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研究成果 2014 2020

  • 397 引用
  • 10 h指数
  • 41 記事
  • 2 レター
フィルター
記事
2020

GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits

Matoba, N., Akiyama, M., Ishigaki, K., Kanai, M., Takahashi, A., Momozawa, Y., Ikegawa, S., Ikeda, M., Iwata, N., Hirata, M., Matsuda, K., Murakami, Y., Kubo, M., Kamatani, Y. & Okada, Y., 1 1 2020, (受理済み/印刷中) : : Nature human behaviour.

研究成果: ジャーナルへの寄稿記事

Soy Foods
Genome-Wide Association Study
Feeding Behavior
Fishes
Cytochrome P-450 CYP1A2

GWAS of five gynecologic diseases and cross-trait analysis in Japanese

Masuda, T., Low, S. K., Akiyama, M., Hirata, M., Ueda, Y., Matsuda, K., Kimura, T., Murakami, Y., Kubo, M., Kamatani, Y. & Okada, Y., 1 1 2020, : : European Journal of Human Genetics. 28, 1, p. 95-107 13 p.

研究成果: ジャーナルへの寄稿記事

公開
Female Genital Diseases
Genome-Wide Association Study
Ovarian Neoplasms
Uterine Neoplasms
Endometriosis
1 引用 (Scopus)

Microaneurysm Imaging Using Multiple En Face OCT Angiography Image Averaging: Morphology and Visualization

Kaizu, Y., Nakao, S., Wada, I., Arima, M., Yamaguchi, M., Ishikawa, K., Akiyama, M., Kishimoto, J., Hisatomi, T. & Sonoda, K. H., 2 2020, : : Ophthalmology Retina. 4, 2, p. 175-186 12 p.

研究成果: ジャーナルへの寄稿記事

Angiography
Diabetic Retinopathy
Fluorescein Angiography
Microaneurysm
Equipment and Supplies
2019
10 引用 (Scopus)

A catalog of genetic loci associated with kidney function from analyses of a million individuals

Lifelines Cohort Study & V. A. Million Veteran Program, 6 1 2019, : : Nature genetics. 51, 6, p. 957-972 16 p.

研究成果: ジャーナルへの寄稿記事

Genetic Loci
Kidney
Glomerular Filtration Rate
Chronic Renal Insufficiency
Translational Medical Research

A frequent variant in the Japanese population determines quasi-Mendelian inheritance of rare retinal ciliopathy

Nikopoulos, K., Cisarova, K., Quinodoz, M., Koskiniemi-Kuendig, H., Miyake, N., Farinelli, P., Rehman, A. U., Khan, M. I., Prunotto, A., Akiyama, M., Kamatani, Y., Terao, C., Miya, F., Ikeda, Y., Ueno, S., Fuse, N., Murakami, A., Wada, Y., Terasaki, H., Sonoda, K. H. および8人, Ishibashi, T., Kubo, M., Cremers, F. P. M., Kutalik, Z., Matsumoto, N., Nishiguchi, K. M., Nakazawa, T. & Rivolta, C., 12 1 2019, : : Nature communications. 10, 1, 2884.

研究成果: ジャーナルへの寄稿記事

公開
Retinal Degeneration
degeneration
mutations
genes
insertion
2 引用 (Scopus)

Association between Genetic Risk and Development of Type 2 Diabetes in a General Japanese Population: The Hisayama Study

Inaishi, J., Hirakawa, Y., Horikoshi, M., Akiyama, M., Higashioka, M., Yoshinari, M., Hata, J., Mukai, N., Kamatani, Y., Momozawa, Y., Kubo, M. & Ninomiya, T., 6 19 2019, : : Journal of Clinical Endocrinology and Metabolism. 104, 8, p. 3213-3222 10 p.

研究成果: ジャーナルへの寄稿記事

Medical problems
Type 2 Diabetes Mellitus
Population
Hazards
Precision Medicine

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

BIRTH-GENE (BIG) Study Working Group, 9 4 2019, : : JAMA network open. 2, 9, p. e1910915

研究成果: ジャーナルへの寄稿記事

公開
Random Allocation
Birth Weight
Type 2 Diabetes Mellitus
Mendelian Randomization Analysis
Single Nucleotide Polymorphism

Associations of autozygosity with a broad range of human phenotypes

Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., Bartz, T. M. および416人, Baumbach, C., Biino, G., Bixley, M. J., Brumat, M., Chai, J. F., Corre, T., Cousminer, D. L., Dekker, A. M., Eccles, D. A., van Eijk, K. R., Fuchsberger, C., Gao, H., Germain, M., Gordon, S. D., de Haan, H. G., Harris, S. E., Hofer, E., Huerta-Chagoya, A., Igartua, C., Jansen, I. E., Jia, Y., Kacprowski, T., Karlsson, T., Kleber, M. E., Li, S. A., Li-Gao, R., Mahajan, A., Matsuda, K., Meidtner, K., Meng, W., Montasser, M. E., van der Most, P. J., Munz, M., Nutile, T., Palviainen, T., Prasad, G., Prasad, R. B., Priyanka, T. D. S., Rizzi, F., Salvi, E., Sapkota, B. R., Shriner, D., Skotte, L., Smart, M. C., Smith, A. V., van der Spek, A., Spracklen, C. N., Strawbridge, R. J., Tajuddin, S. M., Trompet, S., Turman, C., Verweij, N., Viberti, C., Wang, L., Warren, H. R., Wootton, R. E., Yanek, L. R., Yao, J., Yousri, N. A., Zhao, W., Adeyemo, A. A., Afaq, S., Aguilar-Salinas, C. A., Akiyama, M., Albert, M. L., Allison, M. A., Alver, M., Aung, T., Azizi, F., Bentley, A. R., Boeing, H., Boerwinkle, E., Borja, J. B., de Borst, G. J., Bottinger, E. P., Broer, L., Campbell, H., Chanock, S., Chee, M. L., Chen, G., Chen, Y. D. I., Chen, Z., Chiu, Y. F., Cocca, M., Collins, F. S., Concas, M. P., Corley, J., Cugliari, G., van Dam, R. M., Damulina, A., Daneshpour, M. S., Day, F. R., Delgado, G. E., Dhana, K., Doney, A. S. F., Dörr, M., Doumatey, A. P., Dzimiri, N., Ebenesersdóttir, S. S., Elliott, J., Elliott, P., Ewert, R., Felix, J. F., Fischer, K., Freedman, B. I., Girotto, G., Goel, A., Gögele, M., Goodarzi, M. O., Graff, M., Granot-Hershkovitz, E., Grodstein, F., Guarrera, S., Gudbjartsson, D. F., Guity, K., Gunnarsson, B., Guo, Y., Hagenaars, S. P., Haiman, C. A., Halevy, A., Harris, T. B., Hedayati, M., van Heel, D. A., Hirata, M., Höfer, I., Hsiung, C. A., Huang, J., Hung, Y. J., Ikram, M. A., Jagadeesan, A., Jousilahti, P., Kamatani, Y., Kanai, M., Kerrison, N. D., Kessler, T., Khaw, K. T., Khor, C. C., de Kleijn, D. P. V., Koh, W. P., Kolcic, I., Kraft, P., Krämer, B. K., Kutalik, Z., Kuusisto, J., Langenberg, C., Launer, L. J., Lawlor, D. A., Lee, I. T., Lee, W. J., Lerch, M. M., Li, L., Liu, J., Loh, M., London, S. J., Loomis, S., Lu, Y., Luan, J., Mägi, R., Manichaikul, A. W., Manunta, P., Másson, G., Matoba, N., Mei, X. W., Meisinger, C., Meitinger, T., Mezzavilla, M., Milani, L., Millwood, I. Y., Momozawa, Y., Moore, A., Morange, P. E., Moreno-Macías, H., Mori, T. A., Morrison, A. C., Muka, T., Murakami, Y., Murray, A. D., de Mutsert, R., Mychaleckyj, J. C., Nalls, M. A., Nauck, M., Neville, M. J., Nolte, I. M., Ong, K. K., Orozco, L., Padmanabhan, S., Pálsson, G., Pankow, J. S., Pattaro, C., Pattie, A., Polasek, O., Poulter, N., Pramstaller, P. P., Quintana-Murci, L., Räikkönen, K., Ralhan, S., Rao, D. C., van Rheenen, W., Rich, S. S., Ridker, P. M., Rietveld, C. A., Robino, A., van Rooij, F. J. A., Ruggiero, D., Saba, Y., Sabanayagam, C., Sabater-Lleal, M., Sala, C. F., Salomaa, V., Sandow, K., Schmidt, H., Scott, L. J., Scott, W. R., Sedaghati-Khayat, B., Sennblad, B., van Setten, J., Sever, P. J., Sheu, W. H. H., Shi, Y., Shrestha, S., Shukla, S. R., Sigurdsson, J. K., Sikka, T. T., Singh, J. R., Smith, B. H., Stančáková, A., Stanton, A., Starr, J. M., Stefansdottir, L., Straker, L., Sulem, P., Sveinbjornsson, G., Swertz, M. A., Taylor, A. M., Taylor, K. D., Terzikhan, N., Tham, Y. C., Thorleifsson, G., Thorsteinsdottir, U., Tillander, A., Tracy, R. P., Tusié-Luna, T., Tzoulaki, I., Vaccargiu, S., Vangipurapu, J., Veldink, J. H., Vitart, V., Völker, U., Vuoksimaa, E., Wakil, S. M., Waldenberger, M., Wander, G. S., Wang, Y. X., Wareham, N. J., Wild, S., Yajnik, C. S., Yuan, J. M., Zeng, L., Zhang, L., Zhou, J., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Becker, D. M., Lehne, B., Bennett, D. A., van den Berg, L. H., Berndt, S. I., Bharadwaj, D., Bielak, L. F., Bochud, M., Boehnke, M., Bouchard, C., Bradfield, J. P., Brody, J. A., Campbell, A., Carmi, S., Caulfield, M. J., Cesarini, D., Chambers, J. C., Chandak, G. R., Cheng, C. Y., Ciullo, M., Cornelis, M., Cusi, D., Smith, G. D., Deary, I. J., Dorajoo, R., van Duijn, C. M., Ellinghaus, D., Erdmann, J., Eriksson, J. G., Evangelou, E., Evans, M. K., Faul, J. D., Feenstra, B., Feitosa, M., Foisy, S., Franke, A., Friedlander, Y., Gasparini, P., Gieger, C., Gonzalez, C., Goyette, P., Grant, S. F. A., Griffiths, L. R., Groop, L., Gudnason, V., Gyllensten, U., Hakonarson, H., Hamsten, A., van der Harst, P., Heng, C. K., Hicks, A. A., Hochner, H., Huikuri, H., Hunt, S. C., Jaddoe, V. W. V., De Jager, P. L., Johannesson, M., Johansson, Å., Jonas, J. B., Jukema, J. W., Junttila, J., Kaprio, J., Kardia, S. L. R., Karpe, F., Kumari, M., Laakso, M., van der Laan, S. W., Lahti, J., Laudes, M., Lea, R. A., Lieb, W., Lumley, T., Martin, N. G., März, W., Matullo, G., McCarthy, M. I., Medland, S. E., Merriman, T. R., Metspalu, A., Meyer, B. F., Mohlke, K. L., Montgomery, G. W., Mook-Kanamori, D., Munroe, P. B., North, K. E., Nyholt, D. R., O’connell, J. R., Ober, C., Oldehinkel, A. J., Palmas, W., Palmer, C., Pasterkamp, G. G., Patin, E., Pennell, C. E., Perusse, L., Peyser, P. A., Pirastu, M., Polderman, T. J. C., Porteous, D. J., Posthuma, D., Psaty, B. M., Rioux, J. D., Rivadeneira, F., Rotimi, C., Rotter, J. I., Rudan, I., Den Ruijter, H. M., Sanghera, D. K., Sattar, N., Schmidt, R., Schulze, M. B., Schunkert, H., Scott, R. A., Shuldiner, A. R., Sim, X., Small, N., Smith, J. A., Sotoodehnia, N., Tai, E. S., Teumer, A., Timpson, N. J., Toniolo, D., Tregouet, D. A., Tuomi, T., Vollenweider, P., Wang, C. A., Weir, D. R., Whitfield, J. B., Wijmenga, C., Wong, T. Y., Wright, J., Yang, J., Yu, L., Zemel, B. S., Zonderman, A. B., Perola, M., Magnusson, P. K. E., Uitterlinden, A. G., Kooner, J. S., Chasman, D. I., Loos, R. J. F., Franceschini, N., Franke, L., Haley, C. S., Hayward, C., Walters, R. G., Perry, J. R. B., Esko, T., Helgason, A., Stefansson, K., Joshi, P. K., Kubo, M. & Wilson, J. F., 12 1 2019, : : Nature communications. 10, 1, 4957.

研究成果: ジャーナルへの寄稿記事

公開
phenotype
Phenotype
Inbreeding
social factors
fertility
2 引用 (Scopus)

Characterizing rare and low-frequency height-associated variants in the Japanese population

Akiyama, M., Ishigaki, K., Sakaue, S., Momozawa, Y., Horikoshi, M., Hirata, M., Matsuda, K., Ikegawa, S., Takahashi, A., Kanai, M., Suzuki, S., Matsui, D., Naito, M., Yamaji, T., Iwasaki, M., Sawada, N., Tanno, K., Sasaki, M., Hozawa, A., Minegishi, N. および8人, Wakai, K., Tsugane, S., Shimizu, A., Yamamoto, M., Okada, Y., Murakami, Y., Kubo, M. & Kamatani, Y., 12 1 2019, : : Nature communications. 10, 1, 4393.

研究成果: ジャーナルへの寄稿記事

公開
Genes
Genome
low frequencies
genome
Genome-Wide Association Study

Direct comparison of retinal structure and function in retinitis pigmentosa by co-registering microperimetry and optical coherence tomography

Funatsu, J., Murakami, Y., Nakatake, S., Akiyama, M., Fujiwara, K., Shimokawa, S., Tachibana, T., Hisatomi, T., Koyanagi, Y., Momozawa, Y., Sonoda, K. H. & Ikeda, Y., 1 1 2019, : : PloS one. 14, 12, e0226097.

研究成果: ジャーナルへの寄稿記事

公開
Retinitis Pigmentosa
Retinal Pigments
Optical tomography
tomography
Optical Coherence Tomography
Retinal Cone Photoreceptor Cells
Ophthalmoscopy
Retinitis Pigmentosa
Lasers
Visual Field Tests
1 引用 (Scopus)

Functional variants in ADH1B and ALDH2 are non-additively associated with all-cause mortality in Japanese population

Sakaue, S., Akiyama, M., Hirata, M., Matsuda, K., Murakami, Y., Kubo, M., Kamatani, Y. & Okada, Y., 1 1 2019, (受理済み/印刷中) : : European Journal of Human Genetics.

研究成果: ジャーナルへの寄稿記事

公開
Alleles
Genotype
Mortality
Population
Survival Analysis
8 引用 (Scopus)

Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population

Hirata, J., Hosomichi, K., Sakaue, S., Kanai, M., Nakaoka, H., Ishigaki, K., Suzuki, K., Akiyama, M., Kishikawa, T., Ogawa, K., Masuda, T., Yamamoto, K., Hirata, M., Matsuda, K., Momozawa, Y., Inoue, I., Kubo, M., Kamatani, Y. & Okada, Y., 3 1 2019, : : Nature genetics. 51, 3, p. 470-480 11 p.

研究成果: ジャーナルへの寄稿記事

HLA Antigens
Phenotype
Population
Genes
Genome-Wide Association Study
3 引用 (Scopus)

Genetic characteristics of retinitis pigmentosa in 1204 Japanese patients

Koyanagi, Y., Akiyama, M., Nishiguchi, K. M., Momozawa, Y., Kamatani, Y., Takata, S., Inai, C., Iwasaki, Y., Kumano, M., Murakami, Y., Omodaka, K., Abe, T., Komori, S., Gao, D., Hirakata, T., Kurata, K., Hosono, K., Ueno, S., Hotta, Y., Murakami, A. および7人, Terasaki, H., Wada, Y., Nakazawa, T., Ishibashi, T., Ikeda, Y., Kubo, M. & Sonoda, K. H., 10 1 2019, : : Journal of medical genetics. 56, 10, p. 662-670 9 p.

研究成果: ジャーナルへの寄稿記事

Retinitis Pigmentosa
Databases
Population
Genes
Recessive Genes
1 引用 (Scopus)

Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population

Otsuka, I., Akiyama, M., Shirakawa, O., Okazaki, S., Momozawa, Y., Kamatani, Y., Izumi, T., Numata, S., Takahashi, M., Boku, S., Sora, I., Yamamoto, K., Ueno, Y., Toda, T., Kubo, M. & Hishimoto, A., 11 1 2019, : : Neuropsychopharmacology. 44, 12, p. 2119-2124 6 p.

研究成果: ジャーナルへの寄稿記事

Genome-Wide Association Study
Suicide
Population
Single Nucleotide Polymorphism
Japan
5 引用 (Scopus)

Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals

Nakatochi, M., Kanai, M., Nakayama, A., Hishida, A., Kawamura, Y., Ichihara, S., Akiyama, M., Ikezaki, H., Furusyo, N., Shimizu, S., Yamamoto, K., Hirata, M., Okada, R., Kawai, S., Kawaguchi, M., Nishida, Y., Shimanoe, C., Ibusuki, R., Takezaki, T., Nakajima, M. および30人, Takao, M., Ozaki, E., Matsui, D., Nishiyama, T., Suzuki, S., Takashima, N., Kita, Y., Endoh, K., Kuriki, K., Uemura, H., Arisawa, K., Oze, I., Matsuo, K., Nakamura, Y., Mikami, H., Tamura, T., Nakashima, H., Nakamura, T., Kato, N., Matsuda, K., Murakami, Y., Matsubara, T., Naito, M., Kubo, M., Kamatani, Y., Shinomiya, N., Yokota, M., Wakai, K., Okada, Y. & Matsuo, H., 12 1 2019, : : Communications Biology. 2, 1, 115.

研究成果: ジャーナルへの寄稿記事

公開
uric acid
Uric Acid
meta-analysis
Meta-Analysis
Genes

GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

Terao, C., Momozawa, Y., Ishigaki, K., Kawakami, E., Akiyama, M., Loh, P. R., Genovese, G., Sugishita, H., Ohta, T., Hirata, M., Perry, J. R. B., Matsuda, K., Murakami, Y., Kubo, M. & Kamatani, Y., 12 1 2019, : : Nature communications. 10, 1, 4719.

研究成果: ジャーナルへの寄稿記事

公開
blood cells
Y Chromosome
Genome-Wide Association Study
chromosomes
Chromosomes
1 引用 (Scopus)

HLA-DQ and RBFOX1 as susceptibility genes for an outbreak of hydrolyzed wheat allergy

Noguchi, E., Akiyama, M., Yagami, A., Hirota, T., Okada, Y., Kato, Z., Kishikawa, R., Fukutomi, Y., Hide, M., Morita, E., Aihara, M., Hiragun, M., Chinuki, Y., Okabe, T., Ito, A., Adachi, A., Fukunaga, A., Kubota, Y., Aoki, T., Aoki, Y. および30人, Nishioka, K., Adachi, T., Kanazawa, N., Miyazawa, H., Sakai, H., Kozuka, T., Kitamura, H., Hashizume, H., Kanegane, C., Masuda, K., Sugiyama, K., Tokuda, R., Furuta, J., Higashimoto, I., Kato, A., Seishima, M., Tajiri, A., Tomura, A., Taniguchi, H., Kojima, H., Tanaka, H., Sakai, A., Morii, W., Nakamura, M., Kamatani, Y., Takahashi, A., Kubo, M., Tamari, M., Saito, H. & Matsunaga, K., 11 2019, : : Journal of Allergy and Clinical Immunology. 144, 5, p. 1354-1363 10 p.

研究成果: ジャーナルへの寄稿記事

Wheat Hypersensitivity
HLA-DQ Antigens
Disease Outbreaks
Genes
Genome-Wide Association Study
Neovascular Glaucoma
Tenascin
Diabetic Retinopathy
Sclerostomy
Trabecular Meshwork
1 引用 (Scopus)

Phenotypic Features of Oguchi Disease and Retinitis Pigmentosa in Patients with S-Antigen Mutations: A Long-Term Follow-up Study

Nishiguchi, K. M., Ikeda, Y., Fujita, K., Kunikata, H., Akiho, M., Hashimoto, K., Hosono, K., Kurata, K., Koyanagi, Y., Akiyama, M., Suzuki, T., Kawasaki, R., Wada, Y., Hotta, Y., Sonoda, K. H., Murakami, A., Nakazawa, M., Nakazawa, T. & Abe, T., 11 2019, : : Ophthalmology. 126, 11, p. 1557-1566 10 p.

研究成果: ジャーナルへの寄稿記事

Retinitis Pigmentosa
Antigens
Mutation
Retinal Degeneration
Electroretinography

Relationships between serum antioxidant and oxidant statuses and visual function in retinitis pigmentosa

Ishizu, M., Murakami, Y., Fujiwara, K., Funatsu, J., Shimokawa, S., Nakatake, S., Tachibana, T., Hisatomi, T., Koyanagi, Y., Akiyama, M., Momozawa, Y., Ishibashi, T., Sonoda, K. H. & Ikeda, Y., 1 1 2019, : : Investigative Ophthalmology and Visual Science. 60, 13, p. 4462-4468 7 p.

研究成果: ジャーナルへの寄稿記事

公開
Retinitis Pigmentosa
Oxidants
Superoxide Dismutase
Antioxidants
Serum
1 引用 (Scopus)

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

German Chronic Kidney Disease Study, Lifelines Cohort Study & V. A. Million Veteran Program, 10 1 2019, : : Nature genetics. 51, 10, p. 1459-1474 16 p.

研究成果: ジャーナルへの寄稿記事

Uric Acid
Serum
Gout
Genes
Kidney
2018
41 引用 (Scopus)

A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder

Advanced Collaborative Study of Mood Disorder (COSMO) team, 3 1 2018, : : Molecular Psychiatry. 23, 3, p. 639-647 9 p.

研究成果: ジャーナルへの寄稿記事

Genome-Wide Association Study
Bipolar Disorder
Population
Psychiatry
Regulator Genes
1 引用 (Scopus)

Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn's disease in Asians

Han, B., Akiyama, M., Kim, K. K., Oh, H., Choi, H., Lee, C. H., Jung, S., Lee, H. S., Kim, E. E., Cook, S., Haritunians, T., Yamazaki, K., Park, S. H., Ye, B. D., McGovern, D. P. B., Esaki, M., Kawaguchi, T., Khor, S. S., Taylor, K. D., Rotter, J. I. および12人, Suzuki, Y., Matsui, T., Motoya, S., Bang, S. Y., Kim, T. H., Momozawa, Y., Kamatani, Y., Tokunaga, K., Kubo, M., Okada, Y., Yang, S. K. & Song, K., 11 1 2018, : : Human Molecular Genetics. 27, 22, p. 3901-3910 10 p.

研究成果: ジャーナルへの寄稿記事

HLA Antigens
Crohn Disease
Amino Acids
Ulcerative Colitis
Inflammatory Bowel Diseases
19 引用 (Scopus)

Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese

Okada, Y., Momozawa, Y., Sakaue, S., Kanai, M., Ishigaki, K., Akiyama, M., Kishikawa, T., Arai, Y., Sasaki, T., Kosaki, K., Suematsu, M., Matsuda, K., Yamamoto, K., Kubo, M., Hirose, N. & Kamatani, Y., 12 1 2018, : : Nature communications. 9, 1, 1631.

研究成果: ジャーナルへの寄稿記事

公開
sequencing
genome
Genes
Genetic Selection
signatures
4 引用 (Scopus)

Elucidating the genetic architecture of reproductive ageing in the Japanese population

Horikoshi, M., Day, F. R., Akiyama, M., Hirata, M., Kamatani, Y., Matsuda, K., Ishigaki, K., Kanai, M., Wright, H., Toro, C. A., Ojeda, S. R., Lomniczi, A., Kubo, M., Ong, K. K. & Perry, J. R. B., 12 1 2018, : : Nature communications. 9, 1, 1977.

研究成果: ジャーナルへの寄稿記事

公開
Menopause
Receptor-Like Protein Tyrosine Phosphatases
Genes
Aging of materials
time measurement
72 引用 (Scopus)

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

Kanai, M., Akiyama, M., Takahashi, A., Matoba, N., Momozawa, Y., Ikeda, M., Iwata, N., Ikegawa, S., Hirata, M., Matsuda, K., Kubo, M., Okada, Y. & Kamatani, Y., 3 1 2018, : : Nature genetics. 50, 3, p. 390-400 11 p.

研究成果: ジャーナルへの寄稿記事

Population
Genome-Wide Association Study
Genetic Pleiotropy
Phenotype
8 引用 (Scopus)

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Lifelines Cohort Study, 12 1 2018, : : Nature communications. 9, 1, 4455.

研究成果: ジャーナルへの寄稿記事

公開
hormones
genome
Thyroid Hormones
Genes
Thyroid Diseases
17 引用 (Scopus)

Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma

Japan Glaucoma Society Omics Group (JGS-OG) & NEIGHBORHOOD Consortium, 4 15 2018, : : Human Molecular Genetics. 27, 8, p. 1486-1496 11 p.

研究成果: ジャーナルへの寄稿記事

Genome-Wide Association Study
Primary Open Angle Glaucoma
Blindness
Epidermal Growth Factor Receptor
Glaucoma
2 引用 (Scopus)

Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study

Hishida, A., Nakatochi, M., Akiyama, M., Kamatani, Y., Nishiyama, T., Ito, H., Oze, I., Nishida, Y., Hara, M., Takashima, N., Turin, T. C., Watanabe, M., Suzuki, S., Ibusuki, R., Shimoshikiryo, I., Nakamura, Y., Mikami, H., Ikezaki, H., Furusyo, N., Kuriki, K. および12人, Endoh, K., Koyama, T., Matsui, D., Uemura, H., Arisawa, K., Sasakabe, T., Okada, R., Kawai, S., Naito, M., Momozawa, Y., Kubo, M. & Wakai, K., 6 1 2018, : : American Journal of Nephrology. 47, 5, p. 304-316 13 p.

研究成果: ジャーナルへの寄稿記事

Chromosomes, Human, Pair 18
Genome-Wide Association Study
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 2
Japan
1 引用 (Scopus)

Genome-wide association study suggests four variants influencing outcomes with ranibizumab therapy in exudative age-related macular degeneration

Akiyama, M., Takahashi, A., Momozawa, Y., Arakawa, S., Miya, F., Tsunoda, T., Ashikawa, K., Oshima, Y., Yasuda, M., Yoshida, S., Enaida, H., Tan, X., Yanagi, Y., Yasukawa, T., Ogura, Y., Nagai, Y., Takahashi, K., Fujisawa, K., Inoue, M., Arakawa, A. および6人, Tanaka, K., Yuzawa, M., Kadonosono, K., Sonoda, K. H., Ishibashi, T. & Kubo, M., 10 1 2018, : : Journal of Human Genetics. 63, 10, p. 1083-1091 9 p.

研究成果: ジャーナルへの寄稿記事

Genome-Wide Association Study
Macular Degeneration
Visual Acuity
Therapeutics
Vascular Endothelial Growth Factor A
5 引用 (Scopus)

Integration of genetics and miRNA–target gene network identified disease biology implicated in tissue specificity

Sakaue, S., Hirata, J., Maeda, Y., Kawakami, E., Nii, T., Kishikawa, T., Ishigaki, K., Terao, C., Suzuki, K., Akiyama, M., Suita, N., Masuda, T., Ogawa, K., Yamamoto, K., Saeki, Y., Matsushita, M., Yoshimura, M., Matsuoka, H., Ikari, K., Taniguchi, A. および15人, Yamanaka, H., Kawaji, H., Lassmann, T., Itoh, M., Yoshitomi, H., Ito, H., Ohmura, K., Forrest, A. R. R., Hayashizaki, Y., Carninci, P., Kumanogoh, A., Kamatani, Y., de Hoon, M., Yamamoto, K. & Okada, Y., 1 1 2018, : : Nucleic acids research. 46, 22, p. 11898-11909 12 p.

研究成果: ジャーナルへの寄稿記事

公開
Organ Specificity
Gene Regulatory Networks
MicroRNAs
Biomarkers
Genome-Wide Association Study
2 引用 (Scopus)

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

The International Genomics of Blood Pressure (iGEN-BP) Consortium, 12 1 2018, : : Nature communications. 9, 1, 5052.

研究成果: ジャーナルへの寄稿記事

公開
blood pressure
Blood pressure
descent
loci
Blood Pressure
10 引用 (Scopus)

Optical coherence tomography angiography of the macular microvasculature changes in retinitis pigmentosa

Koyanagi, Y., Murakami, Y., Funatsu, J., Akiyama, M., Nakatake, S., Fujiwara, K., Tachibana, T., Nakao, S., Hisatomi, T., Yoshida, S., Ishibashi, T., Sonoda, K. H. & Ikeda, Y., 2 1 2018, : : Acta Ophthalmologica. 96, 1, p. e59-e67

研究成果: ジャーナルへの寄稿記事

Retinitis Pigmentosa
Optical Coherence Tomography
Microvessels
Angiography
Visual Acuity
2017
84 引用 (Scopus)

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

Akiyama, M., Okada, Y., Kanai, M., Takahashi, A., Momozawa, Y., Ikeda, M., Iwata, N., Ikegawa, S., Hirata, M., Matsuda, K., Iwasaki, M., Yamaji, T., Sawada, N., Hachiya, T., Tanno, K., Shimizu, A., Hozawa, A., Minegishi, N., Tsugane, S., Yamamoto, M. および2人, Kubo, M. & Kamatani, Y., 10 1 2017, : : Nature genetics. 49, 10, p. 1458-1467 10 p.

研究成果: ジャーナルへの寄稿記事

Genome-Wide Association Study
Body Mass Index
Obesity
Population
Lymphocyte Count
5 引用 (Scopus)

Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

Sakamoto, Y., Yamamoto, T., Sugano, N., Takahashi, D., Watanabe, T., Atsumi, T., Nakamura, J., Hasegawa, Y., Akashi, K., Narita, I., Miyamoto, T., Takeuchi, T., Ikari, K., Amano, K., Fujie, A., Kubo, T., Tada, Y., Kaneuji, A., Nakamura, H., Miyamura, T. および70人, Kabata, T., Yamaji, K., Okawa, T., Sudo, A., Ohzono, K., Tanaka, Y., Yasunaga, Y., Matsuda, S., Imai, Y., Nakashima, Y., Motomura, G., Ikemura, S., Yamaguchi, R., Karasuyama, K., Sonoda, K., Nishii, T., Sakai, T., Takao, M., Irie, T., Asano, T., Iwasaki, N., Atsumi, T., Tamaoki, S., Nakanishi, R., Tanabe, S., Kishida, S., Hagiwara, S., Seki, T., Tsukamoto, H., Niiro, H., Arinobu, Y., Akahoshi, M., Mitoma, H., Ayano, M., Kuroda, T., Toyama, Y., Funayama, A., Hanaoka, H., Yamaoka, K., Kawaguchi, Y., Yamanaka, H., Hosozawa, T., Momohara, S., Chino, K., Fujioka, M., Ueshima, K., Ishida, M., Saito, M., Hayashi, S., Ikegami, A., Ichiseki, T., Mizokawa, S., Ohta, Y., Kajino, Y., Sekiya, F., Higuchi, F., Hasegawa, M., Miyamoto, N., Miyazaki, S., Yamaguchi, T., Ando, W., Saito, K., Nakano, K., Kuroda, Y., Yamasaki, T., Akiyama, M., Kubo, M., Kamatani, Y., Iwamoto, Y. & Ikegawa, S., 12 1 2017, : : Scientific reports. 7, 1, 15035.

研究成果: ジャーナルへの寄稿記事

Osteonecrosis
Genome-Wide Association Study
Thigh
Hip Joint
Drinking
3 引用 (Scopus)

Genome-wide association study of neovascular age-related macular degeneration in the Thai population

Ruamviboonsuk, P., Tadarati, M., Singhanetr, P., Wattanapokayakit, S., Kunhapan, P., Wanitchanon, T., Wichukchinda, N., Mushiroda, T., Akiyama, M., Momozawa, Y., Kubo, M. & Mahasirimongkol, S., 11 1 2017, : : Journal of Human Genetics. 62, 11, p. 957-962 6 p.

研究成果: ジャーナルへの寄稿記事

Genome-Wide Association Study
Macular Degeneration
Complement Factor H
Population
Genes
2016
29 引用 (Scopus)

Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis

Okada, Y., Suzuki, A., Ikari, K., Terao, C., Kochi, Y., Ohmura, K., Higasa, K., Akiyama, M., Ashikawa, K., Kanai, M., Hirata, J., Suita, N., Teo, Y. Y., Xu, H., Bae, S. C., Takahashi, A., Momozawa, Y., Matsuda, K., Momohara, S., Taniguchi, A. および9人, Yamada, R., Mimori, T., Kubo, M., Brown, M. A., Raychaudhuri, S., Matsuda, F., Yamanaka, H., Kamatani, Y. & Yamamoto, K., 8 4 2016, : : American journal of human genetics. 99, 2, p. 366-374 9 p.

研究成果: ジャーナルへの寄稿記事

公開
HLA Antigens
Rheumatoid Arthritis
Genes
Major Histocompatibility Complex
Population
13 引用 (Scopus)

Low-frequency coding variants in CETP and CFB are associated with susceptibility of exudative age-related macular degeneration in the Japanese population

Momozawa, Y., Akiyama, M., Kamatani, Y., Arakawa, S., Yasuda, M., Yoshida, S., Oshima, Y., Mori, R., Tanaka, K., Mori, K., Inoue, S., Terasaki, H., Yasuma, T., Honda, S., Miki, A., Inoue, M., Fujisawa, K., Takahashi, K., Yasukawa, T., Yanagi, Y. および5人, Kadonosono, K., Sonoda, K. H., Ishibashi, T., Takahashi, A. & Kubo, M., 11 15 2016, : : Human Molecular Genetics. 25, 22, p. 5027-5034 8 p.

研究成果: ジャーナルへの寄稿記事

Macular Degeneration
Population
Genome-Wide Association Study
Gene Frequency
Genes
2015
22 引用 (Scopus)

Correlation between macular blood flow and central visual sensitivity in retinitis pigmentosa

Murakami, Y., Ikeda, Y., Akiyama, M., Fujiwara, K., Yoshida, N., Nakatake, S., Notomi, S., Nabeshima, T., Hisatomi, T., Enaida, H. & Ishibashi, T., 12 1 2015, : : Acta Ophthalmologica. 93, 8, p. e644-e648

研究成果: ジャーナルへの寄稿記事

Retinitis Pigmentosa
Visual Field Tests
Visual Acuity
Lasers
Blood Vessels
2014
10 引用 (Scopus)

Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa

Akiyama, M., Ikeda, Y., Yoshida, N., Notomi, S., Murakami, Y., Hisatomi, T., Enaida, H. & Ishibashi, T., 5 2014, : : Acta Ophthalmologica. 92, 3, p. e229-e234

研究成果: ジャーナルへの寄稿記事

Retinitis Pigmentosa
Therapeutics
isopropyl unoprostone
Neuroprotective Agents
Therapeutic Uses