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研究成果 2000 2018

  • 1053 引用
  • 19 h指数
  • 41 記事
2018
1 引用 (Scopus)

BubR1 insufficiency impairs angiogenesis in aging and in experimental critical limb ischemic mice

Okadome, J., Matsumoto, T., Yoshiya, K., Matsuda, D., Tamada, K., Onimaru, M., Nakano, K., Egashira, K., Yonemitsu, Y. & Maehara, Y., 8 2018, : : Journal of Vascular Surgery. 68, 2, p. 576-586.e1

研究成果: ジャーナルへの寄稿記事

Extremities
Ambulatory Surgical Procedures
Muscles
Ischemia
Vascular Endothelial Growth Factor A
2017
1 引用 (Scopus)

Calcineurin inhibitors exacerbate coronary arteritis via the MyD88 signalling pathway in a murine model of Kawasaki disease

Murata, K., Motomura, Y., Tanaka, T., Kanno, S., Yano, T., Onimaru, M., Shimoyama, A., Nishio, H., Sakai, Y., Oh-Hora, M., Hara, H., Fukase, K., Takada, H., Masuda, S., Ohga, S., Yamasaki, S. & Hara, T., 10 2017, : : Clinical and Experimental Immunology. 190, 1, p. 54-67 14 p.

研究成果: ジャーナルへの寄稿記事

Arteritis
Mucocutaneous Lymph Node Syndrome
Blood Vessels
Severe Combined Immunodeficiency
Coronary Vessels
11 引用 (Scopus)

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

Semba, Y., Harada, A., Maehara, K., Oki, S., Meno, C., Ueda, J., Yamagata, K., Suzuki, A., Onimaru, M., Nogami, J., Okada, S., Akashi, K. & Ohkawa, Y., 9 1 2017, : : Nucleic acids research. 45, 15, p. 8758-8772 15 p.

研究成果: ジャーナルへの寄稿記事

DNA Helicases
Embryonic Stem Cells
Chromatin
Gene Expression
Histones
2016
7 引用 (Scopus)

Activation of Nod1 signaling induces fetal growth restriction and death through fetal and maternal vasculopathy

Inoue, H., Nishio, H., Takada, H., Sakai, Y., Nanishi, E., Ochiai, M., Onimaru, M., Chen, S. J., Matsui, T. & Hara, T., 3 15 2016, : : Journal of Immunology. 196, 6, p. 2779-2787 9 p.

研究成果: ジャーナルへの寄稿記事

Fetal Death
Fetal Development
Nucleotides
Mothers
Fetus
2 引用 (Scopus)

BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality

Ikawa-Yoshida, A., Matsumoto, T., Okano, S., Aoyagi, Y., Matsubara, Y., Furuyama, T., Nakatsu, Y., Tsuzuki, T., Onimaru, M., Ohkusa, T., Nomura, M. & Maehara, Y., 8 26 2016, : : Scientific reports. 6, 32399.

研究成果: ジャーナルへの寄稿記事

Liver Regeneration
Hepatectomy
Desmocollins
Hepatocytes
Liver
2 引用 (Scopus)

BUBR1 insufficiency in mice increases their sensitivity to oxidative stress

Matsuda, D., Matsumoto, T., Honma, K., Ikawa-Yoshida, A., Onimaru, M., Furuyama, T., Nakatsu, Y., Tsuzuki, T. & Maehara, Y., 11 1 2016, : : In Vivo. 30, 6, p. 769-776 8 p.

研究成果: ジャーナルへの寄稿記事

Oxidative stress
Oxidative Stress
Water
Chromosomes
Tumors
12 引用 (Scopus)

Peritoneal dissemination requires an Sp1-dependent CXCR4/CXCL12 signaling axis and extracellular matrix-directed spheroid formation

Kasagi, Y., Harada, Y., Morodomi, Y., Iwai, T., Saito, S., Yoshida, K., Oki, E., Saeki, H., Ohgaki, K., Sugiyama, M., Onimaru, M., Maehara, Y. & Yonemitsu, Y., 1 15 2016, : : Cancer Research. 76, 2, p. 347-357 11 p.

研究成果: ジャーナルへの寄稿記事

Extracellular Matrix
Peritoneal Cavity
Neoplasms
Peritoneal Lavage
Gastrointestinal Neoplasms
2015
17 引用 (Scopus)

Activation of an innate immune receptor, Nod1, accelerates atherogenesis in Apoe2/2 mice

Kanno, S., Nishio, H., Tanaka, T., Motomura, Y., Murata, K., Ihara, K., Onimaru, M., Yamasaki, S., Kono, H., Sueishi, K. & Hara, T., 1 15 2015, : : Journal of Immunology. 194, 2, p. 773-780 8 p.

研究成果: ジャーナルへの寄稿記事

Apolipoprotein E2
Atherosclerosis
Apolipoproteins E
Knockout Mice
Blood Vessels
9 引用 (Scopus)

BubR1 insufficiency inhibits neointimal hyperplasia through impaired vascular smooth muscle cell proliferation in mice

Kyuragi, R., Matsumoto, T., Harada, Y., Saito, S., Onimaru, M., Nakatsu, Y., Tsuzuki, T., Nomura, M., Yonemitsu, Y. & Maehara, Y., 2 2 2015, : : Arteriosclerosis, thrombosis, and vascular biology. 35, 2, p. 341-347 7 p.

研究成果: ジャーナルへの寄稿記事

Vascular Smooth Muscle
Smooth Muscle Myocytes
Hyperplasia
Cell Proliferation
Bone Marrow Transplantation
2014
Gingiva
Squamous Cell Carcinoma
Lymph Nodes
Neoplasm Metastasis
Cell Line
6 引用 (Scopus)
Plasminogen
Chondrocytes
Integrins
Transforming Growth Factor beta
Collagen
2013
19 引用 (Scopus)

Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: Results from the Hisayama Study

Nakano, T., Ninomiya, T., Sumiyoshi, S., Onimaru, M., Fujii, H., Itabe, H., Nakashima, Y., Sueishi, K., Tsuruya, K., Oda, Y., Kitazono, T. & Kiyohara, Y., 8 2013, : : Kidney International. 84, 2, p. 373-380 8 p.

研究成果: ジャーナルへの寄稿記事

Glomerular Filtration Rate
Chronic Renal Insufficiency
Coronary Artery Disease
Hemorrhage
Coronary Vessels
34 引用 (Scopus)

DVC1-0101 to treat peripheral arterial disease: A phase I/IIa open-label dose-escalation clinical trial

Yonemitsu, Y., Matsumoto, T., Itoh, H., Okazaki, J., Uchiyama, M., Yoshida, K., Onimaru, M., Onohara, T., Inoguchi, H., Kyuragi, R., Shimokawa, M., Ban, H., Tanaka, M., Inoue, M., Shu, T., Hasegawa, M., Nakanishi, Y. & Maehara, Y., 3 2013, : : Molecular Therapy. 21, 3, p. 707-714 8 p.

研究成果: ジャーナルへの寄稿記事

Peripheral Arterial Disease
Sendai virus
Clinical Trials
Genes
Fibroblast Growth Factor 2
2 引用 (Scopus)

Ex vivo generation of highly purified and activated natural killer cells from human peripheral blood

Saito, S., Harada, Y., Morodomi, Y., Onimaru, M., Yoshida, K., Kyuragi, R., Matsubara, H. & Yonemitsu, Y., 8 1 2013, : : Human Gene Therapy Methods. 24, 4, p. 241-252 12 p.

研究成果: ジャーナルへの寄稿記事

Natural Killer Cells
NK Cell Lectin-Like Receptor Subfamily K
Adoptive Immunotherapy
Neoplasms
K562 Cells
2012
16 引用 (Scopus)

BioKnife, a uPA activity-dependent oncolytic sendai virus, eliminates pleural spread of malignant mesothelioma via simultaneous stimulation of uPA expression

Morodomi, Y., Yano, T., Kinoh, H., Harada, Y., Saito, S., Kyuragi, R., Yoshida, K., Onimaru, M., Shoji, F., Yoshida, T., Ito, K., Shikada, Y., Maruyama, R., Hasegawa, M., Maehara, Y. & Yonemitsu, Y., 4 2012, : : Molecular Therapy. 20, 4, p. 769-777 9 p.

研究成果: ジャーナルへの寄稿記事

Oncolytic Viruses
Sendai virus
Urokinase Plasminogen Activator Receptors
NFI Transcription Factors
Pleural Cavity
13 引用 (Scopus)

Endogenous cardiac troponin T modulates Ca2+-mediated smooth muscle contraction

Kajioka, S., Takahashi-Yanaga, F., Shahab, N., Onimaru, M., Matsuda, M., Takahashi, R., Asano, H., Morita, H., Morimoto, S., Yonemitsu, Y., Hayashi, M., Seki, N., Sasaguri, T., Hirata, M., Nakayama, S. & Naito, S., 12 1 2012, : : Scientific reports. 2, 979.

研究成果: ジャーナルへの寄稿記事

Troponin T
Muscle Contraction
Smooth Muscle
Actin Cytoskeleton
Tropomyosin
9 引用 (Scopus)
Urinary Bladder Neck Obstruction
rho-Associated Kinases
Carbachol
Protein Kinase C
Smooth Muscle
3 引用 (Scopus)

Transfection of hypoxia-inducible factor-1 decoy oligodeoxynucleotides suppresses expression of vascular endothelial growth factor in oral squamous cell carcinoma cells

Imai, M., Ishibashi, H., Nariai, Y., Kanno, T., Sekine, J., Onimaru, M. & Mori, Y., 10 1 2012, : : Journal of Oral Pathology and Medicine. 41, 9, p. 675-681 7 p.

研究成果: ジャーナルへの寄稿記事

Hypoxia-Inducible Factor 1
Oligodeoxyribonucleotides
Vascular Endothelial Growth Factor A
Transfection
Squamous Cell Carcinoma
2011
18 引用 (Scopus)

Angiogenic and lymphangiogenic cascades in the tumor microenvironment

Onimaru, M. & Yonemitsu, Y., 1 1 2011, : : Frontiers in Bioscience - Scholar. 3 S, 1, p. 216-225 10 p.

研究成果: ジャーナルへの寄稿記事

Tumor Microenvironment
Tumors
Lymph
Blood
Angiogenesis Inducing Agents
11 引用 (Scopus)

Antagonism of VEGF by genetically engineered dendritic cells is essential to induce antitumor immunity against malignant ascites

Sugiyama, M., Kakeji, Y., Tsujitani, S., Harada, Y., Onimaru, M., Yoshida, K., Tanaka, S., Emi, Y., Morita, M., Morodomi, Y., Hasegawa, M., Maehara, Y. & Yonemitsu, Y., 3 1 2011, : : Molecular Cancer Therapeutics. 10, 3, p. 540-549 10 p.

研究成果: ジャーナルへの寄稿記事

Ascites
Dendritic Cells
Vascular Endothelial Growth Factor A
Immunity
Phosphotransferases
23 引用 (Scopus)

High podoplanin expression in cancer cells predicts lower incidence of nodal metastasis in patients with lung squamous cell carcinoma

Suzuki, H., Onimaru, M., Koga, T., Takeshita, M., Yano, T., Maehara, Y., Nakamura, S. & Sueishi, K., 2 15 2011, : : Pathology Research and Practice. 207, 2, p. 111-115 5 p.

研究成果: ジャーナルへの寄稿記事

Squamous Cell Carcinoma
Neoplasm Metastasis
Lung
Incidence
Neoplasms
2010
14 引用 (Scopus)
Angiopoietin-1
Matrix Metalloproteinase 14
Angiopoietin-2
Endothelial Cells
Tissue Inhibitor of Metalloproteinase-3
27 引用 (Scopus)
Lung Neoplasms
Vascular Endothelial Growth Factor C
Lymphangiogenesis
Neoplasms
Squamous Cell Carcinoma
16 引用 (Scopus)

Urokinase-targeted fusion by oncolytic sendai virus eradicates orthotopic glioblastomas by pronounced synergy with interferon-β gene

Hasegawa, Y., Kinoh, H., Iwadate, Y., Onimaru, M., Ueda, Y., Harada, Y., Saito, S., Furuya, A., Saegusa, T., Morodomi, Y., Hasegawa, M., Saito, S., Aoki, I., Saeki, N. & Yonemitsu, Y., 10 2010, : : Molecular Therapy. 18, 10, p. 1778-1786 9 p.

研究成果: ジャーナルへの寄稿記事

Oncolytic Viruses
Sendai virus
Urokinase-Type Plasminogen Activator
Glioblastoma
Interferons
2009
34 引用 (Scopus)

Autocrine Loop between Vascular Endothelial Growth Factor (VEGF)-C and VEGF Receptor-3 Positively Regulates Tumor-Associated Lymphangiogenesis in Oral Squamoid Cancer Cells

Matsuura, M., Onimaru, M., Yonemitsu, Y., Suzuki, H., Nakano, T., Ishibashi, H., Shirasuna, K. & Sueishi, K., 1 1 2009, : : American Journal of Pathology. 175, 4, p. 1709-1721 13 p.

研究成果: ジャーナルへの寄稿記事

Vascular Endothelial Growth Factor Receptor-3
Lymphangiogenesis
Vascular Endothelial Growth Factor C
Mouth Neoplasms
Neoplasms
32 引用 (Scopus)

VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B

Onimaru, M., Yonemitsu, Y., Fujii, T., Tanii, M., Nakano, T., Nakagawa, K., Kohno, R. I., Hasegawa, M., Nishikawa, S. I. & Sueishi, K., 11 1 2009, : : American Journal of Physiology - Heart and Circulatory Physiology. 297, 5, p. H1685-H1696

研究成果: ジャーナルへの寄稿記事

Proto-Oncogene Proteins c-sis
Lymphangiogenesis
Vascular Endothelial Growth Factor C
Fibroblast Growth Factor 2
Endothelial Cells
2008
76 引用 (Scopus)

Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration

Murakami, Y., Ikeda, Y., Yonemitsu, Y., Onimaru, M., Nakagawa, K., Kohno, R. I., Miyazaki, M., Hisatomi, T., Nakamura, M., Yabe, T., Hasegawa, M., Ishibashi, T. & Sueishi, K., 11 2008, : : American Journal of Pathology. 173, 5, p. 1326-1338 13 p.

研究成果: ジャーナルへの寄稿記事

Apoptosis Inducing Factor
Retinal Degeneration
Retinitis Pigmentosa
Apoptosis
Animal Models
24 引用 (Scopus)
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Diabetic Angiopathies
Nitric Oxide
Up-Regulation
Extremities
34 引用 (Scopus)

VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis

Fujii, T., Yonemitsu, Y., Onimaru, M., Inoue, M., Hasegawa, M., Kuwano, H. & Sueishi, K., 9 1 2008, : : Atherosclerosis. 200, 1, p. 51-57 7 p.

研究成果: ジャーナルへの寄稿記事

Fibroblast Growth Factor 2
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
Up-Regulation
Therapeutics
2006
8 引用 (Scopus)

A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia

Kaneko, K., Yonemitsu, Y., Fujii, T., Onimaru, M., Jin, C. H., Inoue, M., Hasegawa, M., Onohara, T., Maehara, Y. & Sueishi, K., 4 1 2006, : : American Journal of Physiology - Heart and Circulatory Physiology. 290, 4, p. H1484-H1492

研究成果: ジャーナルへの寄稿記事

Free Radical Scavengers
Fibroblast Growth Factor 2
Hindlimb
Ischemia
Reperfusion
48 引用 (Scopus)

Diabetic microangiopathy in ischemic limb is a disease of disturbance of the platelet-derived growth factor-BB/protein kinase C axis but not of impaired expression of angiogenic factors

Tanii, M., Yonemitsu, Y., Fujii, T., Shikada, Y., Kohno, R. I., Onimaru, M., Okano, S., Inoue, M., Hasegawa, M., Onohara, T., Maehara, Y. & Sueishi, K., 1 1 2006, : : Circulation research. 98, 1, p. 55-62 8 p.

研究成果: ジャーナルへの寄稿記事

Diabetic Angiopathies
Angiogenesis Inducing Agents
Protein Kinase C
Extremities
Streptozocin
57 引用 (Scopus)

Induction of efficient antitumor immunity using dendritic cells activated by recombinant Sendai virus and its modulation by exogenous IFN-β gene

Shibata, S., Okano, S., Yonemitsu, Y., Onimaru, M., Sata, S., Nagata-Takeshita, H., Inoue, M., Zhu, T., Hasegawa, M., Moroi, Y., Furue, M. & Sueishi, K., 9 15 2006, : : Journal of Immunology. 177, 6, p. 3564-3576 13 p.

研究成果: ジャーナルへの寄稿記事

Sendai virus
Dendritic Cells
Immunity
Genes
Immunotherapy
58 引用 (Scopus)

Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2-mediated therapeutic neovascularization: Critical role of the inflammatory/arteriogenic pathway

Fujii, T., Yonemitsu, Y., Onimaru, M., Tanii, M., Nakano, T., Egashira, K., Takehara, T., Inoue, M., Hasegawa, M., Kuwano, H. & Sueishi, K., 11 1 2006, : : Arteriosclerosis, thrombosis, and vascular biology. 26, 11, p. 2483-2489 7 p.

研究成果: ジャーナルへの寄稿記事

Chemokine CCL2
Fibroblast Growth Factor 2
Vascular Endothelial Growth Factor A
Therapeutics
CCR2 Receptors
33 引用 (Scopus)

The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium

Ikeda, Y., Yonemitsu, Y., Onimaru, M., Nakano, T., Miyazaki, M., Kohno, R. I., Nakagawa, K., Ueno, A., Sueishi, K. & Ishibashi, T., 11 1 2006, : : Experimental Eye Research. 83, 5, p. 1031-1040 10 p.

研究成果: ジャーナルへの寄稿記事

Vascular Endothelial Growth Factors
Vascular Endothelial Growth Factor D
Vascular Endothelial Growth Factor C
Retinal Pigment Epithelium
Vascular Endothelial Growth Factor A
2005
24 引用 (Scopus)

Cytoplasmic expression and extracellular deposition of an antiangiogenic factor, pigment epithelium-derived factor, in human atherosclerotic plaques

Baba, H., Yonemitsu, Y., Nakano, T., Onimaru, M., Miyazaki, M., Ikeda, Y., Sumiyoshi, S., Ueda, Y., Hasegawa, M., Yoshino, I., Maehara, Y. & Sueishi, K., 9 1 2005, : : Arteriosclerosis, thrombosis, and vascular biology. 25, 9, p. 1938-1944 7 p.

研究成果: ジャーナルへの寄稿記事

Atherosclerotic Plaques
Coronary Vessels
Staining and Labeling
Microvessels
Atherosclerosis
70 引用 (Scopus)

Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas

Shikada, Y., Yonemitsu, Y., Koga, T., Onimaru, M., Nakano, T., Okano, S., Sata, S., Nakagawa, K., Yoshino, I., Maehara, Y. & Sueishi, K., 8 15 2005, : : Cancer Research. 65, 16, p. 7241-7248 8 p.

研究成果: ジャーナルへの寄稿記事

Platelet-Derived Growth Factor
Non-Small Cell Lung Carcinoma
Vascular Endothelial Growth Factor A
Neoplasms
Cell Line
2004
66 引用 (Scopus)

Essential role of PDGFRα-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo role of PDGFRα during angiogenesis

Tsutsumi, N., Yonemitsu, Y., Shikada, Y., Onimaru, M., Tanii, M., Okano, S., Kaneko, K., Hasegawa, M., Hashizume, M., Maehara, Y. & Sueishi, K., 5 14 2004, : : Circulation research. 94, 9, p. 1186-1194 9 p.

研究成果: ジャーナルへの寄稿記事

70-kDa Ribosomal Protein S6 Kinases
Platelet-Derived Growth Factor Receptors
Sirolimus
Neoplasms
Vascular Endothelial Growth Factor A
2003
20 引用 (Scopus)

Recombinant Sendai virus vectors for activated T lymphocytes

Okano, S., Yonemitsu, Y., Nagata, S., Sata, S., Onimaru, M., Nakagawa, K., Tomita, Y., Kishihara, K., Hashimoto, S., Nakashima, Y., Sugimachi, K., Hasegawa, M. & Sueishi, K., 8 1 2003, : : Gene Therapy. 10, 16, p. 1381-1391 11 p.

研究成果: ジャーナルへの寄稿記事

Sendai virus
T-Lymphocytes
Antigens
Genetic Therapy
Genes
2002
71 引用 (Scopus)

Fibroblast growth factor-2 gene transfer can stimulate hepatocyte growth factor expression irrespective of hypoxia-mediated downregulation in ischemic limbs

Onimaru, M., Yonemitsu, Y., Tanii, M., Nakagawa, K., Masaki, I., Okano, S., Ishibashi, H., Shirasuna, K., Hasegawa, M. & Sueishi, K., 11 15 2002, : : Circulation research. 91, 10, p. 923-930 8 p.

研究成果: ジャーナルへの寄稿記事

Hepatocyte Growth Factor
Fibroblast Growth Factor 2
Down-Regulation
Extremities
Genes
2001
29 引用 (Scopus)

Hypoxia-induced angiogenesis of cultured human salivary gland carcinoma cells enhances vascular endothelial growth factor production and basic fibroblast growth factor release

Ishibashi, H., Shiratuchi, T., Nakagawa, K., Onimaru, M., Sugiura, T., Sueishi, K. & Shirasuna, K., 1 1 2001, : : Oral Oncology. 37, 1, p. 77-83 7 p.

研究成果: ジャーナルへの寄稿記事

Fibroblast Growth Factor 2
Conditioned Culture Medium
Salivary Glands
Vascular Endothelial Growth Factor A
Carcinoma
2000
96 引用 (Scopus)

Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor/β1, and tissue factor and also cell growth and invasion activities

Ishibashi, H., Nakagawa, K., Onimaru, M., Castellanous, E. J., Kaneda, Y., Nakashima, Y., Shirasuna, K. & Sueishi, K., 12 7 2000, : : Cancer Research. 60, 22, p. 6531-6536 6 p.

研究成果: ジャーナルへの寄稿記事

Oligodeoxyribonucleotides
Thromboplastin
Transforming Growth Factors
Vascular Endothelial Growth Factor A
Carcinoma