K., Akiyama, M., Ashikawa, K., Kanai, M., Hirata, J., Suita, N., Teo, Y. Y., Xu, H., Bae, S. C., Takahashi, A., Momozawa, Y., Matsuda, K., Momohara, S., Taniguchi, A. および9人Yamada, R., Mimori, T., Kubo, M., Brown, M. A., Raychaudhuri, S., Matsuda, F., Yamanaka, H., Kamatani, Y. & Yamamoto, K., 8 4 2016, : : American journal of human genetics. 99, 2, p. 366-374 9 p.

研究成果: ジャーナルへの寄稿記事

公開
HLA Antigens
Rheumatoid Arthritis
Genes
Major Histocompatibility Complex
Population
9 引用 (Scopus)

Low-frequency coding variants in CETP and CFB are associated with susceptibility of exudative age-related macular degeneration in the Japanese population

Momozawa, Y., Akiyama, M., Kamatani, Y., Arakawa, S., Yasuda, M., Yoshida, S., Oshima, Y., Mori, R., Tanaka, K., Mori, K., Inoue, S., Terasaki, H., Yasuma, T., Honda, S., Miki, A., Inoue, M., Fujisawa, K., Takahashi, K., Yasukawa, T., Yanagi, Y. および5人Kadonosono, K., Sonoda, K., Ishibashi, T., Takahashi, A. & Kubo, M., 11 15 2016, : : Human Molecular Genetics. 25, 22, p. 5027-5034 8 p.

研究成果: ジャーナルへの寄稿記事

Macular Degeneration
Population
Genome-Wide Association Study
Gene Frequency
Genes
2015
19 引用 (Scopus)

Correlation between macular blood flow and central visual sensitivity in retinitis pigmentosa

murakami, Y., Ikeda, Y., Akiyama, M., Fujiwara, K., Yoshida, N., Nakatake, S., Notomi, S., Nabeshima, T., Hisatomi, T., Enaida, H. & Ishibashi, T., 12 1 2015, : : Acta Ophthalmologica. 93, 8, p. e644-e648

研究成果: ジャーナルへの寄稿記事

Retinitis Pigmentosa
Visual Field Tests
Visual Acuity
Lasers
Blood Vessels
2014
10 引用 (Scopus)

Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa

Akiyama, M., Ikeda, Y., Yoshida, N., Notomi, S., murakami, Y., Hisatomi, T., Enaida, H. & Ishibashi, T., 1 1 2014, : : Acta Ophthalmologica. 92, 3

研究成果: ジャーナルへの寄稿記事

Retinitis Pigmentosa
Therapeutics
isopropyl unoprostone
Neuroprotective Agents
Therapeutic Uses