• 901 引用
  • 18 h指数
1993 …2019

Research output per year

Pureに変更を加えた場合、すぐここに表示されます。

研究成果

  • 901 引用
  • 18 h指数
  • 44 記事
  • 3 評論記事
  • 1 小調査
2019

Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body

Bai, X., Ihara, E., Otsuka, Y., Tsuruta, S., Hirano, K., Tanaka, Y., Ogino, H., Hirano, M., Chinen, T., Akiho, H., Nakamura, K., Oda, Y. & Ogawa, Y., 8 15 2019, : : European Journal of Pharmacology. 857, 172405.

研究成果: ジャーナルへの寄稿記事

Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension

Kuwabara, Y., Tanaka-Ishikawa, M., Abe, K., Hirano, M., Hirooka, Y., Tsutsui, H., Sunagawa, K. & Hirano, K., 7 1 2019, : : Cardiovascular research. 115, 8, p. 1357-1368 12 p.

研究成果: ジャーナルへの寄稿記事

公開
3 引用 (Scopus)
2018

Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger

Bai, X., Ihara, E., Hirano, K., Tanaka, Y., Nakano, K., Kita, S., Iwamoto, T., Ogino, H., Hirano, M., Oda, Y., Nakamura, K. & Ogawa, Y., 3 2018, : : CMGH. 5, 3, p. 209-221 13 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)
2017
2 引用 (Scopus)
2016
22 引用 (Scopus)
2015

Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter

Tanaka, Y., Ihara, E., Hirano, K., Takahashi, S., Hirano, M., Nakamura, K., Akiho, H., Oda, Y. & Takayanagi, R., 4 5 2015, : : European Journal of Pharmacology. 752, p. 97-105 9 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)
2013

Pivotal role of rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility

Saito, T., Hirano, M., Ide, T., Ichiki, T., Koibuchi, N., Sunagawa, K. & Hirano, K., 1 1 2013, : : Circulation. 127, 1, p. 104-114 11 p.

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)
2012

Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage

Kameda, K., Kikkawa, Y., Hirano, M., Matsuo, S., Sasaki, T. & Hirano, K., 1 1 2012, : : British Journal of Pharmacology. 165, 1, p. 106-119 14 p.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

Mechanisms underlying potentiation of endothelin-1-induced myofilament Ca 2+ sensitization after subarachnoid hemorrhage

Kikkawa, Y., Matsuo, S., Kameda, K., Hirano, M., Nakamizo, A., Sasaki, T. & Hirano, K., 2 1 2012, : : Journal of Cerebral Blood Flow and Metabolism. 32, 2, p. 341-352 12 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)
2011

[Molecular mechanisms underlying the increased contractility of smooth muscle in cerebral artery after subarachnoid hemmorhage].

Kikkawa, Y., Sasaki, T., Hirano, M. & Hirano, K., 12 1 2011, : : Fukuoka igaku zasshi = Hukuoka acta medica. 102, 12, p. 325-332 8 p.

研究成果: ジャーナルへの寄稿評論記事

Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel

Nishioka, K., Nishida, M., Ariyoshi, M., Jian, Z., Saiki, S., Hirano, M., Nakaya, M., Sato, Y., Kita, S., Iwamoto, T., Hirano, K., Inoue, R. & Kurose, H., 10 1 2011, : : Arteriosclerosis, thrombosis, and vascular biology. 31, 10, p. 2278-2286 9 p.

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)
2010

Current perspective on the role of the thrombin receptor in cerebral vasospasm after subarachnoid hemorrhage

Hirano, K. & Hirano, M., 11 22 2010, : : Journal of Pharmacological Sciences. 114, 2, p. 127-133 7 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)
26 引用 (Scopus)

Involvement of reactive oxygen species in thrombin-induced pulmonary vasoconstriction

Maki, J., Hirano, M., Hoka, S., Kanaide, H. & Hirano, K., 12 1 2010, : : American Journal of Respiratory and Critical Care Medicine. 182, 11, p. 1435-1444 10 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)
11 引用 (Scopus)

Upregulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortas

Aman, M., Hirano, M., Kanaide, H. & Hirano, K., 10 1 2010, : : Journal of Vascular Research. 47, 6, p. 494-506 13 p.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)
2009

Enhanced contractile response of the basilar artery to platelet-derived growth factor in subarachnoid hemorrhage

Maeda, Y., Hirano, K., Hirano, M., Kikkawa, Y., Kameda, K., Sasaki, T. & Kanaide, H., 2 1 2009, : : Stroke. 40, 2, p. 591-596 6 p.

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca2+ influx in vascular endothelial cells

Hirano, K., Hirano, M. & Hanada, A., 10 1 2009, : : Journal of Cellular Biochemistry. 108, 2, p. 499-507 9 p.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)
2007

Distinct Ca2+ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR1 and PAR4) in vascular endothelial cells

Hirano, K., Nomoto, N., Hirano, M., Momota, F., Hanada, A. & Kanaide, H., 8 1 2007, : : Journal of Pharmacology and Experimental Therapeutics. 322, 2, p. 668-677 10 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

Involvement of Na +-Ca 2+ exchanger in cAMP-mediated relaxation in mice aorta: Evaluation using transgenic mice

Karashima, E., Nishimura, J., Iwamoto, T., Hirano, K., Hirano, M., Kita, S., Harada, M. & Kanaide, H., 2 1 2007, : : British Journal of Pharmacology. 150, 4, p. 434-444 11 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Plasmin induces endothelium-dependent nitric oxide-mediated relaxation in the porcine coronary artery

Fujiyoshi, T., Hirano, K., Hirano, M., Nishimura, J., Takahashi, S. & Kanaide, H., 4 1 2007, : : Arteriosclerosis, thrombosis, and vascular biology. 27, 4, p. 949-954 6 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Rac1-dependent transcriptional up-regulation of p27Kip1 by homophilic cell-cell contact in vascular endothelial cells

Hirano, M., Kanaide, H. & Hirano, K., 10 1 2007, : : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 10, p. 1500-1510 11 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

Up-regulation of proteinase-activated receptor 1 and increased contractile responses to thrombin after subarachnoid haemorrhage

Maeda, Y., Hirano, K., Kai, Y., Hirano, M., Suzuki, S. O., Sasaki, T. & Kanaide, H., 12 1 2007, : : British Journal of Pharmacology. 152, 7, p. 1131-1139 9 p.

研究成果: ジャーナルへの寄稿記事

27 引用 (Scopus)
2006

Involvement of Gi/o in the PAR-4-induced NO production in endothelial cells

Momota, F., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., 4 7 2006, : : Biochemical and Biophysical Research Communications. 342, 2, p. 365-371 7 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury

Fukunaga, R., Hirano, K., Hirano, M., Niiro, N., Nishimura, J., Maehara, Y. & Kanaide, H., 11 24 2006, : : American Journal of Physiology - Heart and Circulatory Physiology. 291, 5, p. H2388-H2395

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)
2005

Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery

Shiga, N., Hirano, K., Hirano, M., Nishimura, J., Nawata, H. & Kanaide, H., 3 13 2005, : : Circulation research. 96, 9, p. 1014-1021 8 p.

研究成果: ジャーナルへの寄稿記事

68 引用 (Scopus)

Physiology and pathophysiology of proteinase-activated receptors (PARs): Regulation of the expression of PARs

Hirano, K., Yufu, T., Hirano, M., Nishimura, J. & Kanaide, H., 1 1 2005, : : Journal of Pharmacological Sciences. 97, 1, p. 31-37 7 p.

研究成果: ジャーナルへの寄稿小調査

16 引用 (Scopus)

Rac1 regulation of surface expression of protease-activated receptor-1 and responsiveness to thrombin in vascular smooth muscle cells

Yufu, T., Hirano, K., Bi, D., Hirano, M., Nishimura, J., Iwamoto, Y. & Kanaide, H., 7 1 2005, : : Arteriosclerosis, thrombosis, and vascular biology. 25, 7, p. 1506-1511 6 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)
2004

A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells

Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., 7 16 2004, : : FEBS Letters. 570, 1-3, p. 149-154 6 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells

Koga, M., Hirano, K., Hirano, M., Nishimura, J., Nakano, H. & Kanaide, H., 11 5 2004, : : Biochemical and Biophysical Research Communications. 324, 1, p. 321-325 5 p.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

Facilitation of proteasomal degradation of p27Kip1 by N-terminal cleavage and their sequence requirements

Hirano, K., Ihara, E., Hirano, M., Nishimura, J., Nawata, H. & Kanaide, H., 9 10 2004, : : FEBS Letters. 574, 1-3, p. 111-115 5 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells

Nakayama, T., Hirano, K., Hirano, M., Nishimura, J., Kuga, H., Nakamura, K., Takahashi, S. & Kanaide, H., 7 1 2004, : : Biochemical Pharmacology. 68, 1, p. 23-32 10 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle

Hirano, K., Hirano, M. & Kanaide, H., 12 1 2004, : : Journal of Smooth Muscle Research. 40, 6, p. 219-236 18 p.

研究成果: ジャーナルへの寄稿評論記事

60 引用 (Scopus)

Transduction of the N-Terminal Fragments of MYPT1 Enhances Myofilament Ca2+ Sensitivity in an Intact Coronary Artery

Hirano, K., Derkach, D. N., Hirano, M., Nishimura, J., Takahashi, S. & Kanaide, H., 3 1 2004, : : Arteriosclerosis, thrombosis, and vascular biology. 24, 3, p. 464-469 6 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)
2003

Intracellular alkalinization induces Ca2+ influx via non-voltage-operated Ca2+ channels in rat aortic smooth muscle cells

Eto, W., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., 12 2003, : : Cell Calcium. 34, 6, p. 477-484 8 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

Protein kinase network in the regulation of phosphorylation and dephosphorylation of smooth muscle myosin light chain

Hirano, K., Derkach, D. N., Hirano, M., Nishimura, J. & Kanaide, H., 6 1 2003, : : Molecular and cellular biochemistry. 248, 1-2, p. 105-114 10 p.

研究成果: ジャーナルへの寄稿評論記事

70 引用 (Scopus)

Sequence requirement for nuclear localization and growth inhibition of p27Kip1R, a degradation-resistant isoform of p27Kip1

Hirano, K., Zeng, Y., Hirano, M., Nishimura, J. & Kanaide, H., 5 1 2003, : : Journal of Cellular Biochemistry. 89, 1, p. 191-202 12 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)
2002

Mechanism of down-regulation of L-type Ca2+ channel in the proliferating smooth muscle cells of rat aorta

Ihara, E., Hirano, K., Hirano, M., Nishimura, J., Nawata, H. & Kanaide, H., 10 16 2002, : : Journal of Cellular Biochemistry. 87, 2, p. 242-251 10 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)
2001

Cloning and functional expression of a degradation-resistant novel isoform of p27Kip1

Hirano, K., Hirano, M., Zeng, Y., Nishimura, J., Hara, K., Muta, K., Nawata, H. & Kanaide, H., 1 1 2001, : : Biochemical Journal. 353, 1, p. 51-57 7 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Transcriptional up-regulation of p27Kip1 during contact-induced growth arrest in vascular endothelial cells

Hirano, M., Hirano, K., Nishimura, J. & Kanaide, H., 12 10 2001, : : Experimental Cell Research. 271, 2, p. 356-367 12 p.

研究成果: ジャーナルへの寄稿記事

32 引用 (Scopus)
2000

Dissociation between the Ca2+ signal and tube formation induced by vascular endothelial growth factor in bovine aortic endothelial cells

Kawasaki, J., Hirano, K., Hirano, M., Nishimura, J., Nakatsuka, A., Fujishima, M. & Kanaide, H., 6 9 2000, : : European Journal of Pharmacology. 398, 1, p. 19-29 11 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor

Zeng, Y., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., 7 21 2000, : : Biochemical and Biophysical Research Communications. 274, 1, p. 37-42 6 p.

研究成果: ジャーナルへの寄稿記事

50 引用 (Scopus)

Mitogen-induced up-regulation of non-smooth muscle isoform of α- tropomyosin in rat aortic smooth muscle cells

Hirano, K., Hirano, M., Eto, W., Nishimura, J. & Kanaide, H., 10 13 2000, : : European Journal of Pharmacology. 406, 2, p. 209-218 10 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)
1999

Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells

Hirano, M., Niiro, N., Hirano, K., Nishimura, J., Hartshorne, D. J. & Kanaide, H., 1 19 1999, : : Biochemical and Biophysical Research Communications. 254, 2, p. 490-496 7 p.

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

Troglitazone inhibits the capacitative Ca2+ entry in endothelial cells

Kawasaki, J., Hirano, K., Hirano, M., Nishimura, J., Fujishima, M. & Kanaide, H., 5 28 1999, : : European Journal of Pharmacology. 373, 1, p. 111-120 10 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)
1997
8 引用 (Scopus)
1995

Endothall thioanhydride inhibits protein phosphatases-1 and -2A in vivo

Erdodi, F., Toth, B., Hirano, K., Hirano, M., Hartshorne, D. J. & Gergely, P., 1995, : : American Journal of Physiology - Cell Physiology. 269, 5 38-5

研究成果: ジャーナルへの寄稿記事

51 引用 (Scopus)
1993
18 引用 (Scopus)