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研究成果 2004 2019

2019

Logical design of oral glucose ingestion pattern minimizing blood glucose in humans

Fujii, M., Murakami, Y., Karasawa, Y., Sumitomo, Y., Fujita, S., Koyama, M., Uda, S., Kubota, H., Inoue, H., Konishi, K., Oba, S., Ishii, S. & Kuroda, S., 12 1 2019, : : npj Systems Biology and Applications. 5, 1, 31.

研究成果: ジャーナルへの寄稿記事

公開
Glucose
Blood
Blood Glucose
Eating
Insulin

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. I. & Kuroda, S., 1 2019, : : Genes to Cells. 24, 1, p. 82-93 12 p.

研究成果: ジャーナルへの寄稿記事

Insulin
Phosphorylation
Proteins
Protein Kinases
Hepatocellular Carcinoma
1 引用 (Scopus)

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Ohigashi, I., Tanaka, Y., Kondo, K., Fujimori, S., Kondo, H., Palin, A. C., Hoffmann, V., Kozai, M., Matsushita, Y., Uda, S., Motosugi, R., Hamazaki, J., Kubota, H., Murata, S., Tanaka, K., Katagiri, T., Kosako, H. & Takahama, Y., 11 26 2019, : : Cell Reports. 29, 9, p. 2901-2916.e6

研究成果: ジャーナルへの寄稿記事

公開
Epithelial Cells
Cytology
Cyclin D1
Proteasome Endopeptidase Complex
Proteomics
2018
1 引用 (Scopus)
Western Blotting
Insulin
Liver

Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects

Ohashi, K., Fujii, M., Uda, S., Kubota, H., Komada, H., Sakaguchi, K., Ogawa, W. & Kuroda, S., 2018, : : npj Systems Biology and Applications. 4, 14.

研究成果: ジャーナルへの寄稿記事

公開
Insulin
Liver
Serum
Type 2 Diabetes Mellitus
Glucose
4 引用 (Scopus)

Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects

Ohashi, K., Fujii, M., Uda, S., Kubota, H., Komada, H., Sakaguchi, K., Ogawa, W. & Kuroda, S., 12 1 2018, : : npj Systems Biology and Applications. 4, 1, 14.

研究成果: ジャーナルへの寄稿記事

Insulin
Clearance
Decrease
Diabetes Mellitus
Liver
3 引用 (Scopus)

In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

Kubota, H., Uda, S., Matsuzaki, F., Yamauchi, Y. & Kuroda, S., 7 25 2018, : : Cell Systems. 7, 1, p. 118-128.e3

研究成果: ジャーナルへの寄稿記事

Insulin
Liver
Hormones
Homeostasis
Glucose Clamp Technique

Matrix rank minimization approach to signal recovery and nonlinear function estimation for nonlinear ARX model with input nonlinearity

Konishi, K., Fujii, M., Kunida, K., Uda, S. & Kuroda, S., 2 7 2018, 2017 Asian Control Conference, ASCC 2017. Institute of Electrical and Electronics Engineers Inc., p. 1428-1431 4 p. (2017 Asian Control Conference, ASCC 2017; 巻数 2018-January).

研究成果: 著書/レポートタイプへの貢献会議での発言

Nonlinear Estimation
Function Estimation
Autoregressive Model
Nonlinear Function
Nonlinear Model

Matrix rank minimization approach to signal recovery and nonlinear function estimation for nonlinear ARX model with input nonlinearity

Konishi, K., Fujii, M., Kunida, K., Uda, S. & Kuroda, S., 2 8 2018, Control Conference (ASCC), 2017 11th Asian. IEEE

研究成果: 著書/レポートタイプへの貢献会議での発言

Recovery
Signal transduction
Systems Biology

Sparse Gaussian graphical model with missing values

Uda, S. & Kubota, H., 1 8 2018, Proceedings of the 21st Conference of Open Innovations Association, FRUCT 2017. IEEE Computer Society, p. 336-343 8 p.

研究成果: 著書/レポートタイプへの貢献会議での発言

Signal transduction
Molecular interactions
Factorization
Genes
Proteins

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 2018, : : iScience. 7, p. 212-229

研究成果: ジャーナルへの寄稿記事

Gene Regulatory Networks
Metabolic Networks and Pathways
Insulin
Immediate-Early Genes
Metabolomics
7 引用 (Scopus)

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K. I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 9 28 2018, : : iScience. 7, p. 212-229 18 p.

研究成果: ジャーナルへの寄稿記事

公開
Gene Regulatory Networks
Metabolic Networks and Pathways
insulin
Insulin
Immediate-Early Genes
2017
2 引用 (Scopus)

System identification of signaling dependent gene expression with different time-scale data

Tsuchiya, T., Fujii, M., Matsuda, N., Kunida, K., Uda, S., Kubota, H., Konishi, K. & Kuroda, S., 12 2017, : : PLoS Computational Biology. 13, 12, e1005913.

研究成果: ジャーナルへの寄稿記事

System Identification
Gene expression
Gene Expression
gene expression
Identification (control systems)
2016
12 引用 (Scopus)

Analysis of cellular signal transduction from an information theoretic approach

Uda, S. & Kuroda, S., 3 1 2016, : : Seminars in Cell and Developmental Biology. 51, p. 24-31 8 p.

研究成果: ジャーナルへの寄稿評論記事

Signal Transduction
Information Theory
Cell Differentiation
Cell Death
Cell Proliferation
1 引用 (Scopus)

Laguerre filter analysis with partial least square regression reveals a priming effect of ERK and CREB on c-FOS induction

Kudo, T., Uda, S., Tsuchiya, T., Wada, T., Karasawa, Y., Fujii, M., Saito, T. H. & Kuroda, S., 8 2016, : : PloS one. 11, 8, e0160548.

研究成果: ジャーナルへの寄稿記事

Least-Squares Analysis
mitogen-activated protein kinase
least squares
Molecules
Immediate-Early Genes
7 引用 (Scopus)

Selective control of up-regulated and down-regulated genes by temporal patterns and doses of insulin

Sano, T., Kawata, K., Ohno, S., Yugi, K., Kakuda, H., Kubota, H., Uda, S., Fujii, M., Kunida, K., Hoshino, D., Hatano, A., Ito, Y., Sato, M., Suzuki, Y. & Kuroda, S., 11 22 2016, : : Science Signaling. 9, 455, ra112.

研究成果: ジャーナルへの寄稿記事

Genes
Insulin
Transcription
RNA Stability
Medical problems
2015
10 引用 (Scopus)

Glucose homeostatic law: Insulin clearance predicts the progression of glucose intolerance in humans

Ohashi, K., Komada, H., Uda, S., Kubota, H., Iwaki, T., Fukuzawa, H., Komori, Y., Fujii, M., Toyoshima, Y., Sakaguchi, K., Ogawa, W. & Kuroda, S., 12 1 2015, : : PloS one. 10, 12, A38.

研究成果: ジャーナルへの寄稿記事

Glucose Intolerance
glucose tolerance
insulin
Insulin
Glucose
2014
39 引用 (Scopus)

Reconstruction of insulin signal flow from phosphoproteome and metabolome data

Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K. I., Kashikura, K., Endo, K., Ikeda, K., Soga, T. & Kuroda, S., 8 21 2014, : : Cell Reports. 8, 4, p. 1171-1183 13 p.

研究成果: ジャーナルへの寄稿記事

Metabolome
Phosphorylation
Homeostasis
Liver Type Phosphofructokinase-1
Insulin
2013
58 引用 (Scopus)

Robustness and compensation of information transmission of signaling pathways

Uda, S., Saito, T. H., Kudo, T., Kokaji, T., Tsuchiya, T., Kubota, H., Komori, Y., Ozaki, Y. I. & Kuroda, S., 1 1 2013, : : Science. 341, 6145, p. 558-561 4 p.

研究成果: ジャーナルへの寄稿記事

Intercellular Signaling Peptides and Proteins
Entropy
Neurites
Pharmacology
Gene Expression
15 引用 (Scopus)

Temporal Decoding of MAP Kinase and CREB Phosphorylation by Selective Immediate Early Gene Expression

Saito, T. H., Uda, S., Tsuchiya, T., Ozaki, Y. I. & Kuroda, S., 3 4 2013, : : PloS one. 8, 3, e57037.

研究成果: ジャーナルへの寄稿記事

Phosphorylation
Immediate-Early Genes
mitogen-activated protein kinase
Gene expression
Decoding
3 引用 (Scopus)

The Extraction of Simple Relationships in Growth Factor-Specific Multiple-Input and Multiple-Output Systems in Cell-Fate Decisions by Backward Elimination PLS Regression

Akimoto, Y., Yugi, K., Uda, S., Kudo, T., Komori, Y., Kubota, H. & Kuroda, S., 9 9 2013, : : PloS one. 8, 9, e72780.

研究成果: ジャーナルへの寄稿記事

Least-Squares Analysis
mitogen-activated protein kinase
growth factors
least squares
Intercellular Signaling Peptides and Proteins
2012
17 引用 (Scopus)

Latent process genes for cell differentiation are common decoders of neurite extension length

Watanabe, K., Akimoto, Y., Yugi, K., Uda, S., Chung, J., Nakamuta, S., Kaibuchi, K. & Kuroda, S., 5 1 2012, : : Journal of Cell Science. 125, 9, p. 2198-2211 14 p.

研究成果: ジャーナルへの寄稿記事

Neurites
Cell Differentiation
Genes
Nerve Growth Factors
Nerve Growth Factor
15 引用 (Scopus)

Sensitivity control through attenuation of signal transfer efficiency by negative regulation of cellular signalling

Toyoshima, Y., Kakuda, H., Fujita, K. A., Uda, S. & Kuroda, S., 4 4 2012, : : Nature communications. 3, 1745.

研究成果: ジャーナルへの寄稿記事

Cell signaling
S 6
MAP Kinase Signaling System
Epidermal Growth Factor Receptor
attenuation
63 引用 (Scopus)

Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway

Kubota, H., Noguchi, R., Toyoshima, Y., Ozaki, Y. I., Uda, S., Watanabe, K., Ogawa, W. & Kuroda, S., 6 29 2012, : : Molecular Cell. 46, 6, p. 820-832 13 p.

研究成果: ジャーナルへの寄稿記事

Insulin
Phosphorylation
Ribosomal Protein S6 Kinases
Glycogen Synthase Kinase 3
Glucose-6-Phosphatase
2010
23 引用 (Scopus)

A quantitative image cytometry technique for time series or population analyses of signaling networks

Ozaki, Y. I., Uda, S., Saito, T. H., Chung, J., Kubota, H. & Kuroda, S., 9 10 2010, : : PloS one. 5, 4, e9955.

研究成果: ジャーナルへの寄稿記事

Image Cytometry
Cell signaling
Time series
time series analysis
Systems Biology
41 引用 (Scopus)

Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics

Fujita, K. A., Toyoshima, Y., Uda, S., Ozaki, Y. I., Kubota, H. & Kuroda, S., 7 27 2010, : : Science Signaling. 3, 132, p. ra56

研究成果: ジャーナルへの寄稿記事

Phosphorylation
Low pass filters
Epidermal Growth Factor Receptor
Molecules
Ribosomal Protein S6
33 引用 (Scopus)

Timing-dependent actions of NGF required for cell differentiation

Chung, J., Kubota, H., Ozaki, Y. I., Uda, S. & Kuroda, S., 2 2 2010, : : PloS one. 5, 2, e9011.

研究成果: ジャーナルへの寄稿記事

Nerve Growth Factor
cell differentiation
neurites
Cell Differentiation
phosphatidylinositol 3-kinase
2009

Specific features of transient Ras and sustained Rap1 activation

Ozaki, Y., Uda, S. & Kuroda, S., 2009, Systems Biology: the Challenge of Complexity Springer . p. 121-127

研究成果: 著書/レポートタイプへの貢献章 (査読済み)

2006
41 引用 (Scopus)

Analysis of CDMA systems that are characterized by eigenvalue spectrum

Takeda, K., Uda, S. & Kabashima, Y., 2006, : : Europhysics Letters. 76, p. 1193-1199

研究成果: ジャーナルへの寄稿記事

2005
11 引用 (Scopus)

Statistical mechanical development of a sparse Bayesian classifier

Uda, S. & Kabashima, Y., 2005, : : Journal of the Physical Society of Japan. 74, p. 2233-2242

研究成果: ジャーナルへの寄稿記事

2004
6 引用 (Scopus)

A BP-Based Algorithm for Performing Bayesian Inference in Large Perceptron-Type Networks

Kabashima, Y. & Uda, S., 2004, International Conference on Algorithmic Learning Theory. p. 479-493

研究成果: 著書/レポートタイプへの貢献会議での発言

6 引用 (Scopus)

Minimizing the Cross Validation Error to Mix Kernel Matrices of Heterogeneous Biological Data

Tsuda, K., Uda, S., Kin, T. & Asai, K., 2004, : : Neural Processing Letters. 19, p. 63-72

研究成果: ジャーナルへの寄稿記事